Contribution of high basolateral bile salt efflux to the lack of hepatotoxicity in rat in response to drugs inducing cholestasis in human

Toxicological Sciences

Volumn 115, Issue 1, 2010, Pages 80-88

  Jemnitz, Katalin ^a   Veres, Zsuzsa ^a   Vereczkey, László ^a  

^a CHEMICAL RESEARCH CENTER   (Hungary)

Author keywords

Bsep inhibition; Cholestasis; Hepatotoxicity; Sandwich cultured hepatocytes

Indexed keywords

CYCLOSPORIN A; GLIBENCLAMIDE; INDOMETACIN; KETOCONAZOLE; TAUROCHOLIC ACID; TROGLITAZONE; VERLUKAST; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ABC TRANSPORTER; ABCB11 PROTEIN, HUMAN; ABCB11 PROTEIN, RAT; ANTIDIABETIC AGENT; CHOLAGOGUE; CHROMAN DERIVATIVE; COTRANSPORTER; ORGANIC ANION TRANSPORTER; SODIUM BILE ACID COTRANSPORTER; SODIUM-BILE ACID COTRANSPORTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BASOLATERAL MEMBRANE; CELL LEVEL; CHOLESTASIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DRUG RESPONSE; ELIMINATION REACTION; HUMAN; HUMAN CELL; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; LIVER CELL; LIVER TOXICITY; NONHUMAN; RAT; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; INTRAHEPATIC CHOLESTASIS; MALE; METABOLISM; SPECIES DIFFERENCE; TOXIC HEPATITIS; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

RATTUS;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CHOLAGOGUES AND CHOLERETICS; CHOLESTASIS, INTRAHEPATIC; CHROMANS; DRUG-INDUCED LIVER INJURY; HUMANS; HYPOGLYCEMIC AGENTS; MALE; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; RATS; RATS, WISTAR; SPECIES SPECIFICITY; SYMPORTERS; TAUROCHOLIC ACID; THIAZOLIDINEDIONES;

EID: 79953081372     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq044     Document Type: Article

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