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Volumn 23, Issue 7, 2015, Pages 1248-1261

Mesenchymal stromal cells derived from Crohn's patients deploy indoleamine 2,3-dioxygenase-mediated immune suppression, independent of autophagy

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE;

EID: 84934434339     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2015.67     Document Type: Article
Times cited : (51)

References (51)
  • 1
    • 84860238652 scopus 로고    scopus 로고
    • Multipotent mesenchymal stromal cells and the innate immune system
    • Le Blanc, K and Mougiakakos, D (2012). Multipotent mesenchymal stromal cells and the innate immune system. Nat Rev Immunol 12: 383-396.
    • (2012) Nat Rev Immunol , vol.12 , pp. 383-396
    • Le Blanc, K.1    Mougiakakos, D.2
  • 2
    • 84885099905 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: Sensors and switchers of inflammation
    • Bernardo, ME and Fibbe, WE (2013). Mesenchymal stromal cells: sensors and switchers of inflammation. Cell Stem Cell 13: 392-402.
    • (2013) Cell Stem Cell , vol.13 , pp. 392-402
    • Bernardo, M.E.1    Fibbe, W.E.2
  • 3
    • 84892146772 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Environmentally responsive therapeutics for regenerative medicine
    • Murphy, MB, Moncivais, K and Caplan, AI (2013). Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med 45: e54.
    • (2013) Exp Mol Med , vol.45 , pp. e54
    • Murphy, M.B.1    Moncivais, K.2    Caplan, A.I.3
  • 4
    • 78649895490 scopus 로고    scopus 로고
    • Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: Results of a phase i study
    • Duijvestein, M, Vos, AC, Roelofs, H, Wildenberg, ME, Wendrich, BB, Verspaget, HW et al. (2010). Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study. Gut 59: 1662-1669.
    • (2010) Gut , vol.59 , pp. 1662-1669
    • Duijvestein, M.1    Vos, A.C.2    Roelofs, H.3    Wildenberg, M.E.4    Wendrich, B.B.5    Verspaget, H.W.6
  • 7
    • 84884907997 scopus 로고    scopus 로고
    • Use of mesenchymal stem cells (MSC) in chronic inflammatory fistulizing and fibrotic diseases: A comprehensive review
    • Voswinkel, J, Francois, S, Simon, JM, Benderitter, M, Gorin, NC, Mohty, M et al. (2013). Use of mesenchymal stem cells (MSC) in chronic inflammatory fistulizing and fibrotic diseases: a comprehensive review. Clin Rev Allergy Immunol 45: 180-192.
    • (2013) Clin Rev Allergy Immunol , vol.45 , pp. 180-192
    • Voswinkel, J.1    Francois, S.2    Simon, J.M.3    Benderitter, M.4    Gorin, N.C.5    Mohty, M.6
  • 8
    • 28844483809 scopus 로고    scopus 로고
    • Allogeneic marrow stromal cells are immune rejected by MHC class I-And class II-mismatched recipient mice
    • Eliopoulos, N, Stagg, J, Lejeune, L, Pommey, S and Galipeau, J (2005). Allogeneic marrow stromal cells are immune rejected by MHC class I-And class II-mismatched recipient mice. Blood 106: 4057-4065.
    • (2005) Blood , vol.106 , pp. 4057-4065
    • Eliopoulos, N.1    Stagg, J.2    Lejeune, L.3    Pommey, S.4    Galipeau, J.5
  • 9
    • 84906275192 scopus 로고    scopus 로고
    • Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties?
    • Moll, G, Alm, JJ, Davies, LC, von Bahr, L, Heldring, N, Stenbeck-Funke, L et al. (2014). Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties?. Stem Cells 32: 2430-2442.
    • (2014) Stem Cells , vol.32 , pp. 2430-2442
    • Moll, G.1    Alm, J.J.2    Davies, L.C.3    Von Bahr, L.4    Heldring, N.5    Stenbeck-Funke, L.6
  • 10
    • 84864110915 scopus 로고    scopus 로고
    • New insights on translational development of mesenchymal stromal cells for suppressor therapy
    • Francois, M and Galipeau, J (2012). New insights on translational development of mesenchymal stromal cells for suppressor therapy. J Cell Physiol 227: 3535-3538.
    • (2012) J Cell Physiol , vol.227 , pp. 3535-3538
    • Francois, M.1    Galipeau, J.2
  • 11
    • 63649106995 scopus 로고    scopus 로고
    • Casting doubt on the safety of off-The-shelf mesenchymal stem cells for cell therapy
    • Rameshwar, P (2009). Casting doubt on the safety of 'off-The-shelf' mesenchymal stem cells for cell therapy. Mol Ther 17: 216-218.
    • (2009) Mol Ther , vol.17 , pp. 216-218
    • Rameshwar, P.1
  • 12
    • 84875468183 scopus 로고    scopus 로고
    • The mesenchymal stromal cells dilemma-does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?
    • Galipeau, J (2013). The mesenchymal stromal cells dilemma-does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?. Cytotherapy 15: 2-8.
    • (2013) Cytotherapy , vol.15 , pp. 2-8
    • Galipeau, J.1
  • 13
    • 0036493402 scopus 로고    scopus 로고
    • Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: Evidence for a tumor necrosis factor alphamediated effect
    • Papadaki, HA, Kritikos, HD, Gemetzi, C, Koutala, H, Marsh, JC, Boumpas, DT et al. (2002). Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alphamediated effect. Blood 99: 1610-1619.
    • (2002) Blood , vol.99 , pp. 1610-1619
    • Papadaki, H.A.1    Kritikos, H.D.2    Gemetzi, C.3    Koutala, H.4    Marsh, J.C.5    Boumpas, D.T.6
  • 14
    • 84887571005 scopus 로고    scopus 로고
    • Thalidomide corrects impaired mesenchymal stem cell function in inducing tolerogenic DCs in patients with immune thrombocytopenia
    • Ma, J, Ning, YN, Xu, M, Hou, Y, Wang, N, Hou, XY et al. (2013). Thalidomide corrects impaired mesenchymal stem cell function in inducing tolerogenic DCs in patients with immune thrombocytopenia. Blood 122: 2074-2082.
    • (2013) Blood , vol.122 , pp. 2074-2082
    • Ma, J.1    Ning, Y.N.2    Xu, M.3    Hou, Y.4    Wang, N.5    Hou, X.Y.6
  • 15
    • 84866095966 scopus 로고    scopus 로고
    • Gene expression profile reveals abnormalities of multiple signaling pathways in mesenchymal stem cell derived from patients with systemic lupus erythematosus
    • Tang, Y, Ma, X, Zhang, H, Gu, Z, Hou, Y, Gilkeson, GS et al. (2012). Gene expression profile reveals abnormalities of multiple signaling pathways in mesenchymal stem cell derived from patients with systemic lupus erythematosus. Clin Dev Immunol 2012: 826182.
    • (2012) Clin Dev Immunol , vol.2012 , pp. 826182
    • Tang, Y.1    Ma, X.2    Zhang, H.3    Gu, Z.4    Hou, Y.5    Gilkeson, G.S.6
  • 16
    • 41849133613 scopus 로고    scopus 로고
    • Phenotypical and functional characteristics of in vitro expanded bone marrow mesenchymal stem cells from patients with systemic sclerosis
    • Larghero, J, Farge, D, Braccini, A, Lecourt, S, Scherberich, A, Foïs, E et al. (2008). Phenotypical and functional characteristics of in vitro expanded bone marrow mesenchymal stem cells from patients with systemic sclerosis. Ann Rheum Dis 67: 443-449.
    • (2008) Ann Rheum Dis , vol.67 , pp. 443-449
    • Larghero, J.1    Farge, D.2    Braccini, A.3    Lecourt, S.4    Scherberich, A.5    Foïs, E.6
  • 17
    • 33847386693 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stromal cells (BM-MSCs) from healthy donors and auto-immune disease patients reduce the proliferation of autologous-And allogeneic-stimulated lymphocytes in vitro
    • Bocelli-Tyndall, C, Bracci, L, Spagnoli, G, Braccini, A, Bouchenaki, M, Ceredig, R et al. (2007). Bone marrow mesenchymal stromal cells (BM-MSCs) from healthy donors and auto-immune disease patients reduce the proliferation of autologous-And allogeneic-stimulated lymphocytes in vitro. Rheumatology (Oxford) 46: 403-408.
    • (2007) Rheumatology (Oxford) , vol.46 , pp. 403-408
    • Bocelli-Tyndall, C.1    Bracci, L.2    Spagnoli, G.3    Braccini, A.4    Bouchenaki, M.5    Ceredig, R.6
  • 18
    • 70450158753 scopus 로고    scopus 로고
    • Phenotypical/functional characterization of in vitro-expanded mesenchymal stromal cells from patients with Crohn's disease
    • Bernardo, ME, Avanzini, MA, Ciccocioppo, R, Perotti, C, Cometa, AM, Moretta, A et al. (2009). Phenotypical/functional characterization of in vitro-expanded mesenchymal stromal cells from patients with Crohn's disease. Cytotherapy 11: 825-836.
    • (2009) Cytotherapy , vol.11 , pp. 825-836
    • Bernardo, M.E.1    Avanzini, M.A.2    Ciccocioppo, R.3    Perotti, C.4    Cometa, A.M.5    Moretta, A.6
  • 20
    • 84872617225 scopus 로고    scopus 로고
    • Indoleamine 2,3 dioxygenase gene polymorphisms correlate with CD8+ Treg impairment in systemic sclerosis
    • Tardito, S, Negrini, S, Conteduca, G, Ferrera, F, Parodi, A, Battaglia, F et al. (2013). Indoleamine 2,3 dioxygenase gene polymorphisms correlate with CD8+ Treg impairment in systemic sclerosis. Hum Immunol 74: 166-169.
    • (2013) Hum Immunol , vol.74 , pp. 166-169
    • Tardito, S.1    Negrini, S.2    Conteduca, G.3    Ferrera, F.4    Parodi, A.5    Battaglia, F.6
  • 21
    • 33846627302 scopus 로고    scopus 로고
    • A genomewide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe, J, Franke, A, Rosenstiel, P, Till, A, Teuber, M, Huse, K et al. (2007). A genomewide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39: 207-211.
    • (2007) Nat Genet , vol.39 , pp. 207-211
    • Hampe, J.1    Franke, A.2    Rosenstiel, P.3    Till, A.4    Teuber, M.5    Huse, K.6
  • 22
    • 34247554965 scopus 로고    scopus 로고
    • Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
    • Rioux, JD, Xavier, RJ, Taylor, KD, Silverberg, MS, Goyette, P, Huett, A et al. (2007). Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 39: 596-604.
    • (2007) Nat Genet , vol.39 , pp. 596-604
    • Rioux, J.D.1    Xavier, R.J.2    Taylor, K.D.3    Silverberg, M.S.4    Goyette, P.5    Huett, A.6
  • 24
    • 84891746273 scopus 로고    scopus 로고
    • Recent insights on the putative role of autophagy in autoimmune diseases
    • Gianchecchi, E, Delfino, DV and Fierabracci, A (2014). Recent insights on the putative role of autophagy in autoimmune diseases. Autoimmun Rev 13: 231-241.
    • (2014) Autoimmun Rev , vol.13 , pp. 231-241
    • Gianchecchi, E.1    Delfino, D.V.2    Fierabracci, A.3
  • 25
    • 84879993550 scopus 로고    scopus 로고
    • Autophagy: A new target or an old strategy for the treatment of Crohn's disease?
    • Nys, K, Agostinis, P and Vermeire, S (2013). Autophagy: a new target or an old strategy for the treatment of Crohn's disease?. Nat Rev Gastroenterol Hepatol 10: 395-401.
    • (2013) Nat Rev Gastroenterol Hepatol , vol.10 , pp. 395-401
    • Nys, K.1    Agostinis, P.2    Vermeire, S.3
  • 26
    • 80051550866 scopus 로고    scopus 로고
    • Crohn's disease-Associated ATG16L1 polymorphism modulates proinflammatory cytokine responses selectively upon activation of NOD2
    • Plantinga, TS, Crisan, TO, Oosting, M, van de Veerdonk, FL, de Jong, DJ, Philpott, DJ et al. (2011). Crohn's disease-Associated ATG16L1 polymorphism modulates proinflammatory cytokine responses selectively upon activation of NOD2. Gut 60: 1229-1235.
    • (2011) Gut , vol.60 , pp. 1229-1235
    • Plantinga, T.S.1    Crisan, T.O.2    Oosting, M.3    Van De Veerdonk, F.L.4    De Jong, D.J.5    Philpott, D.J.6
  • 27
    • 84881026080 scopus 로고    scopus 로고
    • The effect of platelet lysate fibrinogen on the functionality of MSCs in immunotherapy
    • Copland, IB, Garcia, MA, Waller, EK, Roback, JD and Galipeau, J (2013). The effect of platelet lysate fibrinogen on the functionality of MSCs in immunotherapy. Biomaterials 34: 7840-7850.
    • (2013) Biomaterials , vol.34 , pp. 7840-7850
    • Copland, I.B.1    Garcia, M.A.2    Waller, E.K.3    Roback, J.D.4    Galipeau, J.5
  • 28
    • 84896727247 scopus 로고    scopus 로고
    • IDO-independent suppression of T cell effector function by IFN-?-licensed human mesenchymal stromal cells
    • Chinnadurai, R, Copland, IB, Patel, SR and Galipeau, J (2014). IDO-independent suppression of T cell effector function by IFN-?-licensed human mesenchymal stromal cells. J Immunol 192: 1491-1501.
    • (2014) J Immunol , vol.192 , pp. 1491-1501
    • Chinnadurai, R.1    Copland, I.B.2    Patel, S.R.3    Galipeau, J.4
  • 29
    • 84876007294 scopus 로고    scopus 로고
    • Using blood informative transcripts in geographical genomics: Impact of lifestyle on gene expression in fijians
    • Nath, AP, Arafat, D and Gibson, G (2012). Using blood informative transcripts in geographical genomics: impact of lifestyle on gene expression in fijians. Front Genet 3: 243.
    • (2012) Front Genet , vol.3 , pp. 243
    • Nath, A.P.1    Arafat, D.2    Gibson, G.3
  • 30
    • 84881092225 scopus 로고    scopus 로고
    • Immunological characterization of multipotent mesenchymal stromal cells-The International Society for Cellular Therapy (ISCT) working proposal
    • MSC Committee of the International Society for Cellular Therapy (ISCT).
    • Krampera, M, Galipeau, J, Shi, Y, Tarte, K and Sensebe, L; MSC Committee of the International Society for Cellular Therapy (ISCT) (2013). Immunological characterization of multipotent mesenchymal stromal cells-The International Society for Cellular Therapy (ISCT) working proposal. Cytotherapy 15: 1054-1061.
    • (2013) Cytotherapy , vol.15 , pp. 1054-1061
    • Krampera, M.1    Galipeau, J.2    Shi, Y.3    Tarte, K.4    Sensebe, L.5
  • 31
    • 38649105374 scopus 로고    scopus 로고
    • Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    • Ren, G, Zhang, L, Zhao, X, Xu, G, Zhang, Y, Roberts, AI et al. (2008). Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2: 141-150.
    • (2008) Cell Stem Cell , vol.2 , pp. 141-150
    • Ren, G.1    Zhang, L.2    Zhao, X.3    Xu, G.4    Zhang, Y.5    Roberts, A.I.6
  • 33
    • 39549089300 scopus 로고    scopus 로고
    • Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases
    • Armaka, M, Apostolaki, M, Jacques, P, Kontoyiannis, DL, Elewaut, D and Kollias, G (2008). Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J Exp Med 205: 331-337.
    • (2008) J Exp Med , vol.205 , pp. 331-337
    • Armaka, M.1    Apostolaki, M.2    Jacques, P.3    Kontoyiannis, D.L.4    Elewaut, D.5    Kollias, G.6
  • 34
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells the International Society for Cellular Therapy position statement
    • Dominici, M, Le Blanc, K, Mueller, I, Slaper-Cortenbach, I, Marini, F, Krause, D et al. (2006). Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8: 315-317.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3    Slaper-Cortenbach, I.4    Marini, F.5    Krause, D.6
  • 35
    • 27944435821 scopus 로고    scopus 로고
    • Clarification of the nomenclature for msc: The international society for cellular therapy position statement
    • International Society for Cellular Therapy.
    • Horwitz, EM, Le Blanc, K, Dominici, M, Mueller, I, Slaper-Cortenbach, I, Marini, FC et al.; International Society for Cellular Therapy. (2005). Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy 7: 393-395.
    • (2005) Cytotherapy , vol.7 , pp. 393-395
    • Horwitz, E.M.1    Le Blanc, K.2    Dominici, M.3    Mueller, I.4    Slaper-Cortenbach, I.5    Marini, F.C.6
  • 36
    • 34548630221 scopus 로고    scopus 로고
    • Regulation of MHC class II expression and antigen processing in murine and human mesenchymal stromal cells by IFN-gamma, TGF-beta, and cell density
    • Romieu-Mourez, R, Francois, M, Boivin, MN, Stagg, J and Galipeau, J (2007). Regulation of MHC class II expression and antigen processing in murine and human mesenchymal stromal cells by IFN-gamma, TGF-beta, and cell density. J Immunol 179: 1549-1558.
    • (2007) J Immunol , vol.179 , pp. 1549-1558
    • Romieu-Mourez, R.1    Francois, M.2    Boivin, M.N.3    Stagg, J.4    Galipeau, J.5
  • 37
    • 84856960632 scopus 로고    scopus 로고
    • Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation
    • Francois, M, Romieu-Mourez, R, Li, M and Galipeau, J (2012). Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation. Mol Ther 20: 187-195.
    • (2012) Mol Ther , vol.20 , pp. 187-195
    • Francois, M.1    Romieu-Mourez, R.2    Li, M.3    Galipeau, J.4
  • 38
    • 65549098640 scopus 로고    scopus 로고
    • CD4 T-cell differentiation and inflammatory bowel disease
    • Zenewicz, LA, Antov, A and Flavell, RA (2009). CD4 T-cell differentiation and inflammatory bowel disease. Trends Mol Med 15: 199-207.
    • (2009) Trends Mol Med , vol.15 , pp. 199-207
    • Zenewicz, L.A.1    Antov, A.2    Flavell, R.A.3
  • 39
    • 84860849630 scopus 로고    scopus 로고
    • The immune plasticity of mesenchymal stromal cells from mice and men: Concordances and discrepancies
    • Romieu-Mourez, R, Coutu, DL and Galipeau, J (2012). The immune plasticity of mesenchymal stromal cells from mice and men: concordances and discrepancies. Front Biosci (Elite Ed) 4: 824-837.
    • (2012) Front Biosci (Elite Ed) , Issue.4 , pp. 824-837
    • Romieu-Mourez, R.1    Coutu, D.L.2    Galipeau, J.3
  • 40
    • 79959265855 scopus 로고    scopus 로고
    • Global transcriptome analysis of human bone marrow stromal cells (BMSC) reveals proliferative, mobile and interactive cells that produce abundant extracellular matrix proteins, some of which may affect BMSC potency
    • Ren, J, Jin, P, Sabatino, M, Balakumaran, A, Feng, J, Kuznetsov, SA et al. (2011). Global transcriptome analysis of human bone marrow stromal cells (BMSC) reveals proliferative, mobile and interactive cells that produce abundant extracellular matrix proteins, some of which may affect BMSC potency. Cytotherapy 13: 661-674.
    • (2011) Cytotherapy , vol.13 , pp. 661-674
    • Ren, J.1    Jin, P.2    Sabatino, M.3    Balakumaran, A.4    Feng, J.5    Kuznetsov, S.A.6
  • 41
    • 58149388233 scopus 로고    scopus 로고
    • Mesenchymal stromal cell-derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction
    • Rafei, M, Hsieh, J, Fortier, S, Li, M, Yuan, S, Birman, E et al. (2008). Mesenchymal stromal cell-derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction. Blood 112: 4991-4998.
    • (2008) Blood , vol.112 , pp. 4991-4998
    • Rafei, M.1    Hsieh, J.2    Fortier, S.3    Li, M.4    Yuan, S.5    Birman, E.6
  • 42
    • 50349091769 scopus 로고    scopus 로고
    • Matrix metalloproteinase processing of CXCL11/I-TAC results in loss of chemoattractant activity and altered glycosaminoglycan binding
    • Cox, JH, Dean, RA, Roberts, CR and Overall, CM (2008). Matrix metalloproteinase processing of CXCL11/I-TAC results in loss of chemoattractant activity and altered glycosaminoglycan binding. J Biol Chem 283: 19389-19399.
    • (2008) J Biol Chem , vol.283 , pp. 19389-19399
    • Cox, J.H.1    Dean, R.A.2    Roberts, C.R.3    Overall, C.M.4
  • 43
    • 78249237580 scopus 로고    scopus 로고
    • Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease
    • Schroepf, S, Kappler, R, Brand, S, Prell, C, Lohse, P, Glas, J et al. (2010). Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease. Inflamm Bowel Dis 16: 1882-1890.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1882-1890
    • Schroepf, S.1    Kappler, R.2    Brand, S.3    Prell, C.4    Lohse, P.5    Glas, J.6
  • 44
    • 84890070174 scopus 로고    scopus 로고
    • From single nucleotide polymorphisms to constant immunosuppression: Mesenchymal stem cell therapy for autoimmune diseases
    • Chinnadurai, R, Waller, EK, Galipeau, J and Nooka, AK (2013). From single nucleotide polymorphisms to constant immunosuppression: mesenchymal stem cell therapy for autoimmune diseases. Biomed Res Int 2013: 929842.
    • (2013) Biomed Res Int , vol.2013 , pp. 929842
    • Chinnadurai, R.1    Waller, E.K.2    Galipeau, J.3    Nooka, A.K.4
  • 45
    • 56249090667 scopus 로고    scopus 로고
    • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
    • Saitoh, T, Fujita, N, Jang, MH, Uematsu, S, Yang, BG, Satoh, T et al. (2008). Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 456: 264-268.
    • (2008) Nature , vol.456 , pp. 264-268
    • Saitoh, T.1    Fujita, N.2    Jang, M.H.3    Uematsu, S.4    Yang, B.G.5    Satoh, T.6
  • 46
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell, K, Liu, JY, Brown, SL, Miyoshi, H, Loh, J, Lennerz, JK et al. (2008). A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456: 259-263.
    • (2008) Nature , vol.456 , pp. 259-263
    • Cadwell, K.1    Liu, J.Y.2    Brown, S.L.3    Miyoshi, H.4    Loh, J.5    Lennerz, J.K.6
  • 47
    • 84896730900 scopus 로고    scopus 로고
    • A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3
    • Murthy, A, Li, Y, Peng, I, Reichelt, M, Katakam, AK, Noubade, R et al. (2014). A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. Nature 506: 456-462.
    • (2014) Nature , vol.506 , pp. 456-462
    • Murthy, A.1    Li, Y.2    Peng, I.3    Reichelt, M.4    Katakam, A.K.5    Noubade, R.6
  • 48
    • 84901660514 scopus 로고    scopus 로고
    • Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense
    • Lassen, KG, Kuballa, P, Conway, KL, Patel, KK, Becker, CE, Peloquin, JM et al. (2014). Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense. Proc Natl Acad Sci U S A 111: 7741-7746.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 7741-7746
    • Lassen, K.G.1    Kuballa, P.2    Conway, K.L.3    Patel, K.K.4    Becker, C.E.5    Peloquin, J.M.6
  • 49
    • 70450248450 scopus 로고    scopus 로고
    • Differential involvement of Atg16L1 in Crohn disease and canonical autophagy: Analysis of the organization of the Atg16L1 complex in fibroblasts
    • Fujita, N, Saitoh, T, Kageyama, S, Akira, S, Noda, T and Yoshimori, T (2009). Differential involvement of Atg16L1 in Crohn disease and canonical autophagy: analysis of the organization of the Atg16L1 complex in fibroblasts. J Biol Chem 284: 32602-32609.
    • (2009) J Biol Chem , vol.284 , pp. 32602-32609
    • Fujita, N.1    Saitoh, T.2    Kageyama, S.3    Akira, S.4    Noda, T.5    Yoshimori, T.6
  • 50
    • 84904205093 scopus 로고    scopus 로고
    • Actin cytoskeletal disruption following cryopreservation alters the biodistribution of human mesenchymal stromal cells in vivo
    • Chinnadurai, R, Garcia, MA, Sakurai, Y, Lam, WA, Kirk, AD, Galipeau, J et al. (2014). Actin cytoskeletal disruption following cryopreservation alters the biodistribution of human mesenchymal stromal cells in vivo. Stem Cell Reports 3: 60-72.
    • (2014) Stem Cell Reports , vol.3 , pp. 60-72
    • Chinnadurai, R.1    Garcia, M.A.2    Sakurai, Y.3    Lam, W.A.4    Kirk, A.D.5    Galipeau, J.6
  • 51
    • 84855890176 scopus 로고    scopus 로고
    • Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-licensing
    • Francois, M, Copland, IB, Yuan, S, Romieu-Mourez, R, Waller, EK and Galipeau, J (2012). Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-licensing. Cytotherapy 14: 147-152.
    • (2012) Cytotherapy , vol.14 , pp. 147-152
    • Francois, M.1    Copland, I.B.2    Yuan, S.3    Romieu-Mourez, R.4    Waller, E.K.5    Galipeau, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.