Biphasic edema after hypoxic-ischemic brain injury in neonatal rats reflects early neuronal and late glial damage

Pediatric Research

Volumn 46, Issue 3, 1999, Pages 297-304

  Nedelcu, Johann ^a   Klein, Michael A ^b   Aguzzi, Adriano ^b   Boesiger, Peter ^c   Martin, Ernst ^a  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN EDEMA; BRAIN HYPOXIA; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN SIZE; CELL DEATH; ENERGY METABOLISM; GLIA CELL; HISTOPATHOLOGY; NERVE INJURY; NEWBORN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; TIME;

EID: 0032775312     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199909000-00008     Document Type: Article

References (43)

1. Roberts TPL, Vexier Z, Derugin N, Moseley ME, Kucharczyk J 1993 High speed MRI of ischemic brain injury following stenosis of the middle cerebral artery. J Cereb Blood Flow Metab 13:940-946
2. McCulloch J 1992 Excitatory amino acid antagonists and their potential for the treatment of ischaemic brain damage in man. Br J Clin Pharmacol 34:106-114
3. Vannucci RC, Perlman JM 1997 Interventions for perinatal hypoxic-ischemic encephalopathy. Pediatrics 100:1004-1014
4. 2-weighted MRI and spectroscopy. Magn Reson Med 14:330-346
5. Ginsberg M 1997 The new language of cerebral ischemia. AJNR Am J Neuroradiol 18:1435-1445
6. Rumpcl H, Buchli R, Gehrmann J, Aguzzi A, Illi O, Martin E 1995 Magnetic resonance imaging of brain edema in the neonatal rat: a comparison of short and long term hypoxia-ischemia. Pediatr Res 38:113-118
7. 31P spectra. Magn Reson Med 21:216-221
8. Hennig J, Nauerth A, Friedburg H 1986 RARE-imaging: a fast imaging method for clinical MR. Magn Reson Med 3:823-833
9. Rumpel H, Nedelcu J, Aguzzi A, Martin E 1997 Late glial swelling after acute cerebral hypoxia-ischemia in neonatal rat: a combined magnetic resonance and histochcmical study. Pediatr Res 42:54-59
10. Alsop DC 1997 Phase insensitive preparation of single shot RARE: application to diffusion imaging in humans. Magn Reson Med 38:527-533
11. Paxinos G, Tork I. Tesott LH, Valentine KL 1991 Atlas of the Developing Rat Brain. Academic Press, San Diego, pp 34-39
12. Speck O, Il'Yasow K, Hennig J 1996 Correction of artifacts in DWI and BOLD single shot RARE images with centered phase encoding. In: Proceedings of the 13th annual meeting of European Society of Magnetic Resonance in Medicine and Biology. European Society of Magnetic Resonance in Medicine and Biology, Prague, p 71 (abstr)
13. Edwards AD, Yue X, Squier MV, Thoresen M, Cady EB, Penrice J, Cooper CE, Wyatt JS, Reynolds EOR, Mehmet H 1995 Specific inhibition of apoptosis after cerebral hypoxia-ischaemia by moderate post-insult hypothermia. Biochem Biophys Res Commun 217:1193-1199
14. Hoehn-Berlage M, Norris GD, Kohno K, Mies G, Leibfritz D, Hossmann KA 1995 Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances. J Cereb Blood Flow Metab 15:1002-1011
15. Lo EH, Rogowska J, Bogorodzki, P, Trocha M, Matsumoto K, Saffran B. Wolf GL 1996 Temporal correlation analysis of penumbral dynamics in focal cerebral ischemia. J Cereb Blood Flow Metab 16:60-68
16. Silver IA, Deas J, Erecinska M 1997 Ion homeostasis in brain cells: differences in intracellular ion responses to energy limitation between cultured neurons and glial cells. Neuroscience 78:589-601
17. +, and pH in the developing rat cortex and corpus callosum. J Cereb Blood Flow Metab 17:191-203
18. Torvik A, Svindland A 1986 Is there a transitional zone between brain infarcts and the surrounding brain? Acta Neurol Scand 74:365-370
19. Needergard M 1987 Neuronal injury in the infarct border: a neuropathological study in the rat. Acta Neuropathol Berl 73:267-274
20. Penrice J, Lorek A, Cady EB, Amess PN, Wylezinska M, Cooper CE, D'Souza P, Brown GC, Kirkbride V, Edwards AD, Wyatt JS, Reynolds EOR 1997 Proton magnetic resonance spectroscopy of the brain during acute hypoxia-ischemia and delayed cerebral energy failure in the newborn piglet. Pediatr Res 41:795-802
21. Novelli A, Reilly JA, Lysko PG, Henneberry RC 1988 Glutamate becomes neurotoxic via the NMDA receptor when intracellular energy levels are reduced. Brain Res 451:205-212
22. Matsumoto K, Lo EH, Pierce A, Halpern EF, Newcomb R 1996 Secondary elevation of extracellular neurotransmitter amino acids in the reperfusion phase following focal cerebral ischemia. J Cereb Blood Flow Metab 16:114-124
23. Swanson RA, Farrell K, Simon RP 1995 Acidosis causes failure of astrocyte glutamate uptake during hypoxia. J Cereb Blood Flow Metab 15:417-424
24. Kristian T, Gido G, Siesjö BK 1995 The influence of acidosis on hypoglycemic brain damage. J Cereb Blood Flow Metab 15:78-87
25. Younkin DP 1992 Developmental biochemistry: studies in vivo with nuclear magnetic resonance spectroscopy. In: Polin RA, Fox WW (eds) Fetal and Neonatal Physiology. WB Saunders, Philadelphia, pp 1531-1539
26. Wyatt JS, Edwards AD, Azzopardi D, Reynolds EOR 1989 Magnetic resonance and near infrared spectroscopy for investigation of perinatal hypoxic-ischemic brain injury. Arch Dis Child 63:953-963
27. Hope PL, Costello AM, Cady EB, Delpy DT, Tofts PS, Chu A, Hamilton PA, Reynolds EOR, Wilkie DR 1984 Cerebral energy metabolism studied with phospho rus NMR spectroscopy in normal and birth-asphyxiated infants. Lancet 2:366-370
28. 31P magnetic resonance spectroscopy. Pediatr Res 36:699-706
29. Blumberg RM, Cady E, Wigglesworlh JS, McKenzie JE, Edwards AD 1996 Delayed impairment of cerebral energy metabolism and infarction following transient local hypoxia-ischemia in the developing brain. Exp Brain Res 113:130-137
30. Yager JY, Brucklacher RM, Vannucci RC 1992 Cerebral energy metabolism during hypoxia-ischemia and early recovery in immature rats. Am J Physiol 262:H672-H677
31. Petito CK, Halahy IA 1993 Relationship between ischemia and ischemic neuronal necrosis to astrocyte expression of glial fibrillary acidic protein. Int J Dev Neurosci 11:239-247
32. Mehmet H, Yue X, Squier MV, Hope PL, Azzopardi D, Edwards AD 1995 Increased apoptosis in the cingulate sulcus of newborn piglets following transient hypoxia-ischemia is related to the degree of high energy phosphate depletion during the insult. Neurosci Lett 181:121-125
33. Wallen OM, Lonnbro P, Schon A, Borrebaeck CA 1993 Antibody-induced apoptosis in a human leukemia cell line is energy dependent: thermochemical analysis of cellular metabolism. Cancer Lett 75:103-109
34. Richter C, Schweizer M, Cassarizza A, Franceschi C 1996 Control of apoptosis by the cellular ATP level. FEBS Lett 378:107-110
35. Gardner-Medwin AR, van Bruggen N, Williams SR, Ahier RG 1994 Magnetic resonance imaging of propagating waves of spreading depression in the anesthetized rat. J Cereb Blood Flow Metab 14:7-11
36. Iijima T, Mies G, Hossman KA 1992 Repeated negative DC deflections in the rat cortex following middle cerebral artery occlusion are abolished by MK-801: effect on volume of ischemic injury. J Cereb Blood Flow Metab 12:727-733
37. Bush E, Gyngell ML, Eis M, Hoehn-Berlage M 1996 Potassium-induced cortical spreading depressions during focal cerebral ischemia in rats: contribution to lesion growth assessed by diffusion-weighted NMR and biochemical imaging J Cereb Blood Flow Metab 16:1090-1099
38. Levine S 1960 Anoxic-ischemic encephalopathy in rats. Am J Pathol 36:1-17
39. Rice JE, Vannucci RC, Brierley JV 1981 The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 9:131-141
40. Vannucci RC 1990 Experimental biology of cerebral hypoxia-ischemia: relation to perinatal brain damage. Pediatr Res 27:317-326
41. 31P nuclear magnetic resonance study in unanesthetized neonatal rats. Pediatr Res 42:700-708
42. 2-, and diffusion-weighted magnetic resonance imaging at 9:4T. Proceedings of the ISMRM, 4th Scientific Meeting, New York, vol. 1, p 493
43. Towfighi J, Zec N, Yager J, Housman C, Vannucci RC 1995 Temporal evolution of neuropathologic changes in an immature rat model of cerebral hypoxia: a light microscopic study. Acta Neuropathol 90:375-386