Mechanisms of superoxide signaling in epigenetic processes: Relation to aging and cancer

Aging and Disease

Volumn 6, Issue 3, 2015, Pages 216-227

  Afanas'ev, Igor ^a  

^a Vitamin Research Institute   (Russian Federation)

Author keywords

Aging; Cancer; DNA and histone methylation and acetylation; Superoxide

Indexed keywords

ACETYL COENZYME A; APOPTOSIS SIGNAL REGULATING KINASE 1; CYTOSINE; DIOXYGENASE; DNA METHYLTRANSFERASE 1; EXTRACELLULAR SUPEROXIDE DISMUTASE; FAS LIGAND; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 3; HOMEODOMAIN INTERACTING PROTEIN KINASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OCTAMER TRANSCRIPTION FACTOR 1; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN P16; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; S ADENOSYLMETHIONINE; SUPEROXIDE; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR RUNX3; UVOMORULIN; XANTHINE OXIDASE;

AGING; APOPTOSIS; BARRETT ESOPHAGUS; CARDIOVASCULAR DISEASE; CELL DEATH; CELL SURVIVAL; DIABETES MELLITUS; DNA METHYLATION; EPIGENETICS; ESOPHAGEAL ADENOCARCINOMA; GENE EXPRESSION; HISTONE ACETYLATION; HISTONE DEMETHYLATION; HISTONE METHYLATION; HUMAN; HYDROXYLATION; NEOPLASM; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; SENESCENCE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

EID: 84935423069     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: 10.14336/AD.2014.0924     Document Type: Review

References (111)

1. Afanas'ev IB. Superoxide ion: Chemistry and biological implications. Vol. I. CRC Press, Boca Raton, Florida (1989).
2. Afanas'ev IB. Signaling mechanisms of oxygen and nitrogen free radicals. CRC Press, Taylor & Francis Group. Boca Raton, Florida (2009).
3. McCord JM, Fridovich I (1968). The reduction of cytochrome c by milk xanthine oxidase. J Biol Chem, 243: 5753-5760.
4. Haber F, Weiss J (1934). The catalytic decomposition of hydrogen peroxide by iron salts. Proc R Soc, A147: 332-351.
5. Fenton HJH (1894). Oxidation of tartaric acid in presence of iron. J Chem Soc Trans, 65: 899-911.
6. Niehaus WG (1978). A proposed role of superoxide anion as a biological nucleophile in the deesterification of phospholipids. Bioorganic Chemistry, 7: 77-84.
7. Afanas'ev IB (2005). On mechanism of superoxide signaling under physiological and pathophysiological conditions. Med Hypotheses, 64: 127-129.
8. Wu LC, Santi DV (1987). Kinetic and catalytic mechanism of HhaI methyltransferase. J Biol Chem, 262: 4778-4786.
9. Vilkaitis G, Merkiene E, Serva S, Weinhold E, Klimauskas S 2001). The mechanism of DNAcytosine-5 methylation. Kinetic and mutational dissection of hhai methyltransferase. J Biol Chem, 276: 20924-20934.
10. Gerasimaite R, Merkiene E, Klimasauskas S (2011). Direct observation of cytosine flipping and covalent catalysis in a DNA methyltransferase. Nucleic Acids Res, 39: 377-380.
11. Afanas'ev I (2012). Nucleophilic mechanism of ROS/RNS signaling in cancer epigenetic modifications. Am J Biomed Sci, 4: 285-306.
12. Afanas'ev I (2013). New nucleophilic mechanisms of ros-dependent epigenetic modification: comparison of aging and cancer. Aging Dis, 5: 52-62.
13. Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A (2009). Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL Partner TET1. Science, 324: 930 - 935.
14. Grzyska PK, Appelmanc EH, Hausingera RP, Proshlyakova DA (2010). Insight into the mechanism of an iron dioxygenase by resolution of steps following the FeIV=O species. Proc Nat Acad Sci USA, 107: 3982- 3987.
15. Krest CM, Onderko EL, Yosca TH, Calixto JO, Karp RF, Livada J, Rittle J, Green MT (2013). Reactive intermediates in cytochrome P450 catalysis. J Biol Chem, 288, 17074-17081.
16. Afanas'ev I (2011). Reaction oxygen species signaling in cancer: comparison with aging. Aging Dis, 2:219-230.
17. Brar SS, Corbin Z, Kennedy TP, Hemendinger R, Thornton L, Bommarius B, Arnold RS, Whorton AR, Sturrock AB, Huecksteadt TP, Quinn MT, Krenitsky K, Ardie KG, Lambeth JD, Hoidal JR (2003). NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells. Am J Physiol Cell Physiol, 285: C353-C369.
18. Kumar B, Koul S, Khandrika L, Measchan RB, Koul HK (2008). Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. Cancer Res, 68:1777-1785
19. Veeramani S, Yuan TC, Lin FF, Lin MF (2008). Mitochondrial redox signaling by p66Shc in involved in regulating androgenic growth stimulation of human prostate cancer cell. Oncogene, 27: 5057-5068.
20. Singh SV, Choi S, Zeng Y, Haim ER, Xiao D (2007). Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase. Cancer Res, 67: 7439-7449.
21. Shukla S, Gupta S (2008). Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation. Free Radic Biol Med, 44: 1833- 1845.
22. Antosiewicz J, Herman-Antociewicz A, Marynowski SW, Singh SV (2006). c-Jun NH2-terminal kinase signaling axis regulates diallyl trisulfide-induced generation of reactive oxygen species and cell cycle arrest in human prostate cancer cells. Cancer Res, 66: 5379-5386.
23. Zhao R, Domann FE, Zhong W (2006). Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells. Mol Cancer Ther, 5: 3275-3284.
24. Hong HY, Kim BC (2007). Mixed lineage kinase 3 connects reactive oxygen species to c-Jun NH2-terminal kinase-induced mitochondrial apoptosis in genipin-treated PC3 human prostate cancer cells. Biochem Biophys Res Commun, 362: 307-312.
25. Sun Y, St Clair DK, Xu Y, Crook PA, St Clair WH (2010). A NADPH oxidase-dependent redox signaling pathway mediates the selective radio sensitization effect of parthenolide in prostate cancer cells. Cancer Res, 70: 2880-2890.
26. Vaquero EC, Edderkaoui M, Pandol SJ, Gukovsky I, Gukovskaya AS (2004). Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. J Biol Chem, 279: 34643- 34654.
27. Cullen JJ, Weydert C, Hinkhouse MM, Ritchie J, Domann FE, Spitz D, Oberley LW(2003). The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma. Cancer Res, 63: 1297- 1303.
28. Weydert C, Roling B, Liu J, Hinkhouse MM, Ritchie JM, Oberley LW, Cullen JJ (2003). Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase. Mol Cancer Ther, 2: 361-369.
29. Teoh ML, Sun W, Smith BJ, Oberley LW, Cullen JJ. Modulation of reactive oxygen species in pancreatic cancer. Clin Cancer Res 2007; 13: 7441-7450.
30. Mochizuki N, Furuta S, Mitsushita J, Shang WH, Ito M, Yokoo Y, Yamaura M, Ishizone S, Nakayagai J, Konagai A, Hirose K, Kiyosawa K, Kamata T (2006). Inhibition of NADPH oxidase activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells. Oncogene, 25: 3699-3707.
31. Lee JK, Edderkaoui M, Truong P, Ohno I, Jang KT, Berti A, Pandol SJ, Gukovsaya AS (2007). NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases. Gastroenterology, 133: 1637-1648.
32. Lau ST, Lin ZX, Leung PS (2010). Role of reactive oxygen species in brucein D-mediated p38- mitogenactivated protein kinase and nuclear factor-kappa B signaling pathways in human pancreatic adenocarcinoma cells. Br J Cancer, 102: 583-593.
33. Brar SS, Kennedy TP, Sturrock AB, Huecksteadt TP, Quinn MT, Whorton AR, Hoidal JR (2002). NAD(P)H oxidase regulates growth and transcription in melanoma cells. Am J Physiol Cell Physiol, 282: 1212-1224.
34. Govindarajan B, Sligh JE, Vincent BJ, Li M, Canter JA, Nickoloff BJ, Rodenburg RJ, Smeitink JA, Oberley L, Zhang Y, Slingerland J, Arnold RS, Lambeth JD, Cohen C, Hilenski L, Griendling K, Martínez-Diez M, Cuezva JM, Arbiser JL (2007). Overexpression of Akt converts radial growth melanoma to vertical growth melanoma. J Clin Invest, 117: 719-729.
35. Yamaura M, Mitsushita J, Furuta S, Kiniwa Y, Ashida A, Goto Y, Shang WH, Kubodera M, Kato M, Takata M, Saida T, Kamata T (2009). NADPH oxidase 4 contributes to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression. Cancer Res, 69:2647-2654.
36. Lin CW, Yang LY, Shen SC, Shen YC (2007). IGF-I plus induces proliferation via activation of ROSdependent ERKs and JNKs in human breast carcinoma cell. J Cell Physiol, 212: 666-674.
37. Choi JA, Lee JW, Kim H, Kim EY, Seo JM, Ko J, Kim JH (2010). Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway. Carcinogenesis, 31: 543-551.
38. Cao XH, Wang AH, Wang CL, Mao DZ, Lu MF, Cui YQ, Jiao RZ (2010). Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNKmediated mitochondrial/caspase pathway. Chem Biol Interact, 183: 357-362.
39. Deng YT, Huang HC, Lin JK (2010). Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling. Mol Carcinog, 49: 141-151.
40. Shono T, Yokoyama N, Uesaka T, Kuroda J, Takeya R, Yamasaki T, Amano T, Mizoguchi M, Suzuki SO, Niiro H, Miyamoto K, Akashi K, Iwaki T, Sumimoto H, Sasaki T (2008). Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival. Int J Cancer, 123: 787-792.
41. Caja L, Sancho P, Bertran E, Iglesias-Serret D, Gil J, Fabregat I (2009). Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing upregulation of the NADPH oxidase NOX4. Cancer Res, 69: 7595-7602.
42. Chen FH, Zhang LB, Qiang L, Yang Z, Wu T, Zou MJ, Tao L, You QD, Li ZY, Yang Y, Guo QL (2010). Reactive oxygen species-mitochondria pathway involved in LYG-202-induced apoptosis in human hepatocellular carcinoma HepG(2) cells. Cancer Lett, 296: 96-105.
43. Kim EY, Seo JM, Kim C, Lee JE, Lee KM, Kim JH(2010). BLT2 promotes the invasion and metastasis of aggressive bladder cancer cells through a reactive oxygen species-linked pathway. Free Radic Biol Med, 49: 1072-1081.
44. Park IJ, Hwang JT, Kim YM, Ha J, Park OJ (2006). Differential modulation of AMPK signaling pathways by low or high levels of exogenous reactive oxygen species in colon cancer cells. Ann N Y Acad Sci, 1091: 102-109.
45. Xia C, Meng Q, Liu LZ, Rojanasakul Y, Wang XR, Jiang BH (2007). Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor. Cancer Res, 67:10823-30.
46. Chan DW, Liu VW, Tsao GS, Yao KM, Furukawa T, Chan KK, Ngan HY (2008). Loss of MK3 mediated by oxidative stress enhances tumorigenicity and chemiluminescence of ovarian cancer cells. Carcinogenesis, 29: 1742-1750.
47. Laurent A, Nicco C, Chereau C, Goulvestre C, Alexandre J, Alves A, Levy E, Goldwasser F, Panis Y, Soubrane O, Weill B, Batteux F (2005). Controlling tumor growth by modulating endogenous production of reactive oxygen species. Cancer Res, 65: 948-956.
48. Schumacker PT (2006). Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell, 10: 175-176.
49. Desouki MM, Kulawiec M, Bansal S, Das GM, Singh KK (2005). Cross talk between mitochondria and superoxide generating NADPH Oxidase in breast and ovarian tumors. Cancer Biol Ther, 4: 1367-1373.
50. Ma Q, Cavallin LE, Yan B, Zhu S, Duran EM, Wang H, Hale LP, Dong C, Cesarman E, Mesri EA, Goldschmidt-Clermonta PJ (2009). Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma. Proc Natl Acad Sci USA, 106: 8683-8688.
51. Sawada M, Carlson JC (1987). Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat (1992). Mech Ageing Dev, 41: 125-137.
52. Sawada M, Sester U, Carlson JC (1992). Superoxide radical formation and associated biochemical alterations in the plasma membrane of brain, heart, and liver during the lifetime of the rat. J Cell Biochem, 48: 296-304.
53. Chung HY, Song SH, Kim HJ, Ikeno Y, Yu BP (1999). Modulation of renal xanthine oxidoreductase in aging: gene expression and reactive oxygen species generation. J Nutr Health Aging, 3: 19-23.
54. Moon SK, Thompson LJ, Madamanchi N, Ballinger Papaconstantinou SJ, Horaist C, Ruuge MS, Patterson C. Aging, oxidative responses, and proliferative capacity in cultured mouse aortic smooth muscle cells. Am J Physiol Heart Circ Physiol 2001; 280: H2779-H2788.
55. Chen H, Cangello D, Benson S, Folmer J, Zhu H, Trush MA, Zirkin BR (2001). Age related increase in mitochondrial superoxide generation in the testosterone-producing cells of Brown Norway rat testes: relationship to reduced steroidogenic function? Exp Gerontol, 36: 1361-1373.
56. J acobson AK, Yan C, Gao Q, Rincon-Skinner T, Rivera A, Edwards J, Huang A, Kaley G, Sun D (2007). Aging enhances pressure-induced arterial superoxide formation. Am J Physiol Heart Circ Physiol, 293:1344-1350.
57. Donato AJ, Eskurza I, Silver AE, Levy AS, Pierce GL, Gates PE, Seals DR (2007). Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB. Circ Res, 100:1659-1666.
58. Lener B, Koziel R, Pircher H, Hutter E, Greussing R, Herndler-Brandstetter D, Hermann M, Unterluggauer H, Jansen-Durr P (2009). The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells. Biochem J, 423: 363-374.
59. Rodriguez-Manas L, El-Assar M, Vallejo S, Lopez-Doriga P, Solis J, Petidier R, Montes M, Nevado J, Castro M, Gomez-Guerrero C, Peiro C, Sanchez-Ferrer CF (2009). Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation. Aging Cell, 8: 226-238.
60. Sasaki T, Unno K, Tahara S, Shimada A, Chiba Y, Hoshino M, Kaneko T (2008).Age-related increase of superoxide generation in the brains of mammals and birds. Aging Cell, Apr 14 [Epub ahead of print].
61. Mendoza-Nunez VM, Ruiz-Ramos M, Sanchez-Rodriguez MA, Retana-Ugalde R, Munoz-Sanchez JL (2007). Aging-related oxidative stress in healthy humans. Tohoku J Exp Med 2007; 213: 20.
62. Miyazawa M, Ishii T, Yasuda K, Noda S, Onouchi H, Hartman PS, Ishii N (2009). The role of mitochondrial superoxide anion (O2(-)) on physiological aging in C57BL/6J mice. J Radiat Res, 50: 73-83.
63. Lund DD, Chu Y, Miller JD, Heistad DD (2009). Protective effect of extracellular superoxide dismutase on endothelial function during aging. Am J Physiol Heart Circ Physiol, 296: H1920-H1925.
64. Afanas'ev I (2011). ROS and RNS signaling in heart disorders: could antioxidant treatment be successful? Oxid Med Cell Longev 2011; 2011: 293769.
65. Afanas'ev I (2010). Signaling of reactive oxygen and nitrogen species in Diabetes mellitus. Oxid Med Cell Longev, 3: 361-373.
66. Afanas'ev IB (2006). Competition between superoxide and hydrogen peroxide signaling in heterolytic enzymatic processes. Med Hypotheses, 66: 1125-1128.
67. Larsson R, Cerutti P (1989). Translocation and enhancement of phosphotransferase activity of protein kinase c following exposure in mouse epidermal cells to oxidants. Cancer Res, 49: 5627-5632.
68. Baas AS, Berk BC (1995). Differential activation of mitogen-activated protein kinases by H2O2 and O2.- in vascular smooth muscle cells. Circ Res, 77: 29-36.
69. Li PF, Dietz R, von Harsdorf (1997). H2O2 and O2.-Differential effects of hydrogen peroxide and superoxide anion on apoptosis and proliferation of vascular smooth muscle cells. Circulation, 96: 3602-3609.
70. Devadas S, Zaritskaya L, Rhee SG, et al (2002). Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression. J Exp Med, 195: 59-70.
71. Sawada M, Nakashima S, Kiyono T, et al (2001). p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells. Oncogene, 20: 1368-1378.
72. Hirpara JL, Clement M-V, Pervaiz S (2001). Intracellular acidification triggered by mitochondrialderived hydrogen peroxide is an effector mechanism of for drug-induced apoptosis in tumor cells. J Biol Chem, 276: 514-521.
73. Pervaiz S, Clement MV (2002). A permissive apoptotic environment: function of a decrease in intracellular superoxide anion and cytosolic acidification. Biochem Biophys Res Commun, 290: 1145-1150.
74. Ahmad KA, Clement M-V, Hamif IM, Pervaiz S (2004). Resveratrol inhibits drug-induced apoptosis in human leukemia cells by creating an intracellular milieu nonpermissive for death execution. Cancer Res, 64: 1452-1459.
75. Poh TW, Pervaiz S (2005). LY294002 and LY303511 sensitize tumor cells to drug -induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway. Cancer Res, 65: 6264-6274.
76. Madesh M, Hajnoczky (2001). VDAC-dependent permeabilization of outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J Cell Biol, 156: 1003-1016.
77. Kabra DG, Gupta J, Tikoo, K (2009). Insulin induced alteration in post-translational modifications of histone H3 under a hyperglycemic condition in L6 skeletal muscle myoblasts. Biochim Biophys Acta, 1792: 574-583.
78. Gupta J, Tikoo K (2012). Involvement of insulininduced reversible chromatin modeling in altering the expression of oxidative stress-responsive genes under hyperglycemia in 3T3-L1 preadipocytes. Gene, 504,181-191.
79. Bartling TR, Drumm ML (2009). Oxidative stress causes IL8 promoter hyperacetylation in cystic fibrosis airway cell models. Am J Respir Cell Mol Biol, 40: 58-65.
80. Min JY, Lim SO, Jung G (2010). Downregulation of catalase by reactive oxygen species via hypermethylation of CpG island II on the catalase promoter. FEBS Lett, 584: 2427-2432
81. Quan X, Lim SO, Jung G (2011). Reactive oxygen species downregulate catalase via methylation of a CpG Island in the Oct-1promoter. FEBS Lett, 585: 3436-3441.
82. Molognoni F, de Melo FHM, da Silva CT, Jasiulionis MG (2013). Ras and Rac1frequently mutated in melanomas, are activated by superoxide anion, modulate Dnmt1 level and are causally related to melanocyte malignant transformation. PLOS ONE, 8 (Issue 12): e81937.
83. Sanders YY, Liu H, Zhang X, Hecker L, Bernard K, Desai L, Liu G, Thannickal VJ (2013). Histone modifications in senescence-associated resistance to apoptosis by oxidative stress. Red Biology, 8-16.
84. Bhusari SS, Dobosy JR, FuV, Almassi N, Oberley T, Jarrard DF (2010). Superoxide dismutase 1 knockdown induces oxidative stress and DNA methylation loss in the prostate. Epigenetics, 5: 402-409.
85. Lim SO, Gu JM, Kim MS, Kim H, Park YN, Park CK, Cho JW, Park YM, Jung G (2008). Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter. Gastroenterology, 135: 2128-2140.
86. Campos AC, Molognoni F, Melo FH, Galdieri LG, Carneiro CR, D'Almeida V, Correa M, Jasiulionis MG (2007). Oxidative stress modulates DNA methylation during melanocyte anchorage blockade associated with malignant transformation. Neoplasia, 9: 1111-1121.
87. Hong J, Resnick M, Behar J, Wang LJ, Wands J, De Lellis RA, Souza RF, Spechler SJ, Cao W (2010). Acidinduced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S. Am J Physiol Gastrointest Liver Physiol, 299: G697-706.
88. Kim GH, Ryan JJ, Archer SL (2013). The role of redox signaling in epigenetic and cardiovascular disease. Antioxid Redox Signal, 18: 1920-1936.
89. Xiong F, Xiao D, Zhang L (2012). Norepinephrine causes epigenetic repression of PKC gene in rodent hearts by activating Nox1-dependent reactive oxygen species production. FASEB J, 26: 2753 - 2763.
90. Patterson AJ, Xiao D, Xiong F, Dixon B, Zhang L (2012). Hypoxia-derived oxidative stress mediates epigenetic repression of PKC gene in foetal rat hearts. Cardiovasc Res, 93: 302-310.
91. Nanduri J, Makarenko V, Reddy VD, Yuan G, Pawar A, Wang N, Khan SA, Zhang X, Kinsman B, Peng YJ, Kumar GK, Fox AP, Godley LA, Semenza GL, Prabhakar N (2012). Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. Proc Natl Acad Sci USA, 109: 2515-2520.
92. Chen J, Han J, Wang J (2013). Prevention of cytotoxicity of nickel by quercetin: the role of reactive oxygen species and histone acetylation. Toxicol Ind Health, 29: 360-366.
93. Cui MS, Wang XL, Tang DW, Zang J, Liu Y, Zeng SM (2011). Acetylation of H4K12 in porcine oocytes during in vitro aging: potential role of ooplasmic reactive oxygen species. Theriogenology, 75: 638-646.
94. Choudhury M, Park PH, Jackson D, Shukla SD (2010). Evidence for the role of oxidative stress in the acetylation of histone H3 by ethanol in rat hepatocytes. Alcohol, 44: 531-540.
95. Druz A, Betenbaugh M, Shiloach J (2012). Glucose depletion activates mmu-miR-466h-5p expression through oxidative stress and inhibition of histone deacetylation. Nucleic Acids Res, 40: 7291-7302.
96. Kang KA, Zhang R, Kim GY, Bac SC, Hyun JW (2012). Epigenetic changes by oxidative stress in colorectal cancer cells: methylation of tumor suppressor RUNX3. Tumor Biol, 33: 403-412.
97. Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu GM, Scott Budinger GR, Chandela NS (2010). Mitochondrial metabolism and ROS generation are essential for Krasmediated tumorigenicity. Proc Natl Acad Sci USA, 107: 8788-8793.
98. Wongpaiboonwattana W, Tosukhowong P, Dissayabutra T, Mutirangura A, Boonla C (2013). Oxidative stress induces hypomethylation of LINE-1 and hypermethylation of the RUNX3 promoter in a bladder cancer cell line. Asian Pac J Cancer Prev, 14: 3773-3778.
99. Zhang R, Kang KA, Kim KC, Na SY, Chang WY, Kim GY, Kim HS, Hyun JW (2013). Oxidative stress causes epigenetic alteration of CDX1 expression in colorectal cancer cells. Gene, 524: 214-219.
100. de la Vega L, Grishina I, Moreno R, Kruger M, Braun T, Schmitz MI (2012). A redox-regulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress. Mol Cell, 46: 472-483.
101. Zhang W, Ji W, Yang J, Yang L, Chen W, Zhuang Z (2008). Comparison of global DNA methylation profiles in replicative versus premature senescence. Life Sci, 83: 475-480.
102. Kim YJ, Jung JK, Lee SY, Jang KL (2010). Hepatitis B virus X protein overcomes stressinduced premature senescence by repressing p16(INK4a) expression via DNA methylation. Cancer Lett, 288: 226-235.
103. Gentilini D, Mari D, Castaldi D, Remondini D, Ogliari G, Ostan R, Bucci L, Sirchia SM, Tabano S, Cavagnini F, Monti D, Franceschi C, Di Blasio AM, Vitale G (2013). Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring. Age (Dordr), 35: 1961-1973.
104. Schroeder EA, Raimundo N, Shadel GS (2013). Epigenetic silencing mediates mitochondria stressinduced longevity. Cell Metab, 17: 954-964.
105. Coulter JB, O'Driscoll CM, Bressler JP (2013). Hydroquinone increases 5-hydroxymethylcytosine formation through Ten Eleven Translocation 1 (TET1) 5-methylcytosine dioxygenase. J Biol Chem, 288, 28792-28800.
106. Zhao B, Yang Y, Wang X, Chong Z, Yin R, Song S-H, Zhao C, Li C, Huang H, Sun B-F, Wu D, Jin K-X, Song M, Zhu B-Z, Jiang G, Rendtlew Danielsen JM, Xu G-L, Yang Y-G, Wang H (2013). Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism. Nucleic Acids Res, 10.1093/nar/gkt1090.
107. Du J, Cullen JJ, Buettner GR (2012). Ascorbic acid: Chemistry, biology and the treatment of cancer. Biochim Biophys Acta, 1826: 443-457.
108. Cloos PA, Christensen J, Agger K, Helin K (2008). Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev, 22: 1115-1140.
109. Chung TL, Brena RM, Kolle G, Grimmond SM, Berman BP, Laird PW, Pera MF, Wolvetang EJ (2010). Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells. Stem Cells, 28: 1848-1855.
110. Minor EA, Court BL, Young JI, Wang G (2013). Ascorbate induces Ten-Eleven Translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine. J Biol Chem, 288: 13669-13674.
111. Cyr AR, Domann FE (2011). The redox basis of epigenetic modifications: from mechanisms to functional consequences. Antioxidants & Redox Signaling, 15: Number 2.