Long-term follow-up of patients treated with neoadjuvant chemotherapy and radiotherapy for large, extremity soft tissue sarcomas

Cancer

Volumn 118, Issue 15, 2012, Pages 3758-3765

  Mullen, John T ^a   Kobayashi, Wendy ^a   Wang, Jing Jing ^a   Harmon, David C ^a   Choy, Edwin ^a   Hornicek, Francis J ^a   Rosenberg, Andrew E ^a   Chen, Yen Lin ^a   Spiro, Ira J ^a   Delaney, Thomas F ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Adriamycin (doxorubicin); and dacarbazine (MAID); extremity sarcoma; follow up; ifosfamide; mesna; neoadjuvant chemotherapy; radiotherapy; soft tissue sarcoma

Indexed keywords

DACARBAZINE; DOXORUBICIN; GRANULOCYTE COLONY STIMULATING FACTOR; IFOSFAMIDE; MESNA;

ADJUVANT CHEMORADIOTHERAPY; ADULT; AGED; ARM; ARTICLE; BLOOD TOXICITY; BUTTOCK; CANCER GRADING; CANCER MORTALITY; CLINICAL ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DISEASE SPECIFIC SURVIVAL; DISTANT METASTASIS; DISTANT METASTASIS FREE SURVIVAL; FEMALE; FOLLOW UP; GASTROINTESTINAL TOXICITY; HUMAN; LEG; MALE; MULTIPLE CYCLE TREATMENT; MYELODYSPLASTIC SYNDROME; OVERALL SURVIVAL; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; SOFT TISSUE SARCOMA; THIGH; TREATMENT FAILURE; TUMOR RECURRENCE; WOUND COMPLICATION;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMORADIOTHERAPY; CHEMOTHERAPY, ADJUVANT; DACARBAZINE; DISEASE-FREE SURVIVAL; DOXORUBICIN; EXTREMITIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; IFOSFAMIDE; MALE; MESNA; MIDDLE AGED; NEOADJUVANT THERAPY; RADIOTHERAPY, ADJUVANT; SARCOMA; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 84864151088     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.26696     Document Type: Article

References (18)

1. Sadoski C, Suit HD, Rosenberg A, Mankin H, Efird J,. Preoperative radiation, surgical margins, and local control of extremity sarcomas of soft tissues. J Surg Oncol. 1993; 52: 223-230.
2. Lindberg RD, Martin RG, Romsdahl MM, Barkley HT Jr,. Conservative surgery and postoperative radiotherapy in 300 adults with soft-tissue sarcomas. Cancer. 1981; 47: 2391-2397.
3. Rosenberg SA, Tepper J, Glatstein E, et al. The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann Surg. 1982; 196: 305-315.
4. Pisters PW, Harrison LB, Leung DH, Woodruff JM, Casper ES, Brennan MF,. Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol. 1996; 14: 859-868.
5. Spiro IJ, Gebhardt MC, Jennings LC, Mankin HJ, Harmon DC, Suit HD,. Prognostic factors for local control of sarcomas of the soft tissues managed by radiation and surgery. Semin Oncol. 1997; 24: 540-546.
6. Potter DA, Glenn J, Kinsella T, et al. Patterns of recurrence in patients with high-grade soft-tissue sarcomas. J Clin Oncol. 1985; 3: 353-366.
7. Sarcoma Meta-analysis Collaboration. Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Lancet. 1997; 350: 1647-1654.
8. DeLaney TF, Spiro IJ, Suit HD, et al. Neoadjuvant chemotherapy and radiotherapy for large extremity soft-tissue sarcomas. Int J Radiat Oncol Biol Phys. 2003; 56: 1117-1127.
9. Kraybill WG, Harris J, Spiro IJ, et al. Radiation Therapy Oncology Group Trial 9514. Phase II study of neoadjuvant chemotherapy and radiation therapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514. J Clin Oncol. 2006; 24: 619-625.
10. Kraybill WG, Harris J, Spiro IJ, et al. Long-term results of a phase 2 study of neoadjuvant chemotherapy and radiotherapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514. Cancer. 2010; 116: 4613-4621.
11. Cormier JN, Huang X, Xing Y, et al. Cohort analysis of patients with localized, high-risk, extremity soft tissue sarcoma treated at two cancer centers: chemotherapy-associated outcomes. J Clin Oncol. 2004; 22: 4567-4574.
12. Kaplan EL, Meier P,. Nonparametric estimator from incomplete observations. J Am Stat Assoc. 1958; 53: 457-481.
13. Spiro IJ, Suit H, Gebhardt MC,. Neo-adjuvant chemotherapy for primary high-grade extremity soft tissue sarcoma. Proc Am Soc Clin Oncol. 1996; 15: 524 (abstract 168).
14. Frustaci S, Gherlinzoni F, De Paoli A, et al. Adjuvant chemotherapy for adult soft tissue sarcomas of the extremities and girdles: results of the Italian randomized cooperative trial. J Clin Oncol. 2001; 19: 1238-1247.
15. Pervaiz N, Colterjohn N, Farrokhyar F, Tozer R, Figueredo A, Ghert M,. A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma. Cancer. 2008; 113: 573-581.
16. Frustaci S, De Paoli A, Bidoli E, et al. Ifosfamide in the adjuvant therapy of soft tissue sarcomas. Oncology. 2003; 65 (suppl 2): 80-84.
17. Gortzak E, Azzarelli A, Buesa J, et al. EORTC Soft Tissue Bone Sarcoma Group and the National Cancer Institute of Canada Clinical Trials Group/Canadian Sarcoma Group. A randomised phase II study on neo-adjuvant chemotherapy for 'high-risk' adult soft-tissue sarcoma. Eur J Cancer. 2001; 37: 1096-1103.
18. Grobmyer SR, Maki RG, Demetri GD, et al. Neo-adjuvant chemotherapy for primary high-grade extremity soft tissue sarcoma. Ann Oncol. 2004; 15: 1667-1672.