B cells are critical for autoimmune pathology in Scurfy mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 47, 2013, Pages 19042-19047

  Aschermann, Susanne ^a   Lehmann, Christian H K ^b   Mihai, Sidonia ^a   Schett, Georg ^b   Dudziak, Diana ^b   Nimmerjahn, Falk ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BONE MARROW CELL; CELL INTERACTION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENTEROPATHY; HELPER CELL; HUMAN; IMMUNE DYSREGULATION; INFLAMMATION; IPEX SYNDROME; KIDNEY; LIVER; LUNG; LYMPHOCYTE DEPLETION; MOUSE; NONHUMAN; PHENOTYPE; POLYENDOCRINOPATHY; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SKIN; SURVIVAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ADOPTIVE TRANSFER; ANIMALS; AUTOANTIBODIES; AUTOIMMUNITY; B-LYMPHOCYTES; BLOOD UREA NITROGEN; ENZYME-LINKED IMMUNOSORBENT ASSAY; ENZYME-LINKED IMMUNOSPOT ASSAY; FORKHEAD TRANSCRIPTION FACTORS; GENETIC DISEASES, X-LINKED; IMMUNE TOLERANCE; MICE; MICE, KNOCKOUT; STATISTICS, NONPARAMETRIC; T-LYMPHOCYTES, REGULATORY;

EID: 84888105363     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1313547110     Document Type: Article

References (30)

1. Sakaguchi S, Yamaguchi T, Nomura T, Ono M (2008) Regulatory T cells and immune tolerance. Cell 133(5-775-787.
2. Shevach EM (2011) Biological functions of regulatory T cells. Adv Immunol 112:137-176.
3. Powell BR, Buist NR, Stenzel P (1982) An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy. J Pediatr 100(5-731-737.
4. Josefowicz SZ, Lu LF, Rudensky AY (2012) Regulatory T cells: Mechanisms of differentiation and function. Annu Rev Immunol 30:531-564.
5. Sakaguchi S, Miyara M, Costantino CM, Hafler DA (2010) FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 10(7-490-500.
6. O'Garra A, Vieira P (2004) Regulatory T cells and mechanisms of immune system control. Nat Med 10(8-801-805.
7. Brunkow ME, et al. (2001) Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 27(1- 68-73.
8. Bennett CL, Ochs HD (2001) IPEX is a unique X-linked syndrome characterized by immune dysfunction, polyendocrinopathy, enteropathy, and a variety of autoimmune phenomena. Curr Opin Pediatr 13(6-533-538.
9. Godfrey VL, Wilkinson JE, Russell LB (1991) X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. Am J Pathol 138(6-1379-1387.
10. Baud O, et al. (2001) Treatment of the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) by allogeneic bone marrow transplantation. N Engl J Med 344(23-1758-1762.
11. Sakaguchi S, Takahashi T, Nishizuka Y (1982) Study on cellular events in post-Thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J Exp Med 156(6-1577-1586.
12. Lahl K, et al. (2007) Selective depletion of Foxp3+ regulatory T cells induces a scurfylike disease. J Exp Med 204(1-57-63.
13. Fowell D, Mason D (1993) Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential. J Exp Med 177(3-627-636.
14. Powrie F, Mason D (1990) OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: Prevention by the OX-22low subset. J Exp Med 172(6-1701-1708.
15. Sakaguchi S, Fukuma K, Kuribayashi K, Masuda T (1985) Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-Tolerance; deficit of a T cell subset as a possible cause of autoimmune disease. J Exp Med 161(1-72-87.
16. Smyk-Pearson SK, Bakke AC, Held PK, Wildin RS (2003) Rescue of the autoimmune scurfy mouse by partial bone marrow transplantation or by injection with T-enriched splenocytes. Clin Exp Immunol 133(2-193-199.
17. Blair PJ, et al. (1994) CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse. J Immunol 153(8-3764-3774.
18. Singh N, et al. (2007) Role of CD28 in fatal autoimmune disorder in scurfy mice. Blood 110(4-1199-1206.
19. Waterhouse P, et al. (1995) Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270(5238-985-988.
20. Tivol EA, et al. (1995) Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3(5-541-547.
21. Ju ST, Sharma R, Gaskin F, Fu SM(2012) IL-2 controls trafficking receptor gene expression and Th2 response for skin and lung inflammation. Clin Immunol 145(1-82-88.
22. Huter EN, Natarajan K, Torgerson TR, Glass DD, Shevach EM (2010) Autoantibodies in scurfy mice and IPEX patients recognize keratin 14. J Invest Dermatol 130(5-1391-1399.
23. Leonardo SM, Josephson JA, Hartog NL, Gauld SB (2010) Altered B cell development and anergy in the absence of Foxp3. J Immunol 185(4-2147-2156.
24. Lim HW, Hillsamer P, Banham AH, Kim CH (2005) Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells. J Immunol 175(7-4180-4183.
25. Riewaldt J, et al. (2012) Severe developmental B lymphopoietic defects in Foxp3-deficient mice are refractory to adoptive regulatory T cell therapy. Front Immunol 3:141.
26. Chung Y, et al. (2011) Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med 17(8-983-988.
27. Biburger M, et al. (2011) Monocyte subsets responsible for immunoglobulin G-dependent effector functions in vivo. Immunity 35(6-932-944.
28. Fields ML, et al. (2005) CD4+ CD25+ regulatory T cells inhibit the maturation but not the initiation of an autoantibody response. J Immunol 175(7-4255-4264.
29. McGinness JL, Bivens MM, Greer KE, Patterson JW, Saulsbury FT (2006) Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) associated with pemphigoid nodularis:Acase report and review of the literature.JAmAcadDermatol 55(1-143-148.
30. Ephrem A, et al. (2013) Modulation of Treg cells/T effector function by GITR signaling is context-dependent. Eur J Immunol 43(9-2421-2429.