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Volumn 312, Issue 2, 2003, Pages 415-424

Protection from lethal infection is determined by innate immune responses in a mouse model of Ebola virus infection

Author keywords

Cytokines; Ebola virus; Filovirus; Innate immunity; Interferons; Pathogenesis; Protective immunity; Viral kinetics

Indexed keywords

ALPHA INTERFERON; GAMMA INTERFERON; MONOCYTE CHEMOTACTIC PROTEIN 1; VIRUS ANTIGEN;

EID: 0043166564     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0042-6822(03)00233-2     Document Type: Article
Times cited : (70)

References (46)
  • 1
    • 0018188505 scopus 로고
    • Ebola haemorrhagic fever in Sudan, 1976. Report of a WHO/International Study Team
    • Ebola haemorrhagic fever in Sudan, 1976. Report of a WHO/International Study Team. Bull. World Health Organ. 56:(2):1978;247-270.
    • (1978) Bull. World Health Organ. , vol.56 , Issue.2 , pp. 247-270
  • 2
    • 0018104527 scopus 로고
    • Ebola haemorrhagic fever in Zaire, 1976
    • Ebola haemorrhagic fever in Zaire, 1976. Bull. World Health Organ. 56:(2):1978;271-293.
    • (1978) Bull. World Health Organ. , vol.56 , Issue.2 , pp. 271-293
  • 3
    • 0035830944 scopus 로고    scopus 로고
    • Outbreak of Ebola hemorrhagic fever Uganda, August 2000-January 2001
    • Outbreak of Ebola hemorrhagic fever Uganda, August 2000-January 2001. MMWR Morb. Mortal Wkly. Rep. 50:(5):2001;73-77.
    • (2001) MMWR Morb. Mortal Wkly. Rep. , vol.50 , Issue.5 , pp. 73-77
  • 5
    • 0034066642 scopus 로고    scopus 로고
    • Apoptosis in fatal Ebola infection. Does the virus toll the bell for immune system?
    • Baize S., Leroy E.M., Mavoungou E., Fisher-Hoch S.P. Apoptosis in fatal Ebola infection. Does the virus toll the bell for immune system? Apoptosis. 5:(1):2000;5-7.
    • (2000) Apoptosis , vol.5 , Issue.1 , pp. 5-7
    • Baize, S.1    Leroy, E.M.2    Mavoungou, E.3    Fisher-Hoch, S.P.4
  • 7
    • 0021068190 scopus 로고
    • Ebola virus disease in southern Sudan: Hospital dissemination and intrafamilial spread
    • Baron R.C., McCormick J.B., Zubeir O.A. Ebola virus disease in southern Sudan: hospital dissemination and intrafamilial spread. Bull. World Health Organ. 61:(6):1983;997-1003.
    • (1983) Bull. World Health Organ. , vol.61 , Issue.6 , pp. 997-1003
    • Baron, R.C.1    McCormick, J.B.2    Zubeir, O.A.3
  • 9
    • 0032191176 scopus 로고    scopus 로고
    • Role of early cytokines, including alpha and beta interferons (IFN-alpha/beta), in innate and adaptive immune responses to viral infections
    • Biron C.A. Role of early cytokines, including alpha and beta interferons (IFN-alpha/beta), in innate and adaptive immune responses to viral infections. Semin. Immunol. 10:(5):1998;383-390.
    • (1998) Semin. Immunol. , vol.10 , Issue.5 , pp. 383-390
    • Biron, C.A.1
  • 10
    • 0033178448 scopus 로고    scopus 로고
    • Initial and innate responses to viral infections-pattern setting in immunity or disease
    • Biron C.A. Initial and innate responses to viral infections-pattern setting in immunity or disease. Curr. Opin. Microbiol. 2:(4):1999;374-381.
    • (1999) Curr. Opin. Microbiol. , vol.2 , Issue.4 , pp. 374-381
    • Biron, C.A.1
  • 11
    • 0034993883 scopus 로고    scopus 로고
    • The role of the Type I interferon response in the resistance of mice to filovirus infection
    • Bray M. The role of the Type I interferon response in the resistance of mice to filovirus infection. J. Gen. Virol. 82:(Pt. 6):2001;1365-1373.
    • (2001) J. Gen. Virol. , vol.82 , Issue.PART 6 , pp. 1365-1373
    • Bray, M.1
  • 12
    • 0031688699 scopus 로고    scopus 로고
    • A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever
    • [published erratum appears in J Infect. Dis., 178(5), 1553 (1998)]
    • Bray M., Davis K., Geisbert T., Schmaljohn C., Huggins J. A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever. J. Infect. Dis. 178:(3):1998;651-661. [published erratum appears in J Infect. Dis., 178(5), 1553 (1998)].
    • (1998) J. Infect. Dis. , vol.178 , Issue.3 , pp. 651-661
    • Bray, M.1    Davis, K.2    Geisbert, T.3    Schmaljohn, C.4    Huggins, J.5
  • 13
    • 0035997942 scopus 로고    scopus 로고
    • 3-Deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice
    • Bray M., Raymond J.L., Geisbert T., Baker R.O. 3-Deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice. Antiviral Res. 55:(1):2002;151-159.
    • (2002) Antiviral Res. , vol.55 , Issue.1 , pp. 151-159
    • Bray, M.1    Raymond, J.L.2    Geisbert, T.3    Baker, R.O.4
  • 14
    • 0033583516 scopus 로고    scopus 로고
    • Two roads diverged: Interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection
    • Cousens L.P., Peterson R., Hsu S., Dorner A., Altman J.D., Ahmed R., Biron C.A. Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection. J. Exp. Med. 189:(8):1999;1315-1328.
    • (1999) J. Exp. Med. , vol.189 , Issue.8 , pp. 1315-1328
    • Cousens, L.P.1    Peterson, R.2    Hsu, S.3    Dorner, A.4    Altman, J.D.5    Ahmed, R.6    Biron, C.A.7
  • 15
    • 0032611382 scopus 로고    scopus 로고
    • The glycoproteins of Marburg and Ebola virus and their potential roles in pathogenesis
    • Feldmann H., Volchkov V.E., Volchkova V.A., Klenk H.D. The glycoproteins of Marburg and Ebola virus and their potential roles in pathogenesis. Arch. Virol. Suppl. 15:1999;159-169.
    • (1999) Arch. Virol. Suppl. , vol.15 , pp. 159-169
    • Feldmann, H.1    Volchkov, V.E.2    Volchkova, V.A.3    Klenk, H.D.4
  • 16
  • 18
    • 0035947156 scopus 로고    scopus 로고
    • Monocyte-derived human macrophages and peripheral blood mononuclear cells infected with ebola virus secrete MIP-1alpha and TNF-alpha and inhibit poly-IC-induced IFN-alpha in vitro
    • Gupta M., Mahanty S., Ahmed R., Rollin P.E. Monocyte-derived human macrophages and peripheral blood mononuclear cells infected with ebola virus secrete MIP-1alpha and TNF-alpha and inhibit poly-IC-induced IFN-alpha in vitro. Virology. 284:(1):2001;20-25.
    • (2001) Virology , vol.284 , Issue.1 , pp. 20-25
    • Gupta, M.1    Mahanty, S.2    Ahmed, R.3    Rollin, P.E.4
  • 19
    • 0035040194 scopus 로고    scopus 로고
    • Passive transfer of antibodies protects immunocompetent and imunodeficient mice against lethal Ebola virus infection without complete inhibition of viral replication
    • Gupta M., Mahanty S., Bray M., Ahmed R., Rollin P.E. Passive transfer of antibodies protects immunocompetent and imunodeficient mice against lethal Ebola virus infection without complete inhibition of viral replication. J. Virol. 75:(10):2001;4649-4654.
    • (2001) J. Virol. , vol.75 , Issue.10 , pp. 4649-4654
    • Gupta, M.1    Mahanty, S.2    Bray, M.3    Ahmed, R.4    Rollin, P.E.5
  • 20
    • 0032488226 scopus 로고    scopus 로고
    • Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells
    • Harcourt B.H., Sanchez A., Offermann M.K. Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells. Virology. 252:(1):1998;179-188.
    • (1998) Virology , vol.252 , Issue.1 , pp. 179-188
    • Harcourt, B.H.1    Sanchez, A.2    Offermann, M.K.3
  • 21
    • 0032976232 scopus 로고    scopus 로고
    • Ebola virus selectively inhibits responses to interferons, but not to interleukin-1beta, in endothelial cells
    • Harcourt B.H., Sanchez A., Offermann M.K. Ebola virus selectively inhibits responses to interferons, but not to interleukin-1beta, in endothelial cells. J. Virol. 73:(4):1999;3491-3496.
    • (1999) J. Virol. , vol.73 , Issue.4 , pp. 3491-3496
    • Harcourt, B.H.1    Sanchez, A.2    Offermann, M.K.3
  • 22
    • 0036498098 scopus 로고    scopus 로고
    • Proinflammatory response during Ebola virus infection of primate models: Possible involvement of the tumor necrosis factor receptor superfamily
    • Hensley L.E., Young H.A., Jahrling P.B., Geisbert T.W. Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily. Immunol. Lett. 80:(3):2002;169-179.
    • (2002) Immunol. Lett. , vol.80 , Issue.3 , pp. 169-179
    • Hensley, L.E.1    Young, H.A.2    Jahrling, P.B.3    Geisbert, T.W.4
  • 23
    • 0034798175 scopus 로고    scopus 로고
    • Multiplex analysis of cytokines in the blood of cynomolgus macaques naturally infected with Ebola virus (Reston serotype)
    • Hutchinson K.L., Villinger F., Miranda M.E., Ksiazek T.G., Peters C.J., Rollin P.E. Multiplex analysis of cytokines in the blood of cynomolgus macaques naturally infected with Ebola virus (Reston serotype). J. Med. Virol. 65:(3):2001;561-566.
    • (2001) J. Med. Virol. , vol.65 , Issue.3 , pp. 561-566
    • Hutchinson, K.L.1    Villinger, F.2    Miranda, M.E.3    Ksiazek, T.G.4    Peters, C.J.5    Rollin, P.E.6
  • 29
    • 0032858767 scopus 로고    scopus 로고
    • Cytokine measurement in biological samples after physicochemical treatment for inactivation of biosafety level 4 viral agents
    • Mahanty S., Kalwar R., Rollin P.E. Cytokine measurement in biological samples after physicochemical treatment for inactivation of biosafety level 4 viral agents. J. Med. Virol. 59:(3):1999;341-345.
    • (1999) J. Med. Virol. , vol.59 , Issue.3 , pp. 341-345
    • Mahanty, S.1    Kalwar, R.2    Rollin, P.E.3
  • 30
    • 0036100307 scopus 로고    scopus 로고
    • Pre and postexposure prophylaxis of Ebola virus infection in an animal model by passive transfer of a neutralizing human antibody
    • Parren P.W., Geisbert T.W., Maruyama T., Jahrling P.B., Burton D.R. Pre and postexposure prophylaxis of Ebola virus infection in an animal model by passive transfer of a neutralizing human antibody. J. Virol. 76:(12):2002;6408-6412.
    • (2002) J. Virol. , vol.76 , Issue.12 , pp. 6408-6412
    • Parren, P.W.1    Geisbert, T.W.2    Maruyama, T.3    Jahrling, P.B.4    Burton, D.R.5
  • 31
    • 0033054445 scopus 로고    scopus 로고
    • An introduction of Ebola: The virus and the disease
    • Peters C.J., LeDuc J.W. An introduction of Ebola: the virus and the disease. J. Infect. Dis. 179:(Suppl. 1):1999;ix-xvi.
    • (1999) J. Infect. Dis. , vol.179 , Issue.SUPPL. 1
    • Peters, C.J.1    LeDuc, J.W.2
  • 32
    • 0035854530 scopus 로고    scopus 로고
    • Sensing pathogens and tuning immune responses
    • Pulendran B., Palucka K., Banchereau J. Sensing pathogens and tuning immune responses. Science. 293:(5528):2001;253-256.
    • (2001) Science , vol.293 , Issue.5528 , pp. 253-256
    • Pulendran, B.1    Palucka, K.2    Banchereau, J.3
  • 33
    • 0036720796 scopus 로고    scopus 로고
    • Induction of immune responses in mice and monkeys to Ebola virus after immunization with liposome-encapsulated irradiated Ebola virus: Protection in mice requires CD4(+) T cells
    • Rao M., Bray M., Alving C.R., Jahrling P., Matyas G.R. Induction of immune responses in mice and monkeys to Ebola virus after immunization with liposome-encapsulated irradiated Ebola virus: protection in mice requires CD4(+) T cells. J. Virol. 76:(18):2002;9176-9185.
    • (2002) J. Virol. , vol.76 , Issue.18 , pp. 9176-9185
    • Rao, M.1    Bray, M.2    Alving, C.R.3    Jahrling, P.4    Matyas, G.R.5
  • 34
    • 0033529590 scopus 로고    scopus 로고
    • Cytotoxic T lymphocytes to Ebola Zaire virus are induced in mice by immunization with liposomes containing lipid A
    • Rao M., Matyas G.R., Grieder F., Anderson K., Jahrling P.B., Alving C.R. Cytotoxic T lymphocytes to Ebola Zaire virus are induced in mice by immunization with liposomes containing lipid A. Vaccine. 17:(23-24):1999;2991-2998.
    • (1999) Vaccine , vol.17 , Issue.23-24 , pp. 2991-2998
    • Rao, M.1    Matyas, G.R.2    Grieder, F.3    Anderson, K.4    Jahrling, P.B.5    Alving, C.R.6
  • 36
    • 0031880805 scopus 로고    scopus 로고
    • Marburg and Ebola hemorrhagic fevers: Does the primary course of infection depend on the accessibility of organ-specific macrophages?
    • Schnittler H.J., Feldmann H. Marburg and Ebola hemorrhagic fevers: does the primary course of infection depend on the accessibility of organ-specific macrophages? Clin. Infect. Dis. 27:(2):1998;404-406.
    • (1998) Clin. Infect. Dis. , vol.27 , Issue.2 , pp. 404-406
    • Schnittler, H.J.1    Feldmann, H.2
  • 37
    • 0032615793 scopus 로고    scopus 로고
    • Molecular pathogenesis of filovirus infections: Role of macrophages and endothelial cells
    • Schnittler H.J., Feldmann H. Molecular pathogenesis of filovirus infections: role of macrophages and endothelial cells. Curr. Topics Microbiol. Immunol. 235:1999;175-204.
    • (1999) Curr. Topics Microbiol. Immunol. , vol.235 , pp. 175-204
    • Schnittler, H.J.1    Feldmann, H.2
  • 38
  • 39
    • 0034735774 scopus 로고    scopus 로고
    • Development of a preventive vaccine for Ebola virus infection in primates
    • Sullivan N.J., Sanchez A., Rollin P.E., Yang Z.Y., Nabel G.J. Development of a preventive vaccine for Ebola virus infection in primates. Nature. 408:(6812):2000;605-609.
    • (2000) Nature , vol.408 , Issue.6812 , pp. 605-609
    • Sullivan, N.J.1    Sanchez, A.2    Rollin, P.E.3    Yang, Z.Y.4    Nabel, G.J.5
  • 40
    • 0037229321 scopus 로고    scopus 로고
    • Identification of protective epitopes on Ebola virus glycoprotein at the single amino acid level by using recombinant vesicular stomatitis viruses
    • Takada A., Feldmann H., Stroeher U., Bray M., Watanabe S., Ito H., McGregor M., Kawaoka Y. Identification of protective epitopes on Ebola virus glycoprotein at the single amino acid level by using recombinant vesicular stomatitis viruses. J. Virol. 77:(2):2003;1069-1074.
    • (2003) J. Virol. , vol.77 , Issue.2 , pp. 1069-1074
    • Takada, A.1    Feldmann, H.2    Stroeher, U.3    Bray, M.4    Watanabe, S.5    Ito, H.6    McGregor, M.7    Kawaoka, Y.8
  • 41
    • 0032997843 scopus 로고    scopus 로고
    • Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection
    • Villinger F., Rollin P.E., Brar S.S., Chikkala N.F., Winter J., Sundstrom J.B., Zaki S.R., Swanepoel R., Ansari A.A., Peters C.J. Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection. J. Infect. Dis. 179:(Suppl. 1):1999;S188-S191.
    • (1999) J. Infect. Dis. , vol.179 , Issue.SUPPL. 1
    • Villinger, F.1    Rollin, P.E.2    Brar, S.S.3    Chikkala, N.F.4    Winter, J.5    Sundstrom, J.B.6    Zaki, S.R.7    Swanepoel, R.8    Ansari, A.A.9    Peters, C.J.10
  • 42
    • 0035423215 scopus 로고    scopus 로고
    • Vaccine potential of Ebola virus VP24, VP30, VP35, and VP40 proteins
    • Wilson J.A., Bray M., Bakken R., Hart M.K. Vaccine potential of Ebola virus VP24, VP30, VP35, and VP40 proteins. Virology. 286:(2):2001;384-390.
    • (2001) Virology , vol.286 , Issue.2 , pp. 384-390
    • Wilson, J.A.1    Bray, M.2    Bakken, R.3    Hart, M.K.4
  • 43
    • 0035129921 scopus 로고    scopus 로고
    • Protection from Ebola virus mediated by cytotoxic T lymphocytes specific for the viral nucleoprotein
    • Wilson J.A., Hart M.K. Protection from Ebola virus mediated by cytotoxic T lymphocytes specific for the viral nucleoprotein. J. Virol. 75:(6):2001;2660-2664.
    • (2001) J. Virol. , vol.75 , Issue.6 , pp. 2660-2664
    • Wilson, J.A.1    Hart, M.K.2
  • 46
    • 0031740790 scopus 로고    scopus 로고
    • Pathologic features of filovirus infections in humans
    • Zaki S.R., Goldsmith C.S. Pathologic features of filovirus infections in humans. Curr. Top. Microbiol. Immunol. 235:1999;97-116.
    • (1999) Curr. Top. Microbiol. Immunol. , vol.235 , pp. 97-116
    • Zaki, S.R.1    Goldsmith, C.S.2


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