Statin-induced increases in atrophy gene expression occur independently of changes in PGC1α protein and mitochondrial content

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Goodman, Craig A ^a,b   Pol, Derk ^a   Zacharewicz, Evelyn ^c   Lee Young, Robert S ^d   Snow, Rod J ^c   Russell, Aaron P ^c   McConell, Glenn K ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b VICTORIA UNIVERSITY   (Australia)

^c DEAKIN UNIVERSITY   (Australia)

^d BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYACYL COENZYME A DEHYDROGENASE; ATROGIN 1; CHOLESTEROL; CITRATE SYNTHASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA SUBUNIT; MUSCLE RING FINGER 1 PROTEIN; MYOSTATIN; NEURONAL NITRIC OXIDE SYNTHASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SIMVASTATIN; UNCLASSIFIED DRUG; MUSCLE PROTEIN; PPARGC1A PROTEIN, RAT; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATROGIN 1 GENE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXTENSOR DIGITORUM LONGUS MUSCLE; FAST MUSCLE; FATTY ACID OXIDATION; GENE EXPRESSION; MALE; MITOCHONDRIAL VOLUME; MITOCHONDRION; MURF1 GENE; MUSCLE ATROPHY; MYOSTATIN GENE; NONHUMAN; PLANTARIS MUSCLE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SLOW MUSCLE FIBER; SOLEUS MUSCLE; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; MUSCLE MITOCHONDRION; PATHOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; GENE EXPRESSION REGULATION; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MITOCHONDRIA, MUSCLE; MUSCLE PROTEINS; MUSCULAR ATROPHY; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN; TRANSCRIPTION FACTORS;

EID: 84933055205     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0128398     Document Type: Article

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