-
1
-
-
34250209501
-
Amyotrophic lateral sclerosis
-
Mitchell J.D., and Borasio G.D. Amyotrophic lateral sclerosis. Lancet 369 (2007) 2031-2041
-
(2007)
Lancet
, vol.369
, pp. 2031-2041
-
-
Mitchell, J.D.1
Borasio, G.D.2
-
3
-
-
33747605320
-
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
-
Pasinelli P., and Brown R.H. Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci 7 (2006) 710-723
-
(2006)
Nat Rev Neurosci
, vol.7
, pp. 710-723
-
-
Pasinelli, P.1
Brown, R.H.2
-
4
-
-
0027401203
-
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
-
Rosen D.R., Siddique T., Patterson D., Figlewicz D.A., Sapp P., Hentati A., et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362 (1993) 59-62
-
(1993)
Nature
, vol.362
, pp. 59-62
-
-
Rosen, D.R.1
Siddique, T.2
Patterson, D.3
Figlewicz, D.A.4
Sapp, P.5
Hentati, A.6
-
5
-
-
0029005002
-
Variance of age at onset in a Japanese family with amyotrophic lateral sclerosis associated with a novel Cu/Zn superoxide dismutase mutation
-
Aoki M., Abe K., Houi K., Ogasawara M., Matsubara Y., Kobayashi T., et al. Variance of age at onset in a Japanese family with amyotrophic lateral sclerosis associated with a novel Cu/Zn superoxide dismutase mutation. Ann Neurol 37 (1995) 676-679
-
(1995)
Ann Neurol
, vol.37
, pp. 676-679
-
-
Aoki, M.1
Abe, K.2
Houi, K.3
Ogasawara, M.4
Matsubara, Y.5
Kobayashi, T.6
-
6
-
-
0027452090
-
Mild ALS in Japan associated with novel SOD mutation
-
Aoki M., Ogasawara M., Matsubara Y., Narisawa K., Nakamura S., Itoyama Y., et al. Mild ALS in Japan associated with novel SOD mutation. Nat Genet 5 (1993) 323-324
-
(1993)
Nat Genet
, vol.5
, pp. 323-324
-
-
Aoki, M.1
Ogasawara, M.2
Matsubara, Y.3
Narisawa, K.4
Nakamura, S.5
Itoyama, Y.6
-
7
-
-
0035575761
-
Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease
-
Nagai M., Aoki M., Miyoshi I., Kato M., Pasinelli P., Kasai N., et al. Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease. J Neurosci 21 (2001) 9246-9254
-
(2001)
J Neurosci
, vol.21
, pp. 9246-9254
-
-
Nagai, M.1
Aoki, M.2
Miyoshi, I.3
Kato, M.4
Pasinelli, P.5
Kasai, N.6
-
8
-
-
34249863896
-
Motor neuron disease in transgenic mice with an H46R mutant SOD1 gene
-
Sasaki S., Nagai M., Aoki M., Komori T., Itoyama Y., and Iwata M. Motor neuron disease in transgenic mice with an H46R mutant SOD1 gene. J Neuropathol Exp Neurol 66 (2007) 517-524
-
(2007)
J Neuropathol Exp Neurol
, vol.66
, pp. 517-524
-
-
Sasaki, S.1
Nagai, M.2
Aoki, M.3
Komori, T.4
Itoyama, Y.5
Iwata, M.6
-
9
-
-
49349083891
-
Accumulation of chondroitin sulfate proteoglycans in the microenvironment of spinal motor neurons in amyotrophic lateral sclerosis transgenic rats
-
Mizuno H., Warita H., Aoki M., and Itoyama Y. Accumulation of chondroitin sulfate proteoglycans in the microenvironment of spinal motor neurons in amyotrophic lateral sclerosis transgenic rats. J Neurosci Res 86 (2008) 2512-2523
-
(2008)
J Neurosci Res
, vol.86
, pp. 2512-2523
-
-
Mizuno, H.1
Warita, H.2
Aoki, M.3
Itoyama, Y.4
-
10
-
-
35848963197
-
Intrathecal delivery of hepatocyte growth factor from amyotrophic lateral sclerosis onset suppresses disease progression in rat amyotrophic lateral sclerosis model
-
Ishigaki A., Aoki M., Nagai M., Warita H., Kato S., Kato M., et al. Intrathecal delivery of hepatocyte growth factor from amyotrophic lateral sclerosis onset suppresses disease progression in rat amyotrophic lateral sclerosis model. J Neuropathol Exp Neurol 66 (2007) 1037-1044
-
(2007)
J Neuropathol Exp Neurol
, vol.66
, pp. 1037-1044
-
-
Ishigaki, A.1
Aoki, M.2
Nagai, M.3
Warita, H.4
Kato, S.5
Kato, M.6
-
11
-
-
17644368923
-
Mechanical signal transduction in skeletal muscle growth and adaptation
-
Tidball J.G. Mechanical signal transduction in skeletal muscle growth and adaptation. J Appl Physiol 98 (2005) 1900-1908
-
(2005)
J Appl Physiol
, vol.98
, pp. 1900-1908
-
-
Tidball, J.G.1
-
12
-
-
0035348487
-
Space shuttle flight (STS-90) enhances degradation of rat myosin heavy chain in association with activation of ubiquitin-proteasome pathway
-
Ikemoto M., Nikawa T., Takeda S., Watanabe C., Kitano T., Baldwin K.M., et al. Space shuttle flight (STS-90) enhances degradation of rat myosin heavy chain in association with activation of ubiquitin-proteasome pathway. FASEB J 15 (2001) 1279-1281
-
(2001)
FASEB J
, vol.15
, pp. 1279-1281
-
-
Ikemoto, M.1
Nikawa, T.2
Takeda, S.3
Watanabe, C.4
Kitano, T.5
Baldwin, K.M.6
-
13
-
-
0035941020
-
Identification of ubiquitin ligases required for skeletal muscle atrophy
-
Bodine S.C., Latres E., Baumhueter S., Lai V.K., Nunez L., Clarke B.A., et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294 (2001) 1704-1708
-
(2001)
Science
, vol.294
, pp. 1704-1708
-
-
Bodine, S.C.1
Latres, E.2
Baumhueter, S.3
Lai, V.K.4
Nunez, L.5
Clarke, B.A.6
-
14
-
-
0035807969
-
Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy
-
Gomes M.D., Lecker S.H., Jagoe R.T., Navon A., and Goldberg A.L. Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc Natl Acad Sci U S A 98 (2001) 14440-14445
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 14440-14445
-
-
Gomes, M.D.1
Lecker, S.H.2
Jagoe, R.T.3
Navon, A.4
Goldberg, A.L.5
-
15
-
-
0035736260
-
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
-
Bodine S.C., Stitt T.N., Gonzalez M., Kline W.O., Stover G.L., Bauerlein R., et al. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol 3 (2001) 1014-1019
-
(2001)
Nat Cell Biol
, vol.3
, pp. 1014-1019
-
-
Bodine, S.C.1
Stitt, T.N.2
Gonzalez, M.3
Kline, W.O.4
Stover, G.L.5
Bauerlein, R.6
-
16
-
-
14844336534
-
Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting
-
Song Y.H., Li Y., Du J., Mitch W.E., Rosenthal N., and Delafontaine P. Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting. J Clin Invest 115 (2005) 451-458
-
(2005)
J Clin Invest
, vol.115
, pp. 451-458
-
-
Song, Y.H.1
Li, Y.2
Du, J.3
Mitch, W.E.4
Rosenthal, N.5
Delafontaine, P.6
-
17
-
-
0035735902
-
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
-
Rommel C., Bodine S.C., Clarke B.A., Rossman R., Nunez L., Stitt T.N., et al. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat Cell Biol 3 (2001) 1009-1013
-
(2001)
Nat Cell Biol
, vol.3
, pp. 1009-1013
-
-
Rommel, C.1
Bodine, S.C.2
Clarke, B.A.3
Rossman, R.4
Nunez, L.5
Stitt, T.N.6
-
18
-
-
13244298415
-
Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway
-
Latres E., Amini A.R., Amini A.A., Griffiths J., Martin F.J., Wei Y., et al. Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway. J Biol Chem 280 (2005) 2737-2744
-
(2005)
J Biol Chem
, vol.280
, pp. 2737-2744
-
-
Latres, E.1
Amini, A.R.2
Amini, A.A.3
Griffiths, J.4
Martin, F.J.5
Wei, Y.6
-
19
-
-
5444262078
-
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice
-
Cai D., Frantz J.D., Tawa Jr. N.E., Melendez P.A., Oh B.C., Lidov H.G., et al. IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell 119 (2004) 285-298
-
(2004)
Cell
, vol.119
, pp. 285-298
-
-
Cai, D.1
Frantz, J.D.2
Tawa Jr., N.E.3
Melendez, P.A.4
Oh, B.C.5
Lidov, H.G.6
-
20
-
-
11144356337
-
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy
-
Sandri M., Sandri C., Gilbert A., Skurk C., Calabria E., Picard A., et al. Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 117 (2004) 399-412
-
(2004)
Cell
, vol.117
, pp. 399-412
-
-
Sandri, M.1
Sandri, C.2
Gilbert, A.3
Skurk, C.4
Calabria, E.5
Picard, A.6
-
21
-
-
0031802331
-
Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha
-
Li Y.P., Schwartz R.J., Waddell I.D., Holloway B.R., and Reid M.B. Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha. FASEB J 12 (1998) 871-880
-
(1998)
FASEB J
, vol.12
, pp. 871-880
-
-
Li, Y.P.1
Schwartz, R.J.2
Waddell, I.D.3
Holloway, B.R.4
Reid, M.B.5
-
22
-
-
27644471080
-
Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia
-
Acharyya S., Butchbach M.E., Sahenk Z., Wang H., Saji M., Carathers M., et al. Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia. Cancer Cell 8 (2005) 421-432
-
(2005)
Cancer Cell
, vol.8
, pp. 421-432
-
-
Acharyya, S.1
Butchbach, M.E.2
Sahenk, Z.3
Wang, H.4
Saji, M.5
Carathers, M.6
-
23
-
-
4043154377
-
Cancer cachexia is regulated by selective targeting of skeletal muscle gene products
-
Acharyya S., Ladner K.J., Nelsen L.L., Damrauer J., Reiser P.J., Swoap S., et al. Cancer cachexia is regulated by selective targeting of skeletal muscle gene products. J Clin Invest 114 (2004) 370-378
-
(2004)
J Clin Invest
, vol.114
, pp. 370-378
-
-
Acharyya, S.1
Ladner, K.J.2
Nelsen, L.L.3
Damrauer, J.4
Reiser, P.J.5
Swoap, S.6
-
24
-
-
34848913758
-
NO production results in suspension-induced muscle atrophy through dislocation of neuronal NOS
-
Suzuki N., Motohashi N., Uezumi A., Fukada S., Yoshimura T., Itoyama Y., et al. NO production results in suspension-induced muscle atrophy through dislocation of neuronal NOS. J Clin Invest 117 (2007) 2468-2476
-
(2007)
J Clin Invest
, vol.117
, pp. 2468-2476
-
-
Suzuki, N.1
Motohashi, N.2
Uezumi, A.3
Fukada, S.4
Yoshimura, T.5
Itoyama, Y.6
-
25
-
-
33645897980
-
Alteration of familial ALS-linked mutant SOD1 solubility with disease progression: its modulation by the proteasome and Hsp70
-
Koyama S., Arawaka S., Chang-Hong R., Wada M., Kawanami T., Kurita K., et al. Alteration of familial ALS-linked mutant SOD1 solubility with disease progression: its modulation by the proteasome and Hsp70. Biochem Biophys Res Commun 343 (2006) 719-730
-
(2006)
Biochem Biophys Res Commun
, vol.343
, pp. 719-730
-
-
Koyama, S.1
Arawaka, S.2
Chang-Hong, R.3
Wada, M.4
Kawanami, T.5
Kurita, K.6
-
26
-
-
0035955486
-
Marked reduction of the Cu/Zn superoxide dismutase polypeptide in a case of familial amyotrophic lateral sclerosis with the homozygous mutation
-
Kato M., Aoki M., Ohta M., Nagai M., Ishizaki F., Nakamura S., et al. Marked reduction of the Cu/Zn superoxide dismutase polypeptide in a case of familial amyotrophic lateral sclerosis with the homozygous mutation. Neurosci Lett 312 (2001) 165-168
-
(2001)
Neurosci Lett
, vol.312
, pp. 165-168
-
-
Kato, M.1
Aoki, M.2
Ohta, M.3
Nagai, M.4
Ishizaki, F.5
Nakamura, S.6
-
27
-
-
33644832749
-
Development of a rat model of amyotrophic lateral sclerosis expressing a human SOD1 transgene
-
Aoki M., Kato S., Nagai M., and Itoyama Y. Development of a rat model of amyotrophic lateral sclerosis expressing a human SOD1 transgene. Neuropathology 25 (2005) 365-370
-
(2005)
Neuropathology
, vol.25
, pp. 365-370
-
-
Aoki, M.1
Kato, S.2
Nagai, M.3
Itoyama, Y.4
-
28
-
-
65349153034
-
Mitochondrial alterations in transgenic mice with an H46R mutant Cu/Zn superoxide dismutase gene
-
Sasaki S., Aoki M., Nagai M., Kobayashi M., and Itoyama Y. Mitochondrial alterations in transgenic mice with an H46R mutant Cu/Zn superoxide dismutase gene. J Neuropathol Exp Neurol 68 (2009) 365-373
-
(2009)
J Neuropathol Exp Neurol
, vol.68
, pp. 365-373
-
-
Sasaki, S.1
Aoki, M.2
Nagai, M.3
Kobayashi, M.4
Itoyama, Y.5
-
29
-
-
0029149471
-
Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy
-
Brenman J.E., Chao D.S., Xia H., Aldape K., and Bredt D.S. Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. Cell 82 (1995) 743-752
-
(1995)
Cell
, vol.82
, pp. 743-752
-
-
Brenman, J.E.1
Chao, D.S.2
Xia, H.3
Aldape, K.4
Bredt, D.S.5
-
30
-
-
33645807350
-
Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1
-
Leger B., Vergani L., Soraru G., Hespel P., Derave W., Gobelet C., et al. Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1. FASEB J 20 (2006) 583-585
-
(2006)
FASEB J
, vol.20
, pp. 583-585
-
-
Leger, B.1
Vergani, L.2
Soraru, G.3
Hespel, P.4
Derave, W.5
Gobelet, C.6
-
31
-
-
22844439444
-
Sequential changes of nitric oxide levels in the temporal lobes of kainic acid-treated mice following application of nitric oxide synthase inhibitors and phenobarbital
-
Kato N., Sato S., Yokoyama H., Kayama T., and Yoshimura T. Sequential changes of nitric oxide levels in the temporal lobes of kainic acid-treated mice following application of nitric oxide synthase inhibitors and phenobarbital. Epilepsy Res 65 (2005) 81-91
-
(2005)
Epilepsy Res
, vol.65
, pp. 81-91
-
-
Kato, N.1
Sato, S.2
Yokoyama, H.3
Kayama, T.4
Yoshimura, T.5
-
32
-
-
29344465714
-
Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2
-
Kim S.F., Huri D.A., and Snyder S.H. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science 310 (2005) 1966-1970
-
(2005)
Science
, vol.310
, pp. 1966-1970
-
-
Kim, S.F.1
Huri, D.A.2
Snyder, S.H.3
-
33
-
-
0030851761
-
Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis
-
Beal M.F., Ferrante R.J., Browne S.E., Matthews R.T., Kowall N.W., and Brown Jr. R.H. Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Ann Neurol 42 (1997) 644-654
-
(1997)
Ann Neurol
, vol.42
, pp. 644-654
-
-
Beal, M.F.1
Ferrante, R.J.2
Browne, S.E.3
Matthews, R.T.4
Kowall, N.W.5
Brown Jr., R.H.6
-
34
-
-
0036144231
-
Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis
-
Cassina P., Peluffo H., Pehar M., Martinez-Palma L., Ressia A., Beckman J.S., et al. Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. J Neurosci Res 67 (2002) 21-29
-
(2002)
J Neurosci Res
, vol.67
, pp. 21-29
-
-
Cassina, P.1
Peluffo, H.2
Pehar, M.3
Martinez-Palma, L.4
Ressia, A.5
Beckman, J.S.6
-
35
-
-
33847767167
-
Activities of mitochondrial complexes correlate with nNOS amount in muscle from ALS patients
-
Soraru G., Vergani L., Fedrizzi L., D'Ascenzo C., Polo A., Bernazzi B., et al. Activities of mitochondrial complexes correlate with nNOS amount in muscle from ALS patients. Neuropathol Appl Neurobiol 33 (2007) 204-211
-
(2007)
Neuropathol Appl Neurobiol
, vol.33
, pp. 204-211
-
-
Soraru, G.1
Vergani, L.2
Fedrizzi, L.3
D'Ascenzo, C.4
Polo, A.5
Bernazzi, B.6
-
36
-
-
0032544340
-
Neuronal nitric oxide synthase inhibitor, 7-nitroindazole, delays motor dysfunction and spinal motoneuron degeneration in the Wobbler mouse
-
Ikeda K., Iwasaki Y., and Kinoshita M. Neuronal nitric oxide synthase inhibitor, 7-nitroindazole, delays motor dysfunction and spinal motoneuron degeneration in the Wobbler mouse. J Neurol Sci 160 (1998) 9-15
-
(1998)
J Neurol Sci
, vol.160
, pp. 9-15
-
-
Ikeda, K.1
Iwasaki, Y.2
Kinoshita, M.3
-
37
-
-
0032954386
-
Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis
-
Facchinetti F., Sasaki M., Cutting F.B., Zhai P., MacDonald J.E., Reif D., et al. Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis. Neuroscience 90 (1999) 1483-1492
-
(1999)
Neuroscience
, vol.90
, pp. 1483-1492
-
-
Facchinetti, F.1
Sasaki, M.2
Cutting, F.B.3
Zhai, P.4
MacDonald, J.E.5
Reif, D.6
-
38
-
-
56549102799
-
Intranasal delivery of insulin and a nitric oxide synthase inhibitor in an experimental model of amyotrophic lateral sclerosis
-
Martinez J.A., Francis G.J., Liu W.Q., Pradzinsky N., Fine J., Wilson M., et al. Intranasal delivery of insulin and a nitric oxide synthase inhibitor in an experimental model of amyotrophic lateral sclerosis. Neuroscience 157 (2008) 908-925
-
(2008)
Neuroscience
, vol.157
, pp. 908-925
-
-
Martinez, J.A.1
Francis, G.J.2
Liu, W.Q.3
Pradzinsky, N.4
Fine, J.5
Wilson, M.6
-
39
-
-
1642460628
-
Transmission of arterial baroreflex signals depends on neuronal nitric oxide synthase
-
Talman W.T., and Dragon D.N. Transmission of arterial baroreflex signals depends on neuronal nitric oxide synthase. Hypertension 43 (2004) 820-824
-
(2004)
Hypertension
, vol.43
, pp. 820-824
-
-
Talman, W.T.1
Dragon, D.N.2
-
41
-
-
0034809375
-
The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney
-
Kakoki M., Zou A.P., and Mattson D.L. The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney. Am J Physiol Regul Integr Comp Physiol 281 (2001) R91-R97
-
(2001)
Am J Physiol Regul Integr Comp Physiol
, vol.281
-
-
Kakoki, M.1
Zou, A.P.2
Mattson, D.L.3
-
42
-
-
0032502351
-
N5-(1-Imino-3-butenyl)-l-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase
-
Babu B.R., and Griffith O.W. N5-(1-Imino-3-butenyl)-l-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem 273 (1998) 8882-8889
-
(1998)
J Biol Chem
, vol.273
, pp. 8882-8889
-
-
Babu, B.R.1
Griffith, O.W.2
-
43
-
-
33847048132
-
Conditional neuronal nitric oxide synthase overexpression impairs myocardial contractility
-
Burkard N., Rokita A.G., Kaufmann S.G., Hallhuber M., Wu R., Hu K., et al. Conditional neuronal nitric oxide synthase overexpression impairs myocardial contractility. Circ Res 100 (2007) e32-e44
-
(2007)
Circ Res
, vol.100
-
-
Burkard, N.1
Rokita, A.G.2
Kaufmann, S.G.3
Hallhuber, M.4
Wu, R.5
Hu, K.6
|