Ubiquinol rescues simvastatin-suppression of mitochondrial content, function and metabolism: Implications for statin-induced rhabdomyolysis

European Journal of Pharmacology

Volumn 711, Issue 1-3, 2013, Pages 1-9

  Vaughan, Roger A ^a,b   Garcia Smith, Randi ^b   Bisoffi, Marco ^b   Conn, Carole A ^a   Trujillo, Kristina A ^b  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

Extracellular acidification rate; Mitochondrial biosynthesis; Muscle pain CoQ10; Oxygen consumption rate; PGC

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALCOHOL; DIMETHYL SULFOXIDE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SIMVASTATIN; UBIQUINONE;

ACIDIFICATION; AEROBIC METABOLISM; ARTICLE; CELL METABOLISM; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG ANTAGONISM; DRUG MECHANISM; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; METABOLIC RATE; MITOCHONDRIAL RESPIRATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REACTION TIME; RHABDOMYOLYSIS; RHABDOMYOSARCOMA; SARCOMA CELL;

ADENOSINE TRIPHOSPHATE; BIOLOGICAL MARKERS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; GENE EXPRESSION REGULATION; GLYCOLYSIS; HUMANS; MITOCHONDRIA; OXIDATION-REDUCTION; RHABDOMYOLYSIS; SIMVASTATIN; TIME FACTORS; TRANSCRIPTION FACTORS; UBIQUINONE;

EID: 84877866735     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.04.009     Document Type: Article

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