Simvastatin inhibits central sympathetic outflow in heart failure by a nitric-oxide synthase mechanism

Journal of Pharmacology and Experimental Therapeutics

Volumn 326, Issue 1, 2008, Pages 278-285

  Gao, Lie ^a,b   Wang, Wei ^a   Zucker, Irving H ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; MESSENGER RNA; MEVALONIC ACID; N(G) NITROARGININE METHYL ESTER; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; SIMVASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CENTRAL NERVOUS SYSTEM DEPRESSION; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ENZYME INHIBITION; ENZYME MECHANISM; HEART FAILURE; LATERAL BRAIN VENTRICLE; MALE; MOUSE; NEUROCHEMISTRY; NONHUMAN; NUCLEOTIDE SEQUENCE; OSMOTIC MINIPUMP; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; STATISTICAL SIGNIFICANCE; SYMPATHETIC FUNCTION; UPREGULATION;

ANIMALS; CELLS, CULTURED; HEART FAILURE; HEART RATE; MALE; NITRIC OXIDE SYNTHASE; RABBITS; SIMVASTATIN; SYMPATHETIC FIBERS, POSTGANGLIONIC;

EID: 45749144314     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.136028     Document Type: Article

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