메뉴 건너뛰기




Volumn 9, Issue 6, 2011, Pages 451-462

Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites

Author keywords

[No Author keywords available]

Indexed keywords

GENETICALLY ATTENUATED PARASITE VACCINE; MALARIA VACCINE; RADIATION ATTENUATED SPOROZOITE VACCINE; SPOROZOITE VACCINE; UNCLASSIFIED DRUG;

EID: 79958717556     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2011.05.008     Document Type: Article
Times cited : (193)

References (56)
  • 1
    • 78149488576 scopus 로고    scopus 로고
    • Safety, immunogenicity and duration of protection of the RTS,S/AS02(D) malaria vaccine: One year follow-up of a randomized controlled phase I/IIb trial
    • Aide, P., Aponte, J.J., Renom, M., Nhampossa, T., Sacarlal, J., Mandomando, I., Bassat, Q., Manaca, M.N., Leach, A., Lievens, M., et al. (2010). Safety, immunogenicity and duration of protection of the RTS,S/AS02(D) malaria vaccine: one year follow-up of a randomized controlled phase I/IIb trial. PLoS ONE 5, e13838.
    • (2010) PLoS ONE , vol.5
    • Aide, P.1    Aponte, J.J.2    Renom, M.3    Nhampossa, T.4    Sacarlal, J.5    Mandomando, I.6    Bassat, Q.7    Manaca, M.N.8    Leach, A.9    Lievens, M.10
  • 2
    • 45149123776 scopus 로고    scopus 로고
    • Targeted deletion of SAP1 abolishes the expression of infectivity factors necessary for successful malaria parasite liver infection
    • Aly, A.S., Mikolajczak, S.A., Rivera, H.S., Camargo, N., Jacobs-Lorena, V., Labaied, M., Coppens, I., and Kappe, S.H. (2008). Targeted deletion of SAP1 abolishes the expression of infectivity factors necessary for successful malaria parasite liver infection. Mol. Microbiol. 69, 152-163.
    • (2008) Mol. Microbiol. , vol.69 , pp. 152-163
    • Aly, A.S.1    Mikolajczak, S.A.2    Rivera, H.S.3    Camargo, N.4    Jacobs-Lorena, V.5    Labaied, M.6    Coppens, I.7    Kappe, S.H.8
  • 3
    • 58849104986 scopus 로고    scopus 로고
    • Vaccination with live Plasmodium yoelii blood stage parasites under chloroquine cover induces cross-stage immunity against malaria liver stage
    • Belnoue, E., Voza, T., Costa, F.T., Grüner, A.C., Mauduit, M., Rosa, D.S., Depinay, N., Kayibanda, M., Vigário, A.M., Mazier, D., et al. (2008). Vaccination with live Plasmodium yoelii blood stage parasites under chloroquine cover induces cross-stage immunity against malaria liver stage. J. Immunol. 181, 8552-8558.
    • (2008) J. Immunol. , vol.181 , pp. 8552-8558
    • Belnoue, E.1    Voza, T.2    Costa, F.T.3    Grüner, A.C.4    Mauduit, M.5    Rosa, D.S.6    Depinay, N.7    Kayibanda, M.8    Vigário, A.M.9    Mazier, D.10
  • 5
    • 77951758823 scopus 로고    scopus 로고
    • Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites
    • Butler, N.S., Schmidt, N.W., and Harty, J.T. (2010). Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites. J. Immunol. 184, 2528-2538.
    • (2010) J. Immunol. , vol.184 , pp. 2528-2538
    • Butler, N.S.1    Schmidt, N.W.2    Harty, J.T.3
  • 6
    • 34548276242 scopus 로고    scopus 로고
    • CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes
    • Chakravarty, S., Cockburn, I.A., Kuk, S., Overstreet, M.G., Sacci, J.B., and Zavala, F. (2007). CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes. Nat. Med. 13, 1035-1041.
    • (2007) Nat. Med. , vol.13 , pp. 1035-1041
    • Chakravarty, S.1    Cockburn, I.A.2    Kuk, S.3    Overstreet, M.G.4    Sacci, J.B.5    Zavala, F.6
  • 7
    • 67349154444 scopus 로고    scopus 로고
    • The Effects of radiation on the safety and protective efficacy of an attenuated Plasmodium yoelii sporozoite malaria vaccine
    • Chattopadhyay, R., Conteh, S., Li, M., James, E.R., Epstein, J.E., and Hoffman, S.L. (2009). The Effects of radiation on the safety and protective efficacy of an attenuated Plasmodium yoelii sporozoite malaria vaccine. Vaccine 27, 3675-3680.
    • (2009) Vaccine , vol.27 , pp. 3675-3680
    • Chattopadhyay, R.1    Conteh, S.2    Li, M.3    James, E.R.4    Epstein, J.E.5    Hoffman, S.L.6
  • 8
    • 0016740645 scopus 로고
    • Immunization of man against falciparum and vivax malaria by use of attenuated sporozoites
    • Clyde, D.F. (1975). Immunization of man against falciparum and vivax malaria by use of attenuated sporozoites. Am. J. Trop. Med. Hyg. 24, 397-401.
    • (1975) Am. J. Trop. Med. Hyg. , vol.24 , pp. 397-401
    • Clyde, D.F.1
  • 9
    • 77954051261 scopus 로고    scopus 로고
    • Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites
    • Cockburn, I.A., Chen, Y.C., Overstreet, M.G., Lees, J.R., van Rooijen, N., Farber, D.L., and Zavala, F. (2010). Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites. PLoS Pathog. 6, e1000877.
    • (2010) PLoS Pathog. , vol.6
    • Cockburn, I.A.1    Chen, Y.C.2    Overstreet, M.G.3    Lees, J.R.4    Van Rooijen, N.5    Farber, D.L.6    Zavala, F.7
  • 10
    • 78149466710 scopus 로고    scopus 로고
    • The malaria vaccine candidate RTS,S/AS is in phase III clinical trials
    • Cohen, J., Benns, S., Vekemans, J., and Leach, A. (2010). The malaria vaccine candidate RTS,S/AS is in phase III clinical trials. Ann. Pharm. Fr. 68, 370-379.
    • (2010) Ann. Pharm. Fr. , vol.68 , pp. 370-379
    • Cohen, J.1    Benns, S.2    Vekemans, J.3    Leach, A.4
  • 11
    • 78649838978 scopus 로고    scopus 로고
    • Advances and challenges in malaria vaccine development
    • Crompton, P.D., Pierce, S.K., and Miller, L.H. (2010). Advances and challenges in malaria vaccine development. J. Clin. Invest. 120, 4168-4178.
    • (2010) J. Clin. Invest. , vol.120 , pp. 4168-4178
    • Crompton, P.D.1    Pierce, S.K.2    Miller, L.H.3
  • 12
    • 0034254649 scopus 로고    scopus 로고
    • The complexity of protective immunity against liver-stage malaria
    • Doolan, D.L., and Hoffman, S.L. (2000). The complexity of protective immunity against liver-stage malaria. J. Immunol. 165, 1453-1462. (Pubitemid 30604578)
    • (2000) Journal of Immunology , vol.165 , Issue.3 , pp. 1453-1462
    • Doolan, D.L.1    Hoffman, S.L.2
  • 14
    • 58249090958 scopus 로고    scopus 로고
    • Recombinant viral vaccines expressing merozoite surface protein-1 induce antibody- And T cell-mediated multistage protection against malaria
    • Draper, S.J., Goodman, A.L., Biswas, S., Forbes, E.K., Moore, A.C., Gilbert, S.C., and Hill, A.V. (2009). Recombinant viral vaccines expressing merozoite surface protein-1 induce antibody- and T cell-mediated multistage protection against malaria. Cell Host Microbe 5, 95-105.
    • (2009) Cell Host Microbe , vol.5 , pp. 95-105
    • Draper, S.J.1    Goodman, A.L.2    Biswas, S.3    Forbes, E.K.4    Moore, A.C.5    Gilbert, S.C.6    Hill, A.V.7
  • 15
    • 0035525357 scopus 로고    scopus 로고
    • Towards a blood-stage vaccine for malaria: Are we following all the leads?
    • Good, M.F. (2001). Towards a blood-stage vaccine for malaria: are we following all the leads? Nat. Rev. Immunol. 1, 117-125.
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 117-125
    • Good, M.F.1
  • 16
    • 77958482582 scopus 로고    scopus 로고
    • Malaria vaccine design: Immunological considerations
    • Good, M.F., and Doolan, D.L. (2010). Malaria vaccine design: immunological considerations. Immunity 33, 555-566.
    • (2010) Immunity , vol.33 , pp. 555-566
    • Good, M.F.1    Doolan, D.L.2
  • 17
    • 78751704914 scopus 로고    scopus 로고
    • Immunological correlates of protection for the RTS,S candidate malaria vaccine
    • Greenwood, B. (2011). Immunological correlates of protection for the RTS,S candidate malaria vaccine. Lancet Infect. Dis. 11, 75-76.
    • (2011) Lancet Infect. Dis. , vol.11 , pp. 75-76
    • Greenwood, B.1
  • 19
    • 0035479044 scopus 로고    scopus 로고
    • Expression of the erythrocyte-binding antigen 175 in sporozoites and in liver stages of Plasmodium falciparum
    • Grüner, A.C., Brahimi, K., Letourneur, F., Rénia, L., Eling, W., Snounou, G., and Druilhe, P. (2001b). Expression of the erythrocyte-binding antigen 175 in sporozoites and in liver stages of Plasmodium falciparum. J. Infect. Dis. 184, 892-897.
    • (2001) J. Infect. Dis. , vol.184 , pp. 892-897
    • Grüner, A.C.1    Brahimi, K.2    Letourneur, F.3    Rénia, L.4    Eling, W.5    Snounou, G.6    Druilhe, P.7
  • 20
    • 33644863805 scopus 로고    scopus 로고
    • Protective and pathogenic roles of CD8+ T cells during malaria infection
    • Hafalla, J.C., Cockburn, I.A., and Zavala, F. (2006). Protective and pathogenic roles of CD8+ T cells during malaria infection. Parasite Immunol. 28, 15-24.
    • (2006) Parasite Immunol. , vol.28 , pp. 15-24
    • Hafalla, J.C.1    Cockburn, I.A.2    Zavala, F.3
  • 23
    • 77951051594 scopus 로고    scopus 로고
    • Involvement of CD8+ T cells in protective immunity against murine blood-stage infection with Plasmodium yoelii 17XL strain
    • Imai, T., Shen, J., Chou, B., Duan, X., Tu, L., Tetsutani, K., Moriya, C., Ishida, H., Hamano, S., Shimokawa, C., et al. (2010). Involvement of CD8+ T cells in protective immunity against murine blood-stage infection with Plasmodium yoelii 17XL strain. Eur. J. Immunol. 40, 1053-1061.
    • (2010) Eur. J. Immunol. , vol.40 , pp. 1053-1061
    • Imai, T.1    Shen, J.2    Chou, B.3    Duan, X.4    Tu, L.5    Tetsutani, K.6    Moriya, C.7    Ishida, H.8    Hamano, S.9    Shimokawa, C.10
  • 24
    • 34547614313 scopus 로고    scopus 로고
    • Genetically attenuated Plasmodium berghei liver stages induce sterile protracted protection that is mediated by major histocompatibility complex Class I-dependent interferon-gamma-producing CD8+ T cells
    • Jobe, O., Lumsden, J., Mueller, A.K., Williams, J., Silva-Rivera, H., Kappe, S.H., Schwenk, R.J., Matuschewski, K., and Krzych, U. (2007). Genetically attenuated Plasmodium berghei liver stages induce sterile protracted protection that is mediated by major histocompatibility complex Class I-dependent interferon-gamma-producing CD8+ T cells. J. Infect. Dis. 196, 599-607.
    • (2007) J. Infect. Dis. , vol.196 , pp. 599-607
    • Jobe, O.1    Lumsden, J.2    Mueller, A.K.3    Williams, J.4    Silva-Rivera, H.5    Kappe, S.H.6    Schwenk, R.J.7    Matuschewski, K.8    Krzych, U.9
  • 25
    • 0037074012 scopus 로고    scopus 로고
    • Molecular and functional profiling of memory CD8 T cell differentiation
    • DOI 10.1016/S0092-8674(02)01139-X
    • Kaech, S.M., Hemby, S., Kersh, E., and Ahmed, R. (2002). Molecular and functional profiling of memory CD8 T cell differentiation. Cell 111, 837-851. (Pubitemid 36106405)
    • (2002) Cell , vol.111 , Issue.6 , pp. 837-851
    • Kaech, S.M.1    Hemby, S.2    Kersh, E.3    Ahmed, R.4
  • 26
    • 77952382039 scopus 로고    scopus 로고
    • That was then but this is now: Malaria research in the time of an eradication agenda
    • Kappe, S.H., Vaughan, A.M., Boddey, J.A., and Cowman, A.F. (2010). That was then but this is now: malaria research in the time of an eradication agenda. Science 328, 862-866.
    • (2010) Science , vol.328 , pp. 862-866
    • Kappe, S.H.1    Vaughan, A.M.2    Boddey, J.A.3    Cowman, A.F.4
  • 27
    • 0016826346 scopus 로고
    • Intramuscular immunization of mice with irradiated Plasmodium berghei sporozoites. Enhancement of protection with albumin
    • Kramer, L.D., and Vanderberg, J.P. (1975). Intramuscular immunization of mice with irradiated Plasmodium berghei sporozoites. Enhancement of protection with albumin. Am. J. Trop. Med. Hyg. 24, 913-916.
    • (1975) Am. J. Trop. Med. Hyg. , vol.24 , pp. 913-916
    • Kramer, L.D.1    Vanderberg, J.P.2
  • 28
    • 25644456717 scopus 로고    scopus 로고
    • The dissection of CD8 T cells during liverstage infection
    • Krzych, U., and Schwenk, J. (2005). The dissection of CD8 T cells during liverstage infection. Curr. Top. Microbiol. Immunol. 297, 1-24.
    • (2005) Curr. Top. Microbiol. Immunol. , vol.297 , pp. 1-24
    • Krzych, U.1    Schwenk, J.2
  • 29
    • 84887212463 scopus 로고    scopus 로고
    • Conserved protective mechanisms in radiation and genetically attenuated uis3(-) and uis4(-) Plasmodium sporozoites
    • Kumar, K.A., Baxter, P., Tarun, A.S., Kappe, S.H., and Nussenzweig, V. (2009). Conserved protective mechanisms in radiation and genetically attenuated uis3(-) and uis4(-) Plasmodium sporozoites. PLoS ONE 4, e4480.
    • (2009) PLoS ONE , vol.4
    • Kumar, K.A.1    Baxter, P.2    Tarun, A.S.3    Kappe, S.H.4    Nussenzweig, V.5
  • 30
    • 34547621806 scopus 로고    scopus 로고
    • Plasmodium yoelii sporozoites with simultaneous deletion of P52 and P36 are completely attenuated and confer sterile immunity against infection
    • Labaied, M., Harupa, A., Dumpit, R.F., Coppens, I., Mikolajczak, S.A., and Kappe, S.H. (2007). Plasmodium yoelii sporozoites with simultaneous deletion of P52 and P36 are completely attenuated and confer sterile immunity against infection. Infect. Immun. 75, 3758-3768.
    • (2007) Infect. Immun. , vol.75 , pp. 3758-3768
    • Labaied, M.1    Harupa, A.2    Dumpit, R.F.3    Coppens, I.4    Mikolajczak, S.A.5    Kappe, S.H.6
  • 33
    • 12744278200 scopus 로고    scopus 로고
    • Genetically modified Plasmodium parasites as a protective experimental malaria vaccine
    • Mueller, A.K., Labaied, M., Kappe, S.H., and Matuschewski, K. (2005b). Genetically modified Plasmodium parasites as a protective experimental malaria vaccine. Nature 433, 164-167.
    • (2005) Nature , vol.433 , pp. 164-167
    • Mueller, A.K.1    Labaied, M.2    Kappe, S.H.3    Matuschewski, K.4
  • 34
    • 0014202885 scopus 로고
    • Protective immunity produced by the injection of x-irradiated sporozoites of plasmodium berghei
    • Nussenzweig, R.S., Vanderberg, J., Most, H., and Orton, C. (1967). Protective immunity produced by the injection of x-irradiated sporozoites of plasmodium berghei. Nature 216, 160-162.
    • (1967) Nature , vol.216 , pp. 160-162
    • Nussenzweig, R.S.1    Vanderberg, J.2    Most, H.3    Orton, C.4
  • 35
    • 52049105157 scopus 로고    scopus 로고
    • Protective CD8 T cells against Plasmodium liver stages: Immunobiology of an 'unnatural' immune response
    • Overstreet, M.G., Cockburn, I.A., Chen, Y.C., and Zavala, F. (2008). Protective CD8 T cells against Plasmodium liver stages: immunobiology of an 'unnatural' immune response. Immunol. Rev. 225, 272-283.
    • (2008) Immunol. Rev. , vol.225 , pp. 272-283
    • Overstreet, M.G.1    Cockburn, I.A.2    Chen, Y.C.3    Zavala, F.4
  • 36
    • 76449090046 scopus 로고    scopus 로고
    • Plasmodium pyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection
    • Pei, Y., Tarun, A.S., Vaughan, A.M., Herman, R.W., Soliman, J.M., Erickson- Wayman, A., and Kappe, S.H. (2010). Plasmodium pyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection. Mol. Microbiol. 75, 957-971.
    • (2010) Mol. Microbiol. , vol.75 , pp. 957-971
    • Pei, Y.1    Tarun, A.S.2    Vaughan, A.M.3    Herman, R.W.4    Soliman, J.M.5    Erickson-Wayman, A.6    Kappe, S.H.7
  • 38
    • 50249103780 scopus 로고    scopus 로고
    • Chemically attenuated Plasmodium sporozoites induce specific immune responses, sterile immunity and cross-protection against heterologous challenge
    • Purcell, L.A., Wong, K.A., Yanow, S.K., Lee, M., Spithill, T.W., and Rodriguez, A. (2008). Chemically attenuated Plasmodium sporozoites induce specific immune responses, sterile immunity and cross-protection against heterologous challenge. Vaccine 26, 4880-4884.
    • (2008) Vaccine , vol.26 , pp. 4880-4884
    • Purcell, L.A.1    Wong, K.A.2    Yanow, S.K.3    Lee, M.4    Spithill, T.W.5    Rodriguez, A.6
  • 39
    • 76249117468 scopus 로고    scopus 로고
    • Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts
    • Rai, D., Pham, N.L., Harty, J.T., and Badovinac, V.P. (2009). Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts. J. Immunol. 183, 7672-7681.
    • (2009) J. Immunol. , vol.183 , pp. 7672-7681
    • Rai, D.1    Pham, N.L.2    Harty, J.T.3    Badovinac, V.P.4
  • 40
    • 1842374388 scopus 로고    scopus 로고
    • Immunization with a recombinant C-terminal fragment of Plasmodium yoelii merozoite surface protein 1 protects mice against homologous but not heterologous P. yoelii sporozoite challenge
    • Rénia, L., Ling, I.T., Marussig, M., Miltgen, F., Holder, A.A., and Mazier, D. (1997). Immunization with a recombinant C-terminal fragment of Plasmodium yoelii merozoite surface protein 1 protects mice against homologous but not heterologous P. yoelii sporozoite challenge. Infect. Immun. 65, 4419-4423.
    • (1997) Infect. Immun. , vol.65 , pp. 4419-4423
    • Rénia, L.1    Ling, I.T.2    Marussig, M.3    Miltgen, F.4    Holder, A.A.5    Mazier, D.6
  • 41
    • 0023741661 scopus 로고
    • A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite
    • Robson, K.J., Hall, J.R., Jennings, M.W., Harris, T.J., Marsh, K., Newbold, C.I., Tate, V.E., and Weatherall, D.J. (1988). A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite. Nature 335, 79-82.
    • (1988) Nature , vol.335 , pp. 79-82
    • Robson, K.J.1    Hall, J.R.2    Jennings, M.W.3    Harris, T.J.4    Marsh, K.5    Newbold, C.I.6    Tate, V.E.7    Weatherall, D.J.8
  • 42
    • 77957659569 scopus 로고    scopus 로고
    • Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites
    • Schmidt, N.W., Butler, N.S., Badovinac, V.P., and Harty, J.T. (2010). Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites. PLoS Pathog. 6, e1000998.
    • (2010) PLoS Pathog. , vol.6
    • Schmidt, N.W.1    Butler, N.S.2    Badovinac, V.P.3    Harty, J.T.4
  • 43
    • 35349028384 scopus 로고    scopus 로고
    • Cross-protection between attenuated Plasmodium berghei and P. yoelii sporozoites
    • DOI 10.1111/j.1365-3024.2007.00976.x
    • Sedegah, M., Weiss, W.W., and Hoffman, S.L. (2007). Cross-protection between attenuated Plasmodium berghei and P. yoelii sporozoites. Parasite Immunol. 29, 559-565. (Pubitemid 47609632)
    • (2007) Parasite Immunology , vol.29 , Issue.11 , pp. 559-565
    • Sedegah, M.1    Weiss, W.W.2    Hoffman, S.L.3
  • 45
    • 68949117521 scopus 로고    scopus 로고
    • Antigens for pre-erythrocytic malaria vaccines: Building on success
    • Speake, C., and Duffy, P.E. (2009). Antigens for pre-erythrocytic malaria vaccines: building on success. Parasite Immunol. 31, 539-546.
    • (2009) Parasite Immunol. , vol.31 , pp. 539-546
    • Speake, C.1    Duffy, P.E.2
  • 47
    • 34547624361 scopus 로고    scopus 로고
    • Protracted sterile protection with Plasmodium yoelii pre-erythrocytic genetically attenuated parasite malaria vaccines is independent of significant liver-stage persistence and is mediated by CD8+ T cells
    • Tarun, A.S., Dumpit, R.F., Camargo, N., Labaied, M., Liu, P., Takagi, A., Wang, R., and Kappe, S.H. (2007). Protracted sterile protection with Plasmodium yoelii pre-erythrocytic genetically attenuated parasite malaria vaccines is independent of significant liver-stage persistence and is mediated by CD8+ T cells. J. Infect. Dis. 196, 608-616.
    • (2007) J. Infect. Dis. , vol.196 , pp. 608-616
    • Tarun, A.S.1    Dumpit, R.F.2    Camargo, N.3    Labaied, M.4    Liu, P.5    Takagi, A.6    Wang, R.7    Kappe, S.H.8
  • 49
    • 77956248922 scopus 로고    scopus 로고
    • Regulation of immunity to Plasmodium: Implications from mouse models for blood stage malaria vaccine design
    • Taylor-Robinson, A.W. (2010). Regulation of immunity to Plasmodium: implications from mouse models for blood stage malaria vaccine design. Exp. Parasitol. 126, 406-414.
    • (2010) Exp. Parasitol. , vol.126 , pp. 406-414
    • Taylor-Robinson, A.W.1
  • 50
    • 77956239656 scopus 로고    scopus 로고
    • A retrospective evaluation of the role of T cells in the development of malaria vaccine
    • Tsuji, M. (2010). A retrospective evaluation of the role of T cells in the development of malaria vaccine. Exp. Parasitol. 126, 421-425.
    • (2010) Exp. Parasitol. , vol.126 , pp. 421-425
    • Tsuji, M.1
  • 54
    • 78650062837 scopus 로고    scopus 로고
    • Intradermal immunization of mice with radiation-attenuated sporozoites of Plasmodium yoelii induces effective protective immunity
    • Voza, T., Kebaier, C., and Vanderberg, J.P. (2010). Intradermal immunization of mice with radiation-attenuated sporozoites of Plasmodium yoelii induces effective protective immunity. Malar. J. 9, 362.
    • (2010) Malar. J. , vol.9 , pp. 362
    • Voza, T.1    Kebaier, C.2    Vanderberg, J.P.3
  • 55
    • 0026675372 scopus 로고
    • A T cell clone directed at the circumsporozoite protein which protects mice against both Plasmodium yoelii and Plasmodium berghei
    • Weiss, W.R., Berzofsky, J.A., Houghten, R.A., Sedegah, M., Hollindale, M., and Hoffman, S.L. (1992). A T cell clone directed at the circumsporozoite protein which protects mice against both Plasmodium yoelii and Plasmodium berghei. J. Immunol. 149, 2103-2109.
    • (1992) J. Immunol. , vol.149 , pp. 2103-2109
    • Weiss, W.R.1    Berzofsky, J.A.2    Houghten, R.A.3    Sedegah, M.4    Hollindale, M.5    Hoffman, S.L.6
  • 56
    • 79952193925 scopus 로고    scopus 로고
    • World Health Organization (WHO). (2010). World malaria report 2010. (http://www.who.int/malaria/world-malaria-report-2010/en/index.html).
    • (2010) World Malaria Report 2010


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.