Inducing tumor immunity through the selective engagement of activating Fcγ receptors on dendritic cells

Journal of Experimental Medicine

Volumn 195, Issue 12, 2002, Pages 1653-1659

  Kalergis, Alexis M ^a   Ravetch, Jeffrey V ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

DC maturation; Fc receptors; Immune complexes; Inhibitory activating receptor pairs; T cell immunity

Indexed keywords

FC RECEPTOR; TUMOR ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CELL MATURATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNOLOGICAL TOLERANCE; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TUMOR IMMUNITY;

ANIMALS; DENDRITIC CELLS; LYMPHOCYTE ACTIVATION; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; RECEPTORS, IGG; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0037124367     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020338     Document Type: Article

References (38)

1. Increased immunogenicity of tumor vaccines complexed with anti-Gal: Studies in knockout mice for α1,3galactosyltransferase
2. Antitumor monoclonal antibodies enhance cross-presentation of cellular antigens and the generation of myeloma-specific killer T cells by dendritic cells
3. Immunobiology of dendritic cells
4. Dendritic cells in cancer immunotherapy
5. Regulation of T cell immunity by dendritic cells
6. DC-SIGN: A guide to some mysteries of dendritic cells
7. Dendritic cells: Specialized and regulated antigen processing machines
8. The instructive role of dendritic cells on T cell responses: Lineages, plasticity and kinetics
9. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
10. Fcγ receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization
11. Class I-restricted presentation of exogenous antigen acquired by Fcγ receptor-mediated endocytosis is regulated in dendritic cells
12. + CTL responses in vivo
13. Cross-printing for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay
14. Inaugural article: Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
15. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
16. Comparative analysis of genetically modified dendritic cells and tumor cells as therapeutic cancer vaccines
17. Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: Comparison of prophylaxis and therapy
18. + regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
19. Genetically modified dendritic cells prime autoreactive T cells through a pathway independent of CD40L and interleukin 12: Implications for cancer vaccines
20. IgG-mediated enhancement of antibody responses is low in Fc receptor γ chain-deficient mice and increased in FcγRII-deficient mice
21. Igg fc receptors
22. SHIP modulates immune receptor responses by regulating membrane association of Btk
23. SHIP recruitment attenuates Fcγ RIIB-induced B cell apoptosis
24. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
25. Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection
26. DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323-339 epitope
27. Alleles of the Ly-17 alloantigen define polymorphisms of the murine IgG Fc receptor
28. Targeting antigen into the phagocytic pathway in vivo induces protective tumour immunity
29. Introduction of soluble protein into the class I pathway of antigen processing and presentation
30. + T cell help to elicit antitumor immunity: Implications for the clinical use of dendritic cells
31. A simplified procedure for the preparation of MHC/peptide tetramers: Chemical biotinylation of an unpaired cysteine engineered at the C-terminus of MHC-I
32. Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex
33. Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors
34. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors
35. FcR γ chain deletion results in pleiotrophic effector cell defects
36. High resolution mapping of the binding site on human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and design of IgG1 variants with improved binding to the FcγR
37. Polymorphisms in IgG Fc receptor IIB regulatory regions associated with autoimmune susceptibility
38. Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcγRII