메뉴 건너뛰기




Volumn 22, Issue 8, 2015, Pages 1250-1259

Molecular mechanisms of Ebola virus pathogenesis: Focus on cell death

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; INTERFERON;

EID: 84935696105     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2015.67     Document Type: Review
Times cited : (124)

References (115)
  • 2
    • 33646584499 scopus 로고    scopus 로고
    • Ebola virus: Unravelling pathogenesis to combat a deadly disease
    • Hoenen T, Groseth A, Falzarano D, Feldmann H. Ebola virus: unravelling pathogenesis to combat a deadly disease. Trends Mol Med 2006; 12: 206-215.
    • (2006) Trends Mol Med , vol.12 , pp. 206-215
    • Hoenen, T.1    Groseth, A.2    Falzarano, D.3    Feldmann, H.4
  • 3
    • 84920842318 scopus 로고    scopus 로고
    • Less is more: Ebola surface glycoprotein expression levels regulate virus production and infectivity
    • Mohan GS, Ye L, Li W, Monteiro A, Lin X, Sapkota B et al. Less is more: Ebola surface glycoprotein expression levels regulate virus production and infectivity. J Virol 2014; 89: 1205-1217.
    • (2014) J Virol , vol.89 , pp. 1205-1217
    • Mohan, G.S.1    Ye, L.2    Li, W.3    Monteiro, A.4    Lin, X.5    Sapkota, B.6
  • 4
    • 38449115436 scopus 로고    scopus 로고
    • Ebola virus (EBOV) VP24 inhibits transcription and replication of the EBOV genome
    • Watanabe S, Noda T, Halfmann P, Jasenosky L, Kawaoka Y. Ebola virus (EBOV) VP24 inhibits transcription and replication of the EBOV genome. J Infect Dis 2007; 196: S284-S290.
    • (2007) J Infect Dis , vol.196 , pp. S284-S290
    • Watanabe, S.1    Noda, T.2    Halfmann, P.3    Jasenosky, L.4    Kawaoka, Y.5
  • 5
    • 77953742423 scopus 로고    scopus 로고
    • Oligomerization of Ebola virus VP40 is essential for particle morphogenesis and regulation of viral transcription
    • Hoenen T, Biedenkopf N, Zielecki F, Jung S, Groseth A, Feldmann H et al. Oligomerization of Ebola virus VP40 is essential for particle morphogenesis and regulation of viral transcription. J Virol 2010; 84: 7053-7063.
    • (2010) J Virol , vol.84 , pp. 7053-7063
    • Hoenen, T.1    Biedenkopf, N.2    Zielecki, F.3    Jung, S.4    Groseth, A.5    Feldmann, H.6
  • 6
    • 84912575573 scopus 로고    scopus 로고
    • Nomenclatureand database-compatible names for the two Ebola virus variants that emerged in Guinea and the Democratic Republic of the Congo in 2014
    • Kuhn JH, Andersen KG, Baize S, Baò Y, Bavari S, Berthet N et al. Nomenclatureand database-compatible names for the two Ebola virus variants that emerged in Guinea and the Democratic Republic of the Congo in 2014.Viruses 2014; 6: 4760-4799.
    • (2014) Viruses , vol.6 , pp. 4760-4799
    • Kuhn, J.H.1    Andersen, K.G.2    Baize, S.3    Baò, Y.4    Bavari, S.5    Berthet, N.6
  • 7
    • 79952363727 scopus 로고    scopus 로고
    • Ebola haemorrhagic fever
    • Feldmann H, Geisbert TW. Ebola haemorrhagic fever. Lancet 2011; 377: 849-862.
    • (2011) Lancet , vol.377 , pp. 849-862
    • Feldmann, H.1    Geisbert, T.W.2
  • 8
    • 0036239229 scopus 로고    scopus 로고
    • Association of the caveola vesicular system with cellular entry by filoviruses
    • Empig CJ, Goldsmith MA. Association of the caveola vesicular system with cellular entry by filoviruses. J Virol 2002; 76: 5266-5270.
    • (2002) J Virol , vol.76 , pp. 5266-5270
    • Empig, C.J.1    Goldsmith, M.A.2
  • 9
    • 38449106461 scopus 로고    scopus 로고
    • Analysis of filovirus entry into vero e6 cells, using inhibitors of endocytosis, endosomal acidification, structural integrity, and cathepsin (B and L) activity
    • Sanchez A. Analysis of filovirus entry into vero e6 cells, using inhibitors of endocytosis, endosomal acidification, structural integrity, and cathepsin (B and L) activity. J Infect Dis 2007; 196: S251-S258.
    • (2007) J Infect Dis , vol.196 , pp. S251-S258
    • Sanchez, A.1
  • 10
    • 78149355646 scopus 로고    scopus 로고
    • Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner
    • Nanbo A, Imai M, Watanabe S, Noda T, Takahashi K, Neumann G et al. Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner. PLoS Pathog 2010; 6: e1001121.
    • (2010) PLoS Pathog , vol.6 , pp. e1001121
    • Nanbo, A.1    Imai, M.2    Watanabe, S.3    Noda, T.4    Takahashi, K.5    Neumann, G.6
  • 11
    • 78149301316 scopus 로고    scopus 로고
    • Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes
    • Saeed MF, Kolokoltsov AA, Albrecht T, Davey RA. Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes. PLoS Pathog 2010; 6: e1001110.
    • (2010) PLoS Pathog , vol.6 , pp. e1001110
    • Saeed, M.F.1    Kolokoltsov, A.A.2    Albrecht, T.3    Davey, R.A.4
  • 12
    • 78650045778 scopus 로고    scopus 로고
    • The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus
    • Hunt CL, Kolokoltsov AA, Davey RA, Maury W. The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus. J Virol 2011; 85: 334-347.
    • (2011) J Virol , vol.85 , pp. 334-347
    • Hunt, C.L.1    Kolokoltsov, A.A.2    Davey, R.A.3    Maury, W.4
  • 15
    • 80054774353 scopus 로고    scopus 로고
    • Ebola virus enters host cells by macropinocytosis and clathrin-mediated endocytosis
    • Aleksandrowicz P, Marzi A, Biedenkopf N, Beimforde N, Becker S, Hoenen T et al. Ebola virus enters host cells by macropinocytosis and clathrin-mediated endocytosis. JID 2011; 204: S957-S967.
    • (2011) JID , vol.204 , pp. S957-S967
    • Aleksandrowicz, P.1    Marzi, A.2    Biedenkopf, N.3    Beimforde, N.4    Becker, S.5    Hoenen, T.6
  • 16
    • 0034610176 scopus 로고    scopus 로고
    • Downregulation of beta1 integrins by Ebola virus glycoprotein: Implication for virus entry
    • Takada A, Watanabe S, Ito H, Okazaki K, Kida H, Kawaoka Y. Downregulation of beta1 integrins by Ebola virus glycoprotein: implication for virus entry. Virology 2000; 278: 20-26.
    • (2000) Virology , vol.278 , pp. 20-26
    • Takada, A.1    Watanabe, S.2    Ito, H.3    Okazaki, K.4    Kida, H.5    Kawaoka, Y.6
  • 17
    • 84873494065 scopus 로고    scopus 로고
    • Cholesterol dependence of collagen and echovirus 1 trafficking along the novel 21 integrin internalization pathway
    • Siljamäki E, Rintanen N, Kirsi M, Upla P, Wang W, Karjalainen M et al. Cholesterol dependence of collagen and echovirus 1 trafficking along the novel 21 integrin internalization pathway. PLoS One 2013; 8: e55465.
    • (2013) PLoS One , vol.8 , pp. e55465
    • Siljamäki, E.1    Rintanen, N.2    Kirsi, M.3    Upla, P.4    Wang, W.5    Karjalainen, M.6
  • 18
    • 84857668041 scopus 로고    scopus 로고
    • Filovirus entry: A novelty in the viral fusion world
    • Hunt CL, Lennemann NJ, Maury W. Filovirus entry: a novelty in the viral fusion world. Viruses 2012; 4: 258-275.
    • (2012) Viruses , vol.4 , pp. 258-275
    • Hunt, C.L.1    Lennemann, N.J.2    Maury, W.3
  • 19
    • 0037018099 scopus 로고    scopus 로고
    • Lipid raft microdomains: A gateway for compartmentalized trafficking of Ebola and Marburg viruses
    • Bavari S, Bosio CM, Wiegand E, Ruthel G, Will AB, Geisbert TW et al. Lipid raft microdomains: a gateway for compartmentalized trafficking of Ebola and Marburg viruses. J Exp Med 2002; 195: 593-602.
    • (2002) J Exp Med , vol.195 , pp. 593-602
    • Bavari, S.1    Bosio, C.M.2    Wiegand, E.3    Ruthel, G.4    Will, A.B.5    Geisbert, T.W.6
  • 21
    • 80052868218 scopus 로고    scopus 로고
    • Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection
    • Côté M, Misasi J, Ren T, Bruchez A, Lee K, Filone CM et al. Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection. Nature 2011; 477: 344-348.
    • (2011) Nature , vol.477 , pp. 344-348
    • Côté, M.1    Misasi, J.2    Ren, T.3    Bruchez, A.4    Lee, K.5    Filone, C.M.6
  • 22
    • 84859907529 scopus 로고    scopus 로고
    • Ebola virus entry requires the host-programmed recognition of an intracellular receptor
    • Miller EH, Obernosterer G, Raaben M, Herbert AS, Deffieu MS, Krishnan A et al. Ebola virus entry requires the host-programmed recognition of an intracellular receptor. EMBO J 2012; 31: 1947-1960.
    • (2012) EMBO J , vol.31 , pp. 1947-1960
    • Miller, E.H.1    Obernosterer, G.2    Raaben, M.3    Herbert, A.S.4    Deffieu, M.S.5    Krishnan, A.6
  • 23
    • 0842282793 scopus 로고    scopus 로고
    • Brasseur R Distribution of hydrophobic, residues is crucial for the fusogenic properties of the Ebola virus GP2 fusion peptide
    • Adam B, Lins L, Stroobant V, Thomas A. Brasseur R Distribution of hydrophobic, residues is crucial for the fusogenic properties of the Ebola virus GP2 fusion peptide. J Virol 2004; 78: 2131-2136.
    • (2004) J Virol , vol.78 , pp. 2131-2136
    • Adam, B.1    Lins, L.2    Stroobant, V.3    Thomas, A.4
  • 24
    • 84863393651 scopus 로고    scopus 로고
    • Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change
    • Brecher M, Schornberg KL, Delos SE, Fusco ML, Saphire EO, White JM. Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change. J Virol 2012; 86: 364-372.
    • (2012) J Virol , vol.86 , pp. 364-372
    • Brecher, M.1    Schornberg, K.L.2    Delos, S.E.3    Fusco, M.L.4    Saphire, E.O.5    White, J.M.6
  • 25
    • 84874711539 scopus 로고    scopus 로고
    • A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species-and cell-typespecific manner
    • Martinez O, Ndungo E, Tantral L, Miller EH, Leung LW, Chandran K et al. A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species-and cell-typespecific manner. J Virol 2013; 87: 3324-3334.
    • (2013) J Virol , vol.87 , pp. 3324-3334
    • Martinez, O.1    Ndungo, E.2    Tantral, L.3    Miller, E.H.4    Leung, L.W.5    Chandran, K.6
  • 26
    • 0035666691 scopus 로고    scopus 로고
    • Haematological, biochemical and coagulation changes in mice, Guinea-pigs and monkeys infected with a mouse-adapted variant of Ebola Zaire virus
    • Bray M, Hatfill S, Hensley L, Huggins JW. Haematological, biochemical and coagulation changes in mice, guinea-pigs and monkeys infected with a mouse-adapted variant of Ebola Zaire virus. J Comp Pathol 2001; 125: 243-253.
    • (2001) J Comp Pathol , vol.125 , pp. 243-253
    • Bray, M.1    Hatfill, S.2    Hensley, L.3    Huggins, J.W.4
  • 27
    • 0348147492 scopus 로고    scopus 로고
    • Ebola hemorrhagic fever and septic shock
    • Bray M, Mahanty S. Ebola hemorrhagic fever and septic shock. J Infect Dis 2003; 188: 1613-1617.
    • (2003) J Infect Dis , vol.188 , pp. 1613-1617
    • Bray, M.1    Mahanty, S.2
  • 28
    • 0348053693 scopus 로고    scopus 로고
    • Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: Overexpression of tissue factor in primate monocytes/macrophages is a key event
    • Geisbert TW, Young HA, Jahrling PB, Davis KJ, Kagan E, Hensley LE. Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event. J Infect Dis 2003; 188: 1618-1629.
    • (2003) J Infect Dis , vol.188 , pp. 1618-1629
    • Geisbert, T.W.1    Young, H.A.2    Jahrling, P.B.3    Davis, K.J.4    Kagan, E.5    Hensley, L.E.6
  • 29
    • 10744224131 scopus 로고    scopus 로고
    • Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: Evidence that dendritic cells are early and sustained targets of infection
    • Geisbert TW, Hensley LE, Larsen T, Young HA, Reed DS, Geisbert JB et al. Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection. Am J Pathol 2003; 163: 2347-2370.
    • (2003) Am J Pathol , vol.163 , pp. 2347-2370
    • Geisbert, T.W.1    Hensley, L.E.2    Larsen, T.3    Young, H.A.4    Reed, D.S.5    Geisbert, J.B.6
  • 30
    • 0043166564 scopus 로고    scopus 로고
    • Protection from lethal infection is determined by innate immune responses in a mouse model of Ebola virus infection
    • Mahanty S, Gupta M, Paragas J, Bray M, Ahmed R, Rollin PE. Protection from lethal infection is determined by innate immune responses in a mouse model of Ebola virus infection. Virology 2003; 312: 415-424.
    • (2003) Virology , vol.312 , pp. 415-424
    • Mahanty, S.1    Gupta, M.2    Paragas, J.3    Bray, M.4    Ahmed, R.5    Rollin, P.E.6
  • 31
    • 38449099004 scopus 로고    scopus 로고
    • Cytokine and chemokine expression in humans infected with Sudan Ebola virus
    • Hutchinson KL, Rollin PE. Cytokine and chemokine expression in humans infected with Sudan Ebola virus. J Infect Dis 2007; 196: S357-S363.
    • (2007) J Infect Dis , vol.196 , pp. S357-S363
    • Hutchinson, K.L.1    Rollin, P.E.2
  • 32
    • 84922325609 scopus 로고    scopus 로고
    • Clinical features and pathobiology of Ebolavirus infection
    • Ansari AA. Clinical features and pathobiology of Ebolavirus infection. J Autoimmun 2014; 55C: 1-9.
    • (2014) J Autoimmun , vol.55 C , pp. 1-9
    • Ansari, A.A.1
  • 33
    • 84908312337 scopus 로고    scopus 로고
    • Camouflage and misdirection: The full-on assault of Ebola virus disease
    • Misasi J, Sullivan NJ. Camouflage and misdirection: the full-on assault of Ebola virus disease. Cell 2014; 159: 477-486.
    • (2014) Cell , vol.159 , pp. 477-486
    • Misasi, J.1    Sullivan, N.J.2
  • 34
    • 0032976232 scopus 로고    scopus 로고
    • Ebola virus selectively inhibits responses to interferons, but not to interleukin-1beta, in endothelial cells
    • Harcourt BH, Sanchez A, Offermann MK. Ebola virus selectively inhibits responses to interferons, but not to interleukin-1beta, in endothelial cells. J Virol 1999; 73: 3491-3496.
    • (1999) J Virol , vol.73 , pp. 3491-3496
    • Harcourt, B.H.1    Sanchez, A.2    Offermann, M.K.3
  • 35
    • 0035947156 scopus 로고    scopus 로고
    • Monocyte-derived human macrophages and peripheral blood mononuclear cells infected with ebola virus secrete MIP-1alpha and TNF-alpha and inhibit poly-IC-induced IFN-alpha in vitro
    • Gupta M, Mahanty S, Ahmed R, Rollin PE. Monocyte-derived human macrophages and peripheral blood mononuclear cells infected with ebola virus secrete MIP-1alpha and TNF-alpha and inhibit poly-IC-induced IFN-alpha in vitro. Virology 2001; 284: 20-25.
    • (2001) Virology , vol.284 , pp. 20-25
    • Gupta, M.1    Mahanty, S.2    Ahmed, R.3    Rollin, P.E.4
  • 37
    • 63149113399 scopus 로고    scopus 로고
    • Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1
    • Prins KC, Cardenas WB, Basler CF. Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1. J Virol 2009; 83: 3069-3077.
    • (2009) J Virol , vol.83 , pp. 3069-3077
    • Prins, K.C.1    Cardenas, W.B.2    Basler, C.F.3
  • 38
    • 69249205651 scopus 로고    scopus 로고
    • Ebola virus VP35 antagonizes PKR activity through its C-terminal interferon inhibitory domain
    • Schumann M, Gantke T, Muhlberger E. Ebola virus VP35 antagonizes PKR activity through its C-terminal interferon inhibitory domain. J Virol 2009; 83: 8993-8997.
    • (2009) J Virol , vol.83 , pp. 8993-8997
    • Schumann, M.1    Gantke, T.2    Muhlberger, E.3
  • 39
    • 37149040796 scopus 로고    scopus 로고
    • Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1
    • Reid SP, Valmas C, Martinez O, Sanchez FM, Basler CF. Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1. J Virol 2007; 81: 13469-13477.
    • (2007) J Virol , vol.81 , pp. 13469-13477
    • Reid, S.P.1    Valmas, C.2    Martinez, O.3    Sanchez, F.M.4    Basler, C.F.5
  • 40
    • 84893075305 scopus 로고    scopus 로고
    • Regulation of type i interferon responses
    • Ivashkiv LB, Donlin LT. Regulation of type I interferon responses. Nat Rev Immunol 2014; 14: 36-49.
    • (2014) Nat Rev Immunol , vol.14 , pp. 36-49
    • Ivashkiv, L.B.1    Donlin, L.T.2
  • 41
    • 30344443054 scopus 로고    scopus 로고
    • Introduction: Interferon signals: What is classical and what is nonclassical
    • Platanias LC. Introduction: interferon signals: what is classical and what is nonclassical J Interferon Cytokine Res 2005; 25: 732.
    • (2005) J Interferon Cytokine Res , vol.25 , pp. 732
    • Platanias, L.C.1
  • 42
    • 59649124256 scopus 로고    scopus 로고
    • Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin
    • Jouvenet N, Neil SJ, Zhadina M, Zang T, Kratovac Z, Lee Y et al. Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin. J Virol 2009; 83: 1837-1844.
    • (2009) J Virol , vol.83 , pp. 1837-1844
    • Jouvenet, N.1    Neil, S.J.2    Zhadina, M.3    Zang, T.4    Kratovac, Z.5    Lee, Y.6
  • 43
    • 34548392739 scopus 로고    scopus 로고
    • An interferon-alpha-induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by the HIV-1 Vpu protein
    • Neil SJ, Sandrin V, Sundquist WI, Bieniasz PD. An interferon-alpha-induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by the HIV-1 Vpu protein. Cell Host Microbe 2007; 2: 193-203.
    • (2007) Cell Host Microbe , vol.2 , pp. 193-203
    • Neil, S.J.1    Sandrin, V.2    Sundquist, W.I.3    Bieniasz, P.D.4
  • 44
    • 62449106199 scopus 로고    scopus 로고
    • Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein
    • Kaletsky RL, Francica JR, Agrawal-Gamse C, Bates P. Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein. Proc Natl Acad Sci USA 2009; 106: 2886-2891.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2886-2891
    • Kaletsky, R.L.1    Francica, J.R.2    Agrawal-Gamse, C.3    Bates, P.4
  • 45
  • 46
  • 47
    • 0036498098 scopus 로고    scopus 로고
    • Proinflammatory response during Ebola virus infection of primate models: Possible involvement of the tumor necrosis factor receptor superfamily
    • Hensley LE, Young HA, Jahrling PB, Geisbert TW. Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily. Immunol Lett 2002; 80: 169-179.
    • (2002) Immunol Lett , vol.80 , pp. 169-179
    • Hensley, L.E.1    Young, H.A.2    Jahrling, P.B.3    Geisbert, T.W.4
  • 50
    • 0032997843 scopus 로고    scopus 로고
    • Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection
    • Villinger F, Rollin PE, Brar SS, Chikkala NF, Winter J, Sundstrom JB et al. Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection. J Infect Dis 1999; 179: S188-S191.
    • (1999) J Infect Dis , vol.179 , pp. S188-S191
    • Villinger, F.1    Rollin, P.E.2    Brar, S.S.3    Chikkala, N.F.4    Winter, J.5    Sundstrom, J.B.6
  • 51
    • 78449261317 scopus 로고    scopus 로고
    • Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis
    • Wauquier N, Becquart P, Padilla C, Baize S, Leroy EM. Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis. PLoS Negl Trop Dis 2010; 4: e837.
    • (2010) PLoS Negl Trop Dis , vol.4 , pp. e837
    • Wauquier, N.1    Becquart, P.2    Padilla, C.3    Baize, S.4    Leroy, E.M.5
  • 52
    • 84920866291 scopus 로고    scopus 로고
    • Characterization of clinical and immunological parameters during Ebola virus infection of rhesus macaques
    • Martins K, Cooper C, Warren T, Wells J, Bell T, Raymond J et al. Characterization of clinical and immunological parameters during Ebola virus infection of rhesus macaques. Viral Immunol 2015; 28: 32-41.
    • (2015) Viral Immunol , vol.28 , pp. 32-41
    • Martins, K.1    Cooper, C.2    Warren, T.3    Wells, J.4    Bell, T.5    Raymond, J.6
  • 53
    • 4544228226 scopus 로고    scopus 로고
    • Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: Cellular responses, virus load, and nitric oxide levels
    • Sanchez A, Lukwiya M, Bausch D, Mahanty S, Sanchez AJ, Wagoner KD et al. Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels. J Virol 2004; 78: 10370-10377.
    • (2004) J Virol , vol.78 , pp. 10370-10377
    • Sanchez, A.1    Lukwiya, M.2    Bausch, D.3    Mahanty, S.4    Sanchez, A.J.5    Wagoner, K.D.6
  • 55
    • 74649084140 scopus 로고    scopus 로고
    • Increased serum ferritin levels in patients with Crimean-Congo hemorrhagic fever: Can it be a new severity criterion
    • Barut S, Dincer F, Sahin I, Ozyurt H, Akkus M, Erkorkmaz U. Increased serum ferritin levels in patients with Crimean-Congo hemorrhagic fever: can it be a new severity criterion Int J Infect Dis 2010; 14: e50-e54.
    • (2010) Int J Infect Dis , vol.14 , pp. e50-e54
    • Barut, S.1    Dincer, F.2    Sahin, I.3    Ozyurt, H.4    Akkus, M.5    Erkorkmaz, U.6
  • 56
    • 0347122085 scopus 로고    scopus 로고
    • Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation
    • Bosio CM, Aman MJ, Grogan C, Hogan R, Ruthel G, Negley D et al. Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation. J Infect Dis 2003; 188: 1630-1638.
    • (2003) J Infect Dis , vol.188 , pp. 1630-1638
    • Bosio, C.M.1    Aman, M.J.2    Grogan, C.3    Hogan, R.4    Ruthel, G.5    Negley, D.6
  • 57
    • 0037443448 scopus 로고    scopus 로고
    • Cutting edge: Impairment of dendritic cells and adaptive immunity by Ebola and Lassa viruses
    • Mahanty S, Hutchinson K, Agarwal S, McRae M, Rollin PE, Pulendran B. Cutting edge: impairment of dendritic cells and adaptive immunity by Ebola and Lassa viruses. J Immunol 2003; 170: 2797-2801.
    • (2003) J Immunol , vol.170 , pp. 2797-2801
    • Mahanty, S.1    Hutchinson, K.2    Agarwal, S.3    McRae, M.4    Rollin, P.E.5    Pulendran, B.6
  • 58
  • 59
    • 84920755967 scopus 로고    scopus 로고
    • Ebola virus infection induces irregular dendritic cell gene expression
    • Melanson VR, Kalina WV, Williams P. Ebola virus infection induces irregular dendritic cell gene expression. Viral Immunol 2015; 28: 42-50.
    • (2015) Viral Immunol , vol.28 , pp. 42-50
    • Melanson, V.R.1    Kalina, W.V.2    Williams, P.3
  • 60
    • 84886295904 scopus 로고    scopus 로고
    • The lack of maturation of Ebola virus-infected dendritic cells results from the cooperative effect of at least two viral domains
    • Lubaki NM, Ilinykh P, Pietzsch C, Tigabu B, Freiberg AN, Koup RA et al. The lack of maturation of Ebola virus-infected dendritic cells results from the cooperative effect of at least two viral domains. J Virol 2013; 87: 7471-7485.
    • (2013) J Virol , vol.87 , pp. 7471-7485
    • Lubaki, N.M.1    Ilinykh, P.2    Pietzsch, C.3    Tigabu, B.4    Freiberg, A.N.5    Koup, R.A.6
  • 61
    • 3242782481 scopus 로고    scopus 로고
    • Role of natural killer cells in innate protection against lethal Ebola virus infection
    • Warfield KL, Perkins JG, Swenson DL, Deal EM, Bosio CM, Aman MJ et al. Role of natural killer cells in innate protection against lethal Ebola virus infection. J Exp Med 2004; 200: 169-179.
    • (2004) J Exp Med , vol.200 , pp. 169-179
    • Warfield, K.L.1    Perkins, J.G.2    Swenson, D.L.3    Deal, E.M.4    Bosio, C.M.5    Aman, M.J.6
  • 64
    • 4544293451 scopus 로고    scopus 로고
    • Depletion of peripheral blood T lymphocytes and NK cells during the course of ebola hemorrhagic fever in cynomolgus macaques
    • Reed DS, Hensley LE, Geisbert JB, Jahrling PB, Geisbert TW. Depletion of peripheral blood T lymphocytes and NK cells during the course of ebola hemorrhagic fever in cynomolgus macaques. Viral Immunol 2004; 17: 390-400.
    • (2004) Viral Immunol , vol.17 , pp. 390-400
    • Reed, D.S.1    Hensley, L.E.2    Geisbert, J.B.3    Jahrling, P.B.4    Geisbert, T.W.5
  • 66
    • 79955080720 scopus 로고    scopus 로고
    • The bidirectional crosstalk between human dendritic cells and natural killer cells
    • Wehner R, Dietze K, Bachmann M, Schmitz M. The bidirectional crosstalk between human dendritic cells and natural killer cells. J Innate Immun 2011; 3: 258-263.
    • (2011) J Innate Immun , vol.3 , pp. 258-263
    • Wehner, R.1    Dietze, K.2    Bachmann, M.3    Schmitz, M.4
  • 69
    • 84878483268 scopus 로고    scopus 로고
    • The secret life of viral entry glycoproteins: Moonlighting in immune evasion
    • Cook JD, Lee JE. The secret life of viral entry glycoproteins: moonlighting in immune evasion. PLoS Pathog 2013; 9: e1003258.
    • (2013) PLoS Pathog , vol.9 , pp. e1003258
    • Cook, J.D.1    Lee, J.E.2
  • 70
    • 0034650438 scopus 로고    scopus 로고
    • Ebola virus secretory glycoprotein (sGP) diminishes Fc gamma RIIIB-to-CR3 proximity on neutrophils
    • Kindzelskii AL, Yang Z, Nabel GJ, Todd RF, Petty HR. Ebola virus secretory glycoprotein (sGP) diminishes Fc gamma RIIIB-to-CR3 proximity on neutrophils. J Immunol 2000; 164: 953-958.
    • (2000) J Immunol , vol.164 , pp. 953-958
    • Kindzelskii, A.L.1    Yang, Z.2    Nabel, G.J.3    Todd, R.F.4    Petty, H.R.5
  • 71
    • 0032512668 scopus 로고    scopus 로고
    • Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins
    • Yang Z, Delgado R, Xu L, Todd RF, Nabel EG, Sanchez A et al. Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins. Science 1998; 279: 1034-1037.
    • (1998) Science , vol.279 , pp. 1034-1037
    • Yang, Z.1    Delgado, R.2    Xu, L.3    Todd, R.F.4    Nabel, E.G.5    Sanchez, A.6
  • 72
    • 84872010391 scopus 로고    scopus 로고
    • Antigenic subversion: A novel mechanism of host immune evasion by Ebola virus
    • Mohan GS, Li W, Ye L, Compans RW, Yang C. Antigenic subversion: a novel mechanism of host immune evasion by Ebola virus. PLoS Pathog 2012; 8: e1003065.
    • (2012) PLoS Pathog , vol.8 , pp. e1003065
    • Mohan, G.S.1    Li, W.2    Ye, L.3    Compans, R.W.4    Yang, C.5
  • 73
    • 64749097604 scopus 로고    scopus 로고
    • Correlates of protective immunity for Ebola vaccines: Implications for regulatory approval by the animal rule
    • Sullivan NJ, Martin JE, Graham BS, Nabel GJ. Correlates of protective immunity for Ebola vaccines: implications for regulatory approval by the animal rule. Nat Rev Microbiol 2009; 7: 393-400.
    • (2009) Nat Rev Microbiol , vol.7 , pp. 393-400
    • Sullivan, N.J.1    Martin, J.E.2    Graham, B.S.3    Nabel, G.J.4
  • 74
    • 0032907635 scopus 로고    scopus 로고
    • Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients
    • Baize S, Leroy EM, Georges-Courbot MC, Capron M, Lansoud-Soukate J, Debre P et al. Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients. Nat Med 1999; 5: 423-426.
    • (1999) Nat Med , vol.5 , pp. 423-426
    • Baize, S.1    Leroy, E.M.2    Georges-Courbot, M.C.3    Capron, M.4    Lansoud-Soukate, J.5    Debre, P.6
  • 75
    • 22144488793 scopus 로고    scopus 로고
    • Induction of humoral and CD8+ T cell responses are required for protection against lethal Ebola virus infection
    • Warfield KL, Olinger G, Deal EM, Swenson DL, Bailey M, Negley DL et al. Induction of humoral and CD8+ T cell responses are required for protection against lethal Ebola virus infection. J Immunol 2005; 175: 1184-1191.
    • (2005) J Immunol , vol.175 , pp. 1184-1191
    • Warfield, K.L.1    Olinger, G.2    Deal, E.M.3    Swenson, D.L.4    Bailey, M.5    Negley, D.L.6
  • 76
    • 84855520913 scopus 로고    scopus 로고
    • Protective role of cytotoxic T lymphocytes in filovirus hemorrhagic fever
    • Warfield KL, Olinger GG. Protective role of cytotoxic T lymphocytes in filovirus hemorrhagic fever. J Biomed Biotechnol 2011; 2011: 984241.
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 984241
    • Warfield, K.L.1    Olinger, G.G.2
  • 77
    • 84868265780 scopus 로고    scopus 로고
    • Immune parameters correlate with protection against Ebola virus infection in rodents and nonhuman primates
    • Wong G, Richardson JS, Pillet S, Patel A, Qiu X, Alimonti J et al. Immune parameters correlate with protection against Ebola virus infection in rodents and nonhuman primates. Sci Transl Med 2012; 4: 158-146.
    • (2012) Sci Transl Med , vol.4 , pp. 158-146
    • Wong, G.1    Richardson, J.S.2    Pillet, S.3    Patel, A.4    Qiu, X.5    Alimonti, J.6
  • 78
    • 44849135333 scopus 로고    scopus 로고
    • Functional CD8+ T cell responses in lethal Ebola virus infection
    • Bradfute SB, Warfield KL, Bavari S. Functional CD8+ T cell responses in lethal Ebola virus infection. J Immunol 2008; 180: 4058-4066.
    • (2008) J Immunol , vol.180 , pp. 4058-4066
    • Bradfute, S.B.1    Warfield, K.L.2    Bavari, S.3
  • 80
    • 1642446620 scopus 로고    scopus 로고
    • Ebola virus glycoproteinmediated anoikis of primary human cardiac microvascular endothelial cells
    • Ray RB, Basu A, Steele R, Beyene A, McHowat J, Meyer K et al. Ebola virus glycoproteinmediated anoikis of primary human cardiac microvascular endothelial cells. Virology 2004; 321: 181-188.
    • (2004) Virology , vol.321 , pp. 181-188
    • Ray, R.B.1    Basu, A.2    Steele, R.3    Beyene, A.4    McHowat, J.5    Meyer, K.6
  • 82
    • 16244362671 scopus 로고    scopus 로고
    • Apoptosis, pyroptosis, and necrosis: Mechanistic description of dead and dying eukaryotic cells
    • Fink SL, Cookson BT. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun 2005; 73: 1907-1916.
    • (2005) Infect Immun , vol.73 , pp. 1907-1916
    • Fink, S.L.1    Cookson, B.T.2
  • 83
    • 84862908207 scopus 로고    scopus 로고
    • Cell death and infection: A double-edged sword for host and pathogen survival
    • Ashida H, Mimuro H, Ogawa M, Kobayashi T, Sanada T, Kim M et al. Cell death and infection: a double-edged sword for host and pathogen survival. J Cell Biol 2011; 195: 931-942.
    • (2011) J Cell Biol , vol.195 , pp. 931-942
    • Ashida, H.1    Mimuro, H.2    Ogawa, M.3    Kobayashi, T.4    Sanada, T.5    Kim, M.6
  • 84
    • 57649167477 scopus 로고    scopus 로고
    • Necroptosis: A specialized pathway of programmed necrosis
    • Galluzzi L, Kroemer G. Necroptosis: a specialized pathway of programmed necrosis. Cell 2008; 135: 1161-1163.
    • (2008) Cell , vol.135 , pp. 1161-1163
    • Galluzzi, L.1    Kroemer, G.2
  • 87
    • 0029116432 scopus 로고
    • Lethal experimental infections of rhesus monkeys by aerosolized Ebola virus
    • Johnson E, Jaax N, White J, Jahrling P. Lethal experimental infections of rhesus monkeys by aerosolized Ebola virus. Int J Exp Pathol 1995; 76: 227-236.
    • (1995) Int J Exp Pathol , vol.76 , pp. 227-236
    • Johnson, E.1    Jaax, N.2    White, J.3    Jahrling, P.4
  • 88
    • 0033037010 scopus 로고    scopus 로고
    • An analysis of features of pathogenesis in two animal models of Ebola virus infection
    • Ryabchikova EI, Kolesnikova LV, Luchko SV. An analysis of features of pathogenesis in two animal models of Ebola virus infection. J Infect Dis 1999; 179: S199-S202.
    • (1999) J Infect Dis , vol.179 , pp. S199-S202
    • Ryabchikova, E.I.1    Kolesnikova, L.V.2    Luchko, S.V.3
  • 89
    • 84917671407 scopus 로고    scopus 로고
    • Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses
    • Martines RB, Ng DL, Greer PW, Rollin PE, Zaki SR. Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses. J Pathol 2015; 235: 153-174.
    • (2015) J Pathol , vol.235 , pp. 153-174
    • Martines, R.B.1    Ng, D.L.2    Greer, P.W.3    Rollin, P.E.4    Zaki, S.R.5
  • 90
    • 84907007449 scopus 로고    scopus 로고
    • Ebola virus modulates transforming growth factor signaling and cellular markers of mesenchyme-like transition in hepatocytes
    • Kindrachuk J, Wahl-Jensen V, Safronetz D, Trost B, Hoenen T, Arsenault R et al. Ebola virus modulates transforming growth factor signaling and cellular markers of mesenchyme-like transition in hepatocytes. J Virol 2014; 88: 9877-9892.
    • (2014) J Virol , vol.88 , pp. 9877-9892
    • Kindrachuk, J.1    Wahl-Jensen, V.2    Safronetz, D.3    Trost, B.4    Hoenen, T.5    Arsenault, R.6
  • 91
    • 84875904431 scopus 로고    scopus 로고
    • Pathogenesis of the viral hemorrhagic fevers
    • Paessler S, Walker DH. Pathogenesis of the viral hemorrhagic fevers. Annu Rev Pathol 2013; 8: 411-440.
    • (2013) Annu Rev Pathol , vol.8 , pp. 411-440
    • Paessler, S.1    Walker, D.H.2
  • 94
    • 84910648789 scopus 로고    scopus 로고
    • Emerging role of selective autophagy in human diseases
    • Mizumura K, Choi AM, Ryter SW. Emerging role of selective autophagy in human diseases. Front Pharmacol 2014; 5: 244.
    • (2014) Front Pharmacol , vol.5 , pp. 244
    • Mizumura, K.1    Choi, A.M.2    Ryter, S.W.3
  • 95
    • 84917698011 scopus 로고    scopus 로고
    • Autophagy and checkpoints for intracellular pathogen defense
    • Paulus GL, Xavier RJ. Autophagy and checkpoints for intracellular pathogen defense. Curr Opin Gastroenterol 2015; 31: 14-23.
    • (2015) Curr Opin Gastroenterol , vol.31 , pp. 14-23
    • Paulus, G.L.1    Xavier, R.J.2
  • 97
    • 73849087396 scopus 로고    scopus 로고
    • Autophagy in viral replication and pathogenesis
    • Sir D, Ou JH. Autophagy in viral replication and pathogenesis. Mol Cells 2010; 29: 1-7.
    • (2010) Mol Cells , vol.29 , pp. 1-7
    • Sir, D.1    Ou, J.H.2
  • 98
    • 79951910694 scopus 로고    scopus 로고
    • Autophagy in immunity and cell-autonomous defense against intracellular microbes
    • Deretic V. Autophagy in immunity and cell-autonomous defense against intracellular microbes. Immunol Rev 2011; 240: 92-104.
    • (2011) Immunol Rev , vol.240 , pp. 92-104
    • Deretic, V.1
  • 100
    • 67649585835 scopus 로고    scopus 로고
    • Autophagy pathway intersects with HIV1 biosynthesis and regulates viral yields in macrophages
    • Kyei GB, Dinkins C, Davis AS, Roberts E, Singh SB, Dong C et al. Autophagy pathway intersects with HIV1 biosynthesis and regulates viral yields in macrophages. J Cell Biol 2009; 186: 255-268.
    • (2009) J Cell Biol , vol.186 , pp. 255-268
    • Kyei, G.B.1    Dinkins, C.2    Davis, A.S.3    Roberts, E.4    Singh, S.B.5    Dong, C.6
  • 101
    • 84880152406 scopus 로고    scopus 로고
    • Divergent roles of autophagy in virus infection
    • Chiramel AI, Brady NR, Bartenschlager R. Divergent roles of autophagy in virus infection. Cells 2013; 2: 83-104.
    • (2013) Cells , vol.2 , pp. 83-104
    • Chiramel, A.I.1    Brady, N.R.2    Bartenschlager, R.3
  • 102
    • 84925884548 scopus 로고    scopus 로고
    • Enterovirus 71-induced autophagy increases viral replication and pathogenesis in a suckling mouse model
    • Lee YR, Wang PS, Wang JR, Liu HS. Enterovirus 71-induced autophagy increases viral replication and pathogenesis in a suckling mouse model. J Biomed Sci 2014; 21: 80.
    • (2014) J Biomed Sci , vol.21 , pp. 80
    • Lee, Y.R.1    Wang, P.S.2    Wang, J.R.3    Liu, H.S.4
  • 104
    • 37549043217 scopus 로고    scopus 로고
    • Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
    • Sanjuan MA, Dillon CP, Tait SW, Moshiach S, Dorsey F, Connell S et al. Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature 2007; 450: 1253-1257.
    • (2007) Nature , vol.450 , pp. 1253-1257
    • Sanjuan, M.A.1    Dillon, C.P.2    Tait, S.W.3    Moshiach, S.4    Dorsey, F.5    Connell, S.6
  • 105
    • 3242877218 scopus 로고    scopus 로고
    • Rab7 is required for the normal progression of the autophagic pathway in mammalian cells
    • Gutierrez MG, Munafo DB, Beron W, Colombo MI. Rab7 is required for the normal progression of the autophagic pathway in mammalian cells. J Cell Sci 2004; 117: 2687-2697.
    • (2004) J Cell Sci , vol.117 , pp. 2687-2697
    • Gutierrez, M.G.1    Munafo, D.B.2    Beron, W.3    Colombo, M.I.4
  • 106
    • 84908895410 scopus 로고    scopus 로고
    • Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function
    • Garciá-Dorival I, Wu W, Dowall S, Armstrong S, Touzelet O, Wastling J et al. Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function. J Proteome Res 2014; 13: 5120-5135.
    • (2014) J Proteome Res , vol.13 , pp. 5120-5135
    • Garciá-Dorival, I.1    Wu, W.2    Dowall, S.3    Armstrong, S.4    Touzelet, O.5    Wastling, J.6
  • 107
    • 84923815384 scopus 로고    scopus 로고
    • Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
    • Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N et al. Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. Science 2015; 347: 995-998.
    • (2015) Science , vol.347 , pp. 995-998
    • Sakurai, Y.1    Kolokoltsov, A.A.2    Chen, C.C.3    Tidwell, M.W.4    Bauta, W.E.5    Klugbauer, N.6
  • 108
    • 80051497127 scopus 로고    scopus 로고
    • Nicotinic acid adenine dinucleotide phosphate (NAADP) regulates autophagy in cultured astrocytes
    • Pereira GJ, Hirata H, Fimia GM, do Carmo LG, Bincoletto C, Han SW et al. Nicotinic acid adenine dinucleotide phosphate (NAADP) regulates autophagy in cultured astrocytes. J Biol Chem 2011; 286: 27875-27881.
    • (2011) J Biol Chem , vol.286 , pp. 27875-27881
    • Pereira, G.J.1    Hirata, H.2    Fimia, G.M.3    Do Carmo, L.G.4    Bincoletto, C.5    Han, S.W.6
  • 109
    • 84867430967 scopus 로고    scopus 로고
    • Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellular carcinoma
    • Gong K, Chen C, Zhan Y, Chen Y, Huang Z, Li W. Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellular carcinoma. J Biol Chem 2012; 287: 35576-35588.
    • (2012) J Biol Chem , vol.287 , pp. 35576-35588
    • Gong, K.1    Chen, C.2    Zhan, Y.3    Chen, Y.4    Huang, Z.5    Li, W.6
  • 113
  • 114
    • 80053957554 scopus 로고    scopus 로고
    • The evolving experience with therapeutic TNF inhibition in sepsis: Considering the potential influence of risk of death
    • Qiu P, Cui X, Barochia A, Li Y, Natanson C, Eichacker PQ. The evolving experience with therapeutic TNF inhibition in sepsis: considering the potential influence of risk of death. Expert Opin Investig Drugs 2011; 20: 1555-1564.
    • (2011) Expert Opin Investig Drugs , vol.20 , pp. 1555-1564
    • Qiu, P.1    Cui, X.2    Barochia, A.3    Li, Y.4    Natanson, C.5    Eichacker, P.Q.6
  • 115
    • 84871293547 scopus 로고    scopus 로고
    • Systematic review and meta-analysis on the association between outpatient statins use and infectious disease-related mortality
    • Ma Y, Wen X, Peng J, Lu Y, Guo Z, Lu J. Systematic review and meta-analysis on the association between outpatient statins use and infectious disease-related mortality. PLoS One 2012; 7: e51548.
    • (2012) PLoS One , vol.7 , pp. e51548
    • Ma, Y.1    Wen, X.2    Peng, J.3    Lu, Y.4    Guo, Z.5    Lu, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.