Secretion of Fc-amidated peptide fusion proteins by Chinese hamster ovary cells

BMC Biotechnology

Volumn 15, Issue 1, 2015, Pages

  Carlson, Kristina R ^a   Pomerantz, Steven C ^b   Li, Jiali ^b   Vafa, Omid ^b   Naso, Michael ^b   Strohl, William ^b   Mains, Richard E ^a   Eipper, Betty A ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Amidation; CHO cells; Glucagon like peptide 1; Mass spectrometry; Neuromedin U; Peptide YY

Indexed keywords

AMIDES; BIOACTIVITY; CELL MEMBRANES; CELLS; CYTOLOGY; MASS SPECTROMETRY; PHARMACODYNAMICS; PROTEINS; PURIFICATION;

AMIDATION; CHO CELL; GLUCAGON-LIKE PEPTIDE-1; NEUROMEDIN; PEPTIDE YY;

PEPTIDES;

ALPHA AMIDATING ENZYME; FC RECEPTOR; GLUCAGON LIKE PEPTIDE 1; NEUROMEDIN U; PEPTIDE YY; PROTEINASE; AMIDE; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; NEUROPEPTIDE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CHO CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; IMMUNOASSAY; MASS SPECTROMETRY; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SECRETION; ANIMAL; CHEMISTRY; CRICETULUS; GENETICS; HAMSTER; HUMAN; METABOLISM; PROTEIN STABILITY; SECRETION (PROCESS);

CRICETULUS GRISEUS; RHINOVIRUS;

AMIDES; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; GLUCAGON-LIKE PEPTIDE 1; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; NEUROPEPTIDES; PEPTIDE YY; PROTEIN STABILITY; RECOMBINANT FUSION PROTEINS;

EID: 84933520294     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/s12896-015-0173-5     Document Type: Article

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