Human B-cell ontogeny in humanized NOD/SCID γcnull mice generates a diverse yet auto/poly-and HIV-1-reactive antibody repertoire

Genes and Immunity

Volumn 13, Issue 5, 2012, Pages 399-410

  Chang, H ^a,b,c   Biswas, S ^a,b   Tallarico, A S ^a,b   Sarkis, P T N ^a,b   Geng, S ^a,b,d   Panditrao, M M ^a,b   Zhu, Q ^a,b   Marasco, W A ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HEBEI MEDICAL UNIVERSITY   (China)

^d Tian Guang Shi Biotechnology Co LTD   (China)

Author keywords

antibody repertoire; autoreactive; checkpoint control; humanized mouse; single B cell

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS 1 REACTIVE ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; BONE MARROW; CONTROLLED STUDY; GENE AMPLIFICATION; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IMMUNE SYSTEM; MALE; MOUSE; NONHUMAN; ONTOGENY; PRIORITY JOURNAL;

ANIMALS; AUTOANTIBODIES; B-LYMPHOCYTES; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; FEMALE; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; HIV ANTIBODIES; HIV-1; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; MALE; MICE; MICE, INBRED NOD; MICE, SCID; PROTEIN BINDING; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; V(D)J RECOMBINATION;

HUMAN IMMUNODEFICIENCY VIRUS 1; MUS;

EID: 84864153340     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2012.16     Document Type: Article

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