Regulation of activation induced deaminase via phosphorylation

Advances in Experimental Medicine and Biology

Volumn 596, Issue , 2007, Pages 129-137

  Basu, Uttiya ^a   Chaudhuri, Jayanta ^a,b   Phan, Ryan T ^a   Datta, Abhishek ^a   Alt, Frederick W ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CYTIDINE; DNA; SINGLE STRANDED DNA;

B LYMPHOCYTE; CONFERENCE PAPER; DEAMINATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MODIFICATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING;

EID: 84934438743     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/0-387-46530-8_11     Document Type: Conference Paper

References (39)

1. Honjo, T., Kinoshita, K. & Muramatsu, M. Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation. Annu Rev Immunol 20, 165-96 (2002).
2. Petersen-Mahrt, S. K., Harris, R. S. & Neuberger, M. S. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 418, 99-103. (2002).
3. Neuberger, M. S., Harris, R. S., Di Noia, J. & Petersen-Mahrt, S. K. Immunity through DNA deamination. Trends Biochem Sci 28, 305-12. (2003).
4. Muramatsu, M. et al. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem 274, 18470-6 (1999).
5. Ramiro, A. R., Stavropoulos, P., Jankovic, M. & Nussenzweig, M. C. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat Immunol 4, 452-6. (2003).
6. Chaudhuri, J. et al. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 422, 726-30. (2003).
7. Chaudhuri, J., Khuong, C. & Alt, F. W. Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature 430, 992-8 (2004).
8. Bransteitter, R., Pham, P., Scharff, M. D. & Goodman, M. F. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A 100, 4102-7. (2003).
9. Bransteitter, R., Pham, P., Calabrese, P. & Goodman, M. F. Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase. J Biol Chem 279, 51612-21 (2004).
10. Dickerson, S. K., Market, E., Besmer, E. & Papavasiliou, F. N. AID Mediates Hypermutation by Deaminating Single Stranded DNA. J Exp Med 197, 1291-6. (2003).
11. Nambu, Y. et al. Transcription-coupled events associating with immunoglobulin switch region chromatin. Science 302, 2137-40. (2003).
12. Neuberger, M. S., Harris, R. S., Di Noia, J. & Petersen-Mahrt, S. K. Immunity through DNA deamination. Trends Biochem Sci 28, 305-12 (2003).
13. Neuberger, M. S. et al. Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation. Nat Rev Immunol 5, 171-8 (2005).
14. Di Noia, J. & Neuberger, M. S. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 419, 43-8 (2002).
15. Rada, C. et al. Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice. Curr Biol 12, 1748-55. (2002).
16. Rada, C., Di Noia, J. M. & Neuberger, M. S. Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol Cell 16, 163-71 (2004).
17. Chaudhuri, J. & Alt, F. W. Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol 4, 541-52 (2004).
18. Muramatsu, M. et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102, 553-63. (2000).
19. Zarrin, A. A., Tian, M., Wang, J., Borjeson, T. & Alt, F. W. Influence of switch region length on immunoglobulin class switch recombination. Proc Natl Acad Sci U S A 102, 2466-70 (2005).
20. Stavnezer, J. Immunoglobulin class switching. Curr Opin Immunol 8, 199-205 (1996).
21. Reaban, M. E. & Griffin, J. A. Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region. Nature 348, 342-4. (1990).
22. Reaban, M. E., Lebowitz, J. & Griffin, J. A. Transcription induces the formation of a stable RNA.DNA hybrid in the immunoglobulin alpha switch region. J Biol Chem 269, 21850-7. (1994).
23. Tian, M. & Alt, F. W. Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro. J Biol Chem 275, 24163-72 (2000).
24. Daniels, G. A. & Lieber, M. R. Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences. Proc Natl Acad Sci U S A 92, 5625-9. (1995).
25. Yu, K., Chedin, F., Hsieh, C. L., Wilson, T. E. & Lieber, M. R. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat Immunol 4, 442-51. (2003).
26. Huang, F. T., Yu, K., Hsieh, C. L. & Lieber, M. R. Downstream boundary of chromosomal R-loops at murine switch regions: implications for the mechanism of class switch recombination. Proc Natl Acad Sci U S A 103, 5030-5 (2006).
27. Longerich, S., Basu, U., Alt, F. & Storb, U. AID in somatic hypermutation and class switch recombination. Curr Opin Immunol 18, 164-74 (2006).
28. Zarrin, A. A. et al. An evolutionarily conserved target motif for immunoglobulin class-switch recombination. Nat Immunol 5, 1275-81 (2004).
29. Nagelhus, T. A. et al. A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A. J Biol Chem 272, 6561-6. (1997).
30. Basu, U. et al. The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature 438, 508-11 (2005).
31. Pasqualucci, L., Kitaura, Y., Gu, H. & Dalla-Favera, R. PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. Proc Natl Acad Sci U S A 103, 395-400 (2006).
32. McBride, K. M., Gazumyan, A. ,Woo, E.M. ,Barreto, V.M. ,Robbiani, D.F. ,Chait, B.T. ,Nussenzweig, M.C. Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. Proc Natl Acad Sci U S A 103, 8798-803 (2006).
33. Wang, J. et al. Identification of a specific domain required for dimerization of activation-induced cytidine deaminase. J Biol Chem (2006).
34. Ramiro, A. R. et al. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 440, 105-9 (2006).
35. Schrader, C. E., Linehan, E. K., Mochegova, S. N., Woodland, R. T. & Stavnezer, J. Inducible DNA breaks in Ig S regions are dependent on AID and UNG. J Exp Med 202, 561-8 (2005).
36. McBride, K. M., Barreto, V., Ramiro, A. R., Stavropoulos, P. & Nussenzweig, M. C. Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase. J Exp Med 199, 1235-44 (2004).
37. Shinkura, R. et al. Separate domains of AID are required for somatic hypermutation and class-switch recombination. Nat Immunol 5, 707-12 (2004).
38. Brar, S. S., Watson, M. & Diaz, M. Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks. J Biol Chem 279, 26395-401 (2004).
39. Muto, T. et al. Negative regulation of activation-induced cytidine deaminase in B cells. Proc Natl Acad Sci U S A 103, 2752-7 (2006).