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Volumn 353, Issue 2, 2015, Pages 415-423

Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: Implications for drug-induced liver injury

Author keywords

[No Author keywords available]

Indexed keywords

MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; TAUROCHOLIC ACID; TROGLITAZONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ABCC4 PROTEIN, HUMAN; CHROMAN DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN; PRASTERONE; SULFATE; TROGLITAZONE SULFATE;

EID: 84931305900     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.221564     Document Type: Article
Times cited : (50)

References (42)
  • 1
    • 0036149075 scopus 로고    scopus 로고
    • Transport activity of human MRP3 expressed in sf9 cells: Comparative studies with rat MRP3
    • Akita H, Suzuki H, Hirohashi T, Takikawa H, and Sugiyama Y (2002) Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3. Pharm Res 19:34-41.
    • (2002) Pharm Res , vol.19 , pp. 34-41
    • Akita, H.1    Suzuki, H.2    Hirohashi, T.3    Takikawa, H.4    Sugiyama, Y.5
  • 2
    • 0034802573 scopus 로고    scopus 로고
    • Sinusoidal efflux of taurocholate is enhanced in mrp2-deficient rat liver
    • Akita H, Suzuki H, and Sugiyama Y (2001) Sinusoidal efflux of taurocholate is enhanced in Mrp2-deficient rat liver. Pharm Res 18:1119-1125.
    • (2001) Pharm Res , vol.18 , pp. 1119-1125
    • Akita, H.1    Suzuki, H.2    Sugiyama, Y.3
  • 4
    • 70349430938 scopus 로고    scopus 로고
    • Bile acids: Regulation of synthesis
    • Chiang JY (2009) Bile acids: regulation of synthesis. J Lipid Res 50:1955-1966.
    • (2009) J Lipid Res , vol.50 , pp. 1955-1966
    • Chiang, J.Y.1
  • 5
    • 84455171488 scopus 로고    scopus 로고
    • In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans
    • Dawson S, Stahl S, Paul N, Barber J, and Kenna JG (2012) In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug Metab Dispos 40:130-138.
    • (2012) Drug Metab Dispos , vol.40 , pp. 130-138
    • Dawson, S.1    Stahl, S.2    Paul, N.3    Barber, J.4    Kenna, J.G.5
  • 6
    • 0035126136 scopus 로고    scopus 로고
    • Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: In vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat
    • Funk C, Ponelle C, Scheuermann G, and Pantze M (2001) Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat. Mol Pharmacol 59:627-635.
    • (2001) Mol Pharmacol , vol.59 , pp. 627-635
    • Funk, C.1    Ponelle, C.2    Scheuermann, G.3    Pantze, M.4
  • 7
    • 46749120546 scopus 로고    scopus 로고
    • Use of tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: Integration of in vitro, pharmacokinetic modeling, and simulation studies
    • Ghibellini G, Leslie EM, Pollack GM, and Brouwer KLR (2008) Use of Tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies. Pharm Res 25:1851-1860.
    • (2008) Pharm Res , vol.25 , pp. 1851-1860
    • Ghibellini, G.1    Leslie, E.M.2    Pollack, G.M.3    Brouwer, K.L.R.4
  • 8
    • 0033470181 scopus 로고    scopus 로고
    • Bile acids: The good, the bad, and the ugly
    • Hofmann AF (1999a) Bile Acids: The good, the bad, and the ugly. News Physiol Sci 14:24-29.
    • (1999) News Physiol Sci , vol.14 , pp. 24-29
    • Hofmann, A.F.1
  • 9
    • 0033611305 scopus 로고    scopus 로고
    • The continuing importance of bile acids in liver and intestinal disease
    • Hofmann AF (1999b) The continuing importance of bile acids in liver and intestinal disease. Arch Intern Med 159:2647-2658.
    • (1999) Arch Intern Med , vol.159 , pp. 2647-2658
    • Hofmann, A.F.1
  • 10
    • 7544221726 scopus 로고    scopus 로고
    • Detoxification of lithocholic acid, a toxic bile acid: Relevance to drug hepatotoxicity
    • Hofmann AF (2004) Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity. Drug Metab Rev 36:703-722.
    • (2004) Drug Metab Rev , vol.36 , pp. 703-722
    • Hofmann, A.F.1
  • 11
    • 84867887941 scopus 로고    scopus 로고
    • Hepatocyte hopping of OATP1B substrates contributes to efficient hepatic detoxification
    • Iusuf D, van de Steeg E, and Schinkel AH (2012) Hepatocyte hopping of OATP1B substrates contributes to efficient hepatic detoxification. Clin Pharmacol Ther 92: 559-562.
    • (2012) Clin Pharmacol Ther , vol.92 , pp. 559-562
    • Iusuf, D.1    Van De Steeg, E.2    Schinkel, A.H.3
  • 13
    • 79953081372 scopus 로고    scopus 로고
    • Contribution of high basolateral bile salt efflux to the lack of hepatotoxicity in rat in response to drugs inducing cholestasis in human
    • Jemnitz K, Veres Z, and Vereczkey L (2010) Contribution of high basolateral bile salt efflux to the lack of hepatotoxicity in rat in response to drugs inducing cholestasis in human. Toxicol Sci 115:80-88.
    • (2010) Toxicol Sci , vol.115 , pp. 80-88
    • Jemnitz, K.1    Veres, Z.2    Vereczkey, L.3
  • 14
    • 84887978608 scopus 로고    scopus 로고
    • Risk factors for development of cholestatic drug-induced liver injury: Inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4
    • Köck K, Ferslew BC, Netterberg I, Yang K, Urban TJ, Swaan PW, Stewart PW, and Brouwer KLR (2014) Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4. Drug Metab Dispos 42:665-674.
    • (2014) Drug Metab Dispos , vol.42 , pp. 665-674
    • Köck, K.1    Ferslew, B.C.2    Netterberg, I.3    Yang, K.4    Urban, T.J.5    Swaan, P.W.6    Stewart, P.W.7    Brouwer, K.L.R.8
  • 17
    • 84871536194 scopus 로고    scopus 로고
    • Determination of intracellular volume of rat and human sandwich-cultured hepatocytes (Abstract ID 1595)
    • Lee JK and Brouwer KR (2010) Determination of intracellular volume of rat and human sandwich-cultured hepatocytes (Abstract ID 1595). The Toxicologist. Supplement to Toxicological Sciences 114:339.
    • (2010) The Toxicologist. Supplement to Toxicological Sciences , vol.114 , pp. 339
    • Lee, J.K.1    Brouwer, K.R.2
  • 18
    • 73949093271 scopus 로고    scopus 로고
    • Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: Use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation
    • Lee JK, Marion TL, Abe K, Lim C, Pollack GM, and Brouwer KLR (2010) Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation. J Pharmacol Exp Ther 332:26-34.
    • (2010) J Pharmacol Exp Ther , vol.332 , pp. 26-34
    • Lee, J.K.1    Marion, T.L.2    Abe, K.3    Lim, C.4    Pollack, G.M.5    Brouwer, K.L.R.6
  • 19
    • 34248562942 scopus 로고    scopus 로고
    • Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1) by bosentan: A mechanism for species differences in hepatotoxicity
    • Leslie EM, Watkins PB, Kim RB, and Brouwer KLR (2007) Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1) by bosentan: a mechanism for species differences in hepatotoxicity. J Pharmacol Exp Ther 321:1170-1178.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 1170-1178
    • Leslie, E.M.1    Watkins, P.B.2    Kim, R.B.3    Brouwer, K.L.R.4
  • 20
    • 0031691798 scopus 로고    scopus 로고
    • Partial maintenance of taurocholate uptake by adult rat hepatocytes cultured in a collagen sandwich configuration
    • Liu X, Brouwer KLR, Gan LS, Brouwer KR, Stieger B, Meier PJ, Audus KL, and LeCluyse EL (1998) Partial maintenance of taurocholate uptake by adult rat hepatocytes cultured in a collagen sandwich configuration. Pharm Res 15: 1533-1539.
    • (1998) Pharm Res , vol.15 , pp. 1533-1539
    • Liu, X.1    Brouwer, K.L.R.2    Gan, L.S.3    Brouwer, K.R.4    Stieger, B.5    Meier, P.J.6    Audus, K.L.7    LeCluyse, E.L.8
  • 22
    • 37549011739 scopus 로고    scopus 로고
    • Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity
    • Marion TL, Leslie EM, and Brouwer KLR (2007) Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity. Mol Pharm 4:911-918.
    • (2007) Mol Pharm , vol.4 , pp. 911-918
    • Marion, T.L.1    Leslie, E.M.2    Brouwer, K.L.R.3
  • 25
    • 55049094158 scopus 로고    scopus 로고
    • Bile acids and signal transduction: Role in glucose homeostasis
    • Nguyen A and Bouscarel B (2008) Bile acids and signal transduction: role in glucose homeostasis. Cell Signal 20:2180-2197.
    • (2008) Cell Signal , vol.20 , pp. 2180-2197
    • Nguyen, A.1    Bouscarel, B.2
  • 26
    • 0019827506 scopus 로고
    • Contractility of bile canaliculi: Implications for liver function
    • Oshio C and Phillips MJ (1981) Contractility of bile canaliculi: implications for liver function. Science 212:1041-1042.
    • (1981) Science , vol.212 , pp. 1041-1042
    • Oshio, C.1    Phillips, M.J.2
  • 28
    • 65649124573 scopus 로고    scopus 로고
    • Bile-acid-induced cell injury and protection
    • Perez MJ and Briz O (2009) Bile-acid-induced cell injury and protection. World J Gastroenterol 15:1677-1689.
    • (2009) World J Gastroenterol , vol.15 , pp. 1677-1689
    • Perez, M.J.1    Briz, O.2
  • 29
    • 84891885073 scopus 로고    scopus 로고
    • Role of hepatic efflux transporters in regulating systemic and hepatocyte exposure to xenobiotics
    • Pfeifer ND, Hardwick RN, and Brouwer KLR (2014) Role of hepatic efflux transporters in regulating systemic and hepatocyte exposure to xenobiotics. Annu Rev Pharmacol Toxicol 54:509-535.
    • (2014) Annu Rev Pharmacol Toxicol , vol.54 , pp. 509-535
    • Pfeifer, N.D.1    Hardwick, R.N.2    Brouwer, K.L.R.3
  • 30
    • 84887981860 scopus 로고    scopus 로고
    • Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: Characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes
    • Pfeifer ND, Yang K, and Brouwer KLR (2013) Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes. J Pharmacol Exp Ther 347:727-736.
    • (2013) J Pharmacol Exp Ther , vol.347 , pp. 727-736
    • Pfeifer, N.D.1    Yang, K.2    Brouwer, K.L.R.3
  • 31
    • 0020365345 scopus 로고
    • A study of bile canalicular contractions in isolated hepatocytes
    • Phillips MJ, Oshio C, Miyairi M, Katz H, and Smith CR (1982) A study of bile canalicular contractions in isolated hepatocytes. Hepatology 2:763-768.
    • (1982) Hepatology , vol.2 , pp. 763-768
    • Phillips, M.J.1    Oshio, C.2    Miyairi, M.3    Katz, H.4    Smith, C.R.5
  • 32
    • 33645825217 scopus 로고    scopus 로고
    • Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione
    • Rius M, Hummel-Eisenbeiss J, Hofmann AF, and Keppler D (2006) Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione. Am J Physiol Gastrointest Liver Physiol 290:G640-G649.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , pp. G640-G649
    • Rius, M.1    Hummel-Eisenbeiss, J.2    Hofmann, A.F.3    Keppler, D.4
  • 33
    • 77952541012 scopus 로고    scopus 로고
    • Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes
    • Saha S, New LS, Ho HK, Chui WK, and Chan EC (2010) Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes. Toxicol Lett 195:135-141.
    • (2010) Toxicol Lett , vol.195 , pp. 135-141
    • Saha, S.1    New, L.S.2    Ho, H.K.3    Chui, W.K.4    Chan, E.C.5
  • 35
    • 33749838238 scopus 로고    scopus 로고
    • Determination of the hepatocellularity number for human, dog, rabbit, rat and mouse livers from protein concentration measurements
    • Sohlenius-Sternbeck AK (2006) Determination of the hepatocellularity number for human, dog, rabbit, rat and mouse livers from protein concentration measurements. Toxicol In Vitro 20:1582-1586.
    • (2006) Toxicol in Vitro , vol.20 , pp. 1582-1586
    • Sohlenius-Sternbeck, A.K.1
  • 36
    • 77954362516 scopus 로고    scopus 로고
    • Sandwich-cultured hepatocytes: An in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity
    • Swift B, Pfeifer ND, and Brouwer KLR (2010) Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity. Drug Metab Rev 42:446-471.
    • (2010) Drug Metab Rev , vol.42 , pp. 446-471
    • Swift, B.1    Pfeifer, N.D.2    Brouwer, K.L.R.3
  • 37
    • 81855206579 scopus 로고    scopus 로고
    • Effect of culture time on the basal expression levels of drug transporters in sandwich-cultured primary rat hepatocytes
    • Tchaparian EH, Houghton JS, Uyeda C, Grillo MP, and Jin L (2011) Effect of culture time on the basal expression levels of drug transporters in sandwich-cultured primary rat hepatocytes. Drug Metab Dispos 39:2387-2394.
    • (2011) Drug Metab Dispos , vol.39 , pp. 2387-2394
    • Tchaparian, E.H.1    Houghton, J.S.2    Uyeda, C.3    Grillo, M.P.4    Jin, L.5
  • 38
    • 15444373825 scopus 로고    scopus 로고
    • Molecular regulation of hepatobiliary transport systems: Clinical implications for understanding and treating cholestasis
    • Trauner M, Wagner M, Fickert P, and Zollner G (2005) Molecular regulation of hepatobiliary transport systems: clinical implications for understanding and treating cholestasis. J Clin Gastroenterol 39(4, Suppl 2):S111-S124.
    • (2005) J Clin Gastroenterol , vol.39 , Issue.4 , pp. S111-S124
    • Trauner, M.1    Wagner, M.2    Fickert, P.3    Zollner, G.4
  • 39
    • 0025720142 scopus 로고
    • Motility of bile canaliculi in the living animal: Implications for bile flow
    • Watanabe N, Tsukada N, Smith CR, and Phillips MJ (1991) Motility of bile canaliculi in the living animal: implications for bile flow. J Cell Biol 113:1069-1080.
    • (1991) J Cell Biol , vol.113 , pp. 1069-1080
    • Watanabe, N.1    Tsukada, N.2    Smith, C.R.3    Phillips, M.J.4
  • 40
    • 33645220583 scopus 로고    scopus 로고
    • Drug-induced liver injury: Summary of a single topic clinical research conference
    • Watkins PB and Seeff LB (2006) Drug-induced liver injury: summary of a single topic clinical research conference. Hepatology 43:618-631.
    • (2006) Hepatology , vol.43 , pp. 618-631
    • Watkins, P.B.1    Seeff, L.B.2
  • 41
    • 59649106641 scopus 로고    scopus 로고
    • Relationship between drug/metabolite exposure and impairment of excretory transport function
    • Zamek-Gliszczynski MJ, Kalvass JC, Pollack GM, and Brouwer KLR (2009) Relationship between drug/metabolite exposure and impairment of excretory transport function. Drug Metab Dispos 37:386-390.
    • (2009) Drug Metab Dispos , vol.37 , pp. 386-390
    • Zamek-Gliszczynski, M.J.1    Kalvass, J.C.2    Pollack, G.M.3    Brouwer, K.L.R.4
  • 42
    • 34547870567 scopus 로고    scopus 로고
    • Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis
    • Zollner G, Wagner M, Fickert P, Silbert D, Gumhold J, Zatloukal K, Denk H, and Trauner M (2007) Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis. Liver Int 27:920-929.
    • (2007) Liver Int , vol.27 , pp. 920-929
    • Zollner, G.1    Wagner, M.2    Fickert, P.3    Silbert, D.4    Gumhold, J.5    Zatloukal, K.6    Denk, H.7    Trauner, M.8


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