The progranulin cleavage products, granulins, exacerbate TDP-43 toxicity and increase TDP-43 levels

Journal of Neuroscience

Volumn 35, Issue 25, 2015, Pages 9315-9328

  Salazar, Dominique A ^a   Butler, Victoria J ^a   Argouarch, Andrea R ^a   Hsu, Tsung Yuan ^a   Mason, Amanda ^b   Nakamura, Ayumi ^a   McCurdy, Helen ^a   Cox, David ^a   Ng, Rachel ^a   Pan, Gloria ^a   Seeley, William W ^a   Miller, Bruce L ^a   Kao, Aimee W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GLADSTONE INSTITUTES   (United States)

Author keywords

C elegans; Frontotemporal lobar degeneration; Granulin; Neurodegenerative disease; Progranulin; TDP 43

Indexed keywords

PROGRANULIN; TAR DNA BINDING PROTEIN; DNA BINDING PROTEIN; GRANULIN PRECURSOR PROTEIN; PROGRANULIN A, ZEBRAFISH; PROTEIN TDP-43; SIGNAL PEPTIDE; ZEBRAFISH PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CAENORHABDITIS ELEGANS; DEFECATION; DEVELOPMENTAL STAGE; DNA CLEAVAGE; EGG LAYING; GENE; GENE EXPRESSION; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; LIFESPAN; MICROSCOPY; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; PGRN 1 GENE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TDP 43 PROTEINOPATHY; TOXICITY; WESTERN BLOTTING; ANIMAL; DISEASE MODEL; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; HUMANS; IMMUNOBLOTTING; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; TDP-43 PROTEINOPATHIES; ZEBRAFISH PROTEINS;

EID: 84933574588     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4808-14.2015     Document Type: Article

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