Use of Tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: Integration of in vitro, pharmacokinetic modeling, and simulation studies

Pharmaceutical Research

Volumn 25, Issue 8, 2008, Pages 1851-1860

  Ghibellini, Giulia ^a   Leslie, Elaine M ^a,b   Pollack, Gary M ^a   Brouwer, Kim L R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Biliary excretion; Hepatic transport; MRP2; OATPs; Pharmacokinetic modeling and simulation; Tc 99m mebrofenin

Indexed keywords

ESTRADIOL 17 GLUCURONIDE; MEBROFENIN; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 1B1; ORGANIC ANION TRANSPORTER 1B3; RIFAMPICIN; TECHNETIUM 99M; VERLUKAST;

ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; BILIARY EXCRETION; CELL STRAIN HEK293; CHOLESTASIS; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISPOSITION; DRUG ELIMINATION; DRUG EXCRETION; DRUG TRANSPORT; DRUG UPTAKE; GENETIC TRANSFECTION; HEPATOBILIARY SCINTISCANNING; HEPATOBILIARY SYSTEM; HUMAN; HUMAN CELL; HYPERBILIRUBINEMIA; IN VITRO STUDY; LIVER FUNCTION; MEMBRANE VESICLE; NONHUMAN; NORMAL HUMAN; OOCYTE; PRIORITY JOURNAL; SIMULATION; XENOPUS LAEVIS;

ANIMALS; BILE; BIOLOGICAL TRANSPORT; BIOLOGICAL TRANSPORT, ACTIVE; CELL MEMBRANE; CHOLESTASIS; COMPUTER SIMULATION; ESTRADIOL; GENETIC VECTORS; HUMANS; HYPERBILIRUBINEMIA; IMINO ACIDS; LIVER; MODELS, STATISTICAL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OOCYTES; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; ORGANOTECHNETIUM COMPOUNDS; PROTEIN BINDING; RADIOPHARMACEUTICALS; XENOPUS LAEVIS;

EID: 46749120546     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9597-0     Document Type: Article

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