Anti-IL-6 neutralizing antibody modulates blood-brain barrier function in the ovine fetus

FASEB Journal

Volumn 29, Issue 5, 2015, Pages 1739-1753

  Zhang, Jiyong ^a   Sadowska, Grazyna B ^a   Chen, Xiaodi ^a   Park, Seon Yeong ^a   Kim, Jeong Eun ^a   Bodge, Courtney A ^a   Cummings, Erin ^a   Lim, Yow Pin ^b   Makeyev, Oleksandr ^c   Besio, Walter G ^c   Gaitanis, John ^a   Banks, William A ^d   Stonestreet, Barbara S ^a  

^a BROWN UNIVERSITY   (United States)

^b ProThera Biologics Inc   (United States)

^c The University of Rhode Island   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Development; Ischemia; Monoclonal; Permeability; Tight junction proteins

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; NEUTRALIZING ANTIBODY; TIGHT JUNCTION PROTEIN; CARRIER PROTEIN; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; PLVAP PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN ISCHEMIA; CAROTID ARTERY FLOW; CEREBROSPINAL FLUID; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEEP; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL MEMBRANE PERMEABILITY; DRUG EFFECTS; FEMALE; IMMUNOLOGY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; REPERFUSION INJURY; TIGHT JUNCTION;

OVIS; OVIS ARIES;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; BRAIN ISCHEMIA; CARRIER PROTEINS; CELL MEMBRANE PERMEABILITY; FEMALE; FETUS; INTERLEUKIN-6; MEMBRANE PROTEINS; PREGNANCY; REPERFUSION INJURY; SHEEP; TIGHT JUNCTION PROTEINS; TIGHT JUNCTIONS;

EID: 84932598451     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-258822     Document Type: Article

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