A human anti-D monoclonal antibody selected for enhanced FcγRIII engagement clears RhD+ autologous red cells in human volunteers as efficiently as polyclonal anti-D antibodies

British Journal of Haematology

Volumn 141, Issue 1, 2008, Pages 109-119

  Beliard, Roland ^a   Waegemans, Tony ^a   Notelet, Dominique ^a   Massad, Léna ^a   Dhainaut, Frédéric ^a   Romeuf, Christophe De ^a   Guemas, Eric ^a   Haazen, Wouter ^b   Bourel, Dominique ^a   Teillaud, Jean Luc ^c   Prost, Jean François ^a  

^a Laboratoire Francais du Fractionnement et des Biotechnologies   (France)

^b Stuivenberg General Hospital   (Belgium)

^c CENTRE DE RECHERCHE DES CORDELIERS   (France)

Author keywords

Anti D; Antibody dependent cell cytotoxicity; Clinical trial; Glycosylation; Monoclonal antibody

Indexed keywords

CD16 ANTIGEN; FC GAMMA RECEPTOR 3A; FC RECEPTOR; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY R297; POLYCLONAL ANTIBODY; RHESUS D ANTIBODY; RHOPHYLAC; UNCLASSIFIED DRUG;

ADULT; ALLOIMMUNIZATION; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; CLEARANCE; CLINICAL TRIAL; CONTROLLED STUDY; ERYTHROCYTE; HUMAN; MALE; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PLASMA CLEARANCE; PRIORITY JOURNAL; VOLUNTEER;

ADULT; ANTIBODIES, MONOCLONAL; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ERYTHROCYTES; HEMOLYSIS; HUMANS; IMMUNOGLOBULIN G; ISOANTIBODIES; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, IGG; RHO(D) IMMUNE GLOBULIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 40449102205     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2008.06985.x     Document Type: Article

References (41)