PD-1HIGH follicular CD4 T helper cell subsets residing in lymph node germinal centers correlate with B cell maturation and IgG production in rhesus macaques

Frontiers in Immunology

Volumn 5, Issue MAR, 2014, Pages

  Xu, Huanbin ^a   Wang, Xiaolei ^a   Lackner, Andrew A ^a   Veazey, Ronald S ^a  

^a TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

Author keywords

B cell; Follicular CD4 T helper cells; IgG; Lymph nodes; PD 1

Indexed keywords

CHEMOKINE RECEPTOR CXCR5; IMMUNOGLOBULIN G; INTERLEUKIN 21;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CD4+ T FOLLICULAR HELPER CELL; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL MATURATION; CONFOCAL MICROSCOPY; FLOW CYTOMETRY; GERMINAL CENTER; HELPER CELL; IMMUNOHISTOCHEMISTRY; INFANT; NEWBORN; NONHUMAN; PD 1HIGH CELL; PD 1INT CELL; PROTEIN EXPRESSION; RHESUS MONKEY;

EID: 84897937811     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00085     Document Type: Article

References (25)

1. Reinhardt RL, Liang HE, Locksley RM. Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol (2009) 10:385-93. doi: 10.1038/ni.1715
2. Nurieva RI, Chung Y. Understanding the development and function of T follicular helper cells. Cell Mol Immunol (2010) 7:190-7. doi:10.1038/cmi.2010.24
3. Vinuesa CG, Linterman MA, Goodnow CC, Randall KL. T cells and follicular dendritic cells in germinal center B-cell formation and selection. Immunol Rev (2010) 237:72-89. doi:10.1111/j.1600-065X.2010.00937.x
4. King C, Sprent J. Emerging cellular networks for regulation of T follicular helper cells. Trends Immunol (2012) 33:59-65. doi:10.1016/j.it.2011.11.006
5. Johnston RJ, Poholek AC, Ditoro D, Yusuf I, Eto D, Barnett B, et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science (2009) 325:1006-10. doi:10.1126/science.1175870
6. Yu D, Rao S, Tsai LM, Lee SK, He Y, Sutcliffe EL, et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity (2009) 31:457-68. doi:10.1016/j.immuni.2009.07.002
7. Xu H, Wang X, Pahar B, Moroney-Rasmussen T, Alvarez X, Lackner AA, et al. Increased B7-H1 expression on dendritic cells correlates with programmed death 1 expression on T cells in simian immunodeficiency virus-infected macaques and may contribute to T cell dysfunction and disease progression. J Immunol (2010) 185:7340-8. doi:10.4049/jimmunol.1001642
8. Crotty S. Follicular helper CD4 T cells (TFH). Annu Rev Immunol (2011) 29:621-63. doi:10.1146/annurev-immunol-031210-101400
9. Good-Jacobson KL, Szumilas CG, Chen L, Sharpe AH, Tomayko MM, Shlomchik MJ. PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat Immunol (2010) 11:535-42. doi:10.1038/ni.1877
10. Xu H, Wang X, Liu DX, Moroney-Rasmussen T, Lackner AA, Veazey RS. IL-17-producing innate lymphoid cells are restricted to mucosal tissues and are depleted in SIV-infected macaques. Mucosal Immunol (2012) 5(6):658-69. doi:10.1038/mi.2012.39
11. Onabajo OO, George J, Lewis MG, Mattapallil JJ. Rhesus macaque lymph node PD-1(hi)CD4+ T cells express high levels of CXCR5 and IL-21 and display a CCR7(lo)ICOS+Bcl6+ T-follicular helper (Tfh) cell phenotype. PLoS One (2013) 8:e59758. doi:10.1371/journal.pone.0059758
12. Bailly A, Gartner A. Germ cell apoptosis and DNA damage responses. Adv Exp Med Biol (2013) 757:249-76. doi:10.1007/978-1-4614-4015-4_9
13. Mastelic B, Kamath AT, Fontannaz P, Tougne C, Rochat AF, Belnoue E, et al. Environmental and T cell-intrinsic factors limit the expansion of neonatal follicular T helper cells but may be circumvented by specific adjuvants. J Immunol (2012) 189:5764-72. doi:10.4049/jimmunol.1201143
14. Debock I, Jaworski K, Chadlaoui H, Delbauve S, Passon N, Twyffels L, et al. Neonatal follicular Th cell responses are impaired and modulated by IL-4. J Immunol (2013) 191:1231-9. doi:10.4049/jimmunol.1203288
15. Linterman MA, Beaton L, Yu D, Ramiscal RR, Srivastava M, Hogan JJ, et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med (2010) 207:353-63. doi:10.1084/jem.20091738
16. Zotos D, Coquet JM, Zhang Y, Light A, D'Costa K, Kallies A, et al. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med (2010) 207:365-78. doi:10.1084/jem.20091777
17. Hams E, McCarron MJ, Amu S, Yagita H, Azuma M, Chen L, et al. Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells. J Immunol (2011) 186:5648-55. doi:10.4049/jimmunol.1003161
18. Kawamoto S, Tran TH, Maruya M, Suzuki K, Doi Y, Tsutsui Y, et al. The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut. Science (2012) 336:485-9. doi:10.1126/science.1217718
19. Gulbranson-Judge A, MacLennan I. Sequential antigen-specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c. Eur J Immunol (1996) 26:1830-7. doi:10.1002/eji.1830260825
20. Zheng B, Han S, Zhu Q, Goldsby R, Kelsoe G. Alternative pathways for the selection of antigen-specific peripheral T cells. Nature (1996) 384:263-6. doi:10.1038/384263a0
21. MacLennan IC. Somatic mutation. From the dark zone to the light. Curr Biol (1994) 4:70-2. doi:10.1016/S0960-9822(00)00017-8
22. Kelsoe G. The germinal center reaction. Immunol Today (1995) 16:324-6. doi:10.1016/0167-5699(95)80146-4
23. Yu D, Vinuesa CG. The elusive identity of T follicular helper cells. Trends Immunol (2010) 31:377-83. doi:10.1016/j.it.2010.07.001
24. Schillie SF, Murphy TV. Seroprotection after recombinant hepatitis B vaccination among newborn infants: a review. Vaccine (2013) 31:2506-16. doi:10.1016/j.vaccine.2012.12.012
25. Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol (2009) 10:29-37. doi:10.1038/ni.1679