Use of mesenchymal stem cells (MSC) in chronic inflammatory fistulizing and fibrotic diseases: A comprehensive review

Clinical Reviews in Allergy and Immunology

Volumn 45, Issue 2, 2013, Pages 180-192

  Voswinkel, Jan ^a   Francois, Sabine ^a,b   Simon, Jean Marc ^c   Benderitter, Marc ^b   Gorin, Norbert Claude ^a   Mohty, Mohamad ^a   Fouillard, Loïc ^d   Chapel, Alain ^a,b  

^a SORBONNE UNIVERSITÉ   (France)

^b INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^d CENTRE HOSPITALIER   (France)

Author keywords

Colitis; Connective tissue disease; Fibrosis; Fistulization; Immunology; Immunomodulation; MSC; Radiotherapy; Stem cells

Indexed keywords

B7 ANTIGEN; CD14 ANTIGEN; CD40 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; COLONY STIMULATING FACTOR 1; GAMMA INTERFERON; HLA DR ANTIGEN; HLA G ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; PROSTAGLANDIN E2; SCATTER FACTOR; STROMAL CELL DERIVED FACTOR 1; T LYMPHOCYTE RECEPTOR; T6 ANTIGEN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ADAPTIVE IMMUNITY; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANTIGEN PRESENTING CELL; ANTIINFLAMMATORY ACTIVITY; AUTOIMMUNE DISEASE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; B LYMPHOCYTE; BLEEDING; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL INTERACTION; CELL MATURATION; CHRONIC INFLAMMATION; CLINICAL PRACTICE; COMPASSIONATE USE; CROHN DISEASE; DENDRITIC CELL; DIARRHEA; FIBROSIS; FISTULA; FOLLOW UP; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOMODULATION; INFLAMMATORY DISEASE; INNATE IMMUNITY; LYMPHOCYTE PROLIFERATION; MESENCHYMAL STEM CELL TRANSPLANTATION; MONOCYTE; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PAIN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PROSTATE CANCER; QUALITY OF LIFE; RADIATION INJURY; RECTOVAGINAL FISTULA; REGULATORY T LYMPHOCYTE; REVIEW; SCLERODERMA; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL; ULCERATIVE COLITIS;

ANIMALS; CHRONIC DISEASE; CLINICAL TRIALS AS TOPIC; FIBROSIS; HUMANS; IMMUNE SYSTEM DISEASES; INFLAMMATION; MESENCHYMAL STEM CELL TRANSPLANTATION; RECTAL FISTULA; REGENERATIVE MEDICINE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 84884907997     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-012-8347-6     Document Type: Review

References (71)

1. Djouad F, Bony C, Haupl T et al (2005) Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells. Arthritis Res Ther 7:R1304-R1315
2. De Bari C, Dell'Accio F, Luyten FP (2001) Human periosteum-derived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor age. Arthritis Rheum 44(1):85-95
3. Noel D, Caton D, Roche S et al (2008) Cell specific differences between human adipose-derived and mesenchymal-stromal cells despite similar differentiation potentials. Exp Cell Res 314:1575-1584
4. Fickert S, Fiedler J, Brenner RE (2003) Identification, quantification and isolation of mesenchymal progenitor cells from osteoarthritic synovium by fluorescence automated cell sorting. Osteoarthr Cartil 11:790-800
5. Le Blanc K, Tammik L, Sundberg B, Haynesworth SE, Ringden O (2003) Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol 57:11-20
6. Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC (2003) Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation 75(3):389-397
7. Klyushnenkova E, Mosca JD, Zernetkina V et al (2005) T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression. J Biomed Sci 12:47-57
8. Rasmusson I, Ringden O, Sundberg B, Le Blanc K (2003) Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. Transplantation 76:1208-1213
9. Rasmusson I (2006) Immune modulation by mesenchymal stem cells. Exp Cell Res 312:2169-2179
10. Tokoyoda K, Zehentmeier S, Hegazy AN et al (2009) Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow. Immunity 30:721-730
11. Chen L, Tredget EE, Wu PY, Wu Y (2008) Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 3:e1886
12. Aggarwal S, Pittenger MF (2005) Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105:1815-1822
13. Nemeth K, Leelahavanichkul A, Yuen PS et al (2009) Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 15:42-49
14. Spaggiari GM, Abdelrazik H, Becchetti F, Moretta L (2009) MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2. Blood 113:6576-6583
15. Djouad F, Charbonnier LM, Bouffi C et al (2007) Mesenchymal stem cells inhibit the differentiation of dendritic cells through an interleukin-6- dependent mechanism. Stem Cells 25:2025-2032
16. Jiang XX, Zhang Y, Liu B et al (2005) Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 105:4120-4126
17. Ren G, Su J, Zhang L et al (2009) Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression. Stem Cells 27:1954-1962
18. Sato K, Ozaki K, Oh I et al (2007) Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood 109:228-234
19. Nasef A, Mathieu N, Chapel A et al (2007) Immunosuppressive effects of mesenchymal stem cells: involvement of HLA-G. Transplantation 84:231-237
20. Nasef A, Zhang YZ, Mazurier C et al (2009) Selected Stro-1-enriched bone marrow stromal cells display a major suppressive effect on lymphocyte proliferation. Int J Lab Hematol 31:9-19
21. Prevosto C, Zancolli M, Canevali P, Zocchi MR, Poggi A (2007) Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction. Haematologica 92:881-888
22. Parekkadan B, Tilles AW, Yarmush ML (2008) Bone marrow-derived mesenchymal stem cells ameliorate autoimmune enteropathy independently of regulatory T cells. Stem Cells 26:1913-1919
23. Zappia E, Casazza S, Pedemonte E et al (2005) Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood 106:1755-1761
24. Zhou H, Jin Z, Liu J, Yu S, Cui Q, Yi D (2008) Mesenchymal stem cells might be used to induce tolerance in heart transplantation. Med Hypotheses 70:785-787
25. Haniffa MA, Wang XN, Holtick U et al (2007) Adult human fibroblasts are potent immunoregulatory cells and functionally equivalent to mesenchymal stem cells. J Immunol 179:1595-1604
26. Corcione A, Benvenuto F, Ferretti E et al (2006) Human mesenchymal stem cells modulate B-cell functions. Blood 107:367-372
27. Gonzalez MA, Gonzalez-Rey E, Rico L, Buscher D, Delgado M (2009) Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells. Arthritis Rheum 60:1006-1019
28. Malgieri A, Kantzari E, Patrizi MP, Gambardella S (2010) Bone marrow and umbilical cord blood human mesenchymal stem cells: state of the art. Int J Clin Exp Med 3:248-26
29. Voswinkel, J., and Chapel, A. (2012). Mesenchymal stem cells and rheumatism: state of the art. Z Rheumatol.
30. Beggs KJ, Lyubimov A, Borneman JN et al (2006) Immunologic consequences of multiple, high-dose administration of allogeneic mesenchymal stem cells to baboons. Cell Transplant 15:711-721
31. Le Blanc K, Ringden O (2007) Immunomodulation by mesenchymal stem cells and clinical experience. J Intern Med 262:509-525
32. Rubio D, Garcia-Castro J, Martin MC et al (2005) Spontaneous human adult stem cell transformation. Cancer Res 65:3035-3039
33. Tarte K, Gaillard J, Lataillade JJ et al (2010) Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation. Blood 115:1549-1553
34. Bernardo ME, Zaffaroni N, Novara F et al (2007) Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms. Cancer Res 67:9142-9149
35. Liang J, Zhang H, Hua B et al (2010) Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis 69:1423-1429
36. Sun L, Wang D, Liang J et al (2010) Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum 62:2467-2475
37. Dryden GW (2009) Overview of stem cell therapy for Crohn's disease. Expert Opin Biol Ther 9:841-847
38. Dryden GW Jr (2009) Overview of biologic therapy for Crohn's disease. Expert Opin Biol Ther 9:967-974
39. Ditschkowski M, Einsele H, Schwerdtfeger R et al (2003) Improvement of inflammatory bowel disease after allogeneic stem-cell transplantation. Transplantation 75:1745-1747
40. Garcia-Olmo D, Garcia-Arranz M, Herreros D, Pascual I, Peiro C, Rodriguez-Montes JA (2005) A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum 48:1416-1423
41. Garcia-Olmo D, Herreros D, Pascual I et al (2009) Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial. Dis Colon Rectum 52:79-86
42. Garcia-Olmo D, Herreros D, Pascual M et al (2009) Treatment of enterocutaneous fistula in Crohn's disease with adipose-derived stem cells: a comparison of protocols with and without cell expansion. Int J Colorectal Dis 24:27-30
43. Garcia-Olmo D, Herreros D, De-La-Quintana P et al (2010) Adipose-derived stem cells in Crohn's rectovaginal fistula. Case Report Med 2010:961758
44. Duijvestein M, Vos AC, Roelofs H et al (2010) Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study. Gut 59:1662-1669
45. Lazebnik LB, Konopliannikov AG, Kniazev OV et al (2010) Use of allogeneic mesenchymal stem cells in the treatment of intestinal inflammatory diseases. Ter Arkh 82:38-43
46. Ciccocioppo R, Bernardo ME, Sgarella A et al (2011) Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulizing Crohn's disease. Gut 60:788-798
47. Cipriani P, Guiducci S, Miniati I et al (2007) Impairment of endothelial cell differentiation from bone marrow-derived mesenchymal stem cells: new insight into the pathogenesis of systemic sclerosis. Arthritis Rheum 56:1994-2004
48. Larghero J, Farge D, Braccini A et al (2008) Phenotypical and functional characteristics of in vitro expanded bone marrow mesenchymal stem cells from patients with systemic sclerosis. Ann Rheum Dis 67:443-449
49. Keyszer G, Christopeit M, Fick S et al (2011) Treatment of severe progressive systemic sclerosis with transplantation of mesenchymal stromal cells from allogeneic related donors: report of five cases. Arthritis Rheum 63:2540-2542
50. Deeg HJ (2007) How I treat refractory acute GVHD. Blood 109:4119-4126
51. Ringden O, Uzunel M, Rasmusson I et al (2006) Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 81:1390-1397.52
52. Le Blanc K, Frassoni F, Ball L et al (2008) Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 371:1579-1586
53. Potten CS, Owen G, Roberts SA (1990) The temporal and spatial changes in cell proliferation within the irradiated crypts of the murine small intestine. Int J Radiat Biol 57:185-199
54. Gaugler MH, Vereycken-Holler V, Squiban C, Vandamme M, Vozenin-Brotons MC, Benderitter M (2005) Pravastatin limits endothelial activation after irradiation and decreases the resulting inflammatory and thrombotic responses. Radiat Res 163:479-487
55. Milliat F, Francois A, Isoir M et al (2006) Influence of endothelial cells on vascular smooth muscle cells phenotype after irradiation: implication in radiation-induced vascular damages. Am J Pathol 169:1484-1495
56. Paris F, Fuks Z, Kang A et al (2001) Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293:293-297
57. Zhang J, Gong JF, Zhang W, Zhu WM, Li JS (2008) Effects of transplanted bone marrow mesenchymal stem cells on the irradiated intestine of mice. J Biomed Sci 15:585-594
58. Semont A, Francois S, Mouiseddine M et al (2006) Mesenchymal stem cells increase self-renewal of small intestinal epithelium and accelerate structural recovery after radiation injury. Adv Exp Med Biol 585:19-30
59. Kudo K, Liu Y, Takahashi K et al (2010) Transplantation of mesenchymal stem cells to prevent radiation-induced intestinal injury in mice. J Radiat Res 51:73-79
60. Gao Z, Zhang Q, Han Y, Cheng X, Lu Y, Fan L, Wu Z (2012) Mesenchymal stromal cell-conditioned medium prevents radiation-induced small intestine injury in mice. Cytotherapy 14:267-273
61. Semont A, Mouiseddine M, Francois A et al (2010) Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis. Cell Death Differ 17:952-961
62. Lorenzi B, Pessina F, Lorenzoni P et al (2008) Treatment of experimental injury of anal sphincters with primary surgical repair and injection of bone marrow-derived mesenchymal stem cells. Dis Colon Rectum 51:411-420
63. Saha S, Bhanja P, Kabarriti R, Liu L, Alfieri AA, Guha C (2011) Bone marrow stromal cell transplantation mitigates radiation-induced gastrointestinal syndrome in mice. PLoS One 6:e24072
64. Peiffert D, Simon JM, Eschwege F (2007) Epinal radiotherapy accident: passed, present, future. Cancer Radiother 11:309-312
65. Marchesi V, Aigle D, Peiffert D, Noel A, Simon JM (2009) Securitization of the bi-site radiotherapy activity as part of the resumption of treatments in the Hospital of Epinal by the team of Alexis Vautrin Nancy Cancer Center. Cancer Radiother 13:740-743
66. Choi EW, Shin IS, Park SY et al (2012) Reversal of serologic, immunologic, and histologic dysfunction in mice with systemic lupus erythematosus by long-term serial adipose tissue-derived mesenchymal stem cell transplantation. Arthritis Rheum 64:243-253
67. Von Korff M, Jensen MP, Karoly P (2000) Assessing global pain severity by self-report in clinical and health services research. Spine 25:3140-3151, Phila Pa 1976
68. Tan G, Jensen MP, Thornby JI, Shanti BF (2004) Validation of the Brief Pain Inventory for chronic nonmalignant pain. J Pain 5:133-137
69. Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361-370
70. Ware JE Jr, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30:473-483
71. Sensebe L, Bourin P (2008) Producing MSC according GMP: process and controls. Biomed Mater Eng 18:173-177