Neutralizing anti-interleukin-1β antibodies modulate fetal blood-brain barrier function after ischemia

Neurobiology of Disease

Volumn 73, Issue , 2015, Pages 118-129

  Chen, Xiaodi ^a   Sadowska, Grazyna B ^a   Zhang, Jiyong ^a   Kim, Jeong Eun ^a   Cummings, Erin E ^a   Bodge, Courtney A ^a   Lim, Yow Pin ^b   Makeyev, Oleksandr ^c,f   Besio, Walter G ^c   Gaitanis, John ^a   Threlkeld, Steven W ^a,e   Banks, William A ^d   Stonestreet, Barbara S ^a  

^a BROWN UNIVERSITY   (United States)

^b ProThera Biologics Inc   (United States)

^c The University of Rhode Island   (United States)

^d VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^e RHODE ISLAND COLLEGE   (United States)

^f Dine College   (United States)

Author keywords

Blood brain barrier; Brain; Cytokines; Interleukin 1 ; Ischemia reperfusion; Monoclonal antibody; Ovine fetus; Sheep

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 1BETA ANTIBODY; INTERLEUKIN 6; PLACEBO; TIGHT JUNCTION PROTEIN; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; NEUTRALIZING ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTERIAL GAS; ARTERIAL PRESSURE; ARTICLE; BLOOD BRAIN BARRIER; BODY WEIGHT; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN CORTEX; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN WEIGHT; CAROTID ARTERY; CAUDATE NUCLEUS; CEREBELLUM; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS; GESTATIONAL AGE; HEART RATE; HEMATOCRIT; HIPPOCAMPUS; HYSTEROTOMY; INFERIOR COLLICULUS; MEAN ARTERIAL PRESSURE; MEDULLA OBLONGATA; MOUSE; NONHUMAN; PARIETAL LOBE; PH; PONS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PURIFICATION; REPERFUSION INJURY; SHEEP; SPINAL CORD; SUPERIOR COLLICULUS; THALAMUS; UPREGULATION; WESTERN BLOTTING; WHITE MATTER; ANIMAL; BLOOD FLOW; BLOOD PRESSURE; BRAIN; CAPILLARY PERMEABILITY; CAROTID ARTERY OBSTRUCTION; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; EMBRYOLOGY; FEMALE; FETAL HYPOXIA; FETUS HEART RATE; IMMUNOLOGY; MAMMALIAN EMBRYO; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PREGNANCY;

ANIMALS; ANTIBODIES, NEUTRALIZING; BLOOD PRESSURE; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARY PERMEABILITY; CAROTID STENOSIS; CYTOKINES; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FETAL HYPOXIA; HEART RATE, FETAL; INTERLEUKIN-1BETA; MICE; PREGNANCY; REGIONAL BLOOD FLOW; SHEEP; TIGHT JUNCTION PROTEINS;

EID: 84908604632     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.09.007     Document Type: Article

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