메뉴 건너뛰기




Volumn 194, Issue 4, 2015, Pages 1609-1620

Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR BETA CHAIN;

EID: 84922570656     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401711     Document Type: Article
Times cited : (51)

References (81)
  • 1
    • 79956125257 scopus 로고    scopus 로고
    • Origins of CD4(+) effector and central memory T cells
    • Pepper, M., and M. K. Jenkins. 2011. Origins of CD4(+) effector and central memory T cells. Nat. Immunol. 12: 467-471.
    • (2011) Nat. Immunol. , vol.12 , pp. 467-471
    • Pepper, M.1    Jenkins, M.K.2
  • 2
    • 84871839521 scopus 로고    scopus 로고
    • IFN-γ from CD4 T cells is essential for host survival and enhances CD8 T cell function during mycobac-terium tuberculosis infection
    • Green, A. M., R. Difazio, and J. L. Flynn. 2013. IFN-γ from CD4 T cells is essential for host survival and enhances CD8 T cell function during Mycobac-terium tuberculosis infection. J. Immunol. 190: 270-277.
    • (2013) J. Immunol. , vol.190 , pp. 270-277
    • Green, A.M.1    Difazio, R.2    Flynn, J.L.3
  • 3
    • 84870913790 scopus 로고    scopus 로고
    • Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis
    • Phares, T. W., S. A. Stohlman, D. R. Hinton, and C. C. Bergmann. 2012. Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis. J. Neuroinflammation 9: 269.
    • (2012) J. Neuroinflammation , vol.9 , pp. 269
    • Phares, T.W.1    Stohlman, S.A.2    Hinton, D.R.3    Bergmann, C.C.4
  • 5
    • 33745837090 scopus 로고    scopus 로고
    • TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells
    • Badovinac, V. P., K. A. Messingham, T. S. Griffith, and J. T. Harty. 2006. TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells. J. Immunol. 177: 999-1006.
    • (2006) J. Immunol. , vol.177 , pp. 999-1006
    • Badovinac, V.P.1    Messingham, K.A.2    Griffith, T.S.3    Harty, J.T.4
  • 6
    • 44449096702 scopus 로고    scopus 로고
    • TRAIL deficiency does not rescue impaired CD8+ T cell memory generated in the absence of CD4+ T cell help
    • Sacks, J. A., and M. J. Bevan. 2008. TRAIL deficiency does not rescue impaired CD8+ T cell memory generated in the absence of CD4+ T cell help. J. Immunol. 180: 4570-4576.
    • (2008) J. Immunol. , vol.180 , pp. 4570-4576
    • Sacks, J.A.1    Bevan, M.J.2
  • 7
    • 84892461172 scopus 로고    scopus 로고
    • Tumor-specific CD4+ T cells maintain effector and memory tumor-specific CD8+ T cells
    • Church, S. E., S. M. Jensen, P. A. Antony, N. P. Restifo, and B. A. Fox. 2014. Tumor-specific CD4+ T cells maintain effector and memory tumor-specific CD8+ T cells. Eur. J. Immunol. 44: 69-79.
    • (2014) Eur. J. Immunol. , vol.44 , pp. 69-79
    • Church, S.E.1    Jensen, S.M.2    Antony, P.A.3    Restifo, N.P.4    Fox, B.A.5
  • 8
    • 84859726737 scopus 로고    scopus 로고
    • T cells that promote B-cell maturation in systemic autoimmunity
    • Weinstein, J. S., S. G. Hernandez, and J. Craft. 2012. T cells that promote B-Cell maturation in systemic autoimmunity. Immunol. Rev. 247: 160-171.
    • (2012) Immunol. Rev. , vol.247 , pp. 160-171
    • Weinstein, J.S.1    Hernandez, S.G.2    Craft, J.3
  • 9
    • 84880696388 scopus 로고    scopus 로고
    • T cell-dependent IgM memory B cells generated during bacterial infection are required for IgG responses to antigen challenge
    • Yates, J. L., R. Racine, K. M. McBride, and G. M. Winslow. 2013. T cell-dependent IgM memory B cells generated during bacterial infection are required for IgG responses to antigen challenge. J. Immunol. 191: 1240-1249.
    • (2013) J. Immunol. , vol.191 , pp. 1240-1249
    • Yates, J.L.1    Racine, R.2    Mcbride, K.M.3    Winslow, G.M.4
  • 10
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser, D. M., and J. P. Edwards. 2008. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8: 958-969.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 11
    • 84859208479 scopus 로고    scopus 로고
    • Inpatient care for septicemia or sepsis: A challenge for patients and hospitals
    • Hall, M. J., S. N. Williams, C. J. DeFrances, and A. Golosinskiy. 2011. Inpatient care for septicemia or sepsis: a challenge for patients and hospitals. NCHS Data Brief: 1-8.
    • (2011) NCHS Data Brief , pp. 1-8
    • Hall, M.J.1    Williams, S.N.2    Defrances, C.J.3    Golosinskiy, A.4
  • 12
    • 84255183707 scopus 로고    scopus 로고
    • The search for effective therapy for sepsis: Back to the drawing board?
    • Angus, D. C. 2011. The search for effective therapy for sepsis: back to the drawing board? JAMA 306: 2614-2615.
    • (2011) JAMA , vol.306 , pp. 2614-2615
    • Angus, D.C.1
  • 13
    • 0026874127 scopus 로고
    • American college of chest physicians/Society of critical care medicine consensus conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
    • 1992. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit. Care Med. 20: 864-874.
    • (1992) Crit. Care Med. , vol.20 , pp. 864-874
  • 15
    • 0034108825 scopus 로고    scopus 로고
    • The epidemiology of the systemic inflammatory response
    • Brun-Buisson, C. 2000. The epidemiology of the systemic inflammatory response. Intensive Care Med. 26(Suppl. 1): S64-S74.
    • (2000) Intensive Care Med. , vol.26 , pp. S64-S74
    • Brun-Buisson, C.1
  • 16
    • 84874256945 scopus 로고    scopus 로고
    • Immunosuppression in sepsis: A novel understanding of the disorder and a new therapeutic approach
    • Hotchkiss, R. S., G. Monneret, and D. Payen. 2013. Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect. Dis. 13: 260-268.
    • (2013) Lancet Infect. Dis. , vol.13 , pp. 260-268
    • Hotchkiss, R.S.1    Monneret, G.2    Payen, D.3
  • 17
    • 77953635470 scopus 로고    scopus 로고
    • Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism
    • Unsinger, J., H. Kazama, J. S. McDonough, T. S. Griffith, R. S. Hotchkiss, and T. A. Ferguson. 2010. Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism. J. Immunol. 184: 6766-6772.
    • (2010) J. Immunol. , vol.184 , pp. 6766-6772
    • Unsinger, J.1    Kazama, H.2    Mcdonough, J.S.3    Griffith, T.S.4    Hotchkiss, R.S.5    Ferguson, T.A.6
  • 18
    • 84864140315 scopus 로고    scopus 로고
    • The early phase of human sepsis is characterized by a combination of apoptosis and proliferation of T cells
    • Roger, P. M., H. Hyvernat, M. Ticchioni, G. Kumar, J. Dellamonica, and G. Bernardin. 2012. The early phase of human sepsis is characterized by a combination of apoptosis and proliferation of T cells. J. Crit. Care 27: 384-393.
    • (2012) J. Crit. Care , vol.27 , pp. 384-393
    • Roger, P.M.1    Hyvernat, H.2    Ticchioni, M.3    Kumar, G.4    Dellamonica, J.5    Bernardin, G.6
  • 19
    • 61449142534 scopus 로고    scopus 로고
    • Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury
    • Unsinger, J., H. Kazama, J. S. McDonough, R. S. Hotchkiss, and T. A. Ferguson. 2009. Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury. J. Leukoc. Biol. 85: 382-390.
    • (2009) J. Leukoc. Biol. , vol.85 , pp. 382-390
    • Unsinger, J.1    Kazama, H.2    Mcdonough, J.S.3    Hotchkiss, R.S.4    Ferguson, T.A.5
  • 21
    • 61449154547 scopus 로고    scopus 로고
    • Immunodesign of experimental sepsis by cecal ligation and puncture
    • Rittirsch, D., M. S. Huber-Lang, M. A. Flierl, and P. A. Ward. 2009. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat. Protoc. 4: 31-36.
    • (2009) Nat. Protoc. , vol.4 , pp. 31-36
    • Rittirsch, D.1    Huber-Lang, M.S.2    Flierl, M.A.3    Ward, P.A.4
  • 22
    • 80755172184 scopus 로고    scopus 로고
    • Opposing signals from the bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells
    • Pepper, M., A. J. Pagán, B. Z. Igyártó, J. J. Taylor, and M. K. Jenkins. 2011. Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity 35: 583-595.
    • (2011) Immunity , vol.35 , pp. 583-595
    • Pepper, M.1    Pagán, A.J.2    Igyártó, B.Z.3    Taylor, J.J.4    Jenkins, M.K.5
  • 24
    • 0028790247 scopus 로고
    • The immune response and the eye. TCR alpha-chain related molecules regulate the systemic immunity to antigen presented in the eye
    • Griffith, T. S., J. M. Herndon, J. Lima, M. Kahn, and T. A. Ferguson. 1995. The immune response and the eye. TCR alpha-chain related molecules regulate the systemic immunity to antigen presented in the eye. Int. Immunol. 7: 1617-1625.
    • (1995) Int. Immunol. , vol.7 , pp. 1617-1625
    • Griffith, T.S.1    Herndon, J.M.2    Lima, J.3    Kahn, M.4    Ferguson, T.A.5
  • 25
    • 80555149840 scopus 로고    scopus 로고
    • The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL
    • Brincks, E. L., P. Gurung, R. A. Langlois, E. A. Hemann, K. L. Legge, and T. S. Griffith. 2011. The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL. J. Immunol. 187: 4581-4588.
    • (2011) J. Immunol. , vol.187 , pp. 4581-4588
    • Brincks, E.L.1    Gurung, P.2    Langlois, R.A.3    Hemann, E.A.4    Legge, K.L.5    Griffith, T.S.6
  • 26
    • 84875469030 scopus 로고    scopus 로고
    • Antigen-specific memory regulatory CD4+Foxp3+ T cells control memory responses to influenza virus infection
    • Brincks, E. L., A. D. Roberts, T. Cookenham, S. Sell, J. E. Kohlmeier, M. A. Blackman, and D. L. Woodland. 2013. Antigen-specific memory regulatory CD4+Foxp3+ T cells control memory responses to influenza virus infection. J. Immunol. 190: 3438-3446.
    • (2013) J. Immunol. , vol.190 , pp. 3438-3446
    • Brincks, E.L.1    Roberts, A.D.2    Cookenham, T.3    Sell, S.4    Kohlmeier, J.E.5    Blackman, M.A.6    Woodland, D.L.7
  • 27
    • 0042890384 scopus 로고    scopus 로고
    • Identification of novel immunodo-minant CD4+ th1-type T-cell peptide epitopes from herpes simplex virus gly-coprotein D that confer protective immunity
    • BenMohamed, L., G. Bertrand, C. D. McNamara, H. Gras-Masse, J. Hammer, S. L. Wechsler, and A. B. Nesburn. 2003. Identification of novel immunodo-minant CD4+ Th1-type T-cell peptide epitopes from herpes simplex virus gly-coprotein D that confer protective immunity. J. Virol. 77: 9463-9473.
    • (2003) J. Virol. , vol.77 , pp. 9463-9473
    • Benmohamed, L.1    Bertrand, G.2    Mcnamara, C.D.3    Gras-Masse, H.4    Hammer, J.5    Wechsler, S.L.6    Nesburn, A.B.7
  • 29
    • 34548038390 scopus 로고    scopus 로고
    • Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude
    • Moon, J. J., H. H. Chu, M. Pepper, S. J. McSorley, S. C. Jameson, R. M. Kedl, and M. K. Jenkins. 2007. Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 27: 203-213.
    • (2007) Immunity , vol.27 , pp. 203-213
    • Moon, J.J.1    Chu, H.H.2    Pepper, M.3    Mcsorley, S.J.4    Jameson, S.C.5    Kedl, R.M.6    Jenkins, M.K.7
  • 30
    • 84866184245 scopus 로고    scopus 로고
    • CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs
    • Pagán, A. J., M. Pepper, H. H. Chu, J. M. Green, and M. K. Jenkins. 2012. CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs. J. Immunol. 189: 2909-2917.
    • (2012) J. Immunol. , vol.189 , pp. 2909-2917
    • Pagán, A.J.1    Pepper, M.2    Chu, H.H.3    Green, J.M.4    Jenkins, M.K.5
  • 31
    • 84874881205 scopus 로고    scopus 로고
    • CD4+ T cell persistence and function after infection are maintained by low-level peptide: MHC class II presentation
    • Nelson, R. W., J. B. McLachlan, J. R. Kurtz, and M. K. Jenkins. 2013. CD4+ T cell persistence and function after infection are maintained by low-level peptide: MHC class II presentation. J. Immunol. 190: 2828-2834.
    • (2013) J. Immunol. , vol.190 , pp. 2828-2834
    • Nelson, R.W.1    Mclachlan, J.B.2    Kurtz, J.R.3    Jenkins, M.K.4
  • 32
    • 78049506131 scopus 로고    scopus 로고
    • Negative selection and peptide chemistry determine the size of naive foreign peptide-MHC class II-specific CD4+ T cell populations
    • Chu, H. H., J. J. Moon, A. C. Kruse, M. Pepper, and M. K. Jenkins. 2010. Negative selection and peptide chemistry determine the size of naive foreign peptide-MHC class II-specific CD4+ T cell populations. J. Immunol. 185: 4705-4713.
    • (2010) J. Immunol. , vol.185 , pp. 4705-4713
    • Chu, H.H.1    Moon, J.J.2    Kruse, A.C.3    Pepper, M.4    Jenkins, M.K.5
  • 33
    • 80052677149 scopus 로고    scopus 로고
    • Immune unresponsiveness to secondary heterologous bacterial infection after sepsis induction is TRAIL dependent
    • Gurung, P., D. Rai, S. A. Condotta, J. C. Babcock, V. P. Badovinac, and T. S. Griffith. 2011. Immune unresponsiveness to secondary heterologous bacterial infection after sepsis induction is TRAIL dependent. J. Immunol. 187: 2148-2154.
    • (2011) J. Immunol. , vol.187 , pp. 2148-2154
    • Gurung, P.1    Rai, D.2    Condotta, S.A.3    Babcock, J.C.4    Badovinac, V.P.5    Griffith, T.S.6
  • 34
    • 84874242998 scopus 로고    scopus 로고
    • Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection
    • Condotta, S. A., D. Rai, B. R. James, T. S. Griffith, and V. P. Badovinac. 2013. Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection. J. Immunol. 190: 1991-2000.
    • (2013) J. Immunol. , vol.190 , pp. 1991-2000
    • Condotta, S.A.1    Rai, D.2    James, B.R.3    Griffith, T.S.4    Badovinac, V.P.5
  • 35
    • 84898609117 scopus 로고    scopus 로고
    • Polymicrobial sepsis alters antigen-dependent and - Independent memory CD8 T cell functions
    • Duong, S., S. A. Condotta, D. Rai, M. D. Martin, T. S. Griffith, and V. P. Badovinac. 2014. Polymicrobial sepsis alters antigen-dependent and - independent memory CD8 T cell functions. J. Immunol. 192: 3618-3625.
    • (2014) J. Immunol. , vol.192 , pp. 3618-3625
    • Duong, S.1    Condotta, S.A.2    Rai, D.3    Martin, M.D.4    Griffith, T.S.5    Badovinac, V.P.6
  • 36
    • 84875489516 scopus 로고    scopus 로고
    • The biology of recent thymic emigrants
    • Fink, P. J. 2013. The biology of recent thymic emigrants. Annu. Rev. Immunol. 31: 31-50.
    • (2013) Annu. Rev. Immunol. , vol.31 , pp. 31-50
    • Fink, P.J.1
  • 37
    • 79956105098 scopus 로고    scopus 로고
    • Normal T cell homeostasis: The conversion of naive cells into memory-phenotype cells
    • Sprent, J., and C. D. Surh. 2011. Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. Nat. Immunol. 12: 478-484.
    • (2011) Nat. Immunol. , vol.12 , pp. 478-484
    • Sprent, J.1    Surh, C.D.2
  • 38
    • 0034698828 scopus 로고    scopus 로고
    • Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells
    • Cho, B. K., V. P. Rao, Q. Ge, H. N. Eisen, and J. Chen. 2000. Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells. J. Exp. Med. 192: 549-556.
    • (2000) J. Exp. Med. , vol.192 , pp. 549-556
    • Cho, B.K.1    Rao, V.P.2    Ge, Q.3    Eisen, H.N.4    Chen, J.5
  • 39
    • 0033180491 scopus 로고    scopus 로고
    • The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
    • Ernst, B., D. S. Lee, J. M. Chang, J. Sprent, and C. D. Surh. 1999. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity 11: 173-181.
    • (1999) Immunity , vol.11 , pp. 173-181
    • Ernst, B.1    Lee, D.S.2    Chang, J.M.3    Sprent, J.4    Surh, C.D.5
  • 40
    • 82755186803 scopus 로고    scopus 로고
    • Quantifying antigen-specific CD4 T cells during a viral infection: CD4 T cell responses are larger than we think
    • McDermott, D. S., and S. M. Varga. 2011. Quantifying antigen-specific CD4 T cells during a viral infection: CD4 T cell responses are larger than we think. J. Immunol. 187: 5568-5576.
    • (2011) J. Immunol. , vol.187 , pp. 5568-5576
    • Mcdermott, D.S.1    Varga, S.M.2
  • 43
    • 0036196669 scopus 로고    scopus 로고
    • Tracking salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection
    • McSorley, S. J., S. Asch, M. Costalonga, R. L. Reinhardt, and M. K. Jenkins. 2002. Tracking Salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection. Immunity 16: 365-377.
    • (2002) Immunity , vol.16 , pp. 365-377
    • Mcsorley, S.J.1    Asch, S.2    Costalonga, M.3    Reinhardt, R.L.4    Jenkins, M.K.5
  • 44
    • 0031975635 scopus 로고    scopus 로고
    • Virus-specific MHC-class II-restricted TCR-transgenic mice: Effects on humoral and cellular immune responses after viral infection
    • Oxenius, A., M. F. Bachmann, R. M. Zinkernagel, and H. Hengartner. 1998. Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur. J. Immunol. 28: 390-400.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 390-400
    • Oxenius, A.1    Bachmann, M.F.2    Zinkernagel, R.M.3    Hengartner, H.4
  • 45
    • 84860346184 scopus 로고    scopus 로고
    • The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude
    • Jenkins, M. K., and J. J. Moon. 2012. The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude. J. Immunol. 188: 4135-4140.
    • (2012) J. Immunol. , vol.188 , pp. 4135-4140
    • Jenkins, M.K.1    Moon, J.J.2
  • 46
    • 33747422092 scopus 로고    scopus 로고
    • Surgical critical care: Fungal infections in surgical patients
    • Lipsett, P. A. 2006. Surgical critical care: fungal infections in surgical patients. Crit. Care Med. 34(9, Suppl.)S215-S224.
    • (2006) Crit. Care Med. , vol.34 , Issue.9 , pp. S215-S224
    • Lipsett, P.A.1
  • 47
    • 82655181554 scopus 로고    scopus 로고
    • Immunology in the clinic review series; focus on host responses: T cell responses to herpes simplex viruses
    • Laing, K. J., L. Dong, J. Sidney, A. Sette, and D. M. Koelle. 2012. Immunology in the Clinic Review Series; focus on host responses: T cell responses to herpes simplex viruses. Clin. Exp. Immunol. 167: 47-58.
    • (2012) Clin. Exp. Immunol. , vol.167 , pp. 47-58
    • Laing, K.J.1    Dong, L.2    Sidney, J.3    Sette, A.4    Koelle, D.M.5
  • 49
    • 84856574224 scopus 로고    scopus 로고
    • Population dynamics of naive and memory CD8 T cell responses after antigen stimulations in vivo
    • Martin, M. D., S. A. Condotta, J. T. Harty, and V. P. Badovinac. 2012. Population dynamics of naive and memory CD8 T cell responses after antigen stimulations in vivo. J. Immunol. 188: 1255-1265.
    • (2012) J. Immunol. , vol.188 , pp. 1255-1265
    • Martin, M.D.1    Condotta, S.A.2    Harty, J.T.3    Badovinac, V.P.4
  • 50
    • 84861162719 scopus 로고    scopus 로고
    • Th17 cells in immunity to candida albicans
    • Hernández-Santos, N., and S. L. Gaffen. 2012. Th17 cells in immunity to Candida albicans. Cell Host Microbe 11: 425-435.
    • (2012) Cell Host Microbe , vol.11 , pp. 425-435
    • Hernández-Santos, N.1    Gaffen, S.L.2
  • 53
    • 84860174876 scopus 로고    scopus 로고
    • Spurious inferences about long-term outcomes: The case of severe sepsis and geriatric conditions
    • Iwashyna, T. J., G. Netzer, K. M. Langa, and C. Cigolle. 2012. Spurious inferences about long-term outcomes: the case of severe sepsis and geriatric conditions. Am. J. Respir. Crit. Care Med. 185: 835-841.
    • (2012) Am. J. Respir. Crit. Care Med. , vol.185 , pp. 835-841
    • Iwashyna, T.J.1    Netzer, G.2    Langa, K.M.3    Cigolle, C.4
  • 55
    • 33750288937 scopus 로고    scopus 로고
    • Apoptosis and caspases regulate death and inflammation in sepsis
    • Hotchkiss, R. S., and D. W. Nicholson. 2006. Apoptosis and caspases regulate death and inflammation in sepsis. Nat. Rev. Immunol. 6: 813-822.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 813-822
    • Hotchkiss, R.S.1    Nicholson, D.W.2
  • 56
    • 34250175093 scopus 로고    scopus 로고
    • Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection
    • Badovinac, V. P., J. S. Haring, and J. T. Harty. 2007. Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection. Immunity 26: 827-841.
    • (2007) Immunity , vol.26 , pp. 827-841
    • Badovinac, V.P.1    Haring, J.S.2    Harty, J.T.3
  • 57
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • Mazmanian, S. K., C. H. Liu, A. O. Tzianabos, and D. L. Kasper. 2005. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122: 107-118.
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1    Liu, C.H.2    Tzianabos, A.O.3    Kasper, D.L.4
  • 58
    • 84862276328 scopus 로고    scopus 로고
    • Structure, function and diversity of the healthy human microbiome
    • Human Microbiome Project Consortium. 2012. Structure, function and diversity of the healthy human microbiome. Nature 486: 207-214.
    • (2012) Nature , vol.486 , pp. 207-214
  • 60
    • 57449097558 scopus 로고    scopus 로고
    • Homeostasis of naive and memory T cells
    • Surh, C. D., and J. Sprent. 2008. Homeostasis of naive and memory T cells. Immunity 29: 848-862.
    • (2008) Immunity , vol.29 , pp. 848-862
    • Surh, C.D.1    Sprent, J.2
  • 61
    • 70249143637 scopus 로고    scopus 로고
    • Homeostatic proliferation and survival of naïve and memory T cells
    • Boyman, O., S. Létourneau, C. Krieg, and J. Sprent. 2009. Homeostatic proliferation and survival of naïve and memory T cells. Eur. J. Immunol. 39: 2088-2094.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 2088-2094
    • Boyman, O.1    Létourneau, S.2    Krieg, C.3    Sprent, J.4
  • 65
    • 84873478163 scopus 로고    scopus 로고
    • Blockade of programmed death receptor-1 signaling restores expression of mostly proin-flammatory cytokines in anergic cytomegalovirus-specific T cells
    • Dirks, J., A. Egli, U. Sester, M. Sester, and H. H. Hirsch. 2013. Blockade of programmed death receptor-1 signaling restores expression of mostly proin-flammatory cytokines in anergic cytomegalovirus-specific T cells. Transpl. Infect. Dis. 15: 79-89.
    • (2013) Transpl. Infect. Dis. , vol.15 , pp. 79-89
    • Dirks, J.1    Egli, A.2    Sester, U.3    Sester, M.4    Hirsch, H.H.5
  • 67
    • 79959716811 scopus 로고    scopus 로고
    • Dose-dependent effect of anti-CTLA-4 on survival in sepsis
    • Inoue, S., L. Bo, J. Bian, J. Unsinger, K. Chang, and R. S. Hotchkiss. 2011. Dose-dependent effect of anti-CTLA-4 on survival in sepsis. Shock 36: 38-44.
    • (2011) Shock , vol.36 , pp. 38-44
    • Inoue, S.1    Bo, L.2    Bian, J.3    Unsinger, J.4    Chang, K.5    Hotchkiss, R.S.6
  • 68
    • 77956403940 scopus 로고    scopus 로고
    • Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis
    • Brahmamdam, P., S. Inoue, J. Unsinger, K. C. Chang, J. E. McDunn, and R. S. Hotchkiss. 2010. Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis. J. Leukoc. Biol. 88: 233-240.
    • (2010) J. Leukoc. Biol. , vol.88 , pp. 233-240
    • Brahmamdam, P.1    Inoue, S.2    Unsinger, J.3    Chang, K.C.4    Mcdunn, J.E.5    Hotchkiss, R.S.6
  • 69
    • 78649460067 scopus 로고    scopus 로고
    • PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction
    • Zhang, Y., Y. Zhou, J. Lou, J. Li, L. Bo, K. Zhu, X. Wan, X. Deng, and Z. Cai. 2010. PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction. Crit. Care 14: R220.
    • (2010) Crit. Care , vol.14 , pp. R220
    • Zhang, Y.1    Zhou, Y.2    Lou, J.3    Li, J.4    Bo, L.5    Zhu, K.6    Wan, X.7    Deng, X.8    Cai, Z.9
  • 70
    • 0028918570 scopus 로고
    • Poliovirus-specific CD4+ th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor
    • Mahon, B. P., K. Katrak, A. Nomoto, A. J. Macadam, P. D. Minor, and K. H. Mills. 1995. Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor. J. Exp. Med. 181: 1285-1292.
    • (1995) J. Exp. Med. , vol.181 , pp. 1285-1292
    • Mahon, B.P.1    Katrak, K.2    Nomoto, A.3    Macadam, A.J.4    Minor, P.D.5    Mills, K.H.6
  • 72
    • 80053917022 scopus 로고    scopus 로고
    • Protective contributions against invasive streptococcus pneumoniae pneumonia of antibody and th17-cell responses to nasopharyngeal colonisation
    • Cohen, J. M., S. Khandavilli, E. Camberlein, C. Hyams, H. E. Baxendale, and J. S. Brown. 2011. Protective contributions against invasive Streptococcus pneumoniae pneumonia of antibody and Th17-cell responses to nasopharyngeal colonisation. PLoS ONE 6: e25558.
    • (2011) PLoS ONE , vol.6
    • Cohen, J.M.1    Khandavilli, S.2    Camberlein, E.3    Hyams, C.4    Baxendale, H.E.5    Brown, J.S.6
  • 74
    • 84885171783 scopus 로고    scopus 로고
    • Increased proportion of CD4(+)CD25(+)Foxp3(+) regulatory T cells during early-stage sepsis in ICU patients
    • Leng, F. Y., J. L. Liu, Z. J. Liu, J. Y. Yin, and H. P. Qu. 2013. Increased proportion of CD4(+)CD25(+)Foxp3(+) regulatory T cells during early-stage sepsis in ICU patients. J. Microbiol. Immunol. Infect. 46: 338-344.
    • (2013) J. Microbiol. Immunol. Infect. , vol.46 , pp. 338-344
    • Leng, F.Y.1    Liu, J.L.2    Liu, Z.J.3    Yin, J.Y.4    Qu, H.P.5
  • 75
    • 0041365362 scopus 로고    scopus 로고
    • Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis
    • Monneret, G., A. L. Debard, F. Venet, J. Bohe, O. Hequet, J. Bienvenu, and A. Lepape. 2003. Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis. Crit. Care Med. 31: 2068-2071.
    • (2003) Crit. Care Med. , vol.31 , pp. 2068-2071
    • Monneret, G.1    Debard, A.L.2    Venet, F.3    Bohe, J.4    Hequet, O.5    Bienvenu, J.6    Lepape, A.7
  • 76
    • 8544236263 scopus 로고    scopus 로고
    • Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25- lymphocytes
    • Venet, F., A. Pachot, A. L. Debard, J. Bohé, J. Bienvenu, A. Lepape, and G. Monneret. 2004. Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25- lymphocytes. Crit. Care Med. 32: 2329-2331.
    • (2004) Crit. Care Med. , vol.32 , pp. 2329-2331
    • Venet, F.1    Pachot, A.2    Debard, A.L.3    Bohé, J.4    Bienvenu, J.5    Lepape, A.6    Monneret, G.7
  • 77
    • 18244376372 scopus 로고    scopus 로고
    • Reversal of long-term sepsis-induced immunosuppression by dendritic cells
    • Benjamim, C. F., S. K. Lundy, N. W. Lukacs, C. M. Hogaboam, and S. L. Kunkel. 2005. Reversal of long-term sepsis-induced immunosuppression by dendritic cells. Blood 105: 3588-3595.
    • (2005) Blood , vol.105 , pp. 3588-3595
    • Benjamim, C.F.1    Lundy, S.K.2    Lukacs, N.W.3    Hogaboam, C.M.4    Kunkel, S.L.5
  • 78
    • 29744470619 scopus 로고    scopus 로고
    • Antigen presenting cells (APCs) from thermally injured and/or septic rats modulate CD4+ T cell responses of naive rat
    • Fazal, N., S. Raziuddin, M. Khan, and W. M. Al-Ghoul. 2006. Antigen presenting cells (APCs) from thermally injured and/or septic rats modulate CD4+ T cell responses of naive rat. Biochim. Biophys. Acta 1762: 46-53.
    • (2006) Biochim. Biophys. Acta , vol.1762 , pp. 46-53
    • Fazal, N.1    Raziuddin, S.2    Khan, M.3    Al-Ghoul, W.M.4
  • 79
    • 33646087221 scopus 로고    scopus 로고
    • Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective th1-type immune response
    • Flohé, S. B., H. Agrawal, D. Schmitz, M. Gertz, S. Flohé, and F. U. Schade. 2006. Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1-type immune response. J. Leukoc. Biol. 79: 473-481.
    • (2006) J. Leukoc. Biol. , vol.79 , pp. 473-481
    • Flohé, S.B.1    Agrawal, H.2    Schmitz, D.3    Gertz, M.4    Flohé, S.5    Schade, F.U.6
  • 80
    • 33751231090 scopus 로고    scopus 로고
    • Pneumonia after cecal ligation and puncture: A clinically relevant "two-hit" model of sepsis
    • Muenzer, J. T., C. G. Davis, B. S. Dunne, J. Unsinger, W. M. Dunne, and R. S. Hotchkiss. 2006. Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis. Shock 26: 565-570.
    • (2006) Shock , vol.26 , pp. 565-570
    • Muenzer, J.T.1    Davis, C.G.2    Dunne, B.S.3    Unsinger, J.4    Dunne, W.M.5    Hotchkiss, R.S.6
  • 81
    • 78650211572 scopus 로고    scopus 로고
    • New perspectives on immunomodulatory therapy for bacter-aemia and sepsis
    • Opal, S. M. 2010. New perspectives on immunomodulatory therapy for bacter-aemia and sepsis. Int. J. Antimicrob. Agents 36(Suppl. 2): S70-S73.
    • (2010) Int. J. Antimicrob. Agents , vol.36 , pp. S70-S73
    • Opal, S.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.