메뉴 건너뛰기




Volumn 7, Issue 7, 2015, Pages 554-561

Selective, rapid and optically switchable regulation of protein function in live mammalian cells

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEIN BINDING;

EID: 84932619425     PISSN: 17554330     EISSN: 17554349     Source Type: Journal    
DOI: 10.1038/nchem.2253     Document Type: Article
Times cited : (142)

References (51)
  • 1
    • 0035233367 scopus 로고    scopus 로고
    • Recent advantages in chemical approaches to the study of biological systems
    • Shogren-Knaak, M. A., Alaimo, P. J. & Shokat, K. M. Recent advantages in chemical approaches to the study of biological systems. Annu. Rev. Cell Dev. Biol. 17, 405-433 (2001).
    • (2001) Annu. Rev. Cell Dev. Biol. , vol.17 , pp. 405-433
    • Shogren-Knaak, M.A.1    Alaimo, P.J.2    Shokat, K.M.3
  • 2
    • 33846676987 scopus 로고    scopus 로고
    • Chemical genetics: Where genetics and pharmacology meet
    • Knight, Z. A. & Shokat, K. M. Chemical genetics: where genetics and pharmacology meet. Cell 128, 425-430 (2007).
    • (2007) Cell , vol.128 , pp. 425-430
    • Knight, Z.A.1    Shokat, K.M.2
  • 3
    • 79955563790 scopus 로고    scopus 로고
    • Organic synthesis toward small-molecule probes and drugs
    • Schreiber, S. L. Organic synthesis toward small-molecule probes and drugs. Proc. Natl Acad. Sci. USA 108, 6699-6702 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 6699-6702
    • Schreiber, S.L.1
  • 5
    • 0034699382 scopus 로고    scopus 로고
    • A chemical switch for inhibitor-sensitive alleles of any protein kinase
    • Bishop, A. C. et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407, 395-401 (2000).
    • (2000) Nature , vol.407 , pp. 395-401
    • Bishop, A.C.1
  • 8
    • 50649112213 scopus 로고    scopus 로고
    • Activity-based protein profiling: From enzyme chemistry to proteomic chemistry
    • Cravatt, B. F., Wright, A. T. & Kozarich, J. W. Activity-based protein profiling: from enzyme chemistry to proteomic chemistry. Annu. Rev. Biochem. 77, 383-414 (2008).
    • (2008) Annu. Rev. Biochem. , vol.77 , pp. 383-414
    • Cravatt, B.F.1    Wright, A.T.2    Kozarich, J.W.3
  • 9
    • 84875850730 scopus 로고    scopus 로고
    • Protein organic chemistry and applications for labeling and engineering in live-cell systems
    • Takaoka, Y., Ojida, A. & Hamachi, I. Protein organic chemistry and applications for labeling and engineering in live-cell systems. Angew. Chem. Int. Ed. 52, 4088-4106 (2013).
    • (2013) Angew. Chem. Int. Ed. , vol.52 , pp. 4088-4106
    • Takaoka, Y.1    Ojida, A.2    Hamachi, I.3
  • 11
    • 84874301754 scopus 로고    scopus 로고
    • Developing irreversible inhibitors of the protein kinase cysteinome
    • Liu, Q. et al. Developing irreversible inhibitors of the protein kinase cysteinome. Chem. Biol. 20, 146-159 (2013).
    • (2013) Chem. Biol. , vol.20 , pp. 146-159
    • Liu, Q.1
  • 12
    • 33947317223 scopus 로고    scopus 로고
    • Structure-guided development of affinity probes for tyrosine kinases using chemical genetics
    • Blair, J. A. et al. Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nature Chem. Biol. 3, 229-238 (2007).
    • (2007) Nature Chem. Biol. , vol.3 , pp. 229-238
    • Blair, J.A.1
  • 13
    • 33645218213 scopus 로고    scopus 로고
    • Allosteric control of an ionotropic glutamate receptor with an optical switch
    • Volgraf, M. et al. Allosteric control of an ionotropic glutamate receptor with an optical switch. Nature Chem. Biol. 2, 47-52 (2006).
    • (2006) Nature Chem. Biol. , vol.2 , pp. 47-52
    • Volgraf, M.1
  • 15
    • 84884266765 scopus 로고    scopus 로고
    • Reversible photocontrol of biological systems by the incorporation of molecular photoswitches
    • Szymański, W., Beierle, J. M., Kistemaker, H. A. V., Velema, W. A. & Feringa, B. L. Reversible photocontrol of biological systems by the incorporation of molecular photoswitches. Chem. Rev. 113, 6114-6178 (2013).
    • (2013) Chem. Rev. , vol.113 , pp. 6114-6178
    • Szymański, W.1    Beierle, J.M.2    Kistemaker, H.A.V.3    Velema, W.A.4    Feringa, B.L.5
  • 16
    • 70349917806 scopus 로고    scopus 로고
    • Bioorthogonal chemistry: Fishing for selectivity in a sea of functionality
    • Sletten, E. M. & Bertozzi, C. R. Bioorthogonal chemistry: fishing for selectivity in a sea of functionality. Angew. Chem. Int. Ed. 48, 6974-6998 (2009).
    • (2009) Angew. Chem. Int. Ed. , vol.48 , pp. 6974-6998
    • Sletten, E.M.1    Bertozzi, C.R.2
  • 17
    • 84898072114 scopus 로고    scopus 로고
    • Bioorthogonal reactions for labeling proteins
    • Lang, K. & Chin, J.W. Bioorthogonal reactions for labeling proteins. ACS Chem. Biol. 9, 16-20 (2014).
    • (2014) ACS Chem. Biol. , vol.9 , pp. 16-20
    • Lang, K.1    Chin, J.W.2
  • 18
    • 84899077284 scopus 로고    scopus 로고
    • Cellular incorporation of unnatural amino acids and bioorthogonal labeling of proteins
    • Lang, K. & Chin, J. W. Cellular incorporation of unnatural amino acids and bioorthogonal labeling of proteins. Chem. Rev. 114, 4764-4806 (2014).
    • (2014) Chem. Rev. , vol.114 , pp. 4764-4806
    • Lang, K.1    Chin, J.W.2
  • 19
    • 84857445877 scopus 로고    scopus 로고
    • Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction
    • Lang, K. et al. Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction. Nature Chem. 4, 298-304 (2012).
    • (2012) Nature Chem. , vol.4 , pp. 298-304
    • Lang, K.1
  • 20
    • 84859970111 scopus 로고    scopus 로고
    • Amino acids for Diels-Alder reactions in living cells
    • Plass, T. et al. Amino acids for Diels-Alder reactions in living cells. Angew. Chem. Int. Ed. 51, 4166-4170 (2012).
    • (2012) Angew. Chem. Int. Ed. , vol.51 , pp. 4166-4170
    • Plass, T.1
  • 21
    • 84860174738 scopus 로고    scopus 로고
    • A genetically encoded norbornene amino acid for the mild and selective modification of proteins in a copper free click reaction
    • Kaya, E. et al. A genetically encoded norbornene amino acid for the mild and selective modification of proteins in a copper free click reaction. Angew. Chem. Int. Ed. 51, 4466-4469 (2012).
    • (2012) Angew. Chem. Int. Ed. , vol.51 , pp. 4466-4469
    • Kaya, E.1
  • 22
    • 84856873462 scopus 로고    scopus 로고
    • Genetically encoded tetrazine amino acid directs rapid sitespecific in vivo bioorthogonal ligation with trans-cyclooctenes
    • Seitchik, J. L. et al. Genetically encoded tetrazine amino acid directs rapid sitespecific in vivo bioorthogonal ligation with trans-cyclooctenes. J. Am. Chem. Soc. 134, 2898-2901 (2012).
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 2898-2901
    • Seitchik, J.L.1
  • 23
    • 84863443015 scopus 로고    scopus 로고
    • Genetic encoding of bicyclononynes and trans-cyclooctenes for site-specific protein labeling in vitro and in live mammalian cells via rapid fluorogenic Diels-Alder reactions
    • Lang, K. et al. Genetic encoding of bicyclononynes and trans-cyclooctenes for site-specific protein labeling in vitro and in live mammalian cells via rapid fluorogenic Diels-Alder reactions. J. Am. Chem. Soc. 134, 10317-10320 (2012).
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 10317-10320
    • Lang, K.1
  • 24
    • 84900339887 scopus 로고    scopus 로고
    • Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal
    • Elliott, T. S. et al. Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal. Nature Biotechnol. 32, 465-472 (2014).
    • (2014) Nature Biotechnol. , vol.32 , pp. 465-472
    • Elliott, T.S.1
  • 26
    • 42149143745 scopus 로고    scopus 로고
    • Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding
    • Krishnamurthy, V. M. et al. Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding. Chem. Rev. 108, 946-1051 (2008).
    • (2008) Chem. Rev. , vol.108 , pp. 946-1051
    • Krishnamurthy, V.M.1
  • 27
    • 84885949138 scopus 로고    scopus 로고
    • Simplified models for heterobivalent ligand binding: When are they applicable and which are the factors that affect their target residence time
    • Vauquelin, G. Simplified models for heterobivalent ligand binding: when are they applicable and which are the factors that affect their target residence time. Naunyn-Schmiedeberg's Arch. Pharmacol. 386, 949-962 (2013).
    • (2013) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.386 , pp. 949-962
    • Vauquelin, G.1
  • 29
    • 33846809157 scopus 로고    scopus 로고
    • Dependence of effective molarity on linker length for an intramolecular protein-ligand system
    • Krishnamurthy, V. M., Semetey, V., Bracher, P. J., Shen, N. & Whitesides, G. M. Dependence of effective molarity on linker length for an intramolecular protein-ligand system. J. Am. Chem. Soc. 129, 1312-1320 (2007).
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 1312-1320
    • Krishnamurthy, V.M.1    Semetey, V.2    Bracher, P.J.3    Shen, N.4    Whitesides, G.M.5
  • 30
    • 0036983115 scopus 로고    scopus 로고
    • The Ras-Raf-MEK-ERK pathway in the treatment of cancer
    • Hilger, R. A., Scheulen, M. E. & Strumberg, D. The Ras-Raf-MEK-ERK pathway in the treatment of cancer. Oncol. Res. Treat. 25, 511-518 (2002).
    • (2002) Oncol. Res. Treat. , vol.25 , pp. 511-518
    • Hilger, R.A.1    Scheulen, M.E.2    Strumberg, D.3
  • 31
    • 10344258041 scopus 로고    scopus 로고
    • Targeting the mitogen-activated protein kinase cascade to treat cancer
    • Sebolt-Leopold, J. S. & Herrera, R. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nature Rev. Cancer 4, 937-947 (2004).
    • (2004) Nature Rev. Cancer , vol.4 , pp. 937-947
    • Sebolt-Leopold, J.S.1    Herrera, R.2
  • 32
    • 31144453233 scopus 로고    scopus 로고
    • BRAF mutation predicts sensitivity to MEK inhibition
    • Solit, D. B. et al. BRAF mutation predicts sensitivity to MEK inhibition. Nature 439, 358-362 (2006).
    • (2006) Nature , vol.439 , pp. 358-362
    • Solit, D.B.1
  • 33
    • 0027692679 scopus 로고
    • Mek2 is a kinase related to Mek1 and Ts differentially expressed in murine tissues
    • Brott, B. K. et al. Mek2 is a kinase related to Mek1 and Ts differentially expressed in murine tissues. Cell Growth Differ. 4, 921-929 (1993).
    • (1993) Cell Growth Differ. , vol.4 , pp. 921-929
    • Brott, B.K.1
  • 34
    • 0033535584 scopus 로고    scopus 로고
    • Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta
    • Giroux, S. et al. Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Curr. Biol. 9, 369-376 (1999).
    • (1999) Curr. Biol. , vol.9 , pp. 369-376
    • Giroux, S.1
  • 35
    • 6344235546 scopus 로고    scopus 로고
    • MEK1 and MEK2, different regulators of the G1/S transition
    • Ussar, S. & Voss, T. MEK1 and MEK2, different regulators of the G1/S transition. J. Biol. Chem. 279, 43861-43869 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 43861-43869
    • Ussar, S.1    Voss, T.2
  • 36
    • 84903537320 scopus 로고    scopus 로고
    • The clinical development of MEK inhibitors
    • Zhao, Y. & Adjei, A. A. The clinical development of MEK inhibitors. Nature Rev. Clin. Oncol. 11, 385-400 (2014).
    • (2014) Nature Rev. Clin. Oncol. , vol.11 , pp. 385-400
    • Zhao, Y.1    Adjei, A.A.2
  • 37
    • 57749119314 scopus 로고    scopus 로고
    • Beyond the MEK-pocket: Can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?
    • Tecle, H. et al. Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? Bioorg. Med. Chem. Lett. 19, 226-229 (2009).
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 226-229
    • Tecle, H.1
  • 38
    • 84861017745 scopus 로고    scopus 로고
    • Novel carboxamide-based allosteric MEK inhibitors: Discovery and optimization efforts toward XL518 (GDC-0973)
    • Rice, K. D. et al. Novel carboxamide-based allosteric MEK inhibitors: discovery and optimization efforts toward XL518 (GDC-0973). ACS Med. Chem. Lett. 3, 416-421 (2012).
    • (2012) ACS Med. Chem. Lett. , vol.3 , pp. 416-421
    • Rice, K.D.1
  • 39
    • 84857779702 scopus 로고    scopus 로고
    • Fluorophore targeting to cellular proteins via enzyme-mediated azide ligation and strain-promoted cycloaddition
    • Yao, J. Z. et al. Fluorophore targeting to cellular proteins via enzyme-mediated azide ligation and strain-promoted cycloaddition. J. Am. Chem. Soc. 134, 3720-3728 (2012).
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 3720-3728
    • Yao, J.Z.1
  • 41
    • 70350560916 scopus 로고    scopus 로고
    • Azobenzenes-synthesis and carbohydrate applications
    • Hamon, F., Djedaini-Pilard, F., Barbot, F. & Len, C. Azobenzenes-synthesis and carbohydrate applications. Tetrahedron 65, 10105-10123 (2009).
    • (2009) Tetrahedron , vol.65 , pp. 10105-10123
    • Hamon, F.1    Djedaini-Pilard, F.2    Barbot, F.3    Len, C.4
  • 42
    • 33745294757 scopus 로고    scopus 로고
    • Azobenzene as conformational switch in model peptides
    • Renner, C. & Moroder, L. Azobenzene as conformational switch in model peptides. Chem Bio Chem 7, 868-878 (2006).
    • (2006) Chem Bio Chem , vol.7 , pp. 868-878
    • Renner, C.1    Moroder, L.2
  • 43
  • 45
    • 60849113175 scopus 로고    scopus 로고
    • KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients
    • Gajiwala, K. S. et al. KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients. Proc. Natl Acad. Sci. USA 106, 1542-1547 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 1542-1547
    • Gajiwala, K.S.1
  • 46
    • 7944231534 scopus 로고    scopus 로고
    • Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
    • Palacios, E. H. & Weiss, A. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene 23, 7990-8000 (2004).
    • (2004) Oncogene , vol.23 , pp. 7990-8000
    • Palacios, E.H.1    Weiss, A.2
  • 47
    • 84863482471 scopus 로고    scopus 로고
    • Biophysical mechanism of T-cell receptor triggering in a reconstituted system
    • James, J. R. & Vale, R. D. Biophysical mechanism of T-cell receptor triggering in a reconstituted system. Nature 487, 64-69 (2012).
    • (2012) Nature , vol.487 , pp. 64-69
    • James, J.R.1    Vale, R.D.2
  • 48
    • 61849166005 scopus 로고    scopus 로고
    • The structure, regulation, and function of ZAP-70
    • Au-Yeung, B. B. et al. The structure, regulation, and function of ZAP-70. Immunol. Rev. 228, 41-57 (2009).
    • (2009) Immunol. Rev. , vol.228 , pp. 41-57
    • Au-Yeung, B.B.1
  • 49
    • 84908626417 scopus 로고    scopus 로고
    • Efficient multisite unnatural amino acid incorporation in mammalian cells via optimized pyrrolysyl tRNA synthetase/tRNA expression and engineered eRF1
    • Schmied, W. H., Elsässer, S. J., Uttamapinant, C. & Chin, J.W. Efficient multisite unnatural amino acid incorporation in mammalian cells via optimized pyrrolysyl tRNA synthetase/tRNA expression and engineered eRF1. J. Am. Chem. Soc. 136, 15577-15583 (2014).
    • (2014) J. Am. Chem. Soc. , vol.136 , pp. 15577-15583
    • Schmied, W.H.1    Elsässer, S.J.2    Uttamapinant, C.3    Chin, J.W.4
  • 50
    • 84900314611 scopus 로고    scopus 로고
    • CRISPR-Cas systems for editing, regulating and targeting genomes
    • Sander, J. D. & Joung, J. K. CRISPR-Cas systems for editing, regulating and targeting genomes. Nature Biotechnol. 32, 347-355 (2014).
    • (2014) Nature Biotechnol. , vol.32 , pp. 347-355
    • Sander, J.D.1    Joung, J.K.2
  • 51
    • 0028141496 scopus 로고
    • Transformation of mammalian cells by constitutively active MAP kinase kinase
    • Mansour, S. et al. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265, 966-970 (1994).
    • (1994) Science , vol.265 , pp. 966-970
    • Mansour, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.