-
1
-
-
50049104725
-
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: A case-control study
-
CrossRef PubMed
-
Healy, D.G., Falchi, M., O'Sullivan, S.S., Bonifati, V., Durr, A., Bressman, S., Brice, A., Aasly, J., Zabetian, C.P., Goldwurm, S. et al. (2008) Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study. Lancet Neurol 7, 583-590 CrossRef PubMed
-
(2008)
Lancet Neurol
, vol.7
, pp. 583-590
-
-
Healy, D.G.1
Falchi, M.2
O'Sullivan, S.S.3
Bonifati, V.4
Durr, A.5
Bressman, S.6
Brice, A.7
Aasly, J.8
Zabetian, C.P.9
Goldwurm, S.10
-
2
-
-
70549084415
-
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
-
CrossRef PubMed
-
Satake, W., Nakabayashi, Y., Mizuta, I., Hirota, Y., Ito, C., Kubo, M., Kawaguchi, T., Tsunoda, T., Watanabe, M., Takeda, A. et al. (2009) Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat. Genet. 41, 1303-1307 CrossRef PubMed
-
(2009)
Nat. Genet.
, vol.41
, pp. 1303-1307
-
-
Satake, W.1
Nakabayashi, Y.2
Mizuta, I.3
Hirota, Y.4
Ito, C.5
Kubo, M.6
Kawaguchi, T.7
Tsunoda, T.8
Watanabe, M.9
Takeda, A.10
-
3
-
-
70549088602
-
Genome-wide association study reveals genetic risk underlying Parkinson's disease
-
CrossRef PubMed
-
Simón-Sánchez, J., Schulte, C., Bras, J.M., Sharma, M., Gibbs, J.R., Berg, D., Paisan-Ruiz, C., Lichtner, P., Scholz, S.W., Hernandez, D.G. et al. (2009) Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat. Genet. 41, 1308-1312 CrossRef PubMed
-
(2009)
Nat. Genet.
, vol.41
, pp. 1308-1312
-
-
Simón-Sánchez, J.1
Schulte, C.2
Bras, J.M.3
Sharma, M.4
Gibbs, J.R.5
Berg, D.6
Paisan-Ruiz, C.7
Lichtner, P.8
Scholz, S.W.9
Hernandez, D.G.10
-
4
-
-
77953395313
-
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: Three questions
-
pii:e00002 CrossRef
-
Greggio, E. and Cookson, M.R. (2009) Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions. ASN Neuro. 1, pii:e00002, doi:10.1042/AN20090007 CrossRef
-
(2009)
ASN Neuro
, vol.1
-
-
Greggio, E.1
Cookson, M.R.2
-
5
-
-
84891776413
-
Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies
-
CrossRef PubMed
-
Skibinski, G., Nakamura, K., Cookson, M.R. and Finkbeiner, S. (2014) Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies. J. Neurosci. 34, 418-433 CrossRef PubMed
-
(2014)
J. Neurosci.
, vol.34
, pp. 418-433
-
-
Skibinski, G.1
Nakamura, K.2
Cookson, M.R.3
Finkbeiner, S.4
-
6
-
-
77956441086
-
Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
-
CrossRef PubMed
-
Lee, B.D., Shin, J.H., VanKampen, J., Petrucelli, L., West, A.B., Ko, H.S., Lee, Y.I., Maguire-Zeiss, K.A., Bowers, W.J., Federoff, H.J. et al. (2010) Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nat. Med. 16, 998-1000 CrossRef PubMed
-
(2010)
Nat. Med.
, vol.16
, pp. 998-1000
-
-
Lee, B.D.1
Shin, J.H.2
VanKampen, J.3
Petrucelli, L.4
West, A.B.5
Ko, H.S.6
Lee, Y.I.7
Maguire-Zeiss, K.A.8
Bowers, W.J.9
Federoff, H.J.10
-
7
-
-
33846562487
-
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
-
CrossRef PubMed
-
West, A.B., Moore, D.J., Choi, C., Andrabi, S.A., Li, X., Dikeman, D., Biskup, S., Zhang, Z., Lim, K.L., Dawson, V.L. and Dawson, T.M. (2007) Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. Hum. Mol. Genet. 16, 223-232 CrossRef PubMed
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 223-232
-
-
West, A.B.1
Moore, D.J.2
Choi, C.3
Andrabi, S.A.4
Li, X.5
Dikeman, D.6
Biskup, S.7
Zhang, Z.8
Lim, K.L.9
Dawson, V.L.10
Dawson, T.M.11
-
8
-
-
80051611506
-
LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding
-
CrossRef PubMed
-
Taymans, J.M., Vancraenenbroeck, R., Ollikainen, P., Beilina, A., Lobbestael, E., De Maeyer, M., Baekelandt, V. and Cookson, M.R. (2011) LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding. PLoS One 6, e23207 CrossRef PubMed
-
(2011)
PLoS One
, vol.6
-
-
Taymans, J.M.1
Vancraenenbroeck, R.2
Ollikainen, P.3
Beilina, A.4
Lobbestael, E.5
De Maeyer, M.6
Baekelandt, V.7
Cookson, M.R.8
-
9
-
-
84874541806
-
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2
-
CrossRef PubMed
-
Biosa, A., Trancikova, A., Civiero, L., Glauser, L., Bubacco, L., Greggio, E. and Moore, D.J. (2013) GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2. Hum. Mol. Genet. 22, 1140-1156 CrossRef PubMed
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 1140-1156
-
-
Biosa, A.1
Trancikova, A.2
Civiero, L.3
Glauser, L.4
Bubacco, L.5
Greggio, E.6
Moore, D.J.7
-
10
-
-
77952391573
-
GTPase activity plays a key role in the pathobiology of LRRK2
-
CrossRef PubMed
-
Xiong, Y., Coombes, C.E., Kilaru, A., Li, X., Gitler, A.D., Bowers, W.J., Dawson, V.L., Dawson, T.M. and Moore, D.J. (2010) GTPase activity plays a key role in the pathobiology of LRRK2. PloS Genet 6, e1000902, doi:10.1371/journal.pgen.1000902 CrossRef PubMed
-
(2010)
PloS Genet
, vol.6
-
-
Xiong, Y.1
Coombes, C.E.2
Kilaru, A.3
Li, X.4
Gitler, A.D.5
Bowers, W.J.6
Dawson, V.L.7
Dawson, T.M.8
Moore, D.J.9
-
11
-
-
84891904255
-
Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3
-
CrossRef PubMed
-
Muda, K., Bertinetti, D., Gesellchen, F., Hermann, J.S., von Zweydorf, F., Geerlof, A., Jacob, A., Ueffing, M., Gloeckner, C.J. and Herberg, F.W. (2014) Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3. Proc. Natl. Acad. Sci. U.S.A. 111, E34-E43 CrossRef PubMed
-
(2014)
Proc. Natl. Acad. Sci. U.S.A.
, vol.111
, pp. E34-E43
-
-
Muda, K.1
Bertinetti, D.2
Gesellchen, F.3
Hermann, J.S.4
Von Zweydorf, F.5
Geerlof, A.6
Jacob, A.7
Ueffing, M.8
Gloeckner, C.J.9
Herberg, F.W.10
-
12
-
-
84894322830
-
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
-
CrossRef PubMed
-
Beilina, A., Rudenko, I.N., Kaganovich, A., Civiero, L., Chau, H., Kalia, S.K., Kalia, L.V., Lobbestael, E., Chia, R., Ndukwe, K. et al. (2014) Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. Proc. Natl. Acad. Sci. U.S.A. 111, 2626-2631 CrossRef PubMed
-
(2014)
Proc. Natl. Acad. Sci. U.S.A.
, vol.111
, pp. 2626-2631
-
-
Beilina, A.1
Rudenko, I.N.2
Kaganovich, A.3
Civiero, L.4
Chau, H.5
Kalia, S.K.6
Kalia, L.V.7
Lobbestael, E.8
Chia, R.9
Ndukwe, K.10
-
13
-
-
84898622052
-
Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease
-
CrossRef PubMed
-
Martin, I., Kim, J.W., Lee, B.D., Kang, H.C., Xu, J.C., Jia, H., Stankowski, J., Kim, M.S., Zhong, J., Kumar, M. et al. (2014) Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease. Cell 157, 472-485 CrossRef PubMed
-
(2014)
Cell
, vol.157
, pp. 472-485
-
-
Martin, I.1
Kim, J.W.2
Lee, B.D.3
Kang, H.C.4
Xu, J.C.5
Jia, H.6
Stankowski, J.7
Kim, M.S.8
Zhong, J.9
Kumar, M.10
-
14
-
-
84863012282
-
LRRK2 Parkinson disease mutations enhance its microtubule association
-
CrossRef PubMed
-
Kett, L.R., Boassa, D., Ho, C.C., Rideout, H.J., Hu, J., Terada, M., Ellisman, M. and Dauer, W.T. (2012) LRRK2 Parkinson disease mutations enhance its microtubule association. Hum. Mol. Genet. 21, 890-899 CrossRef PubMed
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 890-899
-
-
Kett, L.R.1
Boassa, D.2
Ho, C.C.3
Rideout, H.J.4
Hu, J.5
Terada, M.6
Ellisman, M.7
Dauer, W.T.8
-
15
-
-
84910004657
-
LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity
-
CrossRef PubMed
-
Gómez-Suaga, P., Rivero-Ríos, P., Fdez, E., Blanca Ramírez, M., Ferrer, I., Aiastui, A., López De Munain, A. and Hilfiker, S. (2014) LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity. Hum. Mol. Genet. 23, 6779-6796 CrossRef PubMed
-
(2014)
Hum. Mol. Genet.
, vol.23
, pp. 6779-6796
-
-
Gómez-Suaga, P.1
Rivero-Ríos, P.2
Fdez, E.3
Blanca Ramírez, M.4
Ferrer, I.5
Aiastui, A.6
López De Munain, A.7
Hilfiker, S.8
-
16
-
-
84873281274
-
Rab7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk
-
CrossRef PubMed
-
MacLeod, D.A., Rhinn, H., Kuwahara, T., Zolin, A., Di Paolo, G., McCabe, B.D., Marder, K.S., Honig, L.S., Clark, L.N., Small, S.A. and Abeliovich, A. (2013) Rab7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. Neuron 77, 425-439 CrossRef PubMed
-
(2013)
Neuron
, vol.77
, pp. 425-439
-
-
MacLeod, D.A.1
Rhinn, H.2
Kuwahara, T.3
Zolin, A.4
Di Paolo, G.5
McCabe, B.D.6
Marder, K.S.7
Honig, L.S.8
Clark, L.N.9
Small, S.A.10
Abeliovich, A.11
-
17
-
-
84875640261
-
Interplay of LRRK2 with chaperone-mediated autophagy
-
CrossRef PubMed
-
Orenstein, S.J., Kuo, S.H., Tasset, I., Arias, E., Koga, E., Fernandez-Carasa, I., Cortes, E., Honig, L.S., Dauer, W., Consiglio, A. et al. (2013) Interplay of LRRK2 with chaperone-mediated autophagy. Nat. Neurosci. 16, 394-406 CrossRef PubMed
-
(2013)
Nat. Neurosci.
, vol.16
, pp. 394-406
-
-
Orenstein, S.J.1
Kuo, S.H.2
Tasset, I.3
Arias, E.4
Koga, E.5
Fernandez-Carasa, I.6
Cortes, E.7
Honig, L.S.8
Dauer, W.9
Consiglio, A.10
-
18
-
-
84863241584
-
Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning
-
CrossRef PubMed
-
Dodson, M.W., Zhang, T., Jiang, C., Chen, S. and Guo, M. (2012) Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning. Hum. Mol. Genet. 21, 1350-1363 CrossRef PubMed
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 1350-1363
-
-
Dodson, M.W.1
Zhang, T.2
Jiang, C.3
Chen, S.4
Guo, M.5
-
19
-
-
84919674911
-
Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo
-
CrossRef PubMed
-
Dodson, M.W., Leung, L.K., Lone, M., Lizzio, M.A. and Guo, M. (2014) Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo. Dis. Model. Mech. 7, 1351-1363 CrossRef PubMed
-
(2014)
Dis. Model. Mech.
, vol.7
, pp. 1351-1363
-
-
Dodson, M.W.1
Leung, L.K.2
Lone, M.3
Lizzio, M.A.4
Guo, M.5
-
20
-
-
84862907943
-
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP
-
CrossRef PubMed
-
Gómez-Suaga, P., Luzón-Toro, B., Churamani, D., Zhang, L., Bloor-Young, D., Patel, S., Woodman, P.G., Churchill, G.C. and Hilfiker, S. (2012) Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP. Hum. Mol. Genet. 21, 511-525 CrossRef PubMed
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 511-525
-
-
Gómez-Suaga, P.1
Luzón-Toro, B.2
Churamani, D.3
Zhang, L.4
Bloor-Young, D.5
Patel, S.6
Woodman, P.G.7
Churchill, G.C.8
Hilfiker, S.9
-
21
-
-
84883420073
-
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies
-
CrossRef PubMed
-
Manzoni, C. and Lewis, P.A. (2013) Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies. FASEB J 27, 3424-3429 CrossRef PubMed
-
(2013)
FASEB J
, vol.27
, pp. 3424-3429
-
-
Manzoni, C.1
Lewis, P.A.2
-
22
-
-
84887956934
-
Genetics of Parkinson's disease-state of the art, 2013
-
CrossRef PubMed
-
Bonifati, V. (2014) Genetics of Parkinson's disease-state of the art, 2013. Parkinsonism Relat. Disord. 20 (Suppl. 1), S23-S28, doi:10.1016/S1353-8020(13)70009-9 CrossRef PubMed
-
(2014)
Parkinsonism Relat. Disord.
, vol.20
, pp. S23-S28
-
-
Bonifati, V.1
-
23
-
-
33847388051
-
Calcium: A fundamental regulator of intracellular membrane fusion?
-
CrossRef PubMed
-
Hay, J.C. (2007) Calcium: a fundamental regulator of intracellular membrane fusion? EMBO Rep. 8, 236-240 CrossRef PubMed
-
(2007)
EMBO Rep.
, vol.8
, pp. 236-240
-
-
Hay, J.C.1
-
24
-
-
78649866553
-
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
-
CrossRef PubMed
-
Guzman, J.N., Sanchez-Padilla, J., Wokosin, D., Kondapalli, J., Ilijic, E., Schumacker, P.T. and Surmeier, D.J. (2010) Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 468, 696-700 CrossRef PubMed
-
(2010)
Nature
, vol.468
, pp. 696-700
-
-
Guzman, J.N.1
Sanchez-Padilla, J.2
Wokosin, D.3
Kondapalli, J.4
Ilijic, E.5
Schumacker, P.T.6
Surmeier, D.J.7
-
25
-
-
84866729462
-
Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson's disease
-
CrossRef PubMed
-
Goldberg, J.A., Guzman, J.N., Estep, C.M., Ilijic, E., Kondapalli, J., Sanchez-Padilla, J. and Surmeier, D.J. (2012) Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson's disease. Nat. Neurosci. 15, 1414-1421 CrossRef PubMed
-
(2012)
Nat. Neurosci.
, vol.15
, pp. 1414-1421
-
-
Goldberg, J.A.1
Guzman, J.N.2
Estep, C.M.3
Ilijic, E.4
Kondapalli, J.5
Sanchez-Padilla, J.6
Surmeier, D.J.7
-
26
-
-
84876214388
-
Calcium, bioenergetics, and neuronal vulnerability in Parkinson's disease
-
CrossRef PubMed
-
Surmeier, D.J. and Schumacker, P.T. (2013) Calcium, bioenergetics, and neuronal vulnerability in Parkinson's disease. J. Biol. Chem. 288, 10736-10741 CrossRef PubMed
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 10736-10741
-
-
Surmeier, D.J.1
Schumacker, P.T.2
-
27
-
-
84872691988
-
Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons
-
CrossRef PubMed
-
Cherra, 3rd, S.J., Steer, E., Gusdon, A.M., Kiselyov, K. and Chu, C.T. (2013) Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons. Am. J. Pathol. 182, 474-484 CrossRef PubMed
-
(2013)
Am. J. Pathol.
, vol.182
, pp. 474-484
-
-
Cherra, S.J.1
Steer, E.2
Gusdon, A.M.3
Kiselyov, K.4
Chu, C.T.5
-
28
-
-
80052233389
-
Endosome maturation
-
CrossRef PubMed
-
Huotari, J. and Helenius, A. (2011) Endosome maturation. EMBO J. 30, 3481-3500 CrossRef PubMed
-
(2011)
EMBO J.
, vol.30
, pp. 3481-3500
-
-
Huotari, J.1
Helenius, A.2
-
29
-
-
33845298032
-
Localization of LRRK2 to membranous and vesicular structures in mammalian brain
-
CrossRef PubMed
-
Biskup, S., Moore, D.J., Celsi, F., Higashi, S., West, A.B., Andrabi, S.A., Kurkinen, K., Yu, S.W., Savitt, J.M., Waldvogel, H.J. et al. (2006) Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann. Neurol. 60, 557-569 CrossRef PubMed
-
(2006)
Ann. Neurol.
, vol.60
, pp. 557-569
-
-
Biskup, S.1
Moore, D.J.2
Celsi, F.3
Higashi, S.4
West, A.B.5
Andrabi, S.A.6
Kurkinen, K.7
Yu, S.W.8
Savitt, J.M.9
Waldvogel, H.J.10
-
30
-
-
70349991886
-
LRRK2 regulates autophagic activity and localizes to specific microdomains in a novel human genomic reporter cellular model
-
CrossRef PubMed
-
Alegre-Abarrategui, J., Christian, H., Lufino, M.M., Mutihac, R., Venda, L.L., Ansorge, O. and Wade-Martins, R. (2009) LRRK2 regulates autophagic activity and localizes to specific microdomains in a novel human genomic reporter cellular model. Hum. Mol. Genet. 18, 4022-4034 CrossRef PubMed
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 4022-4034
-
-
Alegre-Abarrategui, J.1
Christian, H.2
Lufino, M.M.3
Mutihac, R.4
Venda, L.L.5
Ansorge, O.6
Wade-Martins, R.7
-
31
-
-
84902163498
-
Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy
-
CrossRef PubMed
-
Schapansky, J., Nardozzi, J.D., Felizia, F. and LaVoie, M.J. (2014) Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy. Hum. Mol. Genet. 23, 4201-4214 CrossRef PubMed
-
(2014)
Hum. Mol. Genet.
, vol.23
, pp. 4201-4214
-
-
Schapansky, J.1
Nardozzi, J.D.2
Felizia, F.3
LaVoie, M.J.4
-
32
-
-
84924913990
-
LRRK2 localizes to endosomes and interacts with clathrin-light chains to limit Rac1 activation
-
CrossRef
-
Schreij, A.M., Chaineau, M., Ruan, W., Lin, S., Barker, P.A., Fon, E.A. and McPherson, P.S. (2015) LRRK2 localizes to endosomes and interacts with clathrin-light chains to limit Rac1 activation. EMBO Rep. 16, 79-86 CrossRef
-
(2015)
EMBO Rep.
, vol.16
, pp. 79-86
-
-
Schreij, A.M.1
Chaineau, M.2
Ruan, W.3
Lin, S.4
Barker, P.A.5
Fon, E.A.6
McPherson, P.S.7
-
33
-
-
84902152511
-
Novel insights into the neurobiology underlying LRRK2-linked Parkinson's disease
-
CrossRef PubMed
-
Gómez-Suaga, P., Fdez, E., Fernández, B., Martínez-Salvador, M., Blanca Ramírez, M., Madero-Pérez, J., Rivero-Ríos, P., Fuentes, J.M. and Hilfiker, S. (2014) Novel insights into the neurobiology underlying LRRK2-linked Parkinson's disease. Neuropharmacology 85, 45-56 CrossRef PubMed
-
(2014)
Neuropharmacology
, vol.85
, pp. 45-56
-
-
Gómez-Suaga, P.1
Fdez, E.2
Fernández, B.3
Martínez-Salvador, M.4
Blanca Ramírez, M.5
Madero-Pérez, J.6
Rivero-Ríos, P.7
Fuentes, J.M.8
Hilfiker, S.9
-
34
-
-
79955544006
-
Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)
-
CrossRef PubMed
-
Chan, D., Citro, A., Cordy, J.M., Shen, G.C. and Wolozin, B. (2011) Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2). J. Biol. Chem. 286, 16140-16149 CrossRef PubMed
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 16140-16149
-
-
Chan, D.1
Citro, A.2
Cordy, J.M.3
Shen, G.C.4
Wolozin, B.5
-
35
-
-
46549089664
-
LRRK2 regulates synaptic vesicle endocytosis
-
CrossRef
-
Shin, N., Jeong, H., Kwon, J., Heo, H.Y., Kwon, J.J., Yun, H.J., Kim, C.H., Han, B.S., Tong, Y., Shen, J. et al. (2011) LRRK2 regulates synaptic vesicle endocytosis. Exp. Cell Res. 314, 2055-2065 CrossRef
-
(2011)
Exp. Cell Res.
, vol.314
, pp. 2055-2065
-
-
Shin, N.1
Jeong, H.2
Kwon, J.3
Heo, H.Y.4
Kwon, J.J.5
Yun, H.J.6
Kim, C.H.7
Han, B.S.8
Tong, Y.9
Shen, J.10
-
36
-
-
84910002760
-
LRRK2 transport is regulated by its novel interacting partner Rab32
-
CrossRef PubMed
-
Waschbuesch, D., Michels, H., Strassheim, S., Ossendorf, E., Kessler, D., Gloeckner, C.J. and Barnekow, A. (2014) LRRK2 transport is regulated by its novel interacting partner Rab32. PLoS One 9, e111632, doi:10.1371/journal.pone.0111632 CrossRef PubMed
-
(2014)
PLoS One
, vol.9
-
-
Waschbuesch, D.1
Michels, H.2
Strassheim, S.3
Ossendorf, E.4
Kessler, D.5
Gloeckner, C.J.6
Barnekow, A.7
-
37
-
-
84907814142
-
TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2
-
CrossRef PubMed
-
Ruas, M., Chuang, K.T., Davis, L.C., Al-Douri, A., Tynan, P.W., Tunn, R., Teboul, L., Galione, A. and Parrington, J. (2014) TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2. Mol. Cell Biol. 34, 3981-3992 CrossRef PubMed
-
(2014)
Mol. Cell Biol.
, vol.34
, pp. 3981-3992
-
-
Ruas, M.1
Chuang, K.T.2
Davis, L.C.3
Al-Douri, A.4
Tynan, P.W.5
Tunn, R.6
Teboul, L.7
Galione, A.8
Parrington, J.9
-
38
-
-
67349287016
-
NAADP mobilizes calcium from acidic organelles through two-pore channels
-
CrossRef PubMed
-
Calcraft, P.J., Ruas, M., Pan, Z., Cheng, X., Arredouani, A., Hao, X., Tang, J., Rietdorf, K., Teboul, L., Chuang, K.T. et al. (2009) NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 459, 596-600 CrossRef PubMed
-
(2009)
Nature
, vol.459
, pp. 596-600
-
-
Calcraft, P.J.1
Ruas, M.2
Pan, Z.3
Cheng, X.4
Arredouani, A.5
Hao, X.6
Tang, J.7
Rietdorf, K.8
Teboul, L.9
Chuang, K.T.10
-
39
-
-
84898630877
-
2+, NAADP, PI(3,5)P2 and multiple protein kinases
-
CrossRef PubMed
-
2+, NAADP, PI(3,5)P2 and multiple protein kinases. EMBO J. 33, 501-511 CrossRef PubMed
-
(2014)
EMBO J.
, vol.33
, pp. 501-511
-
-
Jha, A.1
Ahuja, M.2
Patel, S.3
Brailoiu, E.4
Muallem, S.5
-
40
-
-
84856068326
-
Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells
-
CrossRef PubMed
-
Lin-Moshier, Y., Walseth, T.F., Churamani, D., Davidson, S.M., Slama, J.T., Hooper, R., Brailoiu, E., Patel, S. and Marchant, J.S. (2012) Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells. J. Biol. Chem. 287, 2296-2307 CrossRef PubMed
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 2296-2307
-
-
Lin-Moshier, Y.1
Walseth, T.F.2
Churamani, D.3
Davidson, S.M.4
Slama, J.T.5
Hooper, R.6
Brailoiu, E.7
Patel, S.8
Marchant, J.S.9
-
41
-
-
20444476585
-
Ion regulation of homotypic vacuole fusion in Saccharomyces cerevisiae
-
CrossRef PubMed
-
Starai, V.J., Thorngren, N., Fratti, R.A. and Wickner, W. (2005) Ion regulation of homotypic vacuole fusion in Saccharomyces cerevisiae. J. Biol. Chem. 280, 16754-16762 CrossRef PubMed
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 16754-16762
-
-
Starai, V.J.1
Thorngren, N.2
Fratti, R.A.3
Wickner, W.4
-
42
-
-
0034729167
-
The role of intraorganellar Ca2 + in late endosome-lysosome heterotypic fusion and in the reformation of lysosomes from hybrid organelles
-
CrossRef PubMed
-
Pryor, P.R., Mullock, B.M., Bright, N.A., Gray, S.R. and Luzio, J.P. (2000) The role of intraorganellar Ca2 + in late endosome-lysosome heterotypic fusion and in the reformation of lysosomes from hybrid organelles. J. Cell Biol. 149, 1053-1062 CrossRef PubMed
-
(2000)
J. Cell Biol.
, vol.149
, pp. 1053-1062
-
-
Pryor, P.R.1
Mullock, B.M.2
Bright, N.A.3
Gray, S.R.4
Luzio, J.P.5
-
43
-
-
0037144587
-
Selective effects of calcium chelators on anterograde and retrograde protein transport in the cell
-
Chen, J.L., Ahluwalia, J.P. and Stamnes, M. (2002) Selective effects of calcium chelators on anterograde and retrograde protein transport in the cell. J. Biol. Chem. 277, 3682-35687
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 3682-35687
-
-
Chen, J.L.1
Ahluwalia, J.P.2
Stamnes, M.3
-
44
-
-
84907001175
-
The two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation
-
CrossRef PubMed
-
Lin-Moshier, Y., Keebler, M.V., Hooper, R., Boulware, M.J., Liu, X., Churamani, D., Abood, M.E., Walseth, T.F., Brailoiu, E., Patel, S. and Marchant, J.S. (2014) The two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation. Proc. Natl. Acad. Sci. U.S.A. 111, 13087-13092 CrossRef PubMed
-
(2014)
Proc. Natl. Acad. Sci. U.S.A.
, vol.111
, pp. 13087-13092
-
-
Lin-Moshier, Y.1
Keebler, M.V.2
Hooper, R.3
Boulware, M.J.4
Liu, X.5
Churamani, D.6
Abood, M.E.7
Walseth, T.F.8
Brailoiu, E.9
Patel, S.10
Marchant, J.S.11
-
46
-
-
84859833144
-
The interaction properties of the human Rab GTPase family-comparative analysis reveals determinants of molecular binding selectivity
-
CrossRef PubMed
-
Stein, M., Pilli, M., Bernauer, S., Habermann, B.H., Zerial, M. and Wade, R.C. (2012) The interaction properties of the human Rab GTPase family-comparative analysis reveals determinants of molecular binding selectivity. PLoS One 7, e34870, doi:10.1371/journal.pone.0034870 CrossRef PubMed
-
(2012)
PLoS One
, vol.7
-
-
Stein, M.1
Pilli, M.2
Bernauer, S.3
Habermann, B.H.4
Zerial, M.5
Wade, R.C.6
-
47
-
-
7244255989
-
Role for Rab7 in maturation of late autophagic vacuoles
-
CrossRef PubMed
-
Jaeger, S., Bucci, C., Tanida, I., Ueno, T., Kominami, E., Saftig, P. and Eskelinen, E.L. (2004) Role for Rab7 in maturation of late autophagic vacuoles. J. Cell Sci. 117, 4837-4848 CrossRef PubMed
-
(2004)
J. Cell Sci.
, vol.117
, pp. 4837-4848
-
-
Jaeger, S.1
Bucci, C.2
Tanida, I.3
Ueno, T.4
Kominami, E.5
Saftig, P.6
Eskelinen, E.L.7
-
48
-
-
84900388122
-
A role of Rab29 in the integrity of the trans-Golgi network and retrograde trafficking of mannose-6-phosphate receptor
-
CrossRef PubMed
-
Wang, S., Ma, Z., Xu, X., Wang, Z., Sun, L., Zhou, Y., Lin, X., Hong, W. and Wang, T. (2014) A role of Rab29 in the integrity of the trans-Golgi network and retrograde trafficking of mannose-6-phosphate receptor. PLoS One 9, e96242, doi:10.1371/journal.pone.0096242 CrossRef PubMed
-
(2014)
PLoS One
, vol.9
-
-
Wang, S.1
Ma, Z.2
Xu, X.3
Wang, Z.4
Sun, L.5
Zhou, Y.6
Lin, X.7
Hong, W.8
Wang, T.9
-
49
-
-
33750367865
-
Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes
-
CrossRef PubMed
-
Wasmeier, C., Romao, M., Plowright, L., Bennett, D.C., Raposo, G. and Seabra, M.C. (2006) Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes. J. Cell Biol. 175, 271-281 CrossRef PubMed
-
(2006)
J. Cell Biol.
, vol.175
, pp. 271-281
-
-
Wasmeier, C.1
Romao, M.2
Plowright, L.3
Bennett, D.C.4
Raposo, G.5
Seabra, M.C.6
-
50
-
-
84891345615
-
Calcium-dependent regulation of Rab activation and vesicle fusion by an intracellular P2X ion channel
-
CrossRef PubMed
-
Parkinson, K., Baines, A.E., Keller, T., Gruenheit, N., Bragg, L., North, R.A. and Thompson, C.R.L. (2014) Calcium-dependent regulation of Rab activation and vesicle fusion by an intracellular P2X ion channel. Nat. Cell Biol. 16, 87-98 CrossRef PubMed
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 87-98
-
-
Parkinson, K.1
Baines, A.E.2
Keller, T.3
Gruenheit, N.4
Bragg, L.5
North, R.A.6
Thompson, C.R.L.7
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