Spontaneous intestinal tumorigenesis in Apc/Min+ mice requires altered t cell development with IL-17A

Journal of Immunology Research

Volumn 2015, Issue , 2015, Pages

  Chae, Wook Jin ^a   Bothwell, Alfred L M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; INTERLEUKIN 17; TRANSCRIPTION FACTOR FOXP3;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CD4+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; FAMILIAL COLON POLYPOSIS; GENE MUTATION; HUMAN; IN VITRO STUDY; INTESTINE TUMOR; LAMINA PROPRIA; MOUSE; NONHUMAN; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TH17 CELL; THYMUS DISEASE; TUMOR GROWTH; TUMOR MICROENVIRONMENT; TUMOR REGRESSION; ANIMAL; CELL TRANSFORMATION; COLON POLYPOSIS; DISEASE MODEL; GENETICS; HETEROZYGOTE; IMMUNOLOGY; IMMUNOPHENOTYPING; INTESTINE MUCOSA; METABOLISM; MUTATION; PATHOLOGY; PHENOTYPE; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

ADENOMATOUS POLYPOSIS COLI; ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; HETEROZYGOTE; IMMUNOPHENOTYPING; INTERLEUKIN-17; INTESTINAL MUCOSA; MICE; MICE, TRANSGENIC; MUTATION; PHENOTYPE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 84934962613     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2015/860106     Document Type: Article

References (35)

1. A. Mantovani, P. Allavena, A. Sica, and F. Balkwill, "Cancerrelated inflammation, " Nature, vol. 454, no. 7203, pp. 436-444, 2008
2. A. Y. Rudensky, "Regulatory T cells and Foxp3, " Immunological Reviews, vol. 241, no. 1, pp. 260-268, 2011
3. S. K. Lathrop, N. A. Santacruz, D. Pham, J. Luo, and C.-S. Hsieh, "Antigen-specific peripheral shaping of the natural regulatory T cell population, " Journal of ExperimentalMedicine, vol. 205, no. 13, pp. 3105-3117, 2008
4. L. J. Thompson, A. C. Valladao, and S. F. Ziegler, "Cutting edge: de novo induction of functional Foxp3+ regulatory CD4 T cells in response to tissue-restricted self antigen, " Journal of Immunology, vol. 186, no. 8, pp. 4551-4555, 2011
5. S. Sakaguchi, T. Yamaguchi, T. Nomura, and M. Ono, "Regulatory T cells and immune tolerance, " Cell, vol. 133, no. 5, pp. 775-787, 2008
6. Y. Wang, M. A. Su, and Y. Y. Wan, "An essential role of the transcription factor GATA-3 for the function of regulatory T cells, " Immunity, vol. 35, no. 3, pp. 337-348, 2011
7. E. A. Wohlfert, J. R. Grainger, N. Bouladoux et al., "GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice, " The Journal of Clinical Investigation, vol. 121, no. 11, pp. 4503-4515, 2011
8. W. Zou, "Regulatory T cells, tumour immunity and immunotherapy, " Nature Reviews Immunology, vol. 6, no. 4, pp. 295-307, 2006
9. W. L. Byrne, K. H. G. Mills, J. A. Lederer, and G. C. O'Sullivan, "Targeting regulatory T cells in cancer, " Cancer Research, vol. 71, no. 22, pp. 6915-6920, 2011
10. P. Salama, M. Phillips, F. Grieu et al., "Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer, " Journal of Clinical Oncology, vol. 27, no. 2, pp. 186-192, 2009
11. F. Pages, A. Berger, M. Camus et al., "Effector memory T cells, early metastasis, and survival in colorectal cancer, " The New England Journal of Medicine, vol. 353, no. 25, pp. 2654-2666, 2005
12. D. M. Frey, R. A. Droeser, C. T. Viehl et al., "High frequency of tumor-infiltrating FOXP3+ regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients, " International Journal of Cancer, vol. 126, no. 11, pp. 2635-2643, 2010
13. S. Ladoire, F. Martin, and F. Ghiringhelli, "Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer, " Cancer Immunology, Immunotherapy, vol. 60, no. 7, pp. 909-918, 2011
14. S. E. Erdman, J. J. Sohn, V. P. Rao et al., "CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice, " Cancer Research, vol. 65, no. 10, pp. 3998-4004, 2005
15. K. W. Kinzler and B. Vogelstein, "Lessons from hereditary colorectal cancer, " Cell, vol. 87, no. 2, pp. 159-170, 1996
16. I. Nathke, "Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC, " Nature Reviews Cancer, vol. 6, no. 12, pp. 967-974, 2006
17. W.-J. Chae, T. F. Gibson, D. Zelterman, L. Hao, O. Henegariu, and A. L. M. Bothwell, "Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis, " Proceedings of the NationalAcademy of Sciences of theUnited States ofAmerica, vol. 107, no. 12, pp. 5540-5544, 2010
18. H. Shibata, K. Toyama, H. Shioya et al., "Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene, " Science, vol. 278, no. 5335, pp. 120-133, 1997
19. B. Weigmann, I. Tubbe, D. Seidel, A. Nicolaev, C. Becker, and M. F. Neurath, "Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue, " Nature Protocols, vol. 2, no. 10, pp. 2307-2311, 2007
20. K. J. Livak and T. D. Schmittgen, "Analysis of relative gene expression data using real-time quantitative PCR and the 2-CT method, " Methods, vol. 25, no. 4, pp. 402-408, 2001
21. P. L. Coletta, A. M. Muller, E. A. Jones et al., "Lymphodepletion in the Apc/+ mouse model of intestinal tumorigenesis, " Blood, vol. 103, pp. 1050-1058, 2004
22. W. Zou and N. P. Restifo, "T17 cells in tumour immunity and immunotherapy, "Nature Reviews Immunology, vol. 10, no. 4, pp. 248-256, 2010
23. J. Shoemaker, M. Saraiva, and A. O'Garra, "GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ Tcells, " The Journal of Immunology, vol. 176, no. 6, pp. 3470-3479, 2006
24. T. Akimova, U. H. Beier, L. Wang, M. H. Levine, and W. W. Hancock, "Helios expression is a marker of T cell activation and proliferation, " PLoS ONE, vol. 6, no. 8, Article ID e24226, 2011
25. R. A. Gottschalk, E. Corse, and J. P. Allison, "Expression of Helios in peripherally induced Foxp3+ regulatory T cells, " Journal of Immunology, vol. 188, no. 3, pp. 976-980, 2012
26. A. M. Thornton, P. E. Korty, D. Q. Tran et al., "Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells, " Journal of Immunology, vol. 184, no. 7, pp. 3433-3441, 2010
27. S. Wu, K.-J. Rhee, E. Albesiano et al., "A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses, " Nature Medicine, vol. 15, no. 9, pp. 1016-1022, 2009
28. I. Kryczek, K. Wu, E. Zhao et al., "IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer, " The Journal of Immunology, vol. 186, no. 7, pp. 4388-4395, 2011
29. J. L. Round and S. K. Mazmanian, "Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota, " Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 27, pp. 12204-12209, 2010
30. M. J. Barnes and F. Powrie, "Regulatory T cells reinforce intestinal homeostasis, " Immunity, vol. 31, no. 3, pp. 401-411, 2009
31. J. van Loosdregt, V. Fleskens, M. Tiemessen et al., "Canonical Wnt signaling negatively modulates regulatory T cell function, " Immunity, vol. 39, no. 2, pp. 298-310, 2013
32. E. Gounaris, N. R. Blatner, K. Dennis et al., "T-regulatory cells shift from a protective anti-inflammatory to a cancerpromoting proinflammatory phenotype in polyposis, " Cancer Research, vol. 69, no. 13, pp. 5490-5497, 2009
33. I. I. Ivanov, R. D. L. Frutos, N. Manel et al., "Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine, " Cell Host andMicrobe, vol. 4, no. 4, pp. 337-349, 2008
34. S. Le Gouvello, S. Bastuji-Garin, N. Aloulou et al., "High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas, " Gut, vol. 57, no. 6, pp. 772-779, 2008
35. G. Betts, E. Jones, S. Junaid et al., "Suppression of tumourspecific CD4+ T cells by regulatory T cells is associated with progression of human colorectal cancer, " Gut, vol. 61, pp. 1163-1171, 2012