Ebola virus selectively inhibits responses to interferons, but not to interleukin-1β, in endothelial cells

Journal of Virology

Volumn 73, Issue 4, 1999, Pages 3491-3496

  Harcourt, Brian H ^a   Sanchez, Anthony ^b   Offermann, Margaret K ^a  

^a EMORY UNIVERSITY   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; ALPHA INTERFERON; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; EBOLA VIRUS; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; VIRUS PATHOGENESIS;

EID: 0032976232     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.4.3491-3496.1999     Document Type: Article

References (33)

1. Agafonov, A. P., G. M. Ignat'ev, V. A. Kuz'min, Z. L. Akimenko, T. V. Kosareva, and E. A. Kashentseva. 1992. The immunogenic properties of Marburg virus proteins. Vopr. Virusol. 37:58-61. (In Russian.)
2. Anonymous. 1978. Ebola haemorrhagic fever in Zaire, 1976. Bull. W.H.O. 56:271-293.
3. Bandyopadhyay, S. K., G. T. Leonard, Jr., T. Bandyopadhyay, G. R. Stark, and G. C. Sen. 1995. Transcriptional induction by double-stranded RNA is mediated by interferon-stimulated response elements without activation of interferon-stimulated gene factor 3. J. Biol. Chem. 270:19624-19629.
4. Bankers-Fulbright, J. L., K. R. Kalli, and D. J. McKean. 1996. Interleukin-1 signal transduction. Life Sci. 59:61-83.
5. Bluyssen, H. A. R., R. Muzaffar, R. J. Vlieststra, A. C. van der Made, S. Leung, G. R. Stark, I. M. Kerr, J. Trapman, and D. E. Levy. 1995. Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses. Proc. Natl. Acad. Sci. USA 92:5645-5649.
6. Boehm, U., T. Klamp, M. Groot, and J. C. Howard. 1997. Cellular responses to interferon-γ. Annu. Rev. Immunol. 15:749-795.
7. Bowen, E. T. W., A. Baskerville, K. Cantell, G. F. Mann, D. I. H. Simpson, and A. J. Zuckerman. 1978. The effect of interferon on experimental Ebola virus infection in rhesus monkeys, p. 245-253. In S. R. Pattyn (ed.), Ebola virus haemorrhagic fever. Elsevier/North-Holland Biomedical Press, Amsterdam, The Netherlands.
8. Collins, T., M. A. Read, A. S. Neish, M. Z. Whitley, D. Thanos, and T. Maniatis. 1995. Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers. FASEB J. 9:899-909.
9. Daly, C., and N. C. Reich. 1993. Double-stranded RNA activates novel factors that bind to the interferon-stimulated response element. Mol. Cell. Biol. 13:3756-3764.
10. Dianzani, U., and F. Malavasi. 1995. Lymphocyte adhesion to endothelium. Crit. Rev. Immunol. 15:167-200.
11. Fisher-Hoch, S. P., G. S. Platt, G. H. Neild, T. Southee, A. Baskerville, R. T. Raymond, G. Lloyd, and D. I. Simpson. 1985. Pathophysiology of shock and hemorrhage in a fulminating viral infection (Ebola). J. Infect. Dis. 152:887-894.
12. Gear, J. S., G. A. Cassel, A. J. Gear, B. Trappler, L. Clausen, A. M. Meyers, M. C. Kew, T. H. Bothwell, R. Sher, G. B. Miller, J. Schneider, H. J. Koornhof, E. D. Gomperts, M. Isaacson, and J. H. Gear. 1975. Outbreak of Marburg virus disease in Johannesburg. Br. Med. J. 4:489-493.
13. Geisbert, T., P. Jahrling, M. Hanes, and P. Zack. 1992. Association of Ebola-related Reston virus particles and antigen with tissue lesions of monkeys imported to the United States. J. Comp. Pathol. 106:137-152.
14. Georges-Courbot, M. C., A. Sanchez, C. Y. Lu, S. Baize, E. Leroy, J. Lansout-Soukate, C. Tevi-Benissan, A. J. Georges, S. G. Trappier, S. R. Zaki, R. Swanepoel, P. A. Leman, P. E. Rollin, C. J. Peters, S. T. Nichol, and T. G. Ksiazek. 1997. Isolation and phylogenetic characterization of Ebola viruses causing different outbreaks in Gabon. Emerg. Infect. Dis. 3:59-62.
15. Germain, R. N. 1994. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76:287-299.
16. Harcourt, B. H., P. A. Rota, K. B. Hummel, W. J. Bellini, and M. K. Offermann. 1999. Induction of ICAM-1 gene expression by measles virus in human umbilical vein endothelial cells. J. Med. Virol. 57:9-16.
17. Harcourt, B. H., A. Sanchez, and M. K. Offermann. 1998. Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells. Virology 252:179-188.
18. Jagus, R., and M. M. Gray. 1994. Proteins that interact with PKR. Biochimie 76:779-791.
19. Johnson, K. M., J. V. Lange, P. A. Webb, and F. A. Murphy. 1977. Isolation and partial characterisation of a new virus causing acute haemorrhagic fever in Zaire. Lancet i:569-571.
20. Kalvakolanu, D., and E. C. Borden. 1996. An overview of the interferon system: signal transduction and mechanisms of action. Cancer Investig. 14: 25-53.
21. Katze, M. G. 1992. The war against the interferon-induced dsRNA-activated protein kinase: can viruses win? J. Interferon Res. 12:241-248.
22. Kumar, A., J. Haque, J. Lacoste, J. Hiscott, and B. R. Williams. 1994. Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B. Proc. Natl. Acad. Sci. USA 91:6288-6292.
23. Leonard, G. T., and G. C. Sen. 1996. Effects of adenovirus E1A protein on interferon-signaling. Virology 224:25-33.
24. Leonard, G. T., and G. C. Sen. 1997. Restoration of interferon responses of adenovirus E1A-expressing HT1080 cell lines by overexpression of p48 protein. J. Virol. 71:5095-5101.
25. Murphy, F. A., D. I. H. Simpson, S. G. Whitfield, I. Zlotnik, and G. B. Carter. 1971. Marburg virus infection in monkeys. Lab. Investig. 24:279-291.
26. Offermann, M. K., J. Zimring, K. H. Mellits, M. K. Hagan, R. Shaw, R. M. Medford, M. B. Mathews, S. Goodbourn, and R. Jagus. 1995. Activation of the double-stranded-RNA-activated protein kinase and induction of vascular cell adhesion molecule-1 by poly (I) · poly (C) in endothelial cells. Eur. J. Biochem. 232:28-36.
27. Paabo, S., L. Severinsson, M. Andersson, I. Martens, T. Nilsson, and P. A. Peterson. 1989. Adenovirus proteins and MHC expression. Adv. Cancer Res. 52:151-163.
28. Peters, C. J., A. Sanchez, P. E. Rollin, T. G. Ksiazek, and F. A. Murphy. 1996. Filoviridae: Marburg and Ebola viruses, p. 1161-1176. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology, 3rd ed., vol. 1. Lippincott-Raven, New York, N.Y.
29. Rota, J. S., J. L. Heath, P. A. Rota, G. E. King, M. L. Celma, J. Carabana, R. Fernandez-Munoz, O. Brown, L. Jin, and W. J. Bellini. 1996. Molecular epidemiology of measles virus: identification of pathways of transmission and implications for measles elimination. J. Infect. Dis. 173:32-37.
30. Ruszczak, Z., and R. A. Schwartz. 1996. Vascular endothelium in the regulation of immune response. Res. Commun. Mol. Pathol. Pharmacol. 94:3-21
31. Sironi, M., F. Breviario, P. Proserpio, A. Biondi, A. Veechi, J. Van Damme, E. Dejana, and A. Mantovani. 1989. IL-1 stimulates IL-6 production in endothelial cells. J. Immunol. 142:549-553.
32. Yamashita, Y., K. Shimokata, S. Mizuno, H. Yamaguchi, and Y. Nishiyama. 1993. Down-regulation of the surface expression of class I MHC antigens by human cytomegalovirus. Virology 193:727-736.
33. Zimring, J. C., S. Goodbourn, and M. K. Offermann. 1998. Human herpes-virus 8 encodes an interferon regulatory factor (IRF) homolog that represses IRF-1-mediated transcription. J. Virol. 72:701-707.