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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 16, 2015, Pages 3164-3167

Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human

(6) Caseley, Emily A a Muench, Stephen P a Baldwin, Stephen A a Simmons, Katie a Fishwick, Colin W a Jiang, Lin Hua a

a UNIVERSITY OF LEEDS (United Kingdom)

Author keywords

Adenosine triphosphate; AZ11645373; KN62; P2X7 receptor; SB203580

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AZ 11645373; PURINERGIC P2X RECEPTOR ANTAGONIST; PURINERGIC P2X7 RECEPTOR; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPETITIVE INHIBITION; COMPUTER MODEL; CRYSTAL STRUCTURE; DRUG BINDING; HUMAN; IC50; NONHUMAN; RAT; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; METABOLISM; MOLECULAR DOCKING; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT;

ANIMALIA; RATTUS;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; PURINERGIC P2X RECEPTOR ANTAGONISTS; RATS; RECEPTORS, PURINERGIC P2X7; SEQUENCE ALIGNMENT;

EID: 84934861238 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.06.001 Document Type: Article

Times cited : (24)

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