Polyclonal T-cell responses to cytochrome P450IID6 are associated with disease activity in autoimmune hepatitis type 2

Gastroenterology

Volumn 130, Issue 3, 2006, Pages 868-882

  Ma, Yun ^a   Bogdanos, Dimitrios P ^a   Hussain, Munther J ^a   Underhill, James ^a   Bansal, Sanjay ^a   Longhi, Maria Serena ^a   Cheeseman, Paul ^a   Mieli Vergani, Giorgina ^a   Vergani, Diego ^a  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2D6; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 4;

ADULT; ARTICLE; AUTOIMMUNE HEPATITIS; B LYMPHOCYTE; BINDING AFFINITY; CELL PROLIFERATION; CELLULAR IMMUNITY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; RELAPSE; REMISSION; T LYMPHOCYTE;

EID: 33644852500     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2005.12.020     Document Type: Article

References (48)

1. G.V. Gregorio, B. Portmann, F. Reid, P.T. Donaldson, D.G. Doherty, M. McCartney, A.P. Mowat, D. Vergani, G. Mieli-Vergani Autoimmune hepatitis in childhood a 20-year experience Hepatology 25 1997 541 547
2. F. Alvarez, P.A. Berg, F.B. Bianchi, L. Bianchi, A.K. Burroughs, E.L. Cancado, R.W. Chapman, W.G. Cooksley, A.J. Czaja, V.J. Desmet, P.T. Donaldson, A.L. Eddleston, L. Fainboim, J. Heathcote, J.C. Homberg, J.H. Hoofnagle, S. Kakumu, E.L. Krawitt, I.R. Mackay, R.N. MacSween, W.C. Maddrey, M.P. Manns, I.G. McFarlane, K.H. Meyer zum Buschenfelde, M. Zeniya International Autoimmune Hepatitis Group Report review of criteria for diagnosis of autoimmune hepatitis J Hepatol 31 1999 929 938
3. A.J. Czaja, P.T. Donaldson Genetic susceptibilities for immune expression and liver cell injury in autoimmune hepatitis Immunol Rev 174 2000 250 259
4. F. Alvarez, O. Bernard, J.C. Homberg, G. Kreibich Anti-liver-kidney microsome antibody recognizes a 50,000 molecular weight protein of the endoplasmic reticulum J Exp Med 161 1985 1231 1236
5. M.P. Manns, K.J. Griffin, K.F. Sullivan, E.F. Johnson LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase J Clin Invest 88 1991 1370 1378
6. N. Kerkar, K. Choudhuri, Y. Ma, A. Mahmoud, D.P. Bogdanos, L. Muratori, F. Bianchi, R. Williams, G. Mieli-Vergani, D. Vergani Cytochrome P4502D6(193-212) a new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease J Immunol 170 2003 1481 1489
7. Y. Ma, M.G. Thomas, M. Okamoto, D.P. Bogdanos, S. Nagl, N. Kerkar, A.R. Lopes, L. Muratori, M. Lenzi, F.B. Bianchi, G. Mieli-Vergani, D. Vergani Key residues of a major cytochrome P4502D6 epitope are located on the surface of the molecule J Immunol 169 2002 277 285
8. D. Vergani, K. Choudhuri, D.P. Bogdanos, G. Mieli-Vergani Pathogenesis of autoimmune hepatitis Clin Liver Dis 6 2002 439 449
9. H.F. Lohr, J.F. Schlaak, A.W. Lohse, W.O. Bocher, M. Arenz, G. Gerken, K.H. Meyer Zum Buschenfelde Autoreactive CD4+ LKM-specific and anticlonotypic T-cell responses in LKM-1 antibody-positive autoimmune hepatitis Hepatology 24 1996 1416 1421
10. P.A. Reche, J.P. Glutting, E.L. Reinherz Prediction of MHC class I binding peptides using profile motifs Hum Immunol 63 2002 701 709
11. M.J. Hussain, J. Maher, T. Warnock, A. Vats, M. Peakman, D. Vergani Cytokine overproduction in healthy first degree relatives of patients with IDDM Diabetologia 41 1998 343 349
12. D. Vergani, F. Alvarez, F.B. Bianchi, E.L. Cancado, I.R. Mackay, M.P. Manns, M. Nishioka, E. Penner Liver autoimmune serology a consensus statement from the committee for autoimmune serology of the International Autoimmune Hepatitis Group J Hepatol 41 2004 677 683
13. Y. Ma, G.V. Gregorio, J. Gäken, L. Muratori, F. Bianchi, G. Mieli-Vergani, D. Vergani Establishment of a novel radioligand assay using eukaryotically expressed cytochrome P4502D6 for the measurement of liver kidney microsomal type 1 antibody in patients with autoimmune hepatitis and hepatitis C virus infection J Hepatol 26 1997 1396 1402
14. J.D. Bignon, M.A. Fernandez-Viρa Protocols of the 12th International Histocompatibility Workshop for typing of HLA class II alleles by DNA amplification by polymerase chain reaction (PCR) and hybridization with sequence specific oligonucleotide probes (SSOP) D. Charron Genetic diversity of HLA, functional and medical implications 1 1997 EDK Paris
15. P.T. Donaldson, M. Clare, P.K. Constantini, N. Hadzic, G. Mieli-Vergani, E. Howard, D. Kelley HLA and cytokine gene polymorphisms in biliary atresia Liver 22 2002 213 219
16. G. Mazza, M. Ponsford, P. Lowrey, M.J. Campbell, J. Zajicek, D.C. Wraith Diversity and dynamics of the T-cell response to MBP in DR2+ve individuals Clin Exp Immunol 128 2002 538 547
17. D.E. Kaufmann, P.M. Bailey, J. Sidney, B. Wagner, P.J. Norris, M.N. Johnston, L.A. Cosimi, M.M. Addo, M. Lichterfeld, M. Altfeld, N. Frahm, C. Brander, A. Sette, B.D. Walker, E.S. Rosenberg Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides J Virol 78 2004 4463 4477
18. G.M. Lauer, E. Barnes, M. Lucas, J. Timm, K. Ouchi, A.Y. Kim, C.L. Day, G.K. Robbins, D.R. Casson, M. Reiser, G. Dusheiko, T.M. Allen, R.T. Chung, B.D. Walker, P. Klenerman High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection Gastroenterology 127 2004 924 936
19. B. Mazzanti, B. Hemmer, E. Traggiai, C. Ballerini, H.F. McFarland, L. Massacesi, R. Martin, M. Vergelli Decrypting the spectrum of antigen-specific T-cell responses the avidity repertoire of MBP-specific T-cells J Neurosci Res 59 2000 86 93
20. A.K. Mangalam, M. Khare, C. Krco, M. Rodriguez, C. David Identification of T-cell epitopes on human proteolipid protein and induction of experimental autoimmune encephalomyelitis in HLA class II-transgenic mice Eur J Immunol 34 2004 280 290
21. H. Arentz-Hansen, S.N. McAdam, O. Molberg, B. Fleckenstein, K.E. Lundin, T.J. Jorgensen, G. Jung, P. Roepstorff, L.M. Sollid Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues Gastroenterology 123 2002 803 809
22. M.C. Honeyman, N.L. Stone, L.C. Harrison T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2 potential for mimicry with rotavirus and other environmental agents Mol Med 4 1998 231 239
23. K. Yusim, C. Kesmir, B. Gaschen, M.M. Addo, M. Altfeld, S. Brunak, A. Chigaev, V. Detours, B.T. Korber Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type 1 (HIV-1) proteins reveal imprints of immune evasion on HIV-1 global variation J Virol 76 2002 8757 8768
24. C.H. Suh, J.H. Freed, P.L. Cohen T-cell reactivity to MHC class II-bound self peptides in systemic lupus erythematosus-prone MRL/lpr mice J Immunol 15 2003 2229 2235 170
25. M. Peakman, E.J. Stevens, T. Lohmann, P. Narendran, J. Dromey, A. Alexander, A.J. Tomlinson, M. Trucco, J.C. Gorga, R.M. Chicz Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4 J Clin Invest 104 1999 1449 1457
26. L. Wen, M. Peakman, A. Lobo-Yeo, B.M. McFarlane, A.P. Mowat, G. Mieli-Vergani, D. Vergani T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis Lancet 2 1990 1527 1530
27. M.S. Longhi, Y. Ma, D.P. Bogdanos, P. Cheeseman, G. Mieli-Vergani, D. Vergani Impairment of CD4(+)CD25(+) regulatory T cells in autoimmune liver disease J Hepatol 41 2004 31 37
28. M.S. Longhi, Y. Ma, R.R. Mitry, D.P. Bogdanos, M. Heneghan, P. Cheeseman, G. Mieli-Vergani, D. Vergani Effect of CD4+CD25+ regulatory T cells on CD8 T-cell function in patients with autoimmune hepatitis J Autoimmun 25 2005 63 71
29. Y. Ma, M.S. Longhi, D.P. Bogdanos, G. Mieli-Vergani, D. Vergani Functional impairment of CD25+CD4+ regulatory T cells characterizes autoimmune hepatitis type 2 Hepatology 38 Suppl 1 2003 163A
30. P.V. Lehmann, T. Forsthuber, A. Miller, E.E. Sercarz Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen Nature 358 1992 155 157
31. C.L. Vanderlugt, S.D. Miller Epitope spreading in immune-mediated diseases implications for immunotherapy Nat Rev Immunol 2 2002 85 95
32. B.L. McRae, C.L. Vanderlugt, M.C. Dal Canto, S.D. Miller Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis J Exp Med 182 1995 75 85
33. M. Yu, J.M. Johnson, V.K. Tuohy A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis a basis for peptide-specific therapy after onset of clinical disease J Exp Med 183 1996 1777 1788
34. B. Brooks-Worrell, V.H. Gersuk, C. Greenbaum, J.P. Palmer Intermolecular antigen spreading occurs during the preclinical period of human type 1 diabetes J Immunol 166 2001 5265 5270
35. J.A. James, M.J. Mamula, J.B. Harley Sequential autoantigenic determinants of the small nuclear ribonucleoprotein Sm D shared by human lupus autoantibodies and MRL lpr/lpr antibodies Clin Exp Immunol 98 1994 419 426
36. A. Ueki, Y. Isozaki, A. Tomokuni, T. Hatayama, H. Ueki, M. Kusaka, M. Shiwa, H. Arikuni, T. Takeshita, K. Morimoto Intramolecular epitope spreading among anti-caspase-8 autoantibodies in patients with silicosis, systemic sclerosis and systemic lupus erythematosus, as well as in healthy individuals Clin Exp Immunol 129 2002 556 561
37. A. Alam, N. Lambert, J. Lule, H. Coppin, B. Mazieres, C. de Preval, A. Cantagrel Persistence of dominant T-cell clones in synovial tissues during rheumatoid arthritis J Immunol 156 1996 3480 3485
38. J.D. Altman, P.A. Moss, P.J. Goulder, D.H. Barouch, M.G. McHeyzer-Williams, J.I. Bell, A.J. McMichael, M.M. Davis Phenotypic analysis of antigen-specific T lymphocytes Science 4 1996 94 96 274
39. W.W. Kwok, J.A. Gebe, A. Liu, S. Agar, N. Ptacek, J. Hammer, D.M. Koelle, G.T. Nepom Rapid epitope identification from complex class-II-restricted T-cell antigens Trends Immunol 22 2001 583 588
40. M.S. Longhi, Y. Ma, D.P. Bogdanos, G. Mieli-Vergani, D. Vergani Immunodominant HLA-A2 restricted CD8 T-cell epitope in autoimmune hepatitis type 2 Hepatology 40 Suppl 1 2004 422A
41. K.W. Wucherpfennig, I. Catz, S. Hausmann, J.L. Strominger, L. Steinman, K.G. Warren Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients Identity of key contact residues in the B-cell and T-cell epitopes J Clin Invest 100 1997 1114 1122
42. S. Shimoda, J. Van de Water, A. Ansari, M. Nakamura, H. Ishibashi, R.L. Coppel, J. Lake, E.B. Keeffe, T.E. Roche, M.E. Gershwin Identification and precursor frequency analysis of a common T-cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis J Clin Invest 102 1998 1831 1840
43. J.A. Dromey, S.M. Weenink, G.H. Peters, J. Endl, P.J. Tighe, I. Todd, M.R. Christie Mapping of epitopes for autoantibodies to the type 1 diabetes autoantigen IA-2 by peptide phage display and molecular modeling overlap of antibody and T cell determinants J Immunol 172 2004 4084 4090
44. S. Amigorena, C. Bonnerot Role of B-cell and Fc receptors in the selection of T-cell epitopes Curr Opin Immunol 10 1998 88 92
45. B.C. Barnett, C.M. Graham, D.S. Burt, J.J. Skehel, D.B. Thomas The immune response of BALB/c mice to influenza hemagglutinin commonality of the B-cell and T-cell repertoires and their relevance to antigenic drift Eur J Immunol 19 1989 515 521
46. A.N. Antoniou, S.L. Blackwood, D. Mazzeo, C. Watts Control of antigen presentation by a single protease cleavage site Immunity 12 2000 391 398
47. J. Sloan-Lancaster, P.M. Allen Altered peptide ligand-induced partial T-cell activation molecular mechanisms and role in T-cell biology Annu Rev Immunol 14 1996 1 27
48. R. Mallone, S.A. Kochik, H. Reijonen, B. Carson, S.F. Ziegler, W.W. Kwok, G.T. Nepom Functional avidity directs T-cell fate in autoreactive CD4+ T cells Blood 106 2005 2798 2805