메뉴 건너뛰기




Volumn 72, Issue 9, 2015, Pages 1825-1837

Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers

Author keywords

Alternative lengthening of telomeres; ICRF 193; Recombination; Telomere

Indexed keywords

4,4'-(1,2-DIMETHYL-1,2-ETHANEDIYL)BIS-2,6-PIPERAZINEDIONE; DNA TOPOISOMERASE (ATP HYDROLYSING); GYRASE INHIBITOR; PIPERAZINE DERIVATIVE; TELOMERASE; TELOMERE BINDING PROTEIN;

EID: 84931458596     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-014-1783-0     Document Type: Article
Times cited : (8)

References (61)
  • 1
    • 84865105439 scopus 로고    scopus 로고
    • Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: Beginning to end
    • 3415994 1:CAS:528:DC%2BC3sXjs1Cnu74%3D 22879408
    • Wellinger RJ, Zakian VA (2012) Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end. Genetics 191:1073-1105
    • (2012) Genetics , vol.191 , pp. 1073-1105
    • Wellinger, R.J.1    Zakian, V.A.2
  • 2
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • 11850778
    • de Lange T (2002) Protection of mammalian telomeres. Oncogene 21:532-540
    • (2002) Oncogene , vol.21 , pp. 532-540
    • De Lange, T.1
  • 3
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • 1:CAS:528:DyaL28Xot12itQ%3D%3D 3907856
    • Greider CW, Blackburn EH (1985) Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43:405-413
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 4
    • 0345169051 scopus 로고    scopus 로고
    • Getting to the end: Telomerase access in yeast and humans
    • 1:CAS:528:DC%2BD3sXpvFChtr0%3D 14685173
    • Vega LR, Mateyak MK, Zakian VA (2003) Getting to the end: telomerase access in yeast and humans. Nat Rev Mol Cell Biol 4:948-959
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 948-959
    • Vega, L.R.1    Mateyak, M.K.2    Zakian, V.A.3
  • 5
    • 0034003333 scopus 로고    scopus 로고
    • A critical role for telomeres in suppressing and facilitating carcinogenesis
    • 1:CAS:528:DC%2BD3cXhslOksrg%3D 10679392
    • Artandi SE, DePinho RA (2000) A critical role for telomeres in suppressing and facilitating carcinogenesis. Curr Opin Genet Dev 10:39-46
    • (2000) Curr Opin Genet Dev , vol.10 , pp. 39-46
    • Artandi, S.E.1    Depinho, R.A.2
  • 6
    • 0030697342 scopus 로고    scopus 로고
    • Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
    • 1:CAS:528:DyaK2sXntFalu7c%3D 9359704
    • Bryan TM, Englezou A, Dalla-Pozza L, Dunham MA, Reddel RR (1997) Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat Med 3:1271-1274
    • (1997) Nat Med , vol.3 , pp. 1271-1274
    • Bryan, T.M.1    Englezou, A.2    Dalla-Pozza, L.3    Dunham, M.A.4    Reddel, R.R.5
  • 7
    • 0033672470 scopus 로고    scopus 로고
    • Telomere maintenance by recombination in human cells
    • 1:CAS:528:DC%2BD3cXptVWgtrs%3D 11101843
    • Dunham MA, Neumann AA, Fasching CL, Reddel RR (2000) Telomere maintenance by recombination in human cells. Nat Genet 26:447-450
    • (2000) Nat Genet , vol.26 , pp. 447-450
    • Dunham, M.A.1    Neumann, A.A.2    Fasching, C.L.3    Reddel, R.R.4
  • 8
  • 9
    • 0027944347 scopus 로고
    • TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
    • 1:CAS:528:DyaK2MXhslKru7Y%3D 7545955
    • Singer MS, Gottschling DE (1994) TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science 266:404-409
    • (1994) Science , vol.266 , pp. 404-409
    • Singer, M.S.1    Gottschling, D.E.2
  • 10
    • 0033513079 scopus 로고    scopus 로고
    • Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae
    • 84893 1:CAS:528:DyaK1MXns1ygtrg%3D 10567534
    • Teng SC, Zakian VA (1999) Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae. Mol Cell Biol 19:8083-8093
    • (1999) Mol Cell Biol , vol.19 , pp. 8083-8093
    • Teng, S.C.1    Zakian, V.A.2
  • 11
    • 0035131699 scopus 로고    scopus 로고
    • Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events
    • 86745 1:CAS:528:DC%2BD3MXhtlGhtr4%3D 11238918
    • Chen Q, Ijpma A, Greider CW (2001) Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events. Mol Cell Biol 21:1819-1827
    • (2001) Mol Cell Biol , vol.21 , pp. 1819-1827
    • Chen, Q.1    Ijpma, A.2    Greider, C.W.3
  • 12
    • 0035936559 scopus 로고    scopus 로고
    • SGS1 is required for telomere elongation in the absence of telomerase
    • 1:CAS:528:DC%2BD3MXhtVSgurw%3D 11231130
    • Huang P, Pryde FE, Lester D et al (2001) SGS1 is required for telomere elongation in the absence of telomerase. Curr Biol 11:125-129
    • (2001) Curr Biol , vol.11 , pp. 125-129
    • Huang, P.1    Pryde, F.E.2    Lester, D.3
  • 13
    • 0035865143 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase
    • 145415 1:CAS:528:DC%2BD3MXhsVyhtbs%3D 11179234
    • Johnson FB, Marciniak RA, McVey M, Stewart SA, Hahn WC, Guarente L (2001) The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase. EMBO J 20:905-913
    • (2001) EMBO J , vol.20 , pp. 905-913
    • Johnson, F.B.1    Marciniak, R.A.2    McVey, M.3    Stewart, S.A.4    Hahn, W.C.5    Guarente, L.6
  • 14
    • 0033636907 scopus 로고    scopus 로고
    • Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process
    • 1:CAS:528:DC%2BD3cXnvVentLw%3D 11090632
    • Teng SC, Chang J, McCowan B, Zakian VA (2000) Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process. Mol Cell 6:947-952
    • (2000) Mol Cell , vol.6 , pp. 947-952
    • Teng, S.C.1    Chang, J.2    McCowan, B.3    Zakian, V.A.4
  • 15
    • 33744951596 scopus 로고    scopus 로고
    • Involvement of topoisomerase III in telomere-telomere recombination
    • 1:CAS:528:DC%2BD28Xkt1ymtbk%3D 16546998
    • Tsai HJ, Huang WH, Li TK et al (2006) Involvement of topoisomerase III in telomere-telomere recombination. J Biol Chem 281:13717-13723
    • (2006) J Biol Chem , vol.281 , pp. 13717-13723
    • Tsai, H.J.1    Huang, W.H.2    Li, T.K.3
  • 16
    • 0033199695 scopus 로고    scopus 로고
    • Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body
    • 10485449
    • Yeager TR, Neumann AA, Englezou A, Huschtscha LI, Noble JR, Reddel RR (1999) Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res 59:4175-4179
    • (1999) Cancer Res , vol.59 , pp. 4175-4179
    • Yeager, T.R.1    Neumann, A.A.2    Englezou, A.3    Huschtscha, L.I.4    Noble, J.R.5    Reddel, R.R.6
  • 17
    • 0031036351 scopus 로고    scopus 로고
    • A protein-counting mechanism for telomere length regulation in yeast
    • 1:CAS:528:DyaK2sXht1CqtLg%3D 9020083
    • Marcand S, Gilson E, Shore D (1997) A protein-counting mechanism for telomere length regulation in yeast. Science 275:986-990
    • (1997) Science , vol.275 , pp. 986-990
    • Marcand, S.1    Gilson, E.2    Shore, D.3
  • 18
    • 0035029153 scopus 로고    scopus 로고
    • Tumor cell death induced by topoisomerase-targeting drugs
    • 11264450
    • Li TK, Liu LF (2001) Tumor cell death induced by topoisomerase-targeting drugs. Annu Rev Pharmacol Toxicol 41:53-77
    • (2001) Annu Rev Pharmacol Toxicol , vol.41 , pp. 53-77
    • Li, T.K.1    Liu, L.F.2
  • 19
    • 0029900745 scopus 로고    scopus 로고
    • Inhibition of topoisomerase II by ICRF-193, the meso isomer of 2,3-bis(2,6-dioxopiperazin-4-yl)butane. Critical dependence on 2,3-butanediyl linker absolute configuration
    • 1:CAS:528:DyaK28XkvVChtbY%3D 8759026
    • Snapka RM, Woo SH, Blokhin AV, Witiak DT (1996) Inhibition of topoisomerase II by ICRF-193, the meso isomer of 2,3-bis(2,6-dioxopiperazin-4-yl)butane. Critical dependence on 2,3-butanediyl linker absolute configuration. Biochem Pharmacol 52:543-549
    • (1996) Biochem Pharmacol , vol.52 , pp. 543-549
    • Snapka, R.M.1    Woo, S.H.2    Blokhin, A.V.3    Witiak, D.T.4
  • 20
    • 0027275284 scopus 로고
    • Use of yeast in the study of anticancer drugs targeting DNA topoisomerases: Expression of a functional recombinant human DNA topoisomerase II alpha in yeast
    • 8393377
    • Wasserman RA, Austin CA, Fisher LM, Wang JC (1993) Use of yeast in the study of anticancer drugs targeting DNA topoisomerases: expression of a functional recombinant human DNA topoisomerase II alpha in yeast. Cancer Res 53:3591-3596
    • (1993) Cancer Res , vol.53 , pp. 3591-3596
    • Wasserman, R.A.1    Austin, C.A.2    Fisher, L.M.3    Wang, J.C.4
  • 21
    • 0028350158 scopus 로고
    • Analysis of yeast DNA topoisomerase II mutants resistant to the antitumor drug amsacrine
    • 8137294
    • Wasserman RA, Wang JC (1994) Analysis of yeast DNA topoisomerase II mutants resistant to the antitumor drug amsacrine. Cancer Res 54:1795-1800
    • (1994) Cancer Res , vol.54 , pp. 1795-1800
    • Wasserman, R.A.1    Wang, J.C.2
  • 22
    • 0023659131 scopus 로고
    • The structure of sister minichromosome DNA before anaphase in Saccharomyces cerevisiae
    • 1:CAS:528:DyaL1cXntF2htw%3D%3D 3317838
    • Koshland D, Hartwell LH (1987) The structure of sister minichromosome DNA before anaphase in Saccharomyces cerevisiae. Science 238:1713-1716
    • (1987) Science , vol.238 , pp. 1713-1716
    • Koshland, D.1    Hartwell, L.H.2
  • 23
    • 0024499711 scopus 로고
    • DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosome breakage
    • 362157 1:CAS:528:DyaL1MXhtV2hu74%3D 2538717
    • Holm C, Stearns T, Botstein D (1989) DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosome breakage. Mol Cell Biol 9:159-168
    • (1989) Mol Cell Biol , vol.9 , pp. 159-168
    • Holm, C.1    Stearns, T.2    Botstein, D.3
  • 24
    • 0024973811 scopus 로고
    • A mutant with a defect in telomere elongation leads to senescence in yeast
    • 1:CAS:528:DyaK3cXntlKhtA%3D%3D 2655926
    • Lundblad V, Szostak JW (1989) A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57:633-643
    • (1989) Cell , vol.57 , pp. 633-643
    • Lundblad, V.1    Szostak, J.W.2
  • 25
    • 2042429168 scopus 로고    scopus 로고
    • Regulation of telomerase by telomeric proteins
    • 1:CAS:528:DC%2BD2cXmslags78%3D 15189140
    • Smogorzewska A, de Lange T (2004) Regulation of telomerase by telomeric proteins. Annu Rev Biochem 73:177-208
    • (2004) Annu Rev Biochem , vol.73 , pp. 177-208
    • Smogorzewska, A.1    De Lange, T.2
  • 26
    • 79953732578 scopus 로고    scopus 로고
    • Rif1 supports the function of the CST complex in yeast telomere capping
    • Anbalagan S, Bonetti D, Lucchini G, Longhese MP (2011) Rif1 supports the function of the CST complex in yeast telomere capping. PLoS Genet, e1002024
    • (2011) PLoS Genet , pp. e1002024
    • Anbalagan, S.1    Bonetti, D.2    Lucchini, G.3    Longhese, M.P.4
  • 27
    • 43249098277 scopus 로고    scopus 로고
    • Multiple pathways inhibit NHEJ at telomeres
    • 2335312 1:CAS:528:DC%2BD1cXlslCqsrg%3D 18451106
    • Marcand S, Pardo B, Gratias A, Cahun S, Callebaut I (2008) Multiple pathways inhibit NHEJ at telomeres. Genes Dev 22:1153-1158
    • (2008) Genes Dev , vol.22 , pp. 1153-1158
    • Marcand, S.1    Pardo, B.2    Gratias, A.3    Cahun, S.4    Callebaut, I.5
  • 28
    • 0037097940 scopus 로고    scopus 로고
    • Rap1-Sir4 binding independent of other Sir, yKu, or histone interactions initiates the assembly of telomeric heterochromatin in yeast
    • 186350 1:CAS:528:DC%2BD38XltVGmtLY%3D 12080091
    • Luo K, Vega-Palas MA, Grunstein M (2002) Rap1-Sir4 binding independent of other Sir, yKu, or histone interactions initiates the assembly of telomeric heterochromatin in yeast. Genes Dev 16:1528-1539
    • (2002) Genes Dev , vol.16 , pp. 1528-1539
    • Luo, K.1    Vega-Palas, M.A.2    Grunstein, M.3
  • 29
    • 0031014229 scopus 로고    scopus 로고
    • Yeast telomeric sequences function as chromosomal anchorage points in vivo
    • 1169656 1:CAS:528:DyaK2sXisVymu7o%3D 9034335
    • Mirabella A, Gartenberg MR (1997) Yeast telomeric sequences function as chromosomal anchorage points in vivo. EMBO J 16:523-533
    • (1997) EMBO J , vol.16 , pp. 523-533
    • Mirabella, A.1    Gartenberg, M.R.2
  • 30
    • 80052283925 scopus 로고    scopus 로고
    • Palmitoylation controls the dynamics of budding-yeast heterochromatin via the telomere-binding protein Rif1
    • 3167557 1:CAS:528:DC%2BC3MXhtFCltbbF 21844336
    • Park S, Patterson EE, Cobb J, Audhya A, Gartenberg MR, Fox CA (2011) Palmitoylation controls the dynamics of budding-yeast heterochromatin via the telomere-binding protein Rif1. Proc Natl Acad Sci USA 108:14572-14577
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 14572-14577
    • Park, S.1    Patterson, E.E.2    Cobb, J.3    Audhya, A.4    Gartenberg, M.R.5    Fox, C.A.6
  • 31
    • 0037178888 scopus 로고    scopus 로고
    • Generation of double-stranded breaks in hypernegatively supercoiled DNA by Drosophila topoisomerase IIIbeta, a type IA enzyme
    • 1:CAS:528:DC%2BD38XlvV2isLo%3D 12023976
    • Wilson-Sali T, Hsieh TS (2002) Generation of double-stranded breaks in hypernegatively supercoiled DNA by Drosophila topoisomerase IIIbeta, a type IA enzyme. J Biol Chem 277:26865-26871
    • (2002) J Biol Chem , vol.277 , pp. 26865-26871
    • Wilson-Sali, T.1    Hsieh, T.S.2
  • 32
    • 0026623241 scopus 로고
    • A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation
    • 1:CAS:528:DyaK3sXhsVWjtLo%3D 1577274
    • Hardy CF, Sussel L, Shore D (1992) A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev 6:801-814
    • (1992) Genes Dev , vol.6 , pp. 801-814
    • Hardy, C.F.1    Sussel, L.2    Shore, D.3
  • 33
    • 0030995534 scopus 로고    scopus 로고
    • A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae
    • 1:CAS:528:DyaK2sXisVGjs78%3D 9087429
    • Wotton D, Shore D (1997) A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae. Genes Dev 11:748-760
    • (1997) Genes Dev , vol.11 , pp. 748-760
    • Wotton, D.1    Shore, D.2
  • 34
    • 2442599792 scopus 로고    scopus 로고
    • Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases
    • 1:CAS:528:DC%2BD2cXltlKktr0%3D 15139806
    • Corbett KD, Berger JM (2004) Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases. Annu Rev Biophys Biomol Struct 33:95-118
    • (2004) Annu Rev Biophys Biomol Struct , vol.33 , pp. 95-118
    • Corbett, K.D.1    Berger, J.M.2
  • 35
    • 0024519424 scopus 로고
    • Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae
    • 2538443
    • Worland ST, Wang JC (1989) Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae. J Biol Chem 264:4412-4416
    • (1989) J Biol Chem , vol.264 , pp. 4412-4416
    • Worland, S.T.1    Wang, J.C.2
  • 36
    • 0034503110 scopus 로고    scopus 로고
    • ALT-associated PML bodies are present in viable cells and are enriched in cells in the G(2)/M phase of the cell cycle
    • 11082050
    • Grobelny JV, Godwin AK, Broccoli D (2000) ALT-associated PML bodies are present in viable cells and are enriched in cells in the G(2)/M phase of the cell cycle. J Cell Sci 113(Pt 24):4577-4585
    • (2000) J Cell Sci , vol.113 , pp. 4577-4585
    • Grobelny, J.V.1    Godwin, A.K.2    Broccoli, D.3
  • 37
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • 1:CAS:528:DC%2BD3sXntVKhsrc%3D 12956959
    • Takai H, Smogorzewska A, de Lange T (2003) DNA damage foci at dysfunctional telomeres. Curr Biol 13:1549-1556
    • (2003) Curr Biol , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    De Lange, T.3
  • 38
    • 61349178505 scopus 로고    scopus 로고
    • FEN1 contributes to telomere stability in ALT-positive tumor cells
    • 1:CAS:528:DC%2BD1MXitlGlsb4%3D 19137021
    • Saharia A, Stewart SA (2009) FEN1 contributes to telomere stability in ALT-positive tumor cells. Oncogene 28:1162-1167
    • (2009) Oncogene , vol.28 , pp. 1162-1167
    • Saharia, A.1    Stewart, S.A.2
  • 39
    • 64649090292 scopus 로고    scopus 로고
    • Targeting DNA topoisomerase II in cancer chemotherapy
    • 2748742 1:CAS:528:DC%2BD1MXks12kur0%3D 19377506
    • Nitiss JL (2009) Targeting DNA topoisomerase II in cancer chemotherapy. Nat Rev Cancer 9:338-350
    • (2009) Nat Rev Cancer , vol.9 , pp. 338-350
    • Nitiss, J.L.1
  • 40
    • 0028345406 scopus 로고
    • Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp
    • 43247 1:CAS:528:DyaK2cXitlGlsr4%3D 8127881
    • Roca J, Ishida R, Berger JM, Andoh T, Wang JC (1994) Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp. Proc Natl Acad Sci USA 91:1781-1785
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1781-1785
    • Roca, J.1    Ishida, R.2    Berger, J.M.3    Andoh, T.4    Wang, J.C.5
  • 41
    • 0014691658 scopus 로고
    • Antitumour activity in a series of bisdiketopiperazines
    • 1:CAS:528:DyaF1MXktFWls78%3D 5782118
    • Creighton AM, Hellmann K, Whitecross S (1969) Antitumour activity in a series of bisdiketopiperazines. Nature 222:384-385
    • (1969) Nature , vol.222 , pp. 384-385
    • Creighton, A.M.1    Hellmann, K.2    Whitecross, S.3
  • 42
    • 0014694520 scopus 로고
    • Preliminary clinical assessment of I.C.R.F. 159 in acute leukaemia and lymphosarcoma
    • 1982474 1:STN:280:DyaF1M7ktF2ltw%3D%3D 5251696
    • Hellmann K, Newton KA, Whitmore DN, Hanham IW, Bond JV (1969) Preliminary clinical assessment of I.C.R.F. 159 in acute leukaemia and lymphosarcoma. Br Med J 1:822-824
    • (1969) Br Med J , vol.1 , pp. 822-824
    • Hellmann, K.1    Newton, K.A.2    Whitmore, D.N.3    Hanham, I.W.4    Bond, J.V.5
  • 43
    • 77951133257 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres: Models, mechanisms and implications
    • 1:CAS:528:DC%2BC3cXkvVSqs70%3D 20351727
    • Cesare AJ, Reddel RR (2010) Alternative lengthening of telomeres: models, mechanisms and implications. Nat Rev Genet 11:319-330
    • (2010) Nat Rev Genet , vol.11 , pp. 319-330
    • Cesare, A.J.1    Reddel, R.R.2
  • 44
    • 78650662899 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres pathway: Recombination-mediated telomere maintenance mechanism in human cells
    • 1:CAS:528:DC%2BC3cXhs1ajt73L 20937668
    • Nabetani A, Ishikawa F (2011) Alternative lengthening of telomeres pathway: recombination-mediated telomere maintenance mechanism in human cells. J Biochem 149:5-14
    • (2011) J Biochem , vol.149 , pp. 5-14
    • Nabetani, A.1    Ishikawa, F.2
  • 45
    • 7044232011 scopus 로고    scopus 로고
    • Homologous recombination generates T-loop-sized deletions at human telomeres
    • 1:CAS:528:DC%2BD2cXpvFOgtb0%3D 15507207
    • Wang RC, Smogorzewska A, de Lange T (2004) Homologous recombination generates T-loop-sized deletions at human telomeres. Cell 119:355-368
    • (2004) Cell , vol.119 , pp. 355-368
    • Wang, R.C.1    Smogorzewska, A.2    De Lange, T.3
  • 46
    • 58149085861 scopus 로고    scopus 로고
    • Purification of proteins associated with specific genomic Loci
    • 3395431 1:CAS:528:DC%2BD1MXhtFOitro%3D 19135898
    • Dejardin J, Kingston RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136:175-186
    • (2009) Cell , vol.136 , pp. 175-186
    • Dejardin, J.1    Kingston, R.E.2
  • 47
    • 84864619205 scopus 로고    scopus 로고
    • Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway
    • 3400581 1:CAS:528:DC%2BC38XhtFSksbrK 22829774
    • Lovejoy CA, Li W, Reisenweber S et al (2012) Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. PLoS Genet 8:e1002772
    • (2012) PLoS Genet , vol.8 , pp. 1002772
    • Lovejoy, C.A.1    Li, W.2    Reisenweber, S.3
  • 48
    • 0345447604 scopus 로고    scopus 로고
    • Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast
    • 1:CAS:528:DC%2BD3sXpt1Oru7g%3D 14622595
    • Ira G, Malkova A, Liberi G, Foiani M, Haber JE (2003) Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast. Cell 115:401-411
    • (2003) Cell , vol.115 , pp. 401-411
    • Ira, G.1    Malkova, A.2    Liberi, G.3    Foiani, M.4    Haber, J.E.5
  • 49
    • 33746600628 scopus 로고    scopus 로고
    • Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration
    • 1544052 1:CAS:528:DC%2BD28XnvVamur4%3D 16849422
    • Plank JL, Wu J, Hsieh TS (2006) Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration. Proc Natl Acad Sci USA 103:11118-11123
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11118-11123
    • Plank, J.L.1    Wu, J.2    Hsieh, T.S.3
  • 50
    • 77954958609 scopus 로고    scopus 로고
    • TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage
    • 1:CAS:528:DC%2BC3cXpsVaiu7s%3D 20655466
    • Ye J, Lenain C, Bauwens S et al (2010) TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage. Cell 142:230-242
    • (2010) Cell , vol.142 , pp. 230-242
    • Ye, J.1    Lenain, C.2    Bauwens, S.3
  • 51
    • 0035000154 scopus 로고    scopus 로고
    • Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break
    • 86809 1:CAS:528:DC%2BD3MXjslWhtL8%3D 11238940
    • Signon L, Malkova A, Naylor ML, Klein H, Haber JE (2001) Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break. Mol Cell Biol 21:2048-2056
    • (2001) Mol Cell Biol , vol.21 , pp. 2048-2056
    • Signon, L.1    Malkova, A.2    Naylor, M.L.3    Klein, H.4    Haber, J.E.5
  • 52
    • 0029820640 scopus 로고    scopus 로고
    • The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae
    • 1:CAS:528:DyaK28Xls1ykt7g%3D 8830766
    • Gotta M, Laroche T, Formenton A, Maillet L, Scherthan H, Gasser SM (1996) The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae. J Cell Biol 134:1349-1363
    • (1996) J Cell Biol , vol.134 , pp. 1349-1363
    • Gotta, M.1    Laroche, T.2    Formenton, A.3    Maillet, L.4    Scherthan, H.5    Gasser, S.M.6
  • 53
    • 67649363870 scopus 로고    scopus 로고
    • Telomerase-associated protein 1, HSP90, and topoisomerase IIalpha associate directly with the BLM helicase in immortalized cells using ALT and modulate its helicase activity using telomeric DNA substrates
    • 2685679 1:CAS:528:DC%2BD1MXmtlChtb0%3D 19329795
    • Bhattacharyya S, Keirsey J, Russell B et al (2009) Telomerase-associated protein 1, HSP90, and topoisomerase IIalpha associate directly with the BLM helicase in immortalized cells using ALT and modulate its helicase activity using telomeric DNA substrates. J Biol Chem 284:14966-14977
    • (2009) J Biol Chem , vol.284 , pp. 14966-14977
    • Bhattacharyya, S.1    Keirsey, J.2    Russell, B.3
  • 54
    • 0036899106 scopus 로고    scopus 로고
    • The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis
    • 1:CAS:528:DC%2BD38XptlGgtrg%3D 12444098
    • Stavropoulos DJ, Bradshaw PS, Li X et al (2002) The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis. Hum Mol Genet 11:3135-3144
    • (2002) Hum Mol Genet , vol.11 , pp. 3135-3144
    • Stavropoulos, D.J.1    Bradshaw, P.S.2    Li, X.3
  • 55
    • 84890052646 scopus 로고    scopus 로고
    • Topoisomerase II regulates yeast genes with singular chromatin architectures
    • 3814376 1:CAS:528:DC%2BC3sXhslWrt7%2FE 23935120
    • Nikolaou C, Bermudez I, Manichanh C et al (2013) Topoisomerase II regulates yeast genes with singular chromatin architectures. Nucleic Acids Res 41:9243-9256
    • (2013) Nucleic Acids Res , vol.41 , pp. 9243-9256
    • Nikolaou, C.1    Bermudez, I.2    Manichanh, C.3
  • 56
    • 84855500815 scopus 로고    scopus 로고
    • Is telomerase a viable target in cancer?
    • 3375693 1:CAS:528:DC%2BC38XlsFWksQ%3D%3D 21802433
    • Buseman CM, Wright WE, Shay JW (2012) Is telomerase a viable target in cancer? Mutat Res 730:90-97
    • (2012) Mutat Res , vol.730 , pp. 90-97
    • Buseman, C.M.1    Wright, W.E.2    Shay, J.W.3
  • 57
    • 0037148281 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres in mammalian cells
    • 1:CAS:528:DC%2BD38Xht1Snur4%3D 11850785
    • Henson JD, Neumann AA, Yeager TR, Reddel RR (2002) Alternative lengthening of telomeres in mammalian cells. Oncogene 21:598-610
    • (2002) Oncogene , vol.21 , pp. 598-610
    • Henson, J.D.1    Neumann, A.A.2    Yeager, T.R.3    Reddel, R.R.4
  • 58
    • 2442659384 scopus 로고    scopus 로고
    • Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition
    • 1:CAS:528:DC%2BD2cXktVWhsL4%3D 15150096
    • Bechter OE, Zou Y, Walker W, Wright WE, Shay JW (2004) Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition. Cancer Res 64:3444-3451
    • (2004) Cancer Res , vol.64 , pp. 3444-3451
    • Bechter, O.E.1    Zou, Y.2    Walker, W.3    Wright, W.E.4    Shay, J.W.5
  • 59
    • 84863116250 scopus 로고    scopus 로고
    • Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer
    • 3286017 1:CAS:528:DC%2BC38XjtFSitr4%3D 22341440
    • Hu J, Hwang SS, Liesa M et al (2012) Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell 148:651-663
    • (2012) Cell , vol.148 , pp. 651-663
    • Hu, J.1    Hwang, S.S.2    Liesa, M.3
  • 60
    • 84862288783 scopus 로고    scopus 로고
    • Cancer. Cancer and telomeres - An ALTernative to telomerase
    • 1:CAS:528:DC%2BC38Xps1alsbY%3D 22700908
    • Shay JW, Reddel RR, Wright WE (2012) Cancer. Cancer and telomeres - an ALTernative to telomerase. Science 336:1388-1390
    • (2012) Science , vol.336 , pp. 1388-1390
    • Shay, J.W.1    Reddel, R.R.2    Wright, W.E.3
  • 61
    • 0030014783 scopus 로고    scopus 로고
    • DNA topoisomerases
    • 1:CAS:528:DyaK28XktFamur0%3D 8811192
    • Wang JC (1996) DNA topoisomerases. Annu Rev Biochem 65:635-692
    • (1996) Annu Rev Biochem , vol.65 , pp. 635-692
    • Wang, J.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.