The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis

Cancer Chemotherapy and Pharmacology

Volumn 72, Issue 2, 2013, Pages 349-357

  Dave, Nimita ^a   Gudelsky, Gary A ^a   Desai, Pankaj B ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Blood brain barrier; Glioma; Letrozole; Pharmacokinetics

Indexed keywords

LETROZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG PENETRATION; DRUG UPTAKE; EXTRACELLULAR FLUID; FEMALE; GLIOMA; INTRACEREBRAL MICRODIALYSIS; MAXIMUM PLASMA CONCENTRATION; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ALGORITHMS; ANIMALS; ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; BRAIN; BRAIN NEOPLASMS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR FLUID; FEMALE; GLIOMA; HUMANS; MICRODIALYSIS; NEOPLASM TRANSPLANTATION; NITRILES; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; TRIAZOLES;

EID: 84880921002     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-013-2205-y     Document Type: Article

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