Hypomethylation of dual specificity phosphatase 22 promoter correlates with duration of service in firefighters and is inducible by low-dose benzo[a]pyrene

Journal of Occupational and Environmental Medicine

Volumn 54, Issue 7, 2012, Pages 774-780

  Ouyang, Bin ^a   Baxter, C Stuart ^a   Lam, Hung Ming ^a   Yeramaneni, Samrat ^b   Levin, Linda ^b   Haynes, Erin ^b   Ho, Shuk Mei ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE; DUAL SPECIFICITY PHOSPHATASE; DUAL SPECIFICITY PHOSPHATASE 22; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; COMBUSTION; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA METHYLATION; EPIGENETICS; EPITHELIUM CELL; FEMALE; FIRE FIGHTER; GENE EXPRESSION; GENE MUTATION; HEALTH HAZARD; HUMAN; HUMAN TISSUE; LEUKEMIA CELL LINE; MALE; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; PROMOTER REGION; PROSTATE EPITHELIUM;

ADULT; BENZO(A)PYRENE; CELLS, CULTURED; DNA; DNA METHYLATION; DUAL-SPECIFICITY PHOSPHATASES; FEMALE; FIREFIGHTERS; GENE EXPRESSION REGULATION; HUMANS; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES; OCCUPATIONAL EXPOSURE; PROMOTER REGIONS, GENETIC; PROSTATE; SMOKE;

EID: 84863837640     PISSN: 10762752     EISSN: 15365948     Source Type: Journal    
DOI: 10.1097/JOM.0b013e31825296bc     Document Type: Article

References (37)

1. Ho SM. Environmental epigenetics of asthma: an update. J Allergy Clin Immunol. 2010;126:453-465.
2. Zhang X, Ho SM. Epigenetics meets endocrinology. J Mol Endocrinol. 2011;46:R11-R32.
3. Caux C, O'Brien C, Viau C. Determination of firefighter exposure to polycyclic aromatic hydrocarbons and benzene during fire fighting using measurement of biological indicators. Appl Occup Environ Hyg. 2002;17:379-386. (Pubitemid 34461668)
4. LemastersGK, GenaidyAM, Succop P, et al. Cancer risk among firefighters: A review andmeta-analysis of 32 studies. J Occup Environ Med. 2006;48:1189-1202. (Pubitemid 44739915)
5. Edelman P, Osterloh J, Pirkle J, et al. Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse. Environ Health Perspect. 2003;111:1906-1911. (Pubitemid 37541202)
6. Baxter CS, Ross CS, Fabian T, et al. Ultrafine particle exposure during fire suppression-is it an important contributory factor for coronary heart disease in firefighters? J Occup Environ Med. 2010;52:791-796.
7. Byczek L, Walton SM, Conrad KM, Reichelt PA, Samo DG. Cardiovascular risks in firefighters: implications for occupational health nurse practice. AAOHN J. 2004;52:66-76.
8. Schulte PA, Burnett CA, Boeniger MF, Johnson J. Neurodegenerative diseases: occupational occurrence and potential risk factors, 1982 through 1991. Am J Public Health. 1996;86:1281-1288. (Pubitemid 26314416)
9. Baird WM, Hooven LA, Mahadevan B. Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action. Environ Mol Mutagen. 2005;45:106-114.
10. Ramos KS, Moorthy B. Bioactivation of polycyclic aromatic hydrocarbon carcinogens within the vascular wall: implications for human atherogenesis. Drug Metab Rev. 2005;37:595-610. (Pubitemid 43068150)
11. Lewtas J. Air pollution combustion emissions: characterization of causative agents and mechanisms associated with cancer, reproductive, and cardiovascular effects. Mutat Res. 2007;636:95-133. (Pubitemid 350123761)
12. Chen A, Dietrich KN, Huo X, Ho SM. Developmental neurotoxicants in ewaste: an emerging health concern. Environ Health Perspect. 2011;119:431-438.
13. Pavanello S, Bollati V, Pesatori AC, et al. Global and gene-specific promoter methylation changes are related to anti-B[a]PDE-DNA adduct levels and influence micronuclei levels in polycyclic aromatic hydrocarbon-exposed individuals. Int J Cancer. 2009;125:1692-1697.
14. Perera F, Tang WY, Herbstman J, et al. Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS One. 2009;4:e4488.
15. Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 2003;33(suppl):245-254. (Pubitemid 36278835)
16. Szyf M. The implications of DNA methylation for toxicology: toward toxicomethylomics, the toxicology of DNA methylation. Toxicol Sci. 2011;120:235-255.
17. Tang WY, Ho SM. Epigenetic reprogramming and imprinting in origins of disease. Rev Endocr Metab Disord. 2007;8:173-182.
18. Jones PA, Laird PW. Cancer epigenetics comes of age. Nat Genet. 1999;21:163-167. (Pubitemid 29070360)
19. Gluckman PD, Hanson MA, Buklijas T, Low FM, Beedle AS. Epigenetic mechanisms that underpin metabolic and cardiovascular diseases. Nat Rev Endocrinol. 2009;5:401-408.
20. Watanabe Y, Maekawa M. Methylation of DNA in cancer. Adv Clin Chem. 2010;52:145-167.
21. Liu J, BallaneyM,Al-alem U, et al. Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo. Toxicol Sci. 2008;102:76-81. (Pubitemid 351265126)
22. Zhang YJ, Chen Y, Ahsan H, et al. Silencing of glutathione S-transferase P1 by promoter hypermethylation and its relationship to environmental chemical carcinogens in hepatocellular carcinoma. Cancer Lett. 2005;221: 135-143. (Pubitemid 40460400)
23. BatesMN. Registry-based case-control study of cancer in California firefighters. Am J Ind Med. 2007;50:339-344. (Pubitemid 46786851)
24. Mobley JA, Leav I, Zielie P, et al. Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitro. Cancer Epidemiol Biomarkers Prev. 2003;12:775-783. (Pubitemid 36993169)
25. Ho SM, Tang WY, Belmonte de FJ, Prins GS. Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res. 2006;66:5624-5632. (Pubitemid 43927114)
26. Bock C, Reither S, Mikeska T, Paulsen M, Walter J, Lengauer T. BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing. Bioinformatics. 2005;21:4067-4068. (Pubitemid 41631851)
27. Ouyang B, Bracken B, Burke B, Chung E, Liang J, Ho SM. A duplex quantitative polymerase chain reaction assay based on quantification of alpha-methylacyl-CoA racemase transcripts and prostate cancer antigen 3 in urine sediments improved diagnostic accuracy for prostate cancer. J Urol. 2009;181:2508-2513.
28. Wu T, Giovannucci E,Welge J,Mallick P, TangWY, Ho SM.Measurement of GSTP1 promotermethylation in body fluidsmay complement PSA screening: A meta-analysis.
29. Cragun JM. Screening for ovarian cancer. Cancer Control. 2011;18:16-21.
30. Ehrlich Y, Baniel J. Late relapse of testis cancer. Urol Clin North Am. 2007;34:253-258. (Pubitemid 46680532)
31. Perrin J, Tassistro V, Mandon M, Grillo JM,Botta A, Sari-Minodier I. Tobacco consumption and benzo(a)pyrene-diol-epoxide-DNAadducts in spermatozoa: in smokers, swim-up procedure selects spermatozoa with decreased DNA damage. Fertil Steril. 2011;95:2013-2017.
32. Patterson KI, Brummer T, O'Brien PM, Daly RJ. Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J. 2009;418:475-489.
33. Chen AJ, Zhou G, Juan T, et al. The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway. J Biol Chem. 2002;277: 36592-36601.
34. Aoyama K, Nagata M, Oshima K, Matsuda T, Aoki N. Molecular cloning and characterization of a novel dual specificity phosphatase, LMWDSP2, that lacks the cdc25 homology domain. J Biol Chem. 2001;276: 27575-27583.
35. Alonso A,Merlo JJ, Na S, et al. Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity phosphatase related to VH1 related (VHR). J Biol Chem. 2002;277:5524-5528. (Pubitemid 34968603)
36. Sekine Y, Ikeda O, Hayakawa Y, et al. DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118. Oncogene. 2007;26:6038-6049. (Pubitemid 47373806)
37. Feldman AL, Dogan A, Smith DI, et al. Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing. Blood. 2011;117:915-919.