Protective role of cytotoxic T lymphocytes in filovirus hemorrhagic fever

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Warfield, Kelly Lyn ^a   Olinger, Gene Garrard ^b  

^a Integrated BioTherapeutics Inc   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FILOVIRUS VACCINE; GLYCOPROTEIN; HUMAN FILOVIRUS VACCINE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 15; INTERLEUKIN 16; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; NUCLEOPROTEIN; PLACEBO; PROTEIN VP40; UNCLASSIFIED DRUG; VIRUS LIKE PARTICLE VACCINE; VIRUS VACCINE; VP24; VP30; VP35; VIRUS ANTIBODY;

B LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; FILOVIRUS; FILOVIRUS INFECTION; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; NONHUMAN; REVIEW; SECONDARY INFECTION; T LYMPHOCYTE; VACCINATION; VIRAL CLEARANCE; VIRUS HEMORRHAGIC FEVER; ANIMAL; DISEASE MODEL; EBOLA HEMORRHAGIC FEVER; EBOLA VIRUS; HUMORAL IMMUNITY; IMMUNOLOGY; MARBURG HEMORRHAGIC FEVER; MARBURG VIRUS; METHODOLOGY; MOUSE; PATHOGENICITY; VIROLOGY;

ANIMALIA; EBOLA VIRUS; MARBURGVIRUS;

ANIMALS; ANTIBODIES, VIRAL; DISEASE MODELS, ANIMAL; EBOLAVIRUS; HEMORRHAGIC FEVER, EBOLA; HUMANS; IMMUNITY, HUMORAL; MARBURG VIRUS DISEASE; MARBURGVIRUS; MICE; T-LYMPHOCYTES, CYTOTOXIC; VACCINATION; VIRAL VACCINES;

EID: 84855520913     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/984241     Document Type: Review

References (124)

1. Towner J. S., Sealy T. K., Khristova M. L., Albario C. G., Conlan S., Reeder S. A., Quan P. L., Lipkin W. I., Downing R., Tappero J. W., Okware S., Lutwama J., Bakamutumaho B., Kayiwa J., Comer J. A., Rollin P. E., Ksiazek T. G., Nichol S. T., Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda PLoS Pathogens 2008 4 11
2. Sanchez A., Kiley M. P., Holloway B. P., Auperin D. D., Sequence analysis of the Ebola virus genome: organization, genetic elements, and comparison with the genome of Marburg virus Virus Research 1993 29 3 215 240 (Pubitemid 23268526)
3. Basler C. F., Wang X., Mhlberger E., Volchkov V., Paragas J., Klenk H. D., Garcia-Sastre A., Palese P., The Ebola virus VP35 protein functions as a type I IFN antagonist Proceedings of the National Academy of Sciences of the United States of America 2000 97 22 12289 12294
4. Mhlberger E., Weik M., Volchkov V. E., Klenk H. D., Becker S., Comparison of the transcription and replication strategies of Marburg virus and ebola virus by using artificial replication systems Journal of Virology 1999 73 3 2333 2342 (Pubitemid 29098138)
5. Burke J., Declerq R., Ghysebrechts G., Ebola haemorrhagic fever in Zaire, 1976. Report of an international commission Bulletin of the World Health Organization 1978 56 2 271 293 (Pubitemid 8360404)
6. Deng I. M., Duku O., Gillo A. L., Ebola haemorrhagic fever in Sudan, 1976. Report of a WHO/International Study Team Bulletin of the World Health Organization 1978 56 2 247 270 (Pubitemid 8360403)
7. Connolly B. M., Steele K. E., Davis K. J., Geisbert T. W., Kell W. M., Jaax N. K., Jahrling P. B., Pathogenesis of experimental Ebola virus infection in guinea pigs Journal of Infectious Diseases 1999 179 supplement 1 S203 S217
8. Ryabchikova E. I., Kolesnikova L. V., Netesov S. V., Animal pathology of filoviral infections Current Topics in Microbiology and Immunology 1999 235 145 173 (Pubitemid 28501321)
9. Strher U., West E., Bugany H., Klenk H. D., Schnittler H. J., Feldmann H., Infection and activation of monocytes by Marburg and Ebola viruses Journal of Virology 2001 75 22 11025 11033 (Pubitemid 33031570)
10. Leroy E. M., Kumulungui B., Pourrut X., Rouquet P., Hassanin A., Yaba P., Délicat A., Paweska J. T., Gonzalez J. P., Swanepoel R., Fruit bats as reservoirs of Ebola virus Nature 2005 438 7068 575 576 (Pubitemid 41740557)
11. Towner J. S., Pourrut X., Albario C. G., Nkogue C. N., Bird B. H., Grard G., Ksiazek T. G., Gonzalez J. P., Nichol S. T., Leroy E. M., Marburg virus infection detected in a common African bat PLoS ONE 2007 2 8, article e764
12. Belanov E. F., Muntianov V. P., Kriuk V. D., Sokolov A. V., Bormotov N. I., P'iankov O. V., Sergeev A. N., Survival of Marburg virus infectivity on contaminated surfaces and in aerosols Voprosy Virusologii 1996 41 1 32 34
13. Frolov V. G., Gusev I. M., Stability of Marburg virus to lyophilization process and subsequent storage at different temperatures Voprosy Virusologii 1996 41 6 275 277
14. Johnson E., Jaax N., White J., Jahrling P., Lethal experimental infections of rhesus monkeys by aerosolized Ebola virus International Journal of Experimental Pathology 1995 76 4 227 236
15. Ryabchikova E., Strelets L., Kolesnikova L., Pyankov O., Sergeev A., Respiratory Marburg virus infection in guinea pigs Archives of Virology 1996 141 11 2177 2190 (Pubitemid 27012279)
16. Jaax N. K., Davis K. J., Geisbert T. J., Vogel P., Jaax G. P., Topper M., Jahrling P. B., Lethal experimental infection of rhesus monkeys with Ebola-Zaire (Mayinga) virus by the oral and conjunctival route of exposure Archives of Pathology and Laboratory Medicine 1996 120 2 140 155 (Pubitemid 26058522)
17. Mohamadzadeh M., Chen L., Schmaljohn A. L., How Ebola and Marburg viruses battle the immune system Nature Reviews Immunology 2007 7 7 556 567 (Pubitemid 46987780)
18. Reed D. S., Mohamadzadeh M., Status and challenges of filovirus vaccines Vaccine 2007 25 11 1923 1934 (Pubitemid 46227672)
19. Hevey M., Negley D., VanderZanden L., Tammariello R. F., Geisbert J., Schmaljohn C., Smith J. F., Jahrling P. B., Schmaljohn A. L., Marburg virus vaccines: comparing classical and new approaches Vaccine 2001 20 3-4 586 593 (Pubitemid 32973804)
20. Ignat'ev G. M., Strel'tsova M. A., Agafonov A. P., Zhukova N. A., Kashentseva E. A., Vorob'eva M. S., The immunity indices of animals immunized with the inactivated Marburg virus after infection with homologous virus Voprosy Virusologii 1994 39 1 13 17
21. Ignatev G. M., Agafonov A. P., Strel'tsova M. A., A comparative study of the immunological indices in guinea pigs administered an inactivated Marburg virus Voprosy Virusologii 1991 36 421 423
22. Ignatyev G. M., Agafonov A. P., Streltsova M. A., Kashentseva E. A., Inactivated marburg virus elicits a nonprotective immune response in Rhesus monkeys Journal of Biotechnology 1996 44 13 111 118 (Pubitemid 26056569)
23. Geisbert T. W., Pushko P., Anderson K., Smith J., Davis K. J., Jahrling P. B., Evaluation in nonhuman primates of vaccines against Ebola virus Emerging Infectious Diseases 2002 8 5 503 507 (Pubitemid 34533328)
24. Lupton H. W., Lambert R. D., Bumgardner D. L., Inactivated vaccine for Ebola virus efficacious in guinea pig model The Lancet 1980 2 8207 1294 1295 (Pubitemid 11197323)
25. Rao M., Bray M., Alving C. R., Jahrling P., Matyas G. R., Induction of immune responses in mice and monkeys to Ebola virus after immunization with liposome-encapsulated irradiated ebola virus: protection in mice requires CD4+ T cells Journal of Virology 2002 76 18 9176 9185 (Pubitemid 34919876)
26. Geisbert T. W., Jahrling P. B., Towards a vaccine against Ebola virus Expert Review of Vaccines 2003 2 6 777 789 (Pubitemid 37541564)
27. Mikhailov V. V., Borisevich I. V., Chernikova N. K., Potryvaeva N. V., Krasnianskii V. P., The evaluation in hamadryas baboons of the possibility for the specific prevention of Ebola fever Voprosy Virusologii 1994 39 2 82 84
28. Hevey M., Negley D., Geisbert J., Jahrling P., Schmaljohn A., Antigenicity and vaccine potential of Marburg virus glycoprotein expressed by baculovirus recombinants Virology 1997 239 1 206 216 (Pubitemid 28027084)
29. Riemenschneider J., Garrison A., Geisbert J., Jahrling P., Hevey M., Negley D., Schmaljohn A., Lee J., Hart M. K., Vanderzanden L., Custer D., Bray M., Ruff A., Ivins B., Bassett A., Rossi C., Schmaljohn C., Comparison of individual and combination DNA vaccines for B. anthracis, Ebola virus, Marburg virus and Venezuelan equine encephalitis virus Vaccine 2003 21 25-26 4071 4080 (Pubitemid 37345136)
30. Geisbert T. W., Bailey M., Geisbert J. B., Asiedu C., Roederer M., Grazia-Pau M., Custers J., Jahrling P., Goudsmit J., Koup R., Sullivan N. J., Vector choice determines immunogenicity and potency of genetic vaccines against Angola Marburg virus in nonhuman primates Journal of Virology 2010 84 19 10386 10394
31. Mellquist-Riemenschneider J. L., Garrison A. R., Geisbert J. B., Saikh K. U., Heidebrink K. D., Jahrling P. B., Ulrich R. G., Schmaljohn C. S., Comparison of the protective efficacy of DNA and baculovirus-derived protein vaccines for Ebola virus in guinea pigs Virus Research 2003 92 2 187 193 (Pubitemid 36398464)
32. Konduru K., Bradfute S. B., Jacques J., Manangeeswaran M., Nakamura S., Morshed S., Wood S. C., Bavari S., Kaplan G. G., Ebola virus glycoprotein Fc fusion protein confers protection against lethal challenge in vaccinated mice Vaccine 2011 29 16 2968 2977
33. Hart M. K., Vaccine research efforts for filoviruses International Journal for Parasitology 2003 33 5-6 583 595 (Pubitemid 36638539)
34. Garbutt M., Liebscher R., Wahl-Jensen V., Jones S., Mller P., Wagner R., Volchkov V., Klenk H. D., Feldmann H., Strher U., Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses Journal of Virology 2004 78 10 5458 5465 (Pubitemid 38581495)
35. Pushko P., Geisbert J., Parker M., Jahrling P., Smith J., Individual and bivalent vaccines based on alphavirus replicons protect guinea pigs against infection with Lassa and Ebola viruses Journal of Virology 2001 75 23 11677 11685 (Pubitemid 33063259)
36. Pushko P., Bray M., Ludwig G. V., Parker M., Schmaljohn A., Sanchez A., Jahrling P. B., Smith J. F., Recombinant RNA replicons derived from attenuated Venezuelan equine encephalitis virus protect guinea pigs and mice from Ebola hemorrhagic fever virus Vaccine 2000 19 1 142 153 (Pubitemid 30618964)
37. Wilson J. A., Hart M. K., Protection from Ebola virus mediated by cytotoxic T lymphocytes specific for the viral nucleoprotein Journal of Virology 2001 75 6 2660 2664 (Pubitemid 32185029)
38. Hevey M., Negley D., Pushko P., Smith J., Schmaljohn A., Marburg virus vaccines based upon alphavirus replicons protect guinea pigs and nonhuman primates Virology 1998 251 1 28 37 (Pubitemid 28527716)
39. Sullivan N. J., Sanchez A., Rollin P. E., Yang Z. Y., Nabel G. J., Development of a preventive vaccine for Ebola virus infection in primates Nature 2000 408 6812 605 609
40. Nabel G. J., Vaccine for AIDS and Ebola virus infection Virus Research 2003 92 2 213 217 (Pubitemid 36398468)
41. Sullivan N. J., Geisbert T. W., Gelsbert J. B., Xu L., Yang Z. Y., Roederer M., Koup R. A., Jahrling P. B., Nabel G. J., Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates Nature 2003 424 6949 681 684 (Pubitemid 36987993)
42. Bukreyev A., Rollin P. E., Tate M. K., Yang L., Zaki S. R., Shieh W. J., Murphy B. R., Collins P. L., Sanchez A., Successful topical respiratory tract immunization of primates against Ebola virus Journal of Virology 2007 81 12 6379 6388 (Pubitemid 46878044)
43. Bukreyev A., Yang L., Zaki S. R., Shieh W. J., Rollin P. E., Murphy B. R., Collins P. L., Sanchez A., A single intranasal inoculation with a paramyxoviras-vectored vaccine protects guinea pigs against a lethal-dose ebola virus challenge Journal of Virology 2006 80 5 2267 2279 (Pubitemid 43271533)
44. Falzarano D., Geisbert T. W., Feldmann H., Progress in filovirus vaccine development: evaluating the potential for clinical use Expert Review of Vaccines 2011 10 1 63 77
45. Bausch D. G., Sprecher A. G., Jeffs B., Boumandouki P., Treatment of Marburg and Ebola hemorrhagic fevers: a strategy for testing new drugs and vaccines under outbreak conditions Antiviral Research 2008 78 1 150 161
46. Geisbert T. W., Hensley L. E., Jahrling P. B., Larsen T., Geisbert J. B., Paragas J., Young H. A., Fredeking T. M., Rote W. E., Vlasuk G. P., Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys The Lancet 2003 362 9400 1953 1958 (Pubitemid 37548417)
47. Hensley L. E., Stevens E. L., Yan S. B., Geisbert J. B., Macias W. L., Larsen T., Daddario-DiCaprio K. M., Cassell G. H., Jahrling P. B., Geisbert T. W., Recombinant human activated protein C for the postexposure treatment of ebola hemorrhagic fever Journal of Infectious Diseases 2007 196 2 S390 S399
48. Daddario-DiCaprio K. M., Geisbert T. W., Strher U., Geisbert J. B., Grolla A., Fritz E. A., Fernando L., Kagan E., Jahrling P. B., Hensley L. E., Jones S. M., Feldmann H., Postexposure protection against Marburg haemorrhagic fever with recombinant vesicular stomatitis virus vectors in non-human primates: an efficacy assessment The Lancet 2006 367 9520 1399 1404
49. Jones S. M., Strher U., Fernando L., Qiu X., Alimonti J., Melito P., Bray M., Klenk H.-D., Feldmann H., Assessment of a vesicular stomatitis virus-based vaccine by use of the mouse model of Ebola virus hemorrhagic fever Journal of Infectious Diseases 2007 196 supplement 2 S404 S412
50. Feldmann H., Jones S. M., Daddario-DiCaprio K. M., Geisbert J. B., Strher U., Grolla A., Bray M., Fritz E. A., Fernando L., Feldmann F., Hensley L. E., Geisbert T. W., Effective post-exposure treatment of Ebola infection PLoS Pathogens 2007 3 1 e2
51. Warfield K. L., Swenson D. L., Olinger G. G., Nichols D. K., Pratt W. D., Blouch R., Stein D. A., Aman M. J., Iversen P. L., Bavari S., Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers PLoS Pathogens 2006 2 1 e1
52. Warren T. K., Warfield K. L., Wells J., Swenson D. L., Donner K. S., Van Tongeren S. A., Garza N. L., Dong L., Mourich D. V., Crumley S., Nichols D. K., Iversen P. L., Bavari S., Advanced antisense therapies for postexposure protection against lethal filovirus infections Nature Medicine 2010 16 9 991 994
53. Geisbert T. W., Hensley L. E., Kagan E., Yu E. Z., Geisbert J. B., Daddario-DiCaprio K., Fritz E. A., Jahrling P. B., McClintock K., Phelps J. R., Lee A. C. H., Judge A., Jeffs L. B., MacLachlan I., Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference Journal of Infectious Diseases 2006 193 12 1650 1657 (Pubitemid 43839469)
54. Geisbert T. W., Lee A. C., Robbins M., Geisbert J. B., Honko A. N., Sood V., Johnson J. C., de Jong S., Tavakoli I., Judge A., Hensley L. E., MacLachlan I., Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study The Lancet 2010 375 9729 1896 1905
55. Baize S., Leroy E. M., Georges-Courbot M. C., Capron M., Lansoud-Soukate J., Debré P., Fisher-Hoch S. P., McCormick J. B., Georges A. J., Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients Nature Medicine 1999 5 4 423 426 (Pubitemid 29180581)
56. Liu Y. J., Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity Cell 2001 106 3 259 262
57. Steinman R. M., Dendritic cells and the control of immunity: enhancing the efficiency of antigen presentation Mount Sinai Journal of Medicine 2001 68 3 160 166 (Pubitemid 33606184)
58. Leroy E. M., Baize S., Debre P., Lansoud-Soukate J., Mavoungou E., Early immune responses accompanying human asymptomatic Ebola infections Clinical and Experimental Immunology 2001 124 3 453 460 (Pubitemid 32701707)
59. Leroy E. M., Baize S., Volchkov V. E., Fisher-Hoch S. P., Georges-Courbot M. C., Lansoud-Soukate J., Capron M., Debré P., McCormick J. B., Georges A. J., Human asymptomatic Ebola infection and strong inflammatory response The Lancet 2000 355 9222 2210 2215 (Pubitemid 30394329)
60. Baize S., Leroy E. M., Georges A. J., Georges-Courbot M. C., Capron M., Bedjabaga I., Lansoud-Soukate J., Mavoungou E., Inflammatory responses in Ebola virus-infected patients Clinical and Experimental Immunology 2002 128 1 163 168 (Pubitemid 34451194)
61. Hutchinson K. L., Rollin P. E., Cytokine and chemokine expression in humans infected with Sudan Ebola virus Journal of Infectious Diseases 2007 196 2 S357 S363
62. Villinger F., Rollin P. E., Brar S. S., Chikkala N. F., Winter J., Sundstrom J. B., Zaki S. R., Swanepoel R., Ansari A. A., Peters C. J., Markedly elevated levels of interferon (IFN)-, IFN-, interleukin (IL)-2, IL-10, and tumor necrosis factor- associated with fatal Ebola virus infection Journal of Infectious Diseases 1999 179 1 S188 S191
63. Wauquier N., Becquart P., Padilla C., Baize S., Leroy E. M., Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis PLoS Neglected Tropical Diseases 2010 4 10, article e837
64. Gupta M., Mahanty S., Ahmed R., Rollin P. E., Monocyte-derived human macrophages and peripheral blood mononuclear cells infected with Ebola virus secrete MIP-1 and TNF- and inhibit poly-IC-induced IFN- in vitro Virology 2001 284 1 20 25 (Pubitemid 32476692)
65. Basler C. F., Amarasinghe G. K., Evasion of interferon responses by ebola and marburg viruses Journal of Interferon and Cytokine Research 2009 29 9 511 520
66. Bosio C. M., Aman M. J., Grogan C., Hogan R., Ruthel G., Negley D., Mohamadzadeh M., Bavari S., Schmaljohn A., Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation Journal of Infectious Diseases 2003 188 11 1630 1638 (Pubitemid 38010672)
67. Mahanty S., Hutchinson K., Agarwal S., Mcrae M., Rollin P. E., Pulendran B., Cutting edge: impairment of dendritic cells and adaptive immunity by Ebola and Lassa viruses Journal of Immunology 2003 170 6 2797 2801 (Pubitemid 36302147)
68. Geisbert T. W., Hensley L. E., Larsen T., Young H. A., Reed D. S., Geisbert J. B., Scott D. P., Kagan E., Jahrling P. B., Davis K. J., Pathogenesis of ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection American Journal of Pathology 2003 163 6 2347 2370 (Pubitemid 37466478)
69. Hensley L. E., Young H. A., Jahrling P. B., Geisbert T. W., Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily Immunology Letters 2002 80 3 169 179 (Pubitemid 34136004)
70. Gibb T. R., Norwood D. A. Jr., Woollen N., Henchal E. A., Viral replication and host gene expression in alveolar macrophages infected with Ebola virus (Zaire strain) Clinical and Diagnostic Laboratory Immunology 2002 9 1 19 27 (Pubitemid 34084270)
71. Reed D. S., Hensley L. E., Geisbert J. B., Jahrling P. B., Geisbert T. W., Depletion of peripheral blood T lymphocytes and NK cells during the course of Ebola hemorrhagic fever in cynomolgus macaques Viral Immunology 2004 17 3 390 400 (Pubitemid 39244761)
72. Warfield K. L., Perkins J. G., Swenson D. L., Deal E. M., Bosio C. M., Aman M. J., Yokoyama W. M., Young H. A., Bavari S., Role of natural killer cells innate protection against lethal Ebola virus infection Journal of Experimental Medicine 2004 200 2 169 179 (Pubitemid 38982176)
73. Geisbert T. W., Daddario-DiCaprio K. M., Williams K. J. N., Geisbert J. B., Leung A., Feldmann F., Hensley L. E., Feldmann H., Jones S. M., Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates Journal of Virology 2008 82 11 5664 5668 (Pubitemid 351705275)
74. Fisher-Hoch S. P., Platt G. S., Neild G. H., Pathophysiology of shock and hemorrhage in a fulminating viral infection (Ebola) Journal of Infectious Diseases 1985 152 5 887 894 (Pubitemid 16236675)
75. Kim S., Iizuka K., Aguila H. L., Weissman I. L., Yokoyama W. M., In vivo natural killer cell activities revealed by natural killer cell-deficient mice Proceedings of the National Academy of Sciences of the United States of America 2000 97 6 2731 2736 (Pubitemid 30159240)
76. Wauquier N., Padilla C., Becquart P., Leroy E., Vieillard V., Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection Immunogenetics 2010 62 11-12 767 771
77. Gupta M., Spiropoulou C., Rollin P. E., Ebola virus infection of human PBMCs causes massive death of macrophages, CD4 and CD8 T cell sub-populations in vitro Virology 2007 364 1 45 54 (Pubitemid 46839124)
78. Hensley L. E., Young H. A., Jahrling P. B., Geisbert T. W., Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily Immunology Letters 2002 80 3 169 179 (Pubitemid 34136004)
79. Ksiazek T. G., Rollin P. E., Williams A. J., Bressler D. S., Martin M. L., Swanepoel R., Burt F. J., Leman P. A., Khan A. S., Rowe A. K., Mukunu R., Sanchez A., Peters C. J., Clinical virology of Ebola hemorrhagic fever (EHF): Virus, virus antigen, and IgG and IgM antibody findings among EHF patients in Kikwit, Democratic Republic of the Congo, 1995 Journal of Infectious Diseases 1999 179 1 S177 S187
80. Bray M., Davis K., Geisbert T., Schmaljohn C., Huggins J., A mouse model for evaluation of prophylaxis and therapy of ebola hemorrhagic fever Journal of Infectious Diseases 1998 178 3 651 661 (Pubitemid 28397211)
81. Bradfute S. B., Braun D. R., Shamblin J. D., Geisbert J. B., Paragas J., Garrison A., Hensley L. E., Geisbert T. W., Lymphocyte death in a mouse model of ebola virus infection Journal of Infectious Diseases 2007 196 2 S296 S304
82. Bradfute S. B., Warfield K. L., Bavari S., Functional CD8+ T cell responses in lethal ebola virus infection Journal of Immunology 2008 180 6 4058 4066
83. Bradfute S. B., Swanson P. E., Smith M. A., Watanabe E., McDunn J. E., Hotchkiss R. S., Bavari S., Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis Journal of Immunology 2010 184 1 327 335
84. Gupta M., Mahanty S., Greer P., Towner J. S., Shieh W. J., Zaki S. R., Ahmed R., Rollin P. E., Persistent infection with Ebola virus under conditions of partial immunity Journal of Virology 2004 78 2 958 967 (Pubitemid 38067617)
85. Sullivan N. J., Martin J. E., Graham B. S., Nabel G. J., Correlates of protective immunity for Ebola vaccines: implications for regulatory approval by the animal rule Nature Reviews Microbiology 2009 7 5 393 400
86. Warfield K. L., Olinger G., Deal E. M., Swenson D. L., Bailey M., Negley D. L., Hart M. K., Bavari S., Induction of humoral and CD8+ T cell responses are required for protection against lethal ebola virus infection Journal of Immunology 2005 175 2 1184 1191 (Pubitemid 41095006)
87. Wilson J. A., Hevey M., Bakken R., Guest S., Bray M., Schmaljohn A. L., Hart M. K., Epitopes involved in antibody-mediated protection from Ebola virus Science 2000 287 5458 1664 1666 (Pubitemid 30127770)
88. Hevey M., Negley D., Schmaljohn A., Characterization of monoclonal antibodies to Marburg virus (strain Musoke) glycoprotein and identification of two protective epitopes Virology 2003 314 1 350 357 (Pubitemid 37153323)
89. Parren P. W. H. I., Geisbert T. W., Maruyama T., Jahrling P. B., Burton D. R., Pre-and postexposure prophylaxis of ebola virus infection in an animal model by passive transfer of a neutralizing human antibody Journal of Virology 2002 76 12 6408 6412 (Pubitemid 34556338)
90. Takada A., Ebihara H., Jones S., Feldmann H., Kawaoka Y., Protective efficacy of neutralizing antibodies against Ebola virus infection Vaccine 2007 25 6 993 999 (Pubitemid 44937459)
91. Sullivan N. J., Hensley L., Asiedu C., Geisbert T. W., Stanley D., Johnson J., Honko A., Olinger G., Bailey M., Geisbert J. B., Reimann K. A., Bao S., Rao S., Roederer M., Jahrling P. B., Koup R. A., Nabel G. J., CD8+ cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates Nature Medicine 2011 17 9 1128 1131
92. Oswald W. B., Geisbert T. W., Davis K. J., Geisbert J. B., Sullivan N. J., Jahrling P. B., Parren P. W., Burton D. R., Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys PLoS Pathogens 2007 3 1 e9
93. Jahrling P. B., Geisbert J. B., Swearengen J. R., Larsen T., Geisbert T. W., Ebola hemorrhagic fever: evaluation of passive immunotherapy in nonhuman primates Journal of Infectious Diseases 2007 196 supplement 2 S400 S403
94. Wilson J. A., Bray M., Bakken R., Hart M. K., Vaccine potential of Ebola virus VP24, VP30, VP35, and VP40 proteins Virology 2001 286 2 384 390 (Pubitemid 32721814)
95. Swenson D. L., Warfield K. L., Negley D. L., Schmaljohn A., Aman M. J., Bavari S., Virus-like particles exhibit potential as a pan-filovirus vaccine for both Ebola and Marburg viral infections Vaccine 2005 23 23 3033 3042 (Pubitemid 40462443)
96. Olinger G. G., Bailey M. A., Dye J. M., Bakken R., Kuehne A., Kondig J., Wilson J., Hogan R. J., Hart M. K., Protective cytotoxic T-cell responses induced by Venezuelan equine encephalitis virus replicons expressing Ebola virus proteins Journal of Virology 2005 79 22 14189 14196 (Pubitemid 41552717)
97. Kuhn J. H., Filoviruses: A Compendium of 40 Years of Epidemiological, Clinical, and Laboratory Studies 2008 New York, NY, USA Springer
98. Dowling W., Thompson E., Badger C., Mellquist J. L., Garrison A. R., Smith J. M., Paragas J., Hogan R. J., Schmaljohn C., Influences of glycosylation on antigenicity, immunogenicity, and protective efficacy of Ebola virus GP DNA vaccines Journal of Virology 2007 81 4 1821 1837 (Pubitemid 46214455)
99. Rao M., Matyas G. R., Grieder F., Anderson K., Jahrling P. B., Alving C. R., Cytotoxic T lymphocytes to Ebola Zaire virus are induced in mice by immunization with liposomes containing lipid A Vaccine 1999 17 23-24 2991 2998 (Pubitemid 29366979)
100. Simmons G., Lee A., Rennekamp A. J., Fan X., Bates P., Shen H., Identification of murine T-cell epitopes in Ebola virus nucleoprotein Virology 2004 318 1 224 230 (Pubitemid 38234276)
101. Sundar K., Boesen A., Coico R., Computational prediction and identification of HLA-A2.1-specific Ebola virus CTL epitopes Virology 2007 360 2 257 263 (Pubitemid 46482607)
102. Kalina W. V., Warfield K. L., Olinger G. G., Bavari S., Discovery of common marburgvirus protective epitopes in a BALB/c mouse model Virology Journal 2009 6, article 132
103. Martin J. E., Sullivan N. J., Enama M. E., Gordon I. J., Roederer M., Koup R. A., Bailer R. T., Chakrabarti B. K., Bailey M. A., Gomez P. L., Andrews C. A., Moodie Z., Gu L., Stein J. A., Nabel G. J., Graham B. S., McCluskey M. M., Larkin B., Hubka S., Holman L., Novik L., Edmonds P., Rucker S., Scott M., Thomas C., Stanford L., Tramont E., Dubois W., Alley T., Eaton E., Sitar S., Thompson E., Catanzaro A., Casazza J., Parrino J., Lemiale L., Sheets R., Turk E., Lamoreaux L., Fischer J., Abashian M., Rathmann J., McNeil A., A DNA vaccine for Ebola virus is safe and immunogenic in a phase I clinical trial Clinical and Vaccine Immunology 2006 13 11 1267 1277 (Pubitemid 46768881)
104. Ledgerwood J. E., Costner P., Desai N., Holman L., Enama M. E., Yamshchikov G., Mulangu S., Hu Z., Andrews C. A., Sheets R. A., Koup R. A., Roederer M., Bailer R., Mascola J. R., Pau M. G., Sullivan N. J., Goudsmit J., Nabel G. J., Graham B. S., A replication defective recombinant Ad5 vaccine expressing Ebola virus GP is safe and immunogenic in healthy adults Vaccine 2010 29 2 304 313
105. Vogel T., Norley S., Beer B., Kurth R., Rapid screening for Mamu-A1-positive rhesus macaques using a SIVmac gag peptide-specific cytotoxic T-lymphocyte assay Immunology 1995 84 3 482 487
106. Smith D. G., Kanthaswamy S., Viray J., Cody L., Additional highly polymorphic microsatellite (STR) loci for estimating kinship in rhesus macaques (Macaca mulatta) American Journal of Primatology 2000 50 1 1 7
107. Penedo M. C. T., Bontrop R. E., Heijmans C. M. C., Otting N., Noort R., Rouweler A. J. M., De Groot N., De Groot N. G., Ward T., Doxiadis G. G. M., Microsatellite typing of the rhesus macaque MHC region Immunogenetics 2005 57 3-4 198 209 (Pubitemid 40775577)
108. Napier J. R., Napier P. H., A Handbook of Living Primates: Morphology, Ecology and Behavior of Nonhuman Primates 1967 New York, NY, USA Academic Press
109. Guidance for industry, animal modelsessential elements to address efficacy under the animal rule. http://www.fda.gov/downloads/Drugs/ GuidanceComplianceRegulatoryInformation/Guidances/ucm078923.pdf
110. Fritz E. A., Geisbert J. B., Geisbert T. W., Hensley L. E., Reed D. S., Cellular immune response to marburg virus infection in cynomolgus macaques Viral Immunology 2008 21 3 355 363
111. Jones S. M., Feldmann H., Strher U., Geisbert J. B., Fernando L., Grolla A., Klenk H. D., Sullivan N. J., Volchkov V. E., Fritz E. A., Daddario K. M., Hensley L. E., Jahrling P. B., Geisbert T. W., Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses Nature Medicine 2005 11 7 786 790 (Pubitemid 41021212)
112. Czerkinsky C. C., Nilsson L. A., Nygren H., A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells Journal of Immunological Methods 1983 65 1-2 109 121 (Pubitemid 14203438)
113. Larsson M., Jin X., Ramratnam B., Ogg G. S., Engelmayer J., Demoitie M. A., McMichael A. J., Cox W. I., Steinman R. M., Nixon D., Bhardwaj N., A recombinant vaccinia virus based ELISPOT assay detects high frequencies of pol-specific CD8 T cells in HIV-1-positive individuals AIDS 1999 13 7 767 777 (Pubitemid 29224578)
114. Currier J. R., Kuta E. G., Turk E., Earhart L. B., Loomis-Price L., Janetzki S., Ferrari G., Birx D. L., Cox J. H., A panel of MHC class I restricted viral peptides for use as a quality control for vaccine trial ELISPOT assays Journal of Immunological Methods 2002 260 1-2 157 172 (Pubitemid 34132882)
115. Hernandez-Fuentes M. P., Warrens A. N., Lechler R. I., Immunologic monitoring Immunological Reviews 2003 196 247 264 (Pubitemid 37468115)
116. Mooij P., Balla-Jhagjhoorsingh S. S., Beenhakker N., Van Haaften P., Baak I., Nieuwenhuis I. G., Heidari S., Wolf H., Frachette M. J., Bieler K., Sheppard N., Harari A., Bart P. A., Liljestrm P., Wagner R., Pantaleo G., Heeney J. L., Comparison of human and rhesus macaque T-cell responses elicited by boosting with NYVAC encoding human immunodeficiency virus type 1 clade C immunogens Journal of Virology 2009 83 11 5881 5889
117. Streeck H., Frahm N., Walker B. D., The role of IFN- Elispot assay in HIV vaccine research Nature Protocols 2009 4 4 461 469
118. Okamoto Y., Abe T., Niwa T., Mizuhashi S., Nishida M., Development of a dual color enzyme-linked immunospot assay for simultaneous detection of murine T helper type 1-and T helper type 2-cells Immunopharmacology 1998 39 2 107 116 (Pubitemid 28321511)
119. Warfield K. L., Swenson D. L., Negley D. L., Schmaljohn A. L., Aman M. J., Bavari S., Marburg virus-like particles protect guinea pigs from lethal Marburg virus infection Vaccine 2004 22 25-26 3495 3502 (Pubitemid 39078769)
120. Warfield K. L., Swenson D. L., Olinger G. G., Kalina W. V., Aman M. J., Bavari S., Ebola virus-like particle-based vaccine protects nonhuman primates against lethal Ebola virus challenge Journal of Infectious Diseases 2007 196 supplement 2 S430 S437
121. Seder R. A., Darrah P. A., Roederer M., T-cell quality in memory and protection: implications for vaccine design Nature Reviews Immunology 2008 8 4 247 258 (Pubitemid 351432801)
122. Roederer M., Brenchley J. M., Betts M. R., De Rosa S. C., Flow cytometric analysis of vaccine responses: how many colors are enough? Clinical Immunology 2004 110 3 199 205 (Pubitemid 38402000)
123. Leffel E. K., Reed D. S., Marburg and Ebola viruses as aerosol threats Biosecurity and Bioterrorism 2004 2 3 186 191
124. Warfield K. L., Bradfute S. B., Wells J., Lofts L., Cooper M. T., Alves D. A., Reed D. K., VanTongeren S. A., Mech C. A., Bavari S., Development and characterization of a mouse model for Marburg hemorrhagic fever Journal of Virology 2009 83 13 6404 6415