Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers

Biomaterials

Volumn 52, Issue 1, 2015, Pages 507-516

  Zhang, Fan ^a,b   Mastorakos, Panagiotis ^a   Mishra, Manoj K ^a   Mangraviti, Antonella ^c   Hwang, Lee ^c   Zhou, Jinyuan ^d   Hanes, Justin ^a,b,c   Brem, Henry ^a,c   Olivi, Alessandro ^c   Tyler, Betty ^c   Kannan, Rangaramanujam M ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b Johns Hopkins University   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d KENNEDY KRIEGER INSTITUTE   (United States)

Author keywords

Biodistribution; Blood brain barrier; Glioblastoma; PAMAM dendrimer; Tumor associated macrophages; Tumor penetration

Indexed keywords

BLOOD; BRAIN; DENDRIMERS; MACROPHAGES;

BIODISTRIBUTIONS; BLOOD-BRAIN BARRIER; GLIOBLASTOMAS; PAMAM DENDRIMER; TUMOR ASSOCIATED MACROPHAGES; TUMOR PENETRATION;

TUMORS;

ANTINEOPLASTIC AGENT; POLYAMIDOAMINE; CARBOCYANINE; CYANINE DYE 5; DENDRIMER; DRUG CARRIER; PAMAM STARBURST;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL SURFACE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; FEMALE; FLUORESCENCE MICROSCOPY; GLIOBLASTOMA; GLIOSARCOMA; HUMAN; HUMAN CELL; INTRACRANIAL TUMOR; MACROPHAGE; MICROGLIA; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT; VOLUME OF DISTRIBUTION; ANIMAL; BLOOD BRAIN BARRIER; BRAIN NEOPLASMS; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FISCHER 344 RAT; INFLAMMATION; PATHOLOGY; PROCEDURES; TISSUE DISTRIBUTION;

RODENTIA;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CARBOCYANINES; DENDRIMERS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FEMALE; GLIOBLASTOMA; GLIOSARCOMA; INFLAMMATION; MACROPHAGES; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; RATS; RATS, INBRED F344; TISSUE DISTRIBUTION;

EID: 84932631797     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.02.053     Document Type: Article

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