Ras and Rac1, frequently mutated in melanomas, are activated by superoxide anion, modulate Dnmt1 level and are causally related to melanocyte malignant transformation

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Molognoni, Fernanda ^a   De Melo, Fabiana Henriques Machado ^a   Da Silva, Camila Tainah ^a   Jasiulionis, Miriam Galvonas ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA METHYLTRANSFERASE 1; MITOGEN ACTIVATED PROTEIN KINASE; RAC1 PROTEIN; RAS PROTEIN; SUPEROXIDE;

ARTICLE; CELL ACTIVATION; CELL TRANSFORMATION; CODON; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DNA METHYLATION; ENZYME ACTIVATION; FEEDBACK SYSTEM; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MELANOCYTE; MELANOMA; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULAR PATHOLOGY; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; MAP KINASE SIGNALING SYSTEM; MELANOCYTES; MELANOMA; MICE; RAC1 GTP-BINDING PROTEIN; RAS PROTEINS; SIGNAL TRANSDUCTION; SUPEROXIDES;

EID: 84893019538     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0081937     Document Type: Article

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