Beyond the MEK-pocket: Can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 1, 2009, Pages 226-229

  Tecle, Haile ^a   Shao, Jianxing ^a   Li, Yanhong ^a   Kothe, Michael ^a   Kazmirski, Steven ^a   Penzotti, Julie ^a   Ding, Yuan Hua ^a   Ohren, Jeffrey ^a   Moshinsky, Deb ^a   Coli, Rocco ^a   Jhawar, Nidhi ^a   Bora, Emilia ^a   Jacques O'Hagan, Suzanne ^a   Wu, Joe ^a  

^a PFIZER INC   (United States)

Author keywords

MEK; Type III NCKIs

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PF 04622664; TYPE III NON CLASSICAL KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; REACTION ANALYSIS; STRUCTURE ANALYSIS;

CATALYTIC DOMAIN; DRUG DESIGN; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PROTEIN KINASE INHIBITORS;

EID: 57749119314     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.108     Document Type: Article

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