Inhibition of topoisomerase II by ICRF-193, the meso isomer of 2,3-bis(2,6-dioxopiperazin-4-yl)butane: Critical dependence on 2,3-butanediyl linker absolute configuration

Biochemical Pharmacology

Volumn 52, Issue 4, 1996, Pages 543-549

  Snapka, Robert M ^a   Woo, Sung Ho ^a   Blokhin, Andrei V ^b   Witiak, Donald T ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Antagonist; Bis(dioxopiperazine); ICRF 193; Inhibitor; Topoisomerase II

Indexed keywords

2,3 BIS(3,5 DIOXO 1 PIPERAZINYL)BUTANE; CYTOTOXIC AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING); TENIPOSIDE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DNA BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; PRIORITY JOURNAL; SIMIAN VIRUS 40; STRUCTURE ACTIVITY RELATION;

ANIMALS; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; PIPERAZINES; STEREOISOMERISM;

EID: 0029900745     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00305-X     Document Type: Article

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