-
1
-
-
0016756272
-
Continuous cultures of fused cells secreting antibody of prede fined specificity
-
Köhler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of prede fined specificity. Nature 256:495-497
-
(1975)
Nature
, vol.256
, pp. 495-497
-
-
Köhler, G.1
Milstein, C.2
-
2
-
-
0017692919
-
Virus induced B lymphocyte cell lines producing speci fic antibodies
-
Steinitz M et al (1977) Virus induced B lymphocyte cell lines producing speci fic antibodies. Nature 269:420-422
-
(1977)
Nature
, vol.269
, pp. 420-422
-
-
Steinitz, M.1
-
3
-
-
40449102205
-
An anti-D monoclonal antibody selected for enhanced Fc g RIII engagement clears RhD-positive autologous red cells in human volunteers as ef ficiently as polyclonal anti-D antibodies
-
Béliard R et al (2008) An anti-D monoclonal antibody selected for enhanced Fc g RIII engagement clears RhD-positive autologous red cells in human volunteers as ef ficiently as polyclonal anti-D antibodies. Br J Haematol 141:109-119
-
(2008)
Br J Haematol
, vol.141
, pp. 109-119
-
-
Béliard, R.1
-
4
-
-
0019133888
-
Human-human hybridomas producing monoclonal antibodies of prede fined antigenic specificity
-
Olsson L, Kaplan HS (1980) Human-human hybridomas producing monoclonal antibodies of prede fined antigenic specificity. Proc Natl Acad Sci USA 77:5429-5431
-
(1980)
Proc Natl Acad Sci USA
, vol.77
, pp. 5429-5431
-
-
Olsson, L.1
Kaplan, H.S.2
-
5
-
-
0022607039
-
In vitro immunization. Effect of growth and differentiation factors on antigen-speci fic cell activation and production of monoclonal antibodies to autolo-gous antigens and immunogens
-
Borrebaeck CA, Möller SA (1986) In vitro immunization. Effect of growth and differentiation factors on antigen-speci fic cell activation and production of monoclonal antibodies to autolo-gous antigens and immunogens. J Immunol 13:3710-3715
-
(1986)
J Immunol
, vol.13
, pp. 3710-3715
-
-
Borrebaeck, C.A.1
Möller, S.A.2
-
6
-
-
0026092621
-
Long-term human B cell lines dependent on interleukin-4 and antibody to CD40
-
Banchereau J et al (1989) Long-term human B cell lines dependent on interleukin-4 and antibody to CD40. Science 251:70-72
-
(1989)
Science
, vol.251
, pp. 70-72
-
-
Banchereau, J.1
-
7
-
-
4043154176
-
An ef ficient method to make human monoclonal antibodies from memory B cells: Potent neutralization of SARS coronavirus
-
Traggiai E et al (2004) An ef ficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus. Nat Med 8:871-875
-
(2004)
Nat Med
, vol.8
, pp. 871-875
-
-
Traggiai, E.1
-
8
-
-
1842588698
-
Development of a human adaptive immune system in cord blood cell-transplanted mice
-
Traggiai E et al (2004) Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 304:104-107
-
(2004)
Science
, vol.304
, pp. 104-107
-
-
Traggiai, E.1
-
9
-
-
0021716682
-
Chimeric human antibody molecules: Mouse antigen-binding domains with human constant region domains
-
Morrison SL et al (1984) Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains. Proc Natl Acad Sci USA 81:6851-6855
-
(1984)
Proc Natl Acad Sci USA
, vol.81
, pp. 6851-6855
-
-
Morrison, S.L.1
-
10
-
-
0024815233
-
A humanized antibody that binds to the interleukin 2 receptor
-
Queen C et al (1989) A humanized antibody that binds to the interleukin 2 receptor. Proc Natl Acad Sci USA 86:10029-10035
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 10029-10035
-
-
Queen, C.1
-
11
-
-
0033527584
-
Selection and analysis of an optimized anti-VEGF antibody: Crystal structure of an affinity-matured Fab in complex with antigen
-
Chen Y et al (1999) Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen. J Mol Biol 293:865-881
-
(1999)
J Mol Biol
, vol.293
, pp. 865-881
-
-
Chen, Y.1
-
12
-
-
0028049374
-
Humanization of murine monoclonal antibodies through variable domain resurfacing
-
Roguska MA et al (1994) Humanization of murine monoclonal antibodies through variable domain resurfacing. Proc Natl Acad Sci USA 91:969-973
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 969-973
-
-
Roguska, M.A.1
-
13
-
-
0021818675
-
Filamentous fusion phage: Novel expression vectors that display cloned antigens on the virion surface
-
Smith GP (1985) Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science 228:1315-1317
-
(1985)
Science
, vol.228
, pp. 1315-1317
-
-
Smith, G.P.1
-
14
-
-
0025226085
-
Phage antibodies: Filamentous phage displaying antibody variable domains
-
McCafferty J et al (1990) Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348:552-554
-
(1990)
Nature
, vol.348
, pp. 552-554
-
-
McCafferty, J.1
-
15
-
-
0026699293
-
Selection of phage antibodies by binding affinity: Mimicking affinity maturation
-
Hawkins RE, Russell SJ, Winter G (1992) Selection of phage antibodies by binding affinity: mimicking affinity maturation. J Mol Biol 226:889-896
-
(1992)
J Mol Biol
, vol.226
, pp. 889-896
-
-
Hawkins, R.E.1
Russell, S.J.2
Winter, G.3
-
16
-
-
0024833055
-
Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda
-
Huse WD et al (1989) Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science 246: 1275-1281
-
(1989)
Science
, vol.246
, pp. 1275-1281
-
-
Huse, W.D.1
-
17
-
-
0037318058
-
Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library
-
Feldhaus MJ et al (2003) Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library. Nat Biotechnol 21:163-170
-
(2003)
Nat Biotechnol
, vol.21
, pp. 163-170
-
-
Feldhaus, M.J.1
-
18
-
-
0033664270
-
Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display
-
Hanes J et al (2000) Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display. Nat Biotechnol 18:1287-1292
-
(2000)
Nat Biotechnol
, vol.18
, pp. 1287-1292
-
-
Hanes, J.1
-
19
-
-
0028222932
-
Antigen-speci fic human antibodies from mice comprising four distinct genetic modi fications
-
Lonberg N et al (1994) Antigen-speci fic human antibodies from mice comprising four distinct genetic modi fications. Nature 368:856-859
-
(1994)
Nature
, vol.368
, pp. 856-859
-
-
Lonberg, N.1
-
20
-
-
0027963484
-
Antigen-speci fic human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs
-
Green LL et al (1994) Antigen-speci fic human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs. Nat Genet 7:13-21
-
(1994)
Nat Genet
, vol.7
, pp. 13-21
-
-
Green, L.L.1
-
21
-
-
0034681121
-
Double trans-chromo-somic mice: Maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies
-
Tomizuka K et al (2000) Double trans-chromo-somic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies. Proc Natl Acad Sci USA 97:722-727
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 722-727
-
-
Tomizuka, K.1
-
22
-
-
0001287770
-
Separation and isolation of fractions of rabbit gamma-globulin containing the antibody and antigenic combining sites
-
Porter RR (1958) Separation and isolation of fractions of rabbit gamma-globulin containing the antibody and antigenic combining sites. Nature 182:670-671
-
(1958)
Nature
, vol.182
, pp. 670-671
-
-
Porter, R.R.1
-
23
-
-
70449276523
-
The hydrolysis of rabbit gamma-globulin and antibodies with crystalline papain
-
Porter RR (1959) The hydrolysis of rabbit gamma-globulin and antibodies with crystalline papain. Biochem J 73:119-26
-
(1959)
Biochem J
, vol.73
, pp. 119-126
-
-
Porter, R.R.1
-
24
-
-
0015733869
-
Three-dimensional structure of the Fab' fragment of a human immuno-globulin at 2.8 A resolution
-
Poljak RJ et al (1973) Three-dimensional structure of the Fab' fragment of a human immuno-globulin at 2.8 A resolution. Proc Natl Acad Sci USA 70:3305-3310
-
(1973)
Proc Natl Acad Sci USA
, vol.70
, pp. 3305-3310
-
-
Poljak, R.J.1
-
25
-
-
0027504398
-
Infusion of Fc gamma fragments for treatment of children with acute immune thrombocytopenic purpura
-
Debré M et al (1993) Infusion of Fc gamma fragments for treatment of children with acute immune thrombocytopenic purpura. Lancet 342:945-949
-
(1993)
Lancet
, vol.342
, pp. 945-949
-
-
Debré, M.1
-
26
-
-
42349085035
-
Recapitulation of IVIG anti-in flammatory activity with a recom-binant IgG Fc
-
Anthony RM et al (2008) Recapitulation of IVIG anti-in flammatory activity with a recom-binant IgG Fc. Science 320:373-376
-
(2008)
Science
, vol.320
, pp. 373-376
-
-
Anthony, R.M.1
-
27
-
-
0021860882
-
Preparation of bispeci fic antibodies by chemical recombination of monoclonal immunoglobulin G1 fragments
-
Brennan M (1985) Preparation of bispeci fic antibodies by chemical recombination of monoclonal immunoglobulin G1 fragments. Science 229:81-83
-
(1985)
Science
, vol.229
, pp. 81-83
-
-
Brennan, M.1
-
28
-
-
0027388920
-
A human tumor xeno-graft of therapy with a bispeci fic monoclonal antibody targeting c-erbB-2 and CD16
-
Weiner LM et al (1993) A human tumor xeno-graft of therapy with a bispeci fic monoclonal antibody targeting c-erbB-2 and CD16. Cancer Res 53:94-100
-
(1993)
Cancer Res
, vol.53
, pp. 94-100
-
-
Weiner, L.M.1
-
29
-
-
0029075901
-
In vitro killing of neuro-blastoma cells by neutrophils derived from granulocyte colony-stimulating factor-treated cancer patients using an anti-disialoganglioside/anti-Fc gamma RI bispecific antibody
-
Michon J et al (1995) In vitro killing of neuro-blastoma cells by neutrophils derived from granulocyte colony-stimulating factor-treated cancer patients using an anti-disialoganglioside/anti-Fc gamma RI bispecific antibody. Blood 86:1124-1130
-
(1995)
Blood
, vol.86
, pp. 1124-1130
-
-
Michon, J.1
-
30
-
-
0015402447
-
Localization of antibody-combining sites within the variable portions of heavy and light chains
-
Inbar D et al (1972) Localization of antibody-combining sites within the variable portions of heavy and light chains. Proc Natl Acad Sci USA 69:2659-2662
-
(1972)
Proc Natl Acad Sci USA
, vol.69
, pp. 2659-2662
-
-
Inbar, D.1
-
31
-
-
0024292736
-
Assembly of a functional immunoglobulin Fv fragment in Escherichia coli
-
Skerra A, Plückthun A (1988) Assembly of a functional immunoglobulin Fv fragment in Escherichia coli. Science 240:1038-1041
-
(1988)
Science
, vol.240
, pp. 1038-1041
-
-
Skerra, A.1
Plückthun, A.2
-
32
-
-
0004198722
-
Protein engineering of antibody binding sites: Recovery of speci fic activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli
-
Huston JS et al (1988) Protein engineering of antibody binding sites: recovery of speci fic activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc Natl Acad Sci USA 85:5879-5883
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 5879-5883
-
-
Huston, J.S.1
-
33
-
-
0024293979
-
Single-chain antigen-binding proteins
-
Bird RE et al (1988) Single-chain antigen-binding proteins. Science 242:423-426
-
(1988)
Science
, vol.242
, pp. 423-426
-
-
Bird, R.E.1
-
34
-
-
0027197493
-
"Diabodies": Small bivalent and bispecific antibody fragments
-
Holliger P et al (1993) "Diabodies": small bivalent and bispecific antibody fragments. Proc Natl Acad Sci USA 90:6444-6448
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 6444-6448
-
-
Holliger, P.1
-
35
-
-
0026334521
-
Protein engineering of single-chain Fv analogs and fusion proteins
-
Huston JS et al (1991) Protein engineering of single-chain Fv analogs and fusion proteins. Methods Enzymol 203:46-88
-
(1991)
Methods Enzymol
, vol.203
, pp. 46-88
-
-
Huston, J.S.1
-
36
-
-
0344242005
-
Intracellular and cell surface displayed single-chain diabod-ies
-
Kontermann RE, Muller R (1999) Intracellular and cell surface displayed single-chain diabod-ies. J Immunol Methods 226:179-188
-
(1999)
J Immunol Methods
, vol.226
, pp. 179-188
-
-
Kontermann, R.E.1
Muller, R.2
-
37
-
-
49649120397
-
Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
-
Bargou R et al (2008) Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 321:974-977
-
(2008)
Science
, vol.321
, pp. 974-977
-
-
Bargou, R.1
-
38
-
-
0031016269
-
Intrabodies: Turning the humoral immune system outside in for intracel-lular immunization
-
Marasco WA (1997) Intrabodies: turning the humoral immune system outside in for intracel-lular immunization. Gene Ther 4:11-15
-
(1997)
Gene Ther
, vol.4
, pp. 11-15
-
-
Marasco, W.A.1
-
39
-
-
0027275371
-
Design, intracellular expression, and activity of a human anti-human immunode ficiency virus type 1 gp120 single-chain antibody
-
Marasco WA, Haseltine WA, Chen S (1993) Design, intracellular expression, and activity of a human anti-human immunode ficiency virus type 1 gp120 single-chain antibody. Proc Natl Acad Sci USA 90:7889-7893
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 7889-7893
-
-
Marasco, W.A.1
Haseltine, W.A.2
Chen, S.3
-
40
-
-
0032521206
-
ras promotes tumor regression
-
ras promotes tumor regression. Cancer Res 58: 1170-1176
-
(1998)
Cancer Res
, vol.58
, pp. 1170-1176
-
-
Cochet, O.1
-
41
-
-
0028955535
-
Phenotypic knockout of the high-affinity human interleukin 2 receptor by intracellular single-chain antibodies against the alpha sub-unit of the receptor
-
Richardson JH et al (1995) Phenotypic knockout of the high-affinity human interleukin 2 receptor by intracellular single-chain antibodies against the alpha sub-unit of the receptor. Proc Natl Acad Sci USA 92:3137-3141
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 3137-3141
-
-
Richardson, J.H.1
-
42
-
-
0005382256
-
Restoration of transcriptional activity of p53 mutants in human tumor cells by intracellular expression of anti-p53 single chain Fv fragments
-
Caron de Fromentel C et al (1999) Restoration of transcriptional activity of p53 mutants in human tumor cells by intracellular expression of anti-p53 single chain Fv fragments. Oncogene 18:551-557
-
(1999)
Oncogene
, vol.18
, pp. 551-557
-
-
Caron De Fromentel, C.1
-
43
-
-
0037993790
-
Recombinant antibodies to the small GTPase Rab6 as conformation sensors
-
Nizak C et al (2003) Recombinant antibodies to the small GTPase Rab6 as conformation sensors. Science 300:984-987
-
(2003)
Science
, vol.300
, pp. 984-987
-
-
Nizak, C.1
-
44
-
-
0034817979
-
Aggresome formation by anti-Ras intracellular scFv fragments. The fate of the antigen-antibody complex
-
Cardinale A, Filesi I, Biocca S (2001) Aggresome formation by anti-Ras intracellular scFv fragments. The fate of the antigen-antibody complex. Eur J Biochem 268:268-277
-
(2001)
Eur J Biochem
, vol.268
, pp. 268-277
-
-
Cardinale, A.1
Filesi, I.2
Biocca, S.3
-
45
-
-
0032716364
-
Selection of antibodies for intracellular function using a two-hybrid in vivo system
-
Visintin M et al (1999) Selection of antibodies for intracellular function using a two-hybrid in vivo system. Proc Nat Acad Sci USA 9:11723-11728
-
(1999)
Proc Nat Acad Sci USA
, vol.9
, pp. 11723-11728
-
-
Visintin, M.1
-
46
-
-
0036299049
-
The intracellular antibody capture technology (IACT): Towards a consensus sequence for intracellular antibodies
-
Visintin M et al (2002) The intracellular antibody capture technology (IACT): towards a consensus sequence for intracellular antibodies. J Mol Biol 317:73-83
-
(2002)
J Mol Biol
, vol.317
, pp. 73-83
-
-
Visintin, M.1
-
47
-
-
0344813702
-
Antibody scFv fragments without disul fide bonds made by molecular evolution
-
Proba K et al (1998) Antibody scFv fragments without disul fide bonds made by molecular evolution. J Mol Biol 275:245-253
-
(1998)
J Mol Biol
, vol.275
, pp. 245-253
-
-
Proba, K.1
-
48
-
-
0032718607
-
Intrabody construction and expression III: Engineering hyperstable V(H) domains
-
Wirtz P, Steipe B (1999) Intrabody construction and expression III: engineering hyperstable V(H) domains. Protein Sci 8:2245-2250
-
(1999)
Protein Sci
, vol.8
, pp. 2245-2250
-
-
Wirtz, P.1
Steipe, B.2
-
49
-
-
0024834988
-
Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity
-
Ross G, Waks T, Eshhar Z (1989) Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc Natl Acad Sci USA 86:10024-10028
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 10024-10028
-
-
Ross, G.1
Waks, T.2
Eshhar, Z.3
-
50
-
-
15244358572
-
Adoptive immuno-therapy of prostate cancer bone lesions using redirected effector lymphocytes
-
Pinthus JH et al (2004) Adoptive immuno-therapy of prostate cancer bone lesions using redirected effector lymphocytes. J Clin Invest 114:1774-1781
-
(2004)
J Clin Invest
, vol.114
, pp. 1774-1781
-
-
Pinthus, J.H.1
-
51
-
-
0035660311
-
By-passing tumor-speci fic and bispecific antibodies: Triggering of antitumor immunity by expression of anti-Fc g R scFv on cancer cell surface
-
Gruel N, Fridman WH, Teillaud JL (2001) By-passing tumor-speci fic and bispecific antibodies: triggering of antitumor immunity by expression of anti-Fc g R scFv on cancer cell surface. Gene Ther 8:1721-1728
-
(2001)
Gene Ther
, vol.8
, pp. 1721-1728
-
-
Gruel, N.1
Fridman, W.H.2
Teillaud, J.L.3
-
52
-
-
0037124367
-
Inducing tumor immunity through the selective engagement of activating Fc g receptors on dendritic cells
-
Kalergis AM, Ravetch JV (2002) Inducing tumor immunity through the selective engagement of activating Fc g receptors on dendritic cells. J Exp Med 195:1653-1659
-
(2002)
J Exp Med
, vol.195
, pp. 1653-1659
-
-
Kalergis, A.M.1
Ravetch, J.V.2
-
53
-
-
0024461313
-
Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli
-
Ward ES et al (1989) Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli. Nature 341:544-546
-
(1989)
Nature
, vol.341
, pp. 544-546
-
-
Ward, E.S.1
-
54
-
-
0027310612
-
Naturally occurring antibodies devoid of light chains
-
Hamers-Casterman C et al (1993) Naturally occurring antibodies devoid of light chains. Nature 363:446-448
-
(1993)
Nature
, vol.363
, pp. 446-448
-
-
Hamers-Casterman, C.1
-
55
-
-
38349164198
-
Isolation and characterization of anti-FcgammaRIII (CD16) llama single-domain antibodies that activate natural killer cells
-
Behar G et al (2008) Isolation and characterization of anti-FcgammaRIII (CD16) llama single-domain antibodies that activate natural killer cells. Protein Eng Des Sel 21:1-10
-
(2008)
Protein Eng des Sel
, vol.21
, pp. 1-10
-
-
Behar, G.1
-
56
-
-
0035831483
-
Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs
-
Els Conrath K et al (2001) Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs. J Biol Chem 276:7346-7350
-
(2001)
J Biol Chem
, vol.276
, pp. 7346-7350
-
-
Els Conrath, K.1
|