Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3

Blood

Volumn 125, Issue 25, 2015, Pages 3886-3895

  Goettel, Jeremy A ^a,b   Biswas, Subhabrata ^b,c   Lexmond, Willem S ^a,b   Yeste, Ada ^b,d   Passerini, Laura ^e   Patel, Bonny ^b,d   Yang, Siyoung ^b   Sun, Jiusong ^b,c   Ouahed, Jodie ^a,b   Shouval, Dror S ^a,b   McCann, Katelyn J ^a   Horwitz, Bruce H ^b,f   Mathis, Diane ^b   Milford, Edgar L ^b,f   Notarangelo, Luigi D ^a,b   Roncarolo, Maria Grazia ^e,g   Fiebiger, Edda ^a,b   Marasco, Wayne A ^b,c   Bacchetta, Rosa ^e   Quintana, Francisco J ^b,d   Pai, Sung Yun ^a,b,c   Klein, Christoph ^h   Muise, Aleixo M ⁱ   Snapper, Scott B ^a,b,f   more..

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d Brigham and Women's Hospital Center for Neurologic Diseases   (United States)

^e SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^h LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

ⁱ HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD34 ANTIGEN; CD4 ANTIGEN; HLA DR1 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; FATALITY; GENE REARRANGEMENT; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IPEX SYNDROME; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; THYMUS; ANIMAL; DEFICIENCY; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; IMMUNOPHENOTYPING; KNOCKOUT MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; XENOGRAFT;

ANIMALS; AUTOIMMUNITY; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGIC DEFICIENCY SYNDROMES; IMMUNOPHENOTYPING; MICE; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 84934976887     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-12-618363     Document Type: Article

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