Synthesis, characterization and apoptotic activity of quinazolinone Schiff base derivatives toward MCF-7 cells via intrinsic and extrinsic apoptosis pathways

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Zahedifard, Maryam ^a   Faraj, Fadhil Lafta ^a   Paydar, Mohammadjavad ^a   Looi, Chung Yeng ^a   Hajrezaei, Maryam ^a   Hasanpourghadi, Mohadeseh ^a   Kamalidehghan, Behnam ^a   Majid, Nazia Abdul ^a   Ali, Hapipah Mohd ^a   Abdulla, Mahmood Ameen ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

3-(5-CHLORO-2-HYDROXYBENZYLIDENEAMINO)-2-(5-CHLORO-2-HYDROXYPHENYL)-2,3-DIHYDROQUINAZOLIN-41(H)-ONE; 3-(5-NITRO-2-HYDROXYBENZYLIDENEAMINO)-2-(5-NITRO-2-HYDROXYPHENYL)-2,3-DIHYDROQUINAZOLIN-4(1H)-ONE; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; HYDRAZONE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; QUINAZOLINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SCHIFF BASE;

ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL SURVIVAL; CHEMISTRY; CONFORMATION; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; HUMAN; MCF-7 CELL LINE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

APOPTOSIS; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; CYTOCHROMES C; HUMANS; HYDRAZONES; MAGNETIC RESONANCE SPECTROSCOPY; MCF-7 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MOLECULAR CONFORMATION; NF-KAPPA B; QUINAZOLINONES; REACTIVE OXYGEN SPECIES; SCHIFF BASES;

EID: 84933056617     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep11544     Document Type: Article

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