Elucidation of the ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function

Journal of Proteome Research

Volumn 13, Issue 11, 2014, Pages 5120-5135

  García Dorival, Isabel ^a,b   Wu, Weining ^a   Dowall, Stuart ^c   Armstrong, Stuart ^a,b   Touzelet, Olivier ^a   Wastling, Jonathan ^a,b   Barr, John N ^d   Matthews, David ^e   Carroll, Miles ^b,c   Hewson, Roger ^b,c   Hiscox, Julian A ^a,b  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b NIHR Health Protection Research Unit in Emerging and Zoonotic Infections   (United Kingdom)

^c PUBLIC HEALTH ENGLAND   (United Kingdom)

^d UNIVERSITY OF LEEDS   (United Kingdom)

^e UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

antiviral; Ebola virus; inhibitor; interactome; label free proteomics; proteomics; virus; VP24 protein

Indexed keywords

CALCIUM PHOSPHATE; CELL PROTEIN; KARYOPHERIN ALPHA; KARYOPHERIN ALPHA6; LAMIN B; LAMIN B1; PLASMID DNA; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1A1; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA; VP24 PROTEIN; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ATP1A1 PROTEIN, HUMAN; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; OUABAIN; VP24 PROTEIN, EBOLA VIRUS;

ARTICLE; CONTROLLED STUDY; EBOLA VIRUS; GENE DISRUPTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOPRECIPITATION; MOLECULAR WEIGHT; NONHUMAN; PROGENY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; TANDEM MASS SPECTROMETRY; VIRUS CELL INTERACTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; EBOLAVIRUS; GENETICS; HEK293 CELL LINE; HOST PATHOGEN INTERACTION; MASS SPECTROMETRY; METABOLISM; PATHOGENICITY; PROCEDURES; PROTEIN ANALYSIS; REPRODUCIBILITY; VIROLOGY;

CELL LINE; EBOLAVIRUS; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; MASS SPECTROMETRY; OUABAIN; PROTEIN INTERACTION MAPPING; PROTEOMICS; REPRODUCIBILITY OF RESULTS; SODIUM-POTASSIUM-EXCHANGING ATPASE; VIRAL PROTEINS;

EID: 84908895410     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr500556d     Document Type: Article

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