Polymicrobial sepsis increases susceptibility to chronic viral infection and exacerbates CD8+ T cell exhaustion

Journal of Immunology

Volumn 195, Issue 1, 2015, Pages 116-125

  Condotta, Stephanie A ^a   Khan, Shaniya H ^a   Rai, Deepa ^a   Griffith, Thomas S ^b,c,d   Badovinac, Vladimir P ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; LYMPHOCYTE ACTIVATION GENE 3 ANTIBODY; LYMPHOCYTE ACTIVATION GENE 3 PROTEIN; LYMPHOCYTE ANTIGEN; PROGRAMMED DEATH 1 LIGAND ANTIBODY; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIBODY; CD223 ANTIGEN; CD244 PROTEIN, MOUSE; IMMUNOGLOBULIN RECEPTOR; LEUKOCYTE ANTIGEN; PDCD1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; EX VIVO STUDY; IN VIVO STUDY; INFECTION SENSITIVITY; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS; VIRUS LOAD; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; COMPLICATION; CONVALESCENCE; DISEASE PREDISPOSITION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOLOGY; LYMPHOCYTE COUNT; PATHOLOGY; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; SURVIVAL; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES; ANTIGENS, CD; CD8-POSITIVE T-LYMPHOCYTES; CONVALESCENCE; DISEASE SUSCEPTIBILITY; GENE EXPRESSION REGULATION; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERFERON-GAMMA; LYMPHOCYTE COUNT; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PRIMARY CELL CULTURE; PROGRAMMED CELL DEATH 1 RECEPTOR; RECEPTORS, IMMUNOLOGIC; SEPSIS; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; TUMOR NECROSIS FACTOR-ALPHA; VIRAL LOAD;

EID: 84932102281     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1402473     Document Type: Article

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