C-terminal modification of monoclonal antibody drugs: Amidated species as a general product-related substance

International Journal of Biological Macromolecules

Volumn 52, Issue 1, 2013, Pages 139-147

  Tsubaki, Masahiro ^a   Terashima, Isamu ^a   Kamata, Kunihiro ^a   Koga, Akiko ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

C terminal processing; Monoclonal antibody; Peptide mapping; Peptidylglycine alpha amidating monooxygenase; Reversed phase high performance liquid chromatography mass spectrometry

Indexed keywords

ALPHA AMIDATING ENZYME; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY A; MONOCLONAL ANTIBODY B; MONOCLONAL ANTIBODY C; MONOCLONAL ANTIBODY D; MONOCLONAL ANTIBODY E; MONOCLONAL ANTIBODY F; MONOCLONAL ANTIBODY G; MONOCLONAL ANTIBODY H; MONOCLONAL ANTIBODY I; MONOCLONAL ANTIBODY J; MONOCLONAL ANTIBODY K; MONOCLONAL ANTIBODY L; UNCLASSIFIED DRUG;

AMIDATION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CHEMICAL MODIFICATION; CONTROLLED STUDY; ENZYME SUBSTRATE; HAMSTER; HEAVY CHAIN; IN VITRO STUDY; MASS SPECTROMETRY; NONHUMAN; OVARY CELL; PEPTIDE MAPPING; PROTEIN CLEAVAGE; PROTEIN PROCESSING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 84869225077     PISSN: 01418130     EISSN: 18790003     Source Type: Journal    
DOI: 10.1016/j.ijbiomac.2012.09.016     Document Type: Article

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