Structural insights on cholesterol endosynthesis: Binding of squalene and 2,3-oxidosqualene to supernatant protein factor

Journal of Structural Biology

Volumn 190, Issue 3, 2015, Pages 261-270

  Christen, Monika ^a   Marcaida, Maria J ^b   Lamprakis, Christos ^a   Aeschimann, Walter ^a   Vaithilingam, Jathana ^a   Schneider, Petra ^c   Hilbert, Manuel ^d   Schneider, Gisbert ^c   Cascella, Michele ^e   Stocker, Achim ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b EPFL   (Switzerland)

^c ETH ZURICH   (Switzerland)

^d PAUL SCHERRER INSTITUTE   (Switzerland)

^e UNIVERSITY OF OSLO   (Norway)

Author keywords

Cholesterol biosynthesis; CRAL TRIO; Free energy perturbation; Lipid binding; SEC 14 like

Indexed keywords

LANOSTEROL SYNTHASE; LIPID TRANSFER PROTEIN; SQUALENE; SUPERNATANT PROTEIN FACTOR; UNCLASSIFIED DRUG; 2,3-OXIDOSQUALENE; CARRIER PROTEIN; CHOLESTEROL; LIGAND; PROTEIN BINDING;

ALPHA HELIX; ARTICLE; BETA SHEET; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHEMICAL INTERACTION; CHOLESTEROL SYNTHESIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN STABILITY; SEQUENCE ALIGNMENT; ANALOGS AND DERIVATIVES; CHEMISTRY; ESCHERICHIA COLI; GOLGI COMPLEX; METABOLISM; PHYSIOLOGY; PROCEDURES; TRANSPORT AT THE CELLULAR LEVEL; X RAY CRYSTALLOGRAPHY;

BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CHOLESTEROL; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; GOLGI APPARATUS; LIGANDS; PROTEIN BINDING; SQUALENE;

EID: 84931562982     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2015.05.001     Document Type: Article

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