HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism

Radiation Research

Volumn 183, Issue 6, 2015, Pages 594-609

  Zhang, Minsi ^a   Qiu, Qiong ^b   Li, Zhizhong ^b   Sachdeva, Mohit ^b   Min, Hooney ^b   Cardona, Diana M ^b   DeLaney, Thomas F ^c   Han, Tracy ^b   Ma, Yan ^b   Luo, Lixia ^b   Ilkayeva, Olga R ^a   Lui, Ki ^a   Nichols, Amanda G ^a   Newgard, Christopher B ^a   Kastan, Michael B ^a,b   Rathmell, Jeffrey C ^a,b   Dewhirst, Mark W ^b   Kirsch, David G ^a,b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; COMPLEMENTARY DNA; DACARBAZINE; DEOXYGLUCOSE; DIMETHYL SULFOXIDE; DOXORUBICIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IFOSFAMIDE; LACTIC ACID; MESNA; MITOCHONDRIAL DNA; OLIGOMYCIN; PROTEIN P53; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; RNA; SUPEROXIDE; TRANSCRIPTION FACTOR PAX7;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BIOGENESIS; CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; CARCINOGENESIS; CELL COUNTING; CELL ISOLATION; CELL LYSATE; CELL METABOLISM; CELL SURVIVAL; CHEMORADIOTHERAPY; COMPARATIVE STUDY; CONTROLLED STUDY; DNA END JOINING REPAIR; DNA SYNTHESIS; ENZYME ACTIVITY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENOTYPE; HUMAN; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; IRRADIATION; MASS SPECTROMETRY; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN CARBONYLATION; RADIATION EXPOSURE; RADIATION RESPONSE; RADIOSENSITIVITY; RADIOSENSITIZATION; RESPIRATORY CHAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SARCOMA CELL; SOFT TISSUE SARCOMA; TISSUE MICROARRAY; TUMOR DIFFERENTIATION; UPREGULATION; WESTERN BLOTTING; ANIMAL; DEFICIENCY; DRUG EFFECTS; GENE SILENCING; GENETICS; METABOLISM; MITOCHONDRIAL VOLUME; MITOCHONDRION; PATHOLOGY; RADIATION DOSE; SARCOMA; TREATMENT OUTCOME; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CHEMORADIOTHERAPY; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MITOCHONDRIA; MITOCHONDRIAL SIZE; RADIATION TOLERANCE; SARCOMA; TREATMENT OUTCOME; UP-REGULATION;

EID: 84931406084     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR14016.1     Document Type: Article

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