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Volumn 10, Issue 10, 2013, Pages 3776-3788

Cathepsin B degradable star-shaped peptidic macromolecules for delivery of 2-methoxyestradiol

Author keywords

2 methoxyestradiol; Cathepsin B; Degradable polymer; Peptidic dendrimer

Indexed keywords

2 METHOXYESTRADIOL; AMINE TERMINATED STAR SHAPED PEPTIDIC MACROMOLECULE; BUFFER; CARBOXYL TERMINATED STAR SHAPED PEPTIDIC MACROMOLECULE; CATHEPSIN B; DENDRIMER; DRUG VEHICLE; TETRAPEPTIDE; UNCLASSIFIED DRUG;

EID: 84888384634     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400261h     Document Type: Article
Times cited : (30)

References (56)
  • 1
    • 78649948637 scopus 로고    scopus 로고
    • Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges
    • Verenich, S.; Gerk, P. M. Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges. Mol. Pharmaceutics 2010, 7, 2030-9.
    • (2010) Mol. Pharmaceutics , vol.7 , pp. 2030-2039
    • Verenich, S.1    Gerk, P.M.2
  • 2
    • 34447106558 scopus 로고    scopus 로고
    • 2-methoxyestradiol-A unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents
    • Sutherland, T. E.; Anderson, R. L.; Hughes, R. A.; Altmann, E.; Schuliga, M.; Ziogas, J.; et al. 2-Methoxyestradiol-A unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents. Drug Discovery Today 2007, 12, 577-84.
    • (2007) Drug Discovery Today , vol.12 , pp. 577-584
    • Sutherland, T.E.1    Anderson, R.L.2    Hughes, R.A.3    Altmann, E.4    Schuliga, M.5    Ziogas, J.6
  • 3
    • 0031015504 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol
    • Klauber, N.; Parangi, S.; Flynn, E.; Hamel, E.; D'Amato, R. J. Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. Cancer Res. 1997, 57, 81-6.
    • (1997) Cancer Res. , vol.57 , pp. 81-86
    • Klauber, N.1    Parangi, S.2    Flynn, E.3    Hamel, E.4    D'Amato, R.J.5
  • 4
    • 0028220858 scopus 로고
    • The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth
    • Fotsis, T.; Zhang, Y.; Pepper, M. S.; Adlercreutz, H.; Montesano, R.; Nawroth, P. P.; et al. The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. Nature 1994, 368, 237-9.
    • (1994) Nature , vol.368 , pp. 237-239
    • Fotsis, T.1    Zhang, Y.2    Pepper, M.S.3    Adlercreutz, H.4    Montesano, R.5    Nawroth, P.P.6
  • 5
    • 77954311612 scopus 로고    scopus 로고
    • 2-methoxyestradiol-biology and mechanism of action
    • Mueck, A. O.; Seeger, H. 2-Methoxyestradiol-biology and mechanism of action. Steroids 2010, 75, 625-31.
    • (2010) Steroids , vol.75 , pp. 625-631
    • Mueck, A.O.1    Seeger, H.2
  • 6
    • 32544433479 scopus 로고    scopus 로고
    • Phase i clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors
    • Dahut, W. L.; Lakhani, N. J.; Gulley, J. L.; Arlen, P. M.; Kohn, E. C.; Kotz, H.; et al. Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors. Cancer Biol. Ther. 2006, 5, 22-7.
    • (2006) Cancer Biol. Ther. , vol.5 , pp. 22-27
    • Dahut, W.L.1    Lakhani, N.J.2    Gulley, J.L.3    Arlen, P.M.4    Kohn, E.C.5    Kotz, H.6
  • 7
    • 33750483598 scopus 로고    scopus 로고
    • Phase i safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer
    • James, J.; Murry, D. J.; Treston, A. M.; Storniolo, A. M.; Sledge, G. W.; Sidor, C.; et al. Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer. Invest. New Drugs 2007, 25, 41-8.
    • (2007) Invest. New Drugs , vol.25 , pp. 41-48
    • James, J.1    Murry, D.J.2    Treston, A.M.3    Storniolo, A.M.4    Sledge, G.W.5    Sidor, C.6
  • 8
    • 84873278168 scopus 로고    scopus 로고
    • Polymer-drug conjugates: Origins, progress to date and future directions
    • Kopecek, J. Polymer-drug conjugates: Origins, progress to date and future directions. Adv. Drug Delivery Rev. 2013, 65, 49-59.
    • (2013) Adv. Drug Delivery Rev. , vol.65 , pp. 49-59
    • Kopecek, J.1
  • 9
    • 84872036618 scopus 로고    scopus 로고
    • Biological rationale for the design of polymeric anti-cancer nanomedicines
    • Zhou, Y.; Kopecek, J. Biological rationale for the design of polymeric anti-cancer nanomedicines. J. Drug Targeting 2013, 21, 1. 26.
    • (2013) J. Drug Targeting , vol.21 , Issue.1 , pp. 26
    • Zhou, Y.1    Kopecek, J.2
  • 10
    • 84873273856 scopus 로고    scopus 로고
    • Polymer therapeutics-prospects for 21st century: The end of the beginning
    • Duncan, R.; Vicent, M. J. Polymer therapeutics-prospects for 21st century: The end of the beginning. Adv. Drug Delivery Rev. 2013, 65, 60-70.
    • (2013) Adv. Drug Delivery Rev. , vol.65 , pp. 60-70
    • Duncan, R.1    Vicent, M.J.2
  • 11
    • 84873252557 scopus 로고    scopus 로고
    • Liposomal drug delivery systems: From concept to clinical applications
    • Allen, T. M.; Cullis, P. R. Liposomal drug delivery systems: From concept to clinical applications. Adv. Drug Delivery Rev. 2013, 65, 36-48.
    • (2013) Adv. Drug Delivery Rev. , vol.65 , pp. 36-48
    • Allen, T.M.1    Cullis, P.R.2
  • 12
    • 84873266331 scopus 로고    scopus 로고
    • Immunoconjugates and long circulating systems: Origins, current state of the art and future directions
    • Koshkaryev, A.; Sawant, R.; Deshpande, M.; Torchilin, V. Immunoconjugates and long circulating systems: Origins, current state of the art and future directions. Adv. Drug Delivery Rev. 2013, 65, 24. 35.
    • (2013) Adv. Drug Delivery Rev. , vol.65 , Issue.24 , pp. 35
    • Koshkaryev, A.1    Sawant, R.2    Deshpande, M.3    Torchilin, V.4
  • 13
    • 84873269060 scopus 로고    scopus 로고
    • Inorganic nanosystems for therapeutic delivery: Status and prospects
    • Kim, C. S.; Tonga, G. Y.; Solfiell, D.; Rotello, V. M. Inorganic nanosystems for therapeutic delivery: Status and prospects. Adv. Drug Delivery Rev. 2013, 65, 93-9.
    • (2013) Adv. Drug Delivery Rev. , vol.65 , pp. 93-99
    • Kim, C.S.1    Tonga, G.Y.2    Solfiell, D.3    Rotello, V.M.4
  • 14
    • 84873273378 scopus 로고    scopus 로고
    • Stimuli-responsive polymers: Biomedical applications and challenges for clinical translation
    • Hoffman, A. S. Stimuli-responsive polymers: Biomedical applications and challenges for clinical translation. Adv. Drug Delivery Rev. 2013, 65, 10-6.
    • (2013) Adv. Drug Delivery Rev. , vol.65 , pp. 10-16
    • Hoffman, A.S.1
  • 15
    • 84864511390 scopus 로고    scopus 로고
    • PH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates
    • Felber, A. E.; Dufresne, M. H.; Leroux, J. C. pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates. Adv. Drug Delivery Rev. 2012, 64, 979-92.
    • (2012) Adv. Drug Delivery Rev. , vol.64 , pp. 979-992
    • Felber, A.E.1    Dufresne, M.H.2    Leroux, J.C.3
  • 16
    • 84864523728 scopus 로고    scopus 로고
    • Redox activation of metal-based prodrugs as a strategy for drug delivery
    • Graf, N.; Lippard, S. J. Redox activation of metal-based prodrugs as a strategy for drug delivery. Adv. Drug Delivery Rev. 2012, 64, 993. 1004.
    • (2012) Adv. Drug Delivery Rev. , vol.64 , Issue.993 , pp. 1004
    • Graf, N.1    Lippard, S.J.2
  • 17
    • 84864527570 scopus 로고    scopus 로고
    • Enzyme-responsive nanoparticles for drug release and diagnostics
    • de la Rica, R.; Aili, D.; Stevens, M. M. Enzyme-responsive nanoparticles for drug release and diagnostics. Adv. Drug Delivery Rev. 2012, 64, 967-78.
    • (2012) Adv. Drug Delivery Rev. , vol.64 , pp. 967-978
    • De La Rica, R.1    Aili, D.2    Stevens, M.M.3
  • 19
    • 0038215389 scopus 로고    scopus 로고
    • Pericellular cathepsin b and malignant progression
    • Roshy, S.; Sloane, B. F.; Moin, K. Pericellular cathepsin B and malignant progression. Cancer Metastasis Rev. 2003, 22, 271-86.
    • (2003) Cancer Metastasis Rev. , vol.22 , pp. 271-286
    • Roshy, S.1    Sloane, B.F.2    Moin, K.3
  • 20
    • 33749017931 scopus 로고    scopus 로고
    • Cysteine cathepsins: Multifunctional enzymes in cancer
    • Mohamed, M. M.; Sloane, B. F. Cysteine cathepsins: multifunctional enzymes in cancer. Nat. Rev. Cancer 2006, 6, 764-75.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 764-775
    • Mohamed, M.M.1    Sloane, B.F.2
  • 21
    • 77957855881 scopus 로고    scopus 로고
    • Specialized roles for cysteine cathepsins in health and disease
    • Reiser, J.; Adair, B.; Reinheckel, T. Specialized roles for cysteine cathepsins in health and disease. J. Clin. Invest. 2010, 120, 3421-31.
    • (2010) J. Clin. Invest. , vol.120 , pp. 3421-3431
    • Reiser, J.1    Adair, B.2    Reinheckel, T.3
  • 22
    • 75749112452 scopus 로고    scopus 로고
    • Do hpma copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities
    • Duncan, R.; Vicent, M. J. Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities. Adv. Drug Delivery Rev. 2010, 62, 272-82.
    • (2010) Adv. Drug Delivery Rev. , vol.62 , pp. 272-282
    • Duncan, R.1    Vicent, M.J.2
  • 23
    • 0032959549 scopus 로고    scopus 로고
    • Phase i clinical and pharmacokinetic study of pk1 [n-(2-hydroxypropyl) methacrylamide copolymer doxorubicin]: First member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer research campaign phase i/ii committee
    • Vasey, P. A.; Kaye, S. B.; Morrison, R.; Twelves, C.; Wilson, P.; Duncan, R.; et al. Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee. Clin. Cancer Res. 1999, 5, 83-94.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 83-94
    • Vasey, P.A.1    Kaye, S.B.2    Morrison, R.3    Twelves, C.4    Wilson, P.5    Duncan, R.6
  • 24
    • 67649417879 scopus 로고    scopus 로고
    • Phase ii studies of polymer-doxorubicin (pk1, fc, e28068) in the treatment of breast, lung and colorectal cancer
    • Seymour, L. W.; Ferry, D. R.; Kerr, D. J.; Rea, D.; Whitlock, M.; Poyner, R.; et al. Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer. Int. J. Oncol. 2009, 34, 1629-36.
    • (2009) Int. J. Oncol. , vol.34 , pp. 1629-1636
    • Seymour, L.W.1    Ferry, D.R.2    Kerr, D.J.3    Rea, D.4    Whitlock, M.5    Poyner, R.6
  • 25
    • 79960942844 scopus 로고    scopus 로고
    • Polymer therapeutics as nanomedicines: New perspectives
    • Duncan, R. Polymer therapeutics as nanomedicines: new perspectives. Curr. Opin. Biotechnol. 2011, 22, 492-501.
    • (2011) Curr. Opin. Biotechnol. , vol.22 , pp. 492-501
    • Duncan, R.1
  • 26
    • 78649238777 scopus 로고    scopus 로고
    • PEG and peg conjugates toxicity: Towards an understanding of the toxicity of peg and its relevance to pegylated biologicals
    • Veronese, F. M., Ed.; Birkhäuser: Basel
    • Webster, R.; Elliott, V.; Park, B. K.; Walker, D.; Hankin, M., Taupin, P. PEG and PEG conjugates toxicity: towards an understanding of the toxicity of PEG and its relevance to PEGylated biologicals. In PEGylated Protein Drugs: Basic Science and Clinical Applications; Veronese, F. M., Ed.; Birkhäuser: Basel; 2009; pp 127-46.
    • (2009) PEGylated Protein Drugs: Basic Science and Clinical Applications , pp. 127-146
    • Webster, R.1    Elliott, V.2    Park, B.K.3    Walker, D.4    Hankin, M.5    Taupin, P.6
  • 27
    • 84857351097 scopus 로고    scopus 로고
    • The optimal formulation variables for tumor targeting
    • Park, K. The optimal formulation variables for tumor targeting. J. Controlled Release 2012, 157, 315-6.
    • (2012) J. Controlled Release , vol.157 , pp. 315-316
    • Park, K.1
  • 28
    • 0036890192 scopus 로고    scopus 로고
    • A new, practical synthesis of 2-methoxyestradiols
    • Rao, P. N.; Cessac, J. W. A new, practical synthesis of 2-methoxyestradiols. Steroids 2002, 67, 1065-70.
    • (2002) Steroids , vol.67 , pp. 1065-1070
    • Rao, P.N.1    Cessac, J.W.2
  • 29
    • 33646838414 scopus 로고    scopus 로고
    • SAR studies of 2-methoxyestradiol and development of its analogs as probes of anti-tumor mechanisms
    • Ho, A.; Kim, Y. E.; Lee, H.; Cyrus, K.; Baek, S. H.; Kim, K. B. SAR studies of 2-methoxyestradiol and development of its analogs as probes of anti-tumor mechanisms. Bioorg. Med. Chem. Lett. 2006, 16, 3383-7.
    • (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 3383-3387
    • Ho, A.1    Kim, Y.E.2    Lee, H.3    Cyrus, K.4    Baek, S.H.5    Kim, K.B.6
  • 30
    • 0034026798 scopus 로고    scopus 로고
    • Poly(ethylene glycol) multiblock copolymer as a carrier of anti-cancer drug doxorubicin
    • Pechar, M.; Ulbrich, K.; Subr, V.; Seymour, L. W.; Schacht, E. H. Poly(ethylene glycol) multiblock copolymer as a carrier of anti-cancer drug doxorubicin. Bioconjugate Chem. 2000, 11, 131-9.
    • (2000) Bioconjugate Chem. , vol.11 , pp. 131-139
    • Pechar, M.1    Ulbrich, K.2    Subr, V.3    Seymour, L.W.4    Schacht, E.H.5
  • 31
    • 67349264695 scopus 로고    scopus 로고
    • Targetable hpma copolymer-aminohexylgeldanamycin conjugates for prostate cancer therapy
    • Borgman, M. P.; Ray, A.; Kolhatkar, R. B.; Sausville, E. A.; Burger, A. M.; Ghandehari, H. Targetable HPMA Copolymer-Aminohexylgeldanamycin Conjugates for Prostate Cancer Therapy. Pharm. Res. 2009, 26, 1407-18.
    • (2009) Pharm. Res. , vol.26 , pp. 1407-1418
    • Borgman, M.P.1    Ray, A.2    Kolhatkar, R.B.3    Sausville, E.A.4    Burger, A.M.5    Ghandehari, H.6
  • 32
    • 0036176019 scopus 로고    scopus 로고
    • Influence of the structure of drug moieties on the in vitro efficacy of hpma copolymer-geldanamycin derivative conjugates
    • Kasuya, Y.; Lu, Z. R.; Kopeckova, P.; Tabibi, S. E.; Kopecek, J. Influence of the structure of drug moieties on the in vitro efficacy of HPMA copolymer-geldanamycin derivative conjugates. Pharm. Res. 2002, 19, 115-23.
    • (2002) Pharm. Res. , vol.19 , pp. 115-123
    • Kasuya, Y.1    Lu, Z.R.2    Kopeckova, P.3    Tabibi, S.E.4    Kopecek, J.5
  • 33
    • 0034280327 scopus 로고    scopus 로고
    • Synthesis of starlike n-(2-hydroxypropyl)methacrylamide copolymers: Potential drug carriers
    • Wang, D.; Kopeckova, J. P.; Minko, T.; Nanayakkara, V.; Kopecek, J. Synthesis of starlike N-(2-hydroxypropyl)methacrylamide copolymers: potential drug carriers. Biomacromolecules 2000, 1, 313-9.
    • (2000) Biomacromolecules , vol.1 , pp. 313-319
    • Wang, D.1    Kopeckova, J.P.2    Minko, T.3    Nanayakkara, V.4    Kopecek, J.5
  • 34
    • 36849034047 scopus 로고    scopus 로고
    • Surface acetylation of polyamidoamine (pamam) dendrimers decreases cytotoxicity while maintaining membrane permeability
    • Kolhatkar, R. B.; Kitchens, K. M.; Swaan, P. W.; Ghandehari, H. Surface acetylation of polyamidoamine (PAMAM) dendrimers decreases cytotoxicity while maintaining membrane permeability. Bioconjugate Chem. 2007, 18, 2054-60.
    • (2007) Bioconjugate Chem. , vol.18 , pp. 2054-2060
    • Kolhatkar, R.B.1    Kitchens, K.M.2    Swaan, P.W.3    Ghandehari, H.4
  • 35
    • 0346634895 scopus 로고    scopus 로고
    • In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis
    • Fischer, D.; Li, Y.; Ahlemeyer, B.; Krieglstein, J.; Kissel, T. In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials 2003, 24, 1121-31.
    • (2003) Biomaterials , vol.24 , pp. 1121-1131
    • Fischer, D.1    Li, Y.2    Ahlemeyer, B.3    Krieglstein, J.4    Kissel, T.5
  • 36
    • 0014217907 scopus 로고
    • A membrane effect of basic polymers dependent on molecular size
    • Ryser, H. J. A membrane effect of basic polymers dependent on molecular size. Nature 1967, 215, 934-6.
    • (1967) Nature , vol.215 , pp. 934-936
    • Ryser, H.J.1
  • 38
    • 84874034404 scopus 로고    scopus 로고
    • Synthesis of long-circulating, backbone degradable hpma copolymer-doxorubicin conjugates and evaluation of molecular-weight-dependent antitumor efficacy
    • Pan, H.; Sima, M.; Yang, J.; Kopecek, J. Synthesis of Long-Circulating, Backbone Degradable HPMA Copolymer-Doxorubicin Conjugates and Evaluation of Molecular-Weight-Dependent Antitumor Efficacy. Macromol. Biosci. 2013, 13, 155-60.
    • (2013) Macromol. Biosci. , vol.13 , pp. 155-160
    • Pan, H.1    Sima, M.2    Yang, J.3    Kopecek, J.4
  • 39
    • 0035145742 scopus 로고    scopus 로고
    • Biodistribution and antitumour efficacy of longcirculating n-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in nude mice
    • Shiah, J. G.; Dvorak, M.; Kopeckova, P.; Sun, Y.; Peterson, C. M.; Kopecek, J. Biodistribution and antitumour efficacy of longcirculating N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in nude mice. Eur. J. Cancer 2001, 37, 131-9.
    • (2001) Eur. J. Cancer , vol.37 , pp. 131-139
    • Shiah, J.G.1    Dvorak, M.2    Kopeckova, P.3    Sun, Y.4    Peterson, C.M.5    Kopecek, J.6
  • 40
    • 0041461026 scopus 로고    scopus 로고
    • High-molecular weight hpma copolymer-adriamycin conjugates
    • Dvorak, M.; Kopeckova, P.; Kopecek, J. High-molecular weight HPMA copolymer-adriamycin conjugates. J. Controlled Release 1999, 60, 321-32.
    • (1999) J. Controlled Release , vol.60 , pp. 321-332
    • Dvorak, M.1    Kopeckova, P.2    Kopecek, J.3
  • 41
    • 0022002504 scopus 로고
    • Stability in rat plasma and serum of lysosomally degradable oligopeptide sequences in n-(2-hydroxypropyl) methacrylamide copolymers
    • Rejmanova, P.; Kopecek, J.; Duncan, R.; Lloyd, J. B. Stability in rat plasma and serum of lysosomally degradable oligopeptide sequences in N-(2-hydroxypropyl) methacrylamide copolymers. Biomaterials 1985, 6, 45-8.
    • (1985) Biomaterials , vol.6 , pp. 45-48
    • Rejmanova, P.1    Kopecek, J.2    Duncan, R.3    Lloyd, J.B.4
  • 42
    • 0002276486 scopus 로고    scopus 로고
    • Synthesis of hpma copolymers containing doxorubicin bound via a hydrazone linkage. Effect of spacer on drug release and in vitro cytotoxicity
    • Etrych, T.; Chytil, P.; Jelinkova, M.; Rihova, B.; Ulbrich, K. Synthesis of HPMA copolymers containing doxorubicin bound via a hydrazone linkage. Effect of spacer on drug release and in vitro cytotoxicity. Macromol. Biosci. 2002, 2, 43-52.
    • (2002) Macromol. Biosci. , vol.2 , pp. 43-52
    • Etrych, T.1    Chytil, P.2    Jelinkova, M.3    Rihova, B.4    Ulbrich, K.5
  • 44
    • 0023141221 scopus 로고
    • Anticancer agents coupled to n-(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro
    • Duncan, R.; Kopeckova-Rejmanova, P.; Strohalm, J.; Hume, I.; Cable, H. C.; Pohl, J.; et al. Anticancer agents coupled to N-(2-hydroxypropyl) methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro. Br. J. Cancer 1987, 55, 165-74.
    • (1987) Br. J. Cancer , vol.55 , pp. 165-174
    • Duncan, R.1    Kopeckova-Rejmanova, P.2    Strohalm, J.3    Hume, I.4    Cable, H.C.5    Pohl, J.6
  • 45
    • 0022273714 scopus 로고
    • Controlled release of drug model from n-(2-hydroxypropyl)-methacrylamide copolymers
    • Kopecek, J.; Rejmanova, P.; Duncan, R.; Lloyd, J. B. Controlled release of drug model from N-(2-hydroxypropyl)-methacrylamide copolymers. Ann. N.Y. Acad. Sci. 1985, 446, 93-104.
    • (1985) Ann. N.Y. Acad. Sci. , vol.446 , pp. 93-104
    • Kopecek, J.1    Rejmanova, P.2    Duncan, R.3    Lloyd, J.B.4
  • 46
    • 0000859980 scopus 로고
    • Polymers containing enzymatically degradable bonds 0-8. Degradation of oligopeptide sequences in n-(2-hydroxypropyl)-methacrylamide co-polymers by bovine spleen cathepsin-b
    • Rejmanova, P.; Kopecek, J.; Pohl, J.; Baudys, M.; Kostka, V. Polymers Containing Enzymatically Degradable Bonds 0-8. Degradation of Oligopeptide Sequences in N-(2-Hydroxypropyl)-Methacrylamide Co-Polymers by Bovine Spleen Cathepsin-B. Makromol. Chem. 1983, 184, 2009-20.
    • (1983) Makromol. Chem. , vol.184 , pp. 2009-2020
    • Rejmanova, P.1    Kopecek, J.2    Pohl, J.3    Baudys, M.4    Kostka, V.5
  • 47
    • 0025802686 scopus 로고
    • A model to explain the ph-dependent specificity of cathepsin b-catalysed hydrolyses
    • Khouri, H. E.; Plouffe, C.; Hasnain, S.; Hirama, T.; Storer, A. C.; Menard, R. A model to explain the pH-dependent specificity of cathepsin B-catalysed hydrolyses. Biochem. J. 1991, 275 (Part 3), 751-7.
    • (1991) Biochem. J. , vol.275 , Issue.PART 3 , pp. 751-757
    • Khouri, H.E.1    Plouffe, C.2    Hasnain, S.3    Hirama, T.4    Storer, A.C.5    Menard, R.6
  • 48
    • 0040084898 scopus 로고    scopus 로고
    • Major increase in endopeptidase activity of human cathepsin b upon removal of occluding loop contacts
    • Nagler, D. K.; Storer, A. C.; Portaro, F. C.; Carmona, E.; Juliano, L.; Menard, R. Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts. Biochemistry 1997, 36, 12608-15.
    • (1997) Biochemistry , vol.36 , pp. 12608-12615
    • Nagler, D.K.1    Storer, A.C.2    Portaro, F.C.3    Carmona, E.4    Juliano, L.5    Menard, R.6
  • 49
    • 12044253640 scopus 로고
    • The refined 2.15 a X-ray crystal structure of human liver cathepsin b: The structural basis for its specificity
    • Musil, D.; Zucic, D.; Turk, D.; Engh, R. A.; Mayr, I.; Huber, R.; et al. The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity. EMBO J. 1991, 10, 2321-30.
    • (1991) EMBO J. , vol.10 , pp. 2321-2330
    • Musil, D.1    Zucic, D.2    Turk, D.3    Engh, R.A.4    Mayr, I.5    Huber, R.6
  • 51
    • 77957271881 scopus 로고    scopus 로고
    • Stefin a displaces the occluding loop of cathepsin b only by as much as required to bind to the active site cleft
    • Renko, M.; Pozgan, U.; Majera, D.; Turk, D. Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft. FEBS J. 2010, 277, 4338-45.
    • (2010) FEBS J. , vol.277 , pp. 4338-4345
    • Renko, M.1    Pozgan, U.2    Majera, D.3    Turk, D.4
  • 52
    • 33745944379 scopus 로고    scopus 로고
    • Fluorescent, internally quenched, peptides for exploring the ph-dependent substrate specificity of cathepsin b
    • Ruzza, P.; Quintieri, L.; Osler, A.; Calderan, A.; Biondi, B.; Floreani, M.; et al. Fluorescent, internally quenched, peptides for exploring the pH-dependent substrate specificity of cathepsin B. J. Pept. Sci. 2006, 12, 455-61.
    • (2006) J. Pept. Sci. , vol.12 , pp. 455-461
    • Ruzza, P.1    Quintieri, L.2    Osler, A.3    Calderan, A.4    Biondi, B.5    Floreani, M.6
  • 53
    • 0036462513 scopus 로고    scopus 로고
    • S2' substrate specificity and the role of his110 and his111 in the exopeptidase activity of human cathepsin b
    • Krupa, J. C.; Hasnain, S.; Nagler, D. K.; Menard, R.; Mort, J. S. S2' substrate specificity and the role of His110 and His111 in the exopeptidase activity of human cathepsin B. Biochem. J. 2002, 361, 613-9.
    • (2002) Biochem. J. , vol.361 , pp. 613-619
    • Krupa, J.C.1    Hasnain, S.2    Nagler, D.K.3    Menard, R.4    Mort, J.S.5
  • 54
    • 0040909177 scopus 로고    scopus 로고
    • The occluding loop in cathepsin b defines the ph dependence of inhibition by its propeptide
    • Quraishi, O.; Nagler, D. K.; Fox, T.; Sivaraman, J.; Cygler, M.; Mort, J. S.; et al. The occluding loop in cathepsin B defines the pH dependence of inhibition by its propeptide. Biochemistry 1999, 38, 5017-23.
    • (1999) Biochemistry , vol.38 , pp. 5017-5023
    • Quraishi, O.1    Nagler, D.K.2    Fox, T.3    Sivaraman, J.4    Cygler, M.5    Mort, J.S.6
  • 55
    • 0032104271 scopus 로고    scopus 로고
    • Quantification of cathepsins b and l in cells
    • Xing, R.; Addington, A. K.; Mason, R. W. Quantification of cathepsins B and L in cells. Biochem. J. 1998, 332 (Part 2), 499-505.
    • (1998) Biochem. J. , vol.332 , Issue.PART 2 , pp. 499-505
    • Xing, R.1    Addington, A.K.2    Mason, R.W.3
  • 56
    • 79953005259 scopus 로고    scopus 로고
    • Injectable delivery system of 2-methoxyestradiol for breast cancer the rapy using biodegradable thermosensitive poly-(organophosphazene) hydrogel
    • Cho, J. K.; Hong, K. Y.; Park, J. W.; Yang, H. K.; Song, S. C. Injectable delivery system of 2-methoxyestradiol for breast cancer the rapy using biodegradable thermosensitive poly-(organophosphazene) hydrogel. J. Drug Targeting 2011, 19, 270-80.
    • (2011) J. Drug Targeting , vol.19 , pp. 270-280
    • Cho, J.K.1    Hong, K.Y.2    Park, J.W.3    Yang, H.K.4    Song, S.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.