Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models

Drug Design, Development and Therapy

Volumn 8, Issue , 2014, Pages 719-733

  Paydar, Mohammadjavad ^a   Kamalidehghan, Behnam ^a   Wong, Yi Li ^a   Wong, Won Fen ^a   Looi, Chung Yeng ^a   Mustafa, Mohd Rais ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Bcl 2 Bax; Boldine; Breast cancer; Caspase cascade; Heat shock protein 70; Nuclear factor kappa B

Indexed keywords

BOLDINE; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTATE DEHYDROGENASE; PROTEIN BAX; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA; ANTINEOPLASTIC AGENT; APORPHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CANCER REGRESSION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; DOSE RESPONSE; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; ENZYME ACTIVITY; ENZYME RELEASE; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MALE; NONHUMAN; PROTEIN MICROARRAY; TOXICITY TESTING; TREATMENT OUTCOME; TUMOR INVASION; TUMOR VOLUME; WESTERN BLOTTING; ANIMAL; BREAST NEOPLASMS; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; DRUG SCREENING; METABOLISM; PATHOLOGY; RAT; STRUCTURE ACTIVITY RELATION; TUMOR CELL CULTURE;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; APORPHINES; BREAST NEOPLASMS; CELL PROLIFERATION; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; L-LACTATE DEHYDROGENASE; MOLECULAR STRUCTURE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84902124922     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S58178     Document Type: Article

References (45)

1. Atawodi SE. Nigerian foodstuffs with prostate cancer chemopreventive polyphenols. Infect Agent Cancer. 2011;6:S9.
2. Jemal A, Siegel R, Ward E, Murray T, Xu J, et al. Cancer statistics, 2007. CA Cancer J Clin. 2007;57:43-66.
3. Garcia M, Jemal A, Ward EM, et al. Global Cancer Facts and Figures 2007. American Cancer Society. 2007. Available from: https://www.cancer.org/acs/groups/content/@nho/documents/document/globalfactsandfigures2007rev2p.pdf. Accessed March 18, 2014.
4. Berry DA, Cronin KA, Plevritis SK, et al. Effect of screening and adjuvant therapy on mortality from breast cancer. N Engl J Med. 2005;353: 1784-1792.
5. Ravdin PM, Cronin KA, Howlader N, et al. The decrease in breast-cancer incidence in 2003 in the United States. N Engl J Med. 2007;356: 1670-1674.
6. Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277-300.
7. Patel MR, Dehmer GJ, Hirshfeld JW, Smith PK, Spertus JA. ACCF/SCAI/STS/AATS/AHA/ASNC 2009. Appropriateness Criteria for Coronary Revascularization. A Report by the American College of Cardiology Foundation Appropriateness Criteria Task Force, Society for Cardiovascular Angiography and Interventions, Society of Thoracic Surgeons, American Association for Thoracic Surgery, American Heart Association, and the American Society of Nuclear Cardiology Endorsed by the American Society of Echocardiography, the Heart Failure Society of America, and the Society of Cardiovascular Computed Tomography. J Am Coll Cardiology. 2009;53:530-553.
8. Scatena R. Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation. In: Advances in Mitochondrial Medicine. New York, NY, USA: Springer; 2012.
9. Verfaillie T, Garg AD, Agostinis P. Targeting ER stress induced apoptosis and inflammation in cancer. Cancer Lett. 2013;332:249-264.
10. Lee MJ, Ye AS, Gardino AK, et al. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell. 2012;149:780-794.
11. Chakraborty A, Kumar P, Ghosh K, Roy P. Evaluation of a Schiff base copper complex compound as potent anticancer molecule with multiple targets of action. Eur J Pharmacol. 2010;647:1-12.
12. Rey NA, Neves A, Silva PP, et al. A synthetic dinuclear copper (II) hydrolase and its potential as antitumoral: cytotoxicity, cellular uptake, and DNA cleavage. J Inorg Biochem. 2009;103:1323-1330.
13. Suzuki R, Yasui Y, Kohno H, et al. Catalpa seed oil rich in 9t, 11t, 13c-conjugated linolenic acid suppresses the development of colonic aberrant crypt foci induced by azoxymethane in rats. Oncol Rep. 2006;16:989-996.
14. Speisky H, Cassels BK. Boldo and boldine: an emerging case of natural drug development. Pharmacol Res. 1994;29:1-12.
15. Morello A, Lipchenka I, Cassels BK, Speisky H, Aldunate J, Repetto Y. Trypanocidal effect of boldine and related alkaloids upon several strains of Trypanosoma cruzi. Comp Biochem Physiol Pharmacol Toxicol Endocrinol. 1994;107:367-371.
16. Jiménez I, Speisky H. Biological disposition of boldine: in vitro and in vivo studies. Phytother Res. 2000;14:254-260.
17. Backhouse N, Delporte C, Givernau M, et al. Anti-inflammatory and antipyretic effects of boldine. Agents Actions. 1994;42:114-117.
18. Gerhardt D, Horn AP, Gaelzer MM, et al. Boldine: a potential new antiproliferative drug against glioma cell lines. Invest New Drugs. 2009;27:517-525.
19. Gerhardt D, Bertola G, Dietrich F, et al. Boldine induces cell cycle arrest and apoptosis in T24 human bladder cancer cell line via regulation of ERK, AKT AND GSK-3ß. Urol Oncol. 2014;32:36. e1-e9.
20. Gummadi VR, Rajagopalan S, Looi CY, et al. Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: wild type and mutant (L1196M) active compounds with unique binding mode. Bioorg Med Chem Lett. 2013;23:4911-4918.
21. Looi CY, Imanishi M, Takaki S, et al. Octa-arginine mediated delivery of wild-type Lnk protein inhibits TPO-induced M-MOK megakaryoblastic leukemic cell growth by promoting apoptosis. PLoS One. 2011;6:e23640.
22. Looi CY, Moharram B, Paydar M, et al. Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways. BMC Complement Altern Med. 2013;13:166.
23. Choi EJ, Lee JI, Kim G-H. Evaluation of the anticancer activities of thioflavanone and thioflavone in human breast cancer cell lines. Int J Mol Med. 2012;29:252-256.
24. Collins JA, Schandl CA, Young KK, Vesely J, Willingham MC. Major DNA fragmentation is a late event in apoptosis. J Histochem Cytochem. 1997;45:923-934.
25. Hartwell LH, Weinert TA. Checkpoints: controls that ensure the order of cell cycle events. Science. 1989;246:629-634.
26. Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature. 2004;432:316-323.
27. Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 2001;15:2177-2196.
28. Zhou BB, Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature. 2000;408:433-439.
29. Meyers M, Hwang A, Wagner MW, Boothman DA. Role of DNA mismatch repair in apoptotic responses to therapeutic agents. Environ Mol Mutagen. 2004;44:249-264.
30. waf1/cip1promoter by Sp1. Cancer Res. 2004;64: 743-750.
31. Li LY, Luo X, Wang X. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature. 2001;412:95-99.
32. Tang D, Kidd VJ. Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis. J Biol Chem. 1998;273:28549-28552.
33. Boucher D, Blais V, Denault JB. Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis. Proc Natl Acad Sci U S A. 2012;109:5669-5674.
34. El-Ghany RM, Sharaf NM, Kassem LA, Mahran LG, Heikal OA. Thymoquinone triggers anti-apoptotic signaling targeting death ligand and apoptotic regulators in a model of hepatic ischemia reperfusion injury. Drug Discov Ther. 2009;3:296-306.
35. Hyer ML, Shi R, Krajewska M, et al. Apoptotic activity and mechanism of 2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic-acid and related synthetic triterpenoids in prostate cancer. Cancer Res. 2008;68:2927-2933.
36. Qi F, Li A, Inagaki Y, et al. Induction of apoptosis by cinobufacini preparation through mitochondria-and Fas-mediated caspase-dependent pathways in human hepatocellular carcinoma cells. Food Chem Toxicol. 2012;50:295-302.
37. Soengas MS, Alarcon RM, Yoshida H, et al. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science. 1999;284:156-159.
38. Cui H, Schroering A, Ding HF. p53 mediates DNA damaging drug-induced apoptosis through a caspase-9-dependent pathway in SH-SY5Y neuroblastoma cells. Mol Cancer Ther. 2002;1:679-686.
39. Wu GS, Ding Z. Caspase 9 is required for p53-dependent apoptosis and chemosensitivity in a human ovarian cancer cell line. Oncogene. 2002;21:1-8.
40. Szegezdi E, Logue SE, Gorman AM, Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. 2006;7:880-885.
41. Vogler M, Hamali HA, Sun XM, et al. BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation. Blood. 2011;117:7145-7154.
42. Tracey L, Pérez-Rosado A, Artiga MJ, et al. Expression of the NF-kappaB targets BCL2 and BIRC5/Survivin characterizes small B-cell and aggressive B-cell lymphomas, respectively. J Pathol. 2005;206:123-134.
43. Mayer MP, Bukau B. Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci. 2005;62:670-684.
44. Nylandsted J, Rohde M, Brand K, Bastholm L, Elling F, Jäättelä M. Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2. Proc Natl Acad Sci U S A. 2000;97:7871-7876.
45. The European Agency for the Evaluation of Medicinal Products [webpage on the Internet]. Committee for Veterinary Medicinal Products. Summary Report. 1999. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500011107.pdf. Accessed April 25, 2014.